A multi-microsphere microfluidic chip, a co-coating instrument and a multi-microsphere microfluidic method

By designing a multi-microsphere microfluidic chip with gradient channel width and flow channel layout, and combining it with pneumatic drive, passive synchronization of multiple microspheres was achieved, solving the problem of low microsphere co-encapsulation efficiency in microfluidic systems, simplifying manufacturing and improving co-encapsulation rate and system simplicity.

CN122209505APending Publication Date: 2026-06-16SHANGHAI DAPU BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI DAPU BIOTECHNOLOGY CO LTD
Filing Date
2026-04-22
Publication Date
2026-06-16

AI Technical Summary

Technical Problem

Existing microfluidic systems struggle to achieve efficient co-encapsulation of multiple types of microspheres without complex external control. Traditional solutions have high requirements for microsphere size consistency and flow rate matching, resulting in complex structures and high manufacturing difficulty.

Method used

A multi-microsphere microfluidic chip is designed, which adopts a merging section with a gradually varying channel width and a microsphere coupling region. Combined with the flow channel layout and air pressure drive, the microspheres are buffered and arranged in a single row. The passive synchronization of the microspheres is achieved through a flow resistance coupling mechanism.

Benefits of technology

It increases the probability of multiple microspheres entering the same droplet in a one-to-one correspondence, reduces the generation of empty droplets and multi-sphere droplets, simplifies the drive system, reduces manufacturing difficulty and cost, and is suitable for high-throughput operation.

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Abstract

The application discloses a kind of multi-microsphere microfluidic chip, co-wrapping instrument and multi-microsphere microfluidic method, microfluidic chip includes at least one chip unit, reagent flow channel is equipped on chip unit, and it is sequentially merged into multiple microsphere flow channels and oil phase flow channel along the flow direction of reagent flow channel, then confluence forms outlet flow channel;Every microsphere flow channel is equipped with merging-in portion, and is connected reagent flow channel by merging-in portion, and the channel width of merging-in portion is gradually set, and along the flow direction of fluid, its channel width presents the trend of decreasing;The reagent flow channel section between the last one of multiple microsphere flow channels and the oil phase flow channel constitutes microsphere coupling region.The application can improve the probability that multiple microspheres one-to-one correspond to enter the same droplet without external complex control, and reduce the generation of empty droplet and multi-sphere droplet.
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