A cefcapene pivoxil hydrochloride reaction device

Abstract

The application provides a cefcapene pivoxil hydrochloride reaction device, and relates to the technical field of drug synthesis reaction equipment, which comprises a reaction kettle, an annular block is rotatably installed on the outer circumferential surface of the reaction kettle through two groups of bearings, and an extension block body is arranged on the front side of the outer circumferential surface of the annular block. The meshing transmission structure of the motor, the driving gear and the outer circumferential gear of the reaction kettle is used in cooperation with the two groups of bearings to realize the rotating cooperation of the annular block and the reaction kettle, the annular block can accurately control the extension block body to rotate 1 / 6 of the circumference of the reaction kettle clockwise each time, and the whole circumference of the reaction kettle can be completely covered after six cycles of displacement, so that the forced and full-coverage inspection is realized from the mechanical structure, and the problems of missing inspection, incomplete coverage, insufficient investigation depth and personnel absence are solved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical synthesis reaction equipment technology, and in particular to a cefoperazone hydrochloride reaction apparatus. Background Technology

[0002] Cefcapin hydrochloride, a commonly used oral cephalosporin antibiotic in clinical practice, has extremely high requirements for the sealing, temperature stability, and pressure controllability of the reaction equipment during its synthesis process. As the core synthesis equipment, the reaction vessel needs to be inspected regularly to identify potential problems such as sealing failure, abnormal operating conditions, and component wear, so as to ensure the safety and controllability of the reaction process and the stability of product quality.

[0003] Currently, the reactors used in the synthesis process of cefotaxime hydrochloride are subject to strict inspections. Although the procedures require inspectors to conduct detailed checks around the reactor during routine inspections, the existing equipment lacks supporting mandatory constraints and process control mechanisms. In practice, inspections often only involve a simple check of a single facade of the equipment, resulting in problems such as missed areas, incomplete inspection coverage, and insufficient inspection depth. This makes it impossible to achieve full coverage inspection of the reactor without blind spots, making it difficult to accurately detect abnormalities in hidden parts of the equipment, and also makes it impossible to predict and identify potential operational failure risks in a timely manner, thus posing hidden dangers to the safe and stable operation of cephalosporin raw material synthesis and production. Furthermore, the lack of on-duty personnel identification functions makes it impossible to determine whether operators have arrived on time to complete inspections, which can easily lead to problems such as inspection absences and dereliction of duty, causing potential equipment operation hazards. Summary of the Invention

[0004] This invention relates to a cefcapine hydrochloride reaction apparatus, which solves the problems of existing cefcapine hydrochloride synthesis reactors lacking mandatory inspection constraints, process control and on-duty performance identification mechanisms, resulting in missed inspections, incomplete coverage, insufficient investigation depth and personnel absence from their posts during daily inspections.

[0005] This invention provides a cefoperazone hydrochloride reaction apparatus, specifically comprising: a reaction vessel, wherein an annular block is rotatably mounted on the outer peripheral surface of the reaction vessel via two sets of bearings, and an extension block is provided on the front side of the outer peripheral surface of the annular block; A mounting notch is provided between the top surface and the front surface of the extension block. A set of motors is fixedly installed on the bottom surface of the inner end of the mounting notch. The shaft end of the motor passes through the bottom surface of the extension block and a drive gear is fixedly installed through the drive shaft. A ring of gear teeth is fixedly installed on the outer circumference of the reactor in a uniform distribution pattern, and the gear teeth mesh with the drive gear; Each time the motor shaft rotates clockwise one revolution, the ring block rotates one-sixth of a revolution clockwise along the reactor via the meshing of the gear teeth and the drive gear.

[0006] Furthermore, the top surface of the extended block is lower than the top surface of the annular block, and a flashing indicator light strip is fixedly installed around the area from the top surface of the extended block to the top surface of the annular block on the outer peripheral surface of the annular block.

[0007] Furthermore, a microcontroller is installed inside the extended block, and the microcontroller is electrically connected to the flashing indicator light strip and the motor. The extension block is connected to the same power supply line as the reactor. The extended block is also equipped with a patrol timing module electrically connected to the microcontroller. The timing value of the patrol timing module is set according to the interval patrol time of the reactor.

[0008] Furthermore, a sensing groove is formed on the inner circumferential surface of the annular block relative to the left side of the extended block. A set of circumferential inspection feedback switches is fixedly installed inside the sensing groove. The circumferential inspection feedback switches are proximity switches and are electrically connected to the microcontroller. A mating sensing block that can be sensed and cooperated with the surrounding inspection feedback switch is fixedly installed on the front side of the outer periphery of the reactor. The mating sensing block and the sensing groove are on the same horizontal line. In the initial state, the sensing slot and the mating sensing block are in a staggered position, with the sensing slot located to the left of the mating sensing block and the mating sensing block not within the sensing range of the surrounding inspection feedback switch. When the sensing slot and the mating sensing block are aligned, the mating sensing block is within the sensing range of the surrounding inspection feedback switch.

[0009] Furthermore, a flashing light electrically connected to the microcontroller is fixedly installed on the left side of the front end face of the extension block; a surround check confirmation switch electrically connected to the microcontroller is fixedly installed on the right side of the front end face of the extension block; and an audible and visual alarm electrically connected to the microcontroller is fixedly installed on the top surface of the extension block.

[0010] Furthermore, the extended block is also equipped with a surround check timing module and a duty identification timing module electrically connected to the microcontroller; the timing value of the surround check timing module is one minute; the timing value of the duty identification timing module is ten seconds.

[0011] Furthermore, when the reactor is powered on and started, the inspection timing module starts timing synchronously. When the timing value of the inspection timing module is reached, the inspection timing module sends a feedback signal to the microcontroller. The microcontroller controls the flashing indicator light strip to start and also controls the surrounding inspection timing module to start timing at the same time. When the surround inspection feedback switch senses the mating sensing block, it sends a feedback signal to the microcontroller. The microcontroller then controls the surround inspection timing module and the flashing indicator light strip to turn off, and restarts the inspection timing module.

[0012] Furthermore, when the timing value of the surround inspection timing module is reached, the surround inspection timing module sends a feedback signal to the microcontroller, which controls the flashing light to start and simultaneously controls the watchkeeper identification timing module to start timing. When the timing value of the duty identification and timing module is reached, the duty identification and timing module sends a feedback signal to the microcontroller, and the microcontroller controls the sound and light alarm to start. When the surround check confirmation switch is pressed, the surround check confirmation switch sends a feedback signal to the microcontroller. The microcontroller controls the flashing light and the duty identification timing module to turn off, and at the same time controls the motor shaft to rotate clockwise one revolution, and restarts the surround check timing module.

[0013] This invention provides a cefoperazone hydrochloride reaction apparatus, which has the following beneficial effects: This invention relies on the meshing transmission structure of the motor, drive gear, and outer peripheral gear teeth of the reactor, and with the cooperation of two sets of bearings, realizes the rotational engagement between the annular block and the reactor. It can precisely control the annular block to drive the extension block to rotate 1 / 6 of the circumference clockwise along the reactor each time. After six cycles of shifting, it can completely cover all the areas to be inspected around the reactor. From the mechanical structure, it realizes forced, full-coverage inspection, completely avoiding the problem of missed inspections and inadequate inspections of local areas of the reactor during the synthesis of cefcapine hydrochloride, and ensuring the all-dimensional operation and maintenance management of the equipment.

[0014] This invention relies on a comprehensive, all-around inspection mechanism and an audible and visual alarm function for inspection omissions. It can detect abnormalities in key operating parameters such as the sealing status, temperature, and pressure of the reaction vessel in real time and comprehensively. This allows for early identification and prevention of equipment failures and production safety hazards in the synthesis process of cefoperazone hydrochloride, ensuring the personal safety of production personnel and ensuring a stable and controllable reaction process, thus maintaining the consistency and stability of product quality.

[0015] This invention utilizes three timing control modules: a patrol inspection timing module, a surround inspection timing module, and a duty identification timing module. It allows for flexible customization of timing parameters based on the actual patrol intervals of the cefoperazone hydrochloride synthesis reactor. Furthermore, through the linkage between the duty identification timing module and the surround inspection confirmation switch, combined with the logic judgment of the microcontroller, it can identify whether patrol personnel have arrived on time to complete the inspection confirmation. If the patrol personnel fail to press the confirmation switch within the specified time limit, the system will automatically trigger an audible and visual alarm, providing a direct warning of patrol absence or dereliction of duty, effectively avoiding potential equipment malfunctions caused by personnel negligence, and reinforcing the responsibility of maintenance personnel. Attached Figure Description

[0016] To more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings of the embodiments will be briefly described below.

[0017] The accompanying drawings described below are only related to some embodiments of the invention and are not intended to limit the invention.

[0018] In the attached diagram: Figure 1 This is an isometric structural diagram of the top of the present invention.

[0019] Figure 2 This is an isometric structural diagram of the bottom end of the present invention.

[0020] Figure 3 This is the invention Figure 2 Enlarged view of the structure at point A in the middle.

[0021] Figure 4 This is an isometric structural diagram of the top section of the present invention in its split state.

[0022] Figure 5 This is an isometric structural diagram of the bottom end of the present invention in its disassembled state.

[0023] Figure 6 This is the invention Figure 5 Enlarged view of the structure at point B in the middle.

[0024] Figure 7 This is the main view structural diagram of the present invention.

[0025] Figure 8 This is the invention Figure 7 Enlarged cross-sectional view of the central CC section.

[0026] Figure 9 This is a system composition block diagram of the present invention.

[0027] List of reference numerals 1. Reactor; 101. Gear teeth; 102. Bearing; 103. Fitting induction block; 2. Annular block; 201. Flashing indicator light strip; 202. Extension block; 203. Mounting notch; 204. Motor; 205. Drive gear; 206. Flashing light; 207. Surround inspection confirmation switch; 208. Audible and visual alarm; 209. Drive shaft; 2010. Induction slot; 2011. Surround inspection feedback switch; 2012. Inspection timing module; 2013. Surround inspection timing module; 2014. Duty identification timing module; 2015. Microcontroller. Detailed Implementation

[0028] refer to Figures 1 to 9 : This invention proposes a cefoperazone hydrochloride reaction apparatus, comprising: a reaction vessel 1, an annular block 2 rotatably mounted on the outer periphery of the reaction vessel 1 via two sets of bearings 102, and an extension block 202 disposed on the front side of the outer periphery of the annular block 2; An installation notch 203 is provided between the top surface and the front surface of the extension block 202. A set of motors 204 is fixedly installed on the bottom surface of the inner end of the installation notch 203. The shaft end of the motor 204 passes through the bottom surface of the extension block 202 and a drive gear 205 is fixedly installed through the drive shaft 209. A ring of gear teeth 101 is fixedly installed on the outer circumference of the reactor 1 in a uniformly distributed manner, and the gear teeth 101 mesh with the drive gear 205; Whenever the shaft of motor 204 rotates clockwise one revolution, the ring block 2 rotates one-sixth of a revolution clockwise along the reactor 1 through the meshing transmission of gear teeth 101 and drive gear 205; The top surface of the extension block 202 is lower than the top surface of the ring block 2. A flashing indicator light strip 201 is fixedly installed around the outer periphery of the ring block 2 relative to the area from the top surface of the extension block 202 to the top surface of the ring block 2. A microcontroller 2015 is provided inside the extension block 202. The microcontroller 2015 is electrically connected to the flashing indicator light strip 201 and the motor 204. The extension block 202 shares the same power supply line as the reactor 1; The extension block 202 is also equipped with an inspection timing module 2012 electrically connected to the microcontroller 2015. The timing value of the inspection timing module 2012 is matched and set according to the interval inspection time of the reactor 1. A sensing groove 2010 is opened on the inner circumferential surface of the annular block 2 relative to the left side of the extension block 202. A set of surrounding inspection feedback switches 2011 is fixedly installed inside the sensing groove 2010. The surrounding inspection feedback switches 2011 are proximity switches and are electrically connected to the microcontroller 2015. A mating sensing block 103 is fixedly installed on the front side of the outer periphery of the reactor 1, which can be sensed and cooperated with the surrounding inspection feedback switch 2011. The mating sensing block 103 and the sensing groove 2010 are on the same horizontal line. In the initial state, the sensing slot 2010 and the mating sensing block 103 are in a staggered position. The sensing slot 2010 is located to the left of the mating sensing block 103, and the mating sensing block 103 is not within the sensing range of the surrounding inspection feedback switch 2011. When the sensing slot 2010 and the mating sensing block 103 are in corresponding positions, the mating sensing block 103 is within the sensing range of the surrounding inspection feedback switch 2011.

[0029] Furthermore, a flashing light 206 electrically connected to the microcontroller 2015 is fixedly installed on the left side of the front end face of the extension block 202; a surround check confirmation switch 207 electrically connected to the microcontroller 2015 is fixedly installed on the right side of the front end face of the extension block 202; an audible and visual alarm 208 electrically connected to the microcontroller 2015 is fixedly installed on the top surface of the extension block 202; the extension block 202 also has a surround check timing module 2013 and a duty identification timing module 2014 electrically connected to the microcontroller 2015 inside; the timing value of the surround check timing module 2013 is one minute; the timing value of the duty identification timing module 2014 is ten seconds.

[0030] When the reactor 1 is powered on, the inspection timing module 2012 starts timing synchronously. When the timing value of the inspection timing module 2012 is reached, the inspection timing module 2012 sends a feedback signal to the microcontroller 2015. The microcontroller 2015 controls the flashing indicator light strip 201 to start, and at the same time controls the surrounding inspection timing module 2013 to start timing. When the surround inspection feedback switch 2011 senses the cooperating sensing block 103, the surround inspection feedback switch 2011 sends a feedback signal to the microcontroller 2015. The microcontroller 2015 controls the surround inspection timing module 2013 and the flashing indicator light strip 201 to turn off, and controls the inspection timing module 2012 to start timing again. When the timing value of the surround inspection timing module 2013 is reached, the surround inspection timing module 2013 sends a feedback signal to the microcontroller 2015, and the microcontroller 2015 controls the flashing light 206 to start, and at the same time controls the duty identification timing module 2014 to start timing. When the timing value of the duty identification timing module 2014 is reached, the duty identification timing module 2014 sends a feedback signal to the microcontroller 2015, and the microcontroller 2015 controls the sound and light alarm 208 to start. When the surround check confirmation switch 207 is pressed, the surround check confirmation switch 207 sends a feedback signal to the microcontroller 2015. The microcontroller 2015 controls the flashing light 206 and the duty identification timing module 2014 to turn off. At the same time, it also controls the shaft of the motor 204 to rotate clockwise one revolution and restarts the surround check timing module 2013.

[0031] Working principle: After the reactor 1 is powered on and started, following the industrial synthesis process specifications of cefoperazone hydrochloride, the core reaction unit operations such as precise quantitative feeding, closed temperature and pressure control, condensation-esterification-salt formation series reaction, liquid-liquid layer washing and impurity removal, low temperature crystallization and vacuum drying are completed in sequence to start the drug synthesis reaction. Since the extension block 202 is connected to the same power supply line as the reactor 1, the inspection timing module 2012 starts synchronously when the reactor 1 is powered on. The timing value of the inspection timing module 2012 is matched and set according to the interval inspection time of the reactor 1, providing a time reference for timed inspection. When the timing value of the inspection timing module 2012 is reached, the inspection timing module 2012 sends a feedback signal to the microcontroller 2015. The microcontroller 2015 controls the flashing indicator light strip 201 to start, and at the same time controls the timing of the surround inspection timing module 2013 to start. The flashing indicator light strip 201 visually reminds the inspection personnel that a standard inspection of reactor 1 is required at this time. The timing value of the surround inspection timing module 2013 is one minute, allowing sufficient time for the current inspection personnel to conduct a detailed inspection of the corresponding area of ​​the reactor 1 based on the area where the extension block 202 is located. When the timing value of the surround inspection timing module 2013 is reached, the surround inspection timing module 2013 sends a feedback signal to the microcontroller 2015, and the microcontroller 2015 controls the flashing light 206 to start, and at the same time controls the duty identification timing module 2014 to start timing. By flashing the flashing light 206, a more conspicuous single-point flashing prompts the inspection personnel to conduct inspection and confirmation; The duty identification and timing module 2014 has a timing value of ten seconds. It determines whether the inspection personnel have performed the inspection operation on the reactor 1 within the prescribed time, accurately determining whether the inspection personnel are on duty. If they have not come as required, the duty identification and timing module 2014 cannot be turned off. When the timing value of the duty identification and timing module 2014 is reached, the duty identification and timing module 2014 sends a feedback signal to the microcontroller 2015. The microcontroller 2015 controls the sound and light alarm 208 to start, realizing the warning alarm and reminding that the inspection of the reactor 1 is not in place and there is an operational risk. If the inspection personnel perform the inspection operation on the reactor 1 at the prescribed time, the flashing light 206 will remind them. At this time, they can press the surround inspection confirmation switch 207. The surround inspection confirmation switch 207 will send a feedback signal to the microcontroller 2015. The microcontroller 2015 will control the flashing light 206 and the duty identification timing module 2014 to turn off. At the same time, it will also control the shaft of the motor 204 to rotate clockwise one revolution and restart the surround inspection timing module 2013. Because every time the shaft end of motor 204 rotates clockwise one revolution, the ring block 2 rotates clockwise one-sixth revolution along reactor 1 through bearing 102 via gear 101 and drive gear 205. Therefore, at this time, the extension block 202 rotates to the next area to be inspected in reactor 1, and the timing is started again based on the timing of the surrounding inspection timing module 2013, and the above operation is repeated. Based on the above clockwise rotation cycle operation steps, the extension block 202 repeats the process of "checking the timing → prompting confirmation → shifting" after each shift. Through six cycles of shifting, it can cover all areas around the reactor 1, forcibly achieving a comprehensive and thorough inspection of the reactor 1 without any blind spots, and eliminating the problem of missing inspection in some areas. As the extension block 202 rotates to the initial position area of ​​the reactor 1, at a certain moment, the sensing groove 2010 will be in a positional correspondence with the mating sensing block 103. At this time, the mating sensing block 103 is within the sensing range of the surrounding inspection feedback switch 2011. After the surrounding inspection feedback switch 2011 senses the mating sensing block 103, it sends a feedback signal to the microcontroller 2015. The microcontroller 2015 controls the surrounding inspection timing module 2013 and the flashing indicator light strip 201 to turn off, and restarts the inspection timing module 2012, thus completing one inspection operation and waiting for the next inspection operation, forming a complete inspection control closed loop.

Claims

1. A cefoperazone hydrochloride reaction apparatus, comprising a reaction vessel (1), characterized in that, An annular block (2) is rotatably mounted on the outer periphery of the reactor (1) via two sets of bearings (102), and an extension block (202) is provided on the front side of the outer periphery of the annular block (2). An installation notch (203) is provided between the top surface and the front surface of the extension block (202). A set of motors (204) is fixedly installed on the bottom surface of the inner end of the installation notch (203). The shaft end of the motor (204) passes through the bottom surface of the extension block (202) and a drive gear (205) is fixedly installed through the drive shaft (209). The outer circumferential surface of the reactor (1) is fixedly equipped with a ring of gear teeth (101) in a uniform distribution, and the gear teeth (101) mesh with the drive gear (205); Whenever the shaft end of the motor (204) rotates clockwise one revolution, the ring block (2) rotates one-sixth revolution clockwise along the reactor (1) through the meshing transmission of the gear teeth (101) and the drive gear (205); A flashing indicator light strip (201) is fixedly installed on the outer circumference of the annular block (2); The extension block (202) is equipped with a microcontroller (2015) and an inspection timing module (2012), a surround inspection timing module (2013), and a duty identification timing module (2014) that are electrically connected to it. The microcontroller (2015) is electrically connected to the flashing indicator light strip (201); An induction slot (2010) is provided on the inner circumferential surface of the annular block (2). A set of circumferential inspection feedback switches (2011) is fixedly installed inside the induction slot (2010). The circumferential inspection feedback switches (2011) are electrically connected to the microcontroller (2015). The outer peripheral surface of the reactor (1) is fixedly equipped with a matching induction block (103); The extension block (202) is fixedly equipped with a flashing light (206), a surround check confirmation switch (207), and an audible and visual alarm (208) that are electrically connected to the microcontroller (2015). When the reactor (1) is powered on, the inspection timing module (2012) starts timing synchronously. When the timing value of the inspection timing module (2012) is reached, the inspection timing module (2012) sends a feedback signal to the microcontroller (2015). The microcontroller (2015) controls the flashing indicator light strip (201) to start, and at the same time controls the surrounding inspection timing module (2013) to start timing. When the surround inspection feedback switch (2011) senses the mating sensing block (103), the surround inspection feedback switch (2011) sends a feedback signal to the microcontroller (2015), the microcontroller (2015) controls the surround inspection timing module (2013) and the flashing indicator light strip (201) to turn off, and controls the inspection timing module (2012) to start timing again; When the timing value of the surround inspection timing module (2013) is reached, the surround inspection timing module (2013) sends a feedback signal to the microcontroller (2015), and the microcontroller (2015) controls the flashing light (206) to start, and at the same time controls the duty identification timing module (2014) to start timing; When the timing value of the duty identification timing module (2014) is reached, the duty identification timing module (2014) sends a feedback signal to the microcontroller (2015), and the microcontroller (2015) controls the sound and light alarm (208) to start. When the surround check confirmation switch (207) is pressed, the surround check confirmation switch (207) sends a feedback signal to the microcontroller (2015), which controls the flashing light (206) and the duty identification timing module (2014) to turn off. At the same time, it also controls the shaft of the motor (204) to rotate clockwise one revolution and restarts the surround check timing module (2013) timing.

2. The cefoperazone hydrochloride reaction apparatus according to claim 1, characterized in that, The top surface of the extended block (202) is lower than the top surface of the annular block (2); A flashing indicator light strip (201) is arranged around the area from the top surface of the extension block (202) to the top surface of the ring block (2).

3. The cefoperazone hydrochloride reaction apparatus according to claim 1, characterized in that, The microcontroller (2015) is electrically connected to the motor (204); The extension block (202) is connected to the reactor (1) via the same power supply line; The timing value of the inspection timing module (2012) is set according to the interval inspection time of the reactor (1).

4. The cefoperazone hydrochloride reaction apparatus according to claim 1, characterized in that, The sensing groove (2010) is located on the left side of the extension block (202); The surround inspection feedback switch (2011) is a proximity switch; The matching sensing block (103) is fixedly installed on the front side of the outer periphery of the reactor (1); the matching sensing block (103) can be sensing and matching with the surrounding inspection feedback switch (2011), and the matching sensing block (103) and the sensing groove (2010) are on the same horizontal line; In the initial state, the sensing slot (2010) and the mating sensing block (103) are in a staggered position. The sensing slot (2010) is located to the left of the mating sensing block (103), and the mating sensing block (103) is not within the sensing range of the surrounding inspection feedback switch (2011). When the sensing slot (2010) and the mating sensing block (103) are in corresponding positions, the mating sensing block (103) is within the sensing range of the surrounding inspection feedback switch (2011).

5. The cefoperazone hydrochloride reaction apparatus according to claim 1, characterized in that, The flashing light (206) is fixedly installed on the left side of the front end face of the extension block (202); the surround check confirmation switch (207) is fixedly installed on the right side of the front end face of the extension block (202); the audible and visual alarm (208) is fixedly installed on the top surface of the extension block (202).

6. The cefoperazone hydrochloride reaction apparatus according to claim 1, characterized in that, The timing value of the surround inspection timing module (2013) is one minute; the timing value of the duty identification timing module (2014) is ten seconds.

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