Synthesis and detection method of L-2-(9H-fluoren-9-methoxycarbonylamino)-3-iodopropionic acid methyl ester
By using elemental iodine for iodination at low temperature, combined with sodium sulfite quenching and high-performance liquid chromatography detection, the problems of high cost, low safety and low purity in the existing technology are solved, and the safe, low-cost synthesis and efficient detection of high-purity L-2-(9H-fluorene-9-methoxycarbonylamino)-3-iodopropionate are realized.
CN122187690APending Publication Date: 2026-06-12上海吉奉生物科技有限公司
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- 上海吉奉生物科技有限公司
- Filing Date
- 2026-03-11
- Publication Date
- 2026-06-12
AI Technical Summary
Technical Problem
The existing production process of methyl L-2-(9H-fluorene-9-methoxycarbonylamino)-3-iodopropionate is characterized by high cost, low safety, low product purity, and the easy generation of peroxide impurities when using sodium iodide for iodination.
Method used
Iodination was carried out using elemental iodine at low temperature, and the reaction was quenched using a 10% sodium sulfite aqueous solution. The reaction was then detected by high-performance liquid chromatography, and the product was purified by filtration and mixed solvents to obtain a high-purity product.
Benefits of technology
A safe and low-cost synthesis process was achieved, with product purity exceeding 99%. The detection method is simple and accurate, avoiding the generation of peroxide impurities.
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Figure CN122187690A_ABST
Abstract
This application relates to the field of synthesis and detection technology of iodinated compounds, and discloses a chemical synthesis and detection method for methyl iodide-L-2-(9H-fluorene-9-methoxycarbonylamino)-3-iodopropionate, which mainly solves the technical problems of cost, safety, and purity detection in the production process. The invention includes the following steps: 1. Chemical synthesis process of the product; 2. Preparation of reagents for preparation; 3. High-performance liquid chromatography (HPLC) determination using an Agilent 1260 chromatograph with a VWD ultraviolet detector. The chromatographic column is packed with octadecylsilane-bonded silica gel (C18), and the mobile phase is a 0.025% formic acid aqueous solution (A) and a 0.025% formic acid acetonitrile solution (B). This invention improves the safety, reduces cost, and increases the purity of the chemical synthesis of methyl iodide-L-2-(9H-fluorene-9-methoxycarbonylamino)-3-iodopropionate.
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