Solution injection device and method for using a solution injection device

Abstract

The application discloses a solution injection device and a solution injection device use method in the technical field of liquid injection production. The solution injection device comprises an object phase output mechanism and an actuating mechanism. The vibration generated by the actuating mechanism is transmitted to the needle tube, so that the conical tip nozzle of the needle tube reciprocates at a certain frequency, and the air near the conical tip nozzle forms a sound vortex to promote the diffusion phase to be sprayed from the needle tube. The solution injection device use method comprises the following steps: S1, preparing a diffusion phase; S2, sucking the diffusion phase by a syringe, selecting a 30G metal sharpened needle, and connecting the syringe and a syringe pump; S3, setting the pump-out flow q of the syringe pump and the working parameters of the actuator. Through the effect of the sound vortex effect, the diffusion phase is continuously sprayed from the needle tube, so that the volume of the liquid droplets sprayed by the liquid is homogenized, and different spraying states of the liquid are realized, so as to meet the demand of the actual situation on different liquid spraying states.

Description

Technical Field

[0001] This invention belongs to the field of liquid jetting technology, specifically relating to a solution jetting device and its usage method. Background Technology

[0002] In recent years, liquid jetting technology has been widely used in various technological fields such as military, mechanical engineering, and biomedicine. For example, in the medical field, liquid jetting technology can control the size of aerosol particles to improve the absorption efficiency of drugs or related nutrients.

[0003] Traditional liquid jetting technologies include pressure jetting and pneumatic jetting. Pressure jetting, based on Bernoulli's principle, involves a liquid being pressurized by a high-pressure pump and ejected at high speed through a nozzle. Due to the reduced cross-sectional area of ​​the flow channel at the nozzle, the liquid velocity increases, the pressure decreases, and surrounding gas is entrained, causing the liquid to break into droplets. Pneumatic jetting, on the other hand, relies on the impact and friction between a high-speed airflow and the liquid jet, causing uneven forces on the liquid surface and resulting in droplet breakage. Existing liquid jetting technologies offer a limited range of liquid jetting patterns, failing to adequately meet the diverse needs of real-world applications, and suffer from low jetting efficiency and uneven droplet size. Summary of the Invention

[0004] The purpose of this invention is to disclose a solution jetting device and a method for using the solution jetting device, which can effectively realize various liquid jetting patterns, improve the liquid jetting rate, and achieve uniform droplet size.

[0005] To achieve the above objectives, the present invention discloses a solution spraying device comprising: A diffusion phase output mechanism includes a needle tube, one end of which is provided with a conical tip nozzle for releasing the diffusion phase, and the other end for replenishing the diffusion phase; The actuation mechanism includes a mounting bracket and a Luer connector, the Luer connector being fixedly connected to the mounting bracket, and the needle tube communicating with the Luer connector; the mounting bracket is provided with an actuator, the direction of the output vibration of the actuator being perpendicular to the length direction of the needle tube.

[0006] As an optional implementation, the diffusion phase output mechanism further includes a syringe and an injection pump; the syringe is used to store the diffusion phase; one end of the syringe is equipped with the injection pump, and the other end is connected to the Luer connector via a hose.

[0007] As an optional implementation, the mounting bracket has a cavity that mates with the Luer connector. The cavity has a locking block for positioning the Luer connector and a reinforcing opening for securing the Luer connector. The reinforcing opening has fasteners for fixing the Luer connector to the mounting bracket.

[0008] As an optional implementation, the mounting bracket is provided with a positioning hole, the normal of which is perpendicular to the length direction of the needle tube, and the positioning hole is used to fix the actuator.

[0009] As an optional implementation, the syringe diameter is selected from 18G to 34G, and the length is ≥6.5mm.

[0010] Another aspect of the present invention discloses a method of using a solution spraying device, comprising: S1. Using pure water as a solvent, prepare a 1% lecithin solution as the diffusion phase; S2. Use a syringe to draw in the diffusion phase, and select a 30G metal ground-tipped needle as the syringe tube; connect the syringe to the injection pump, and connect the injection pump to the metal ground-tipped needle through a tubing; S3. Set the operating parameters of the equipment, including the pumping flow rate q of the injection pump being in the range of 10μL / min-2000μL / min, the operating voltage U, operating frequency f1, and stopping frequency f2 of the actuator when it is working; wherein, the operating voltage U is in the range of 20V-120V, the operating frequency f1 is in the range of 7kHz-9.2kHz, and the stopping frequency f2 is in the range of 2Hz-100Hz.

[0011] As an optional implementation, the metal-tipped needle is selected as the needle tube, the working voltage U is set to 30V, the working frequency f1 is set to 7.2kHz, and the pump flow rate q is set to the range of 10μL / min-500μL / min, so that the diffused phase is sprayed in a mist.

[0012] As an optional implementation, the metal-tipped needle is selected as the needle tube, the working voltage U is set to 30V, the working frequency f1 is set to 7.2kHz, and the pump flow rate q is set to 1000μL / min, so that the diffused phase is sprayed in a jet shape.

[0013] As an optional implementation, a mixture of paraffin oil and 5% emulsifying stabilizer is used as the receiving phase, and the receiving phase is placed in a petri dish to receive droplets ejected from the metal-tipped needle; the petri dish is then continuously rotated at 90 rpm for 20 minutes.

[0014] As an optional implementation, a solution of 0.5% w / v sodium alginate prepared with pure water is selected as the diffusion phase, and a calcium chloride solution with a concentration of 1% w / v is selected as the receiving phase; the pump flow rate q of the diffusion phase is set to 50 μL / min, the voltage U is set to 20V, and the operating frequency f1 is set to 8.9kHz.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: (1) In the solution jetting device, the diffuse phase is released through the conical tip of the needle tube, and the direction of the actuator output vibration is perpendicular to the length direction of the needle tube. This facilitates the high-frequency radial oscillation of the needle tube, causing the diffuse phase to flow out from the nozzle of the conical tip under the action of centrifugal force, and the outflowing diffuse phase can break up in a uniform volume, thereby achieving the technical effect of uniform droplet size in the jetting.

[0016] (2) In the solution spraying device, an actuator is provided on the mounting bracket. Through the high-frequency vibration of the actuator, a high-throughput droplet is formed at the conical tip nozzle of the needle tube to improve the liquid spraying efficiency.

[0017] (3) In the method of using the solution jetting device, by adjusting the pumping flow rate q, voltage U, working frequency f1 and stopping frequency f2 of the injection pump, the conical tip nozzle vibrates at a specific frequency to control the volume and frequency of the ejected droplets, and to make the diffused phase liquid near the conical tip nozzle ejected from the conical tip in different forms to meet the diverse needs of reality. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0019] Figure 1 This is a structural diagram of the solution jetting device disclosed in this invention; Figure 2 This is a cross-sectional view of the mounting bracket disclosed in this invention; Figure 3 This is a perspective view of the mounting bracket disclosed in this invention; Figure 4 This is a flowchart of the usage method disclosed in this invention; Figure 5 It is a waveform diagram of the composite frequency of the actuator input voltage; Figure 6 This is a schematic diagram of the diffused phase inside the needle being sprayed out in an atomized state, as disclosed in this invention. Figure 7 This is a schematic diagram of the diffused phase inside the needle being ejected in a jet state, as disclosed in this invention. Figure 8 This is a schematic diagram showing how the state of liquid ejected from the syringe changes with the pump flow rate q, as disclosed in this invention. Figure 9This is a schematic diagram of a petri dish that receives sprayed droplets, as disclosed in this invention. Explanation of key figure labels: 1. Diffusion phase output mechanism; 11. Needle tube; 111. Conical tip nozzle; 2. Actuating mechanism; 21. Mounting bracket; 211. Cavity; 212. Locking block; 213. Reinforcing port; 214. Positioning hole; 22. Luer connector; 221. Hoses; 23. Actuator; 3. Petri dish; D1, Preset direction; Detailed Implementation The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0020] In this invention, the terms "upper," "lower," "left," "right," "front," "rear," "top," "bottom," "inner," "outer," "middle," "vertical," "horizontal," "lateral," and "longitudinal" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for the purpose of better describing the invention and its embodiments, and are not intended to limit the indicated devices, elements, or components to having a specific orientation, or to be constructed and operated in a specific orientation.

[0021] Furthermore, in addition to indicating direction or positional relationship, some of the aforementioned terms may also have other meanings. For example, the term "above" may also be used in certain situations to indicate a dependency or connection. Those skilled in the art can understand the specific meaning of these terms in this invention based on the specific circumstances.

[0022] Furthermore, the terms "installation," "setup," "equipped with," "connection," and "linked" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral structure; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium, or an internal connection between two devices, components, or parts. Those skilled in the art can understand the specific meaning of these terms in this invention based on the specific circumstances.

[0023] Furthermore, the terms "first," "second," etc., are primarily used to distinguish different devices, components, or parts (which may be the same or different in specific type and construction), and are not intended to indicate or imply the relative importance or quantity of the indicated devices, components, or parts. Unless otherwise stated, "a plurality of" means two or more.

[0024] The technical solution of the present invention will be further described below with reference to the embodiments and accompanying drawings.

[0025] Please see Figure 1 As shown, one embodiment of this application discloses a solution jetting device, including a diffusion phase output mechanism 1 and an actuation mechanism 2. The diffusion phase output mechanism 1 is used to continuously supply diffusion phase liquid. The diffusion phase output mechanism 1 includes a needle 11, one end of which is provided with a conical nozzle 111 for releasing the diffusion phase, and the other end for replenishing the diffusion phase. The needle 11 is a commercially available needle, which has the characteristics of higher safety, reliability, accuracy and durability.

[0026] The function of the actuation mechanism 2 is to provide a vibration source, causing the needle tube 11 to swing along the preset direction D1, so that the diffused phase is continuously ejected from the conical tip nozzle 111.

[0027] The actuation mechanism 2 includes a mounting bracket 21 and a Luer connector 22. The Luer connector 22 is fixedly connected to the mounting bracket 21, and the needle tube 11 is connected to the Luer connector 22. An actuator 23 is provided on the mounting bracket 21. The vibration generated by the actuator 23 is transmitted to the needle tube 11 through the mounting bracket 21, causing the conical tip nozzle 111 of the needle tube 11 to swing along a preset direction D1. Through the high-frequency vibration of the actuator, a high-throughput droplet is formed at the conical tip nozzle 111 of the needle tube 11, thereby improving the liquid jetting efficiency.

[0028] The diffused phase is released through the conical tip of the needle tube 11, and the direction of the vibration output by the actuator 23 is perpendicular to the length direction of the needle tube 11. This facilitates high-frequency radial oscillation of the needle tube 11. Furthermore, the tapered nozzle 111 with its gradually decreasing diameter at the end of the needle tube 11 promotes the formation of at least one pair of acoustic vortices with opposite flow directions near the nozzle 111. As the diffused phase flows out from the nozzle 111, it is formed into uniformly sized droplets under the action of the acoustic vortices, achieving a technical effect of uniform droplet size.

[0029] In some embodiments, the diffusion phase output mechanism 1 further includes a syringe and an injection pump. The syringe is used to store the diffusion phase, and one end of the syringe is equipped with an injection pump, while the other end is connected to a Luer connector 22 via a hose 221.

[0030] Syringes, as storage containers for the diffusing phase, typically have precise graduations, allowing for the metered loading of a specific volume of the diffusing phase liquid, facilitating volume pre-setting before experiments or production. The cylindrical cavity and piston structure of the syringe provide a sound mechanical basis for the stable delivery of the diffusing phase liquid. A syringe pump is a high-precision fluid delivery device capable of driving the syringe piston with extremely precise speed and volume, thereby controlling the flow rate and supply rate of the diffusing phase liquid. By setting different pump speeds, a micro-volume, continuous, and stable supply of the diffusing phase can be achieved.

[0031] The Luer connector 22 is a standardized medical-grade connection interface, characterized by tight connection, good sealing, and convenient assembly and disassembly, effectively preventing leakage of the diffused phase liquid or external contamination. The tubing 221 connects the injection pump and the syringe 11, providing flexible transmission, which facilitates spatial layout and device integration, and also mitigates the direct impact of mechanical vibration on the syringe or pump, protecting the stability of the diffused phase output mechanism 1.

[0032] Please see Figure 2 and Figure 3 As shown, in some embodiments, the mounting bracket 21 has a cavity 211 for mating with the Luer connector 22. The cavity 211 has a locking block 212 for quickly positioning the Luer connector 22 and a reinforcing port 213 for reinforcing the Luer connector 22. The reinforcing port 213 has fasteners for fixing the Luer connector 22 and the mounting bracket 21.

[0033] The cavity 211 within the mounting bracket 21 is shaped to match the external contour of the Luer connector 22, enabling physical positioning and guidance of the Luer connector 22. This ensures accurate positioning and proper insertion of the Luer connector 22 during installation, preventing misalignment or displacement between the Luer connector 22 and the mounting bracket 21. One end of the Luer connector 22 typically has a groove. Through the cooperation of the groove and the locking block 212, the Luer connector 22, after being assembled into the cavity 211, can quickly maintain a relatively fixed positional relationship with the mounting bracket 21.

[0034] The reinforcing port 213 is generally located at a position different from the threaded connection between the Luer connector 22 and the mounting bracket 21. It is generally located on the side of the mounting bracket 21 or in the radial direction of the Luer connector 22. The interior of the reinforcing port 213 is equipped with fasteners, such as screws, clips or clamping rings, which can apply clamping or fixing force to the Luer connector 22 from the side or radial direction, further preventing it from rotating, shaking or axially displacing.

[0035] Especially in scenarios involving high-frequency vibration or long-term operation, this dual fixing mechanism, namely the positioning of the locking block 212 and the further reinforcement of the reinforcing port 213, can effectively prevent connection failure between the Luer connector 22 and the mounting bracket 21, ensuring that the liquid injection device as a whole maintains a stable operating state.

[0036] In some embodiments, the mounting bracket 21 is provided with a positioning hole 214, the normal of the positioning hole 214 is perpendicular to the length direction of the needle tube 11, and the positioning hole 214 is used to fix the actuator 23.

[0037] The positioning hole 214 provides a clear mounting reference point for the actuator 23, enabling the actuator 23 to be precisely positioned during installation while maintaining a position perpendicular to the length direction of the needle tube 11. This ensures that the direction of motion output by the actuator 23 is orthogonal to the length direction of the needle tube 11, guaranteeing that the needle tube 11 swings along the preset direction D1.

[0038] The actuator 23 is precisely fixed in the optimal operating position relative to the syringe 11 via the positioning hole 214, generally near the nozzle. The vibration generated by the actuator 23 can be transmitted to the syringe 11 through the mounting bracket 21 via the shortest and most direct path, reducing energy loss and transmission error. At the same time, since the positioning hole 214 restricts the installation direction of the actuator 23, that is, the output vibration direction of the actuator 23 is perpendicular to the length direction of the syringe 11, the syringe 11 can swing precisely along the preset direction D1, avoiding invalid or interfering force components, such as axial force, from affecting the injection process.

[0039] In some embodiments, when assembling the actuator 23, Luer connector 22 and its associated fasteners onto the mounting bracket 21, resin may be applied at the connection point with the mounting bracket 21.

[0040] Resins such as epoxy resin, quick-drying adhesive, and structural adhesive possess high strength, strong adhesion, and good durability after curing. Applying resin to the connection interface between the actuator 23, Luer connector 22, or fasteners and the mounting bracket 21 firmly bonds these components to the bracket, creating a dual fixing effect of mechanical locking and chemical adhesion. Under conditions of high-frequency vibration or dynamic loads from the actuator 23, resin bonding can effectively prevent problems such as screw loosening and connector displacement. Resin can fill tiny gaps, uneven surfaces, or assembly gaps, further improving the overall airtightness of the solution spraying device.

[0041] In some embodiments, the diameter of the needle 11 is selected from 18G to 34G, and the length is ≥6.5mm. As the diameter of the needle 11 increases, the power required to drive the needle 11 to oscillate at a certain frequency is greater, meaning the operating voltage of the actuator 23 increases. Consequently, the droplet volume generated by the needle 11 is also larger, and the radiation range of the liquid ejected from the tip of the needle 11 decreases. Replacing the needle 11 with a larger diameter needle allows for more concentrated liquid jetting, meeting the needs of precise aiming or localized applications, such as medical injections or precision coatings.

[0042] Under the same vibration conditions, a needle tube 11 with a shorter length experiences less deflection, making it less likely to vibrate and the liquid to be ejected from the conical nozzle 111. When the length of the needle tube 11 is ≥6.5mm, as the length of the needle tube 11 increases, the oscillation amplitude during vibration increases, and the radiation range of the liquid ejection increases. The liquid ejection range can be controlled by replacing the needle tube 11 with needle tubes of different lengths.

[0043] The needle 11 can be made of either a metal-tipped needle or a polypropylene TT needle. The metal-tipped needle has the advantages of high hardness and rigidity. Under the action of the actuator 23, the metal-tipped needle 11 more easily transmits and amplifies vibrations, thus allowing it to adapt to various spraying modes, from atomization to continuous jetting. By adjusting the vibration parameters, it is possible to switch between atomization and jetting to meet different application requirements.

[0044] The metal-tipped needle 11 vibrates more noticeably and is easier to switch between atomization and jet modes. The polypropylene TT needle tip is typically made of softer plastic, resin, or specially coated metal, exhibiting high flexibility and low rigidity, making the needle tip less prone to significant deformation due to vibration. The vibration energy of the actuator 23 is easily absorbed or weakened in the soft needle 11, resulting in significant vibration attenuation of the polypropylene TT needle tip. The polypropylene TT needle 11 is suitable for liquid jet injection modes. Due to the absence of vibration interference, the jet mode is more uniform and continuous, suitable for scenarios requiring stable liquid delivery, such as industrial injection and large-dose injection. It is also less prone to clogging. The polypropylene TT needle 11 is better suited for certain viscous or particulate liquids.

[0045] The smaller the G-value, the larger the inner diameter of the needle 11, resulting in less resistance to liquid flow, a larger flow rate, and a faster flow velocity, making it suitable for conveying low-viscosity, high-flow-rate liquids. The larger the G-value, the smaller the inner diameter of the needle 11, resulting in greater resistance to liquid flow, a smaller flow rate, and a slower flow velocity, but it is more suitable for high-precision, small-volume, low-flow-rate control.

[0046] Please see Figure 4 As shown, another aspect of the present invention provides a method of using a solution spraying device, comprising the following steps: S1. Use pure water as a solvent to prepare a 1% lecithin solution as the diffusion phase; S2. Use a syringe to draw in the diffusion phase, and select a 30G metal ground-tipped needle as the syringe tube 11; connect the syringe to the injection pump, and connect the injection pump to the metal ground-tipped needle through a tubing 221. S3. Set the operating parameters of the equipment, including the pump flow rate q of the injection pump, which is in the range of 10μL / min-2000μL / min, the operating voltage U, operating frequency f1, and stopping frequency f2 of the actuator when it is working; wherein, the operating voltage U is in the range of 20V-120V, the operating frequency f1 is in the range of 7kHz-9.2kHz, and the stopping frequency f2 is in the range of 2Hz-100Hz.

[0047] Regarding step S1, there was no significant difference observed between the 1% lecithin solution and pure water. Lecithin possesses an amphiphilic molecular structure with both a hydrophilic head and a hydrophobic tail, which can reduce interfacial tension, stabilize the dispersion system, and reduce droplet aggregation. Lecithin is a natural phospholipid derived from soybeans and egg yolks. A 1% concentration of lecithin is non-cytotoxic and suitable for preparing emulsions for biopharmaceutical use.

[0048] Regarding step S2, the syringe has clear graduations, enabling precise aspiration of the required volume of diffusion phase. The amount of diffusion phase aspirated can be flexibly adjusted according to actual needs. Whether a small amount of diffusion phase is aspirated or a relatively large volume is obtained, this can be easily achieved by selecting a syringe of appropriate specifications. This flexibility allows the system to adapt to various operational scenarios of different scales and requirements, enabling adjustment of the amount of diffusion phase aspirated according to production needs and preventing material waste. When the syringe is connected to the injection pump, it can push the diffusion phase at a stable and uniform speed under the drive of the injection pump, ensuring a continuous and stable ejection of the diffusion phase. A 30G diameter needle tube 11 is selected to facilitate vibration of the needle tube 11 within the lower power range of the equipment, allowing the liquid diffusion phase to be smoothly ejected from the air.

[0049] Regarding step S3, by adjusting the pumping flow rate q, voltage U, and operating frequency f1 and stopping frequency f2 of the injection pump, the conical nozzle 111 is made to vibrate at a specific frequency to control the size of the ejected droplets and to make the diffused liquid near the conical nozzle 111 ejected from the conical tip in different forms to meet the diverse liquid injection needs in reality.

[0050] Please see Figure 5 As shown, the horizontal axis of the coordinate system represents time t, and the vertical axis represents the operating voltage value U of the actuator. Multiple horizontal lines represent the change in the stopping frequency f2. The length of the horizontal line coinciding with the horizontal axis indicates the duration the actuator is not connected to voltage, and the length of the horizontal line parallel to the horizontal axis indicates the duration the actuator is connected to voltage value U. The curve represents the change of the actuator's connected voltage value U over time, and the number of times the voltage value U changes periodically per unit time is the operating frequency f1.

[0051] In some embodiments, the method of using the present invention further includes a device debugging step S0 before producing microfibers: the voltage U is set to 20V, and the operating frequency f1 is slowly swept from 1kHz to 15kHz at 1kHz intervals, with each dwell time at the frequency being 30s, to check whether the actuation mechanism 2 has any abnormal noises or loose parts. Device debugging can expose problems that are detrimental to production due to objective factors such as component aging and operational errors in advance. This allows for early detection and resolution of problems, preventing adverse factors from affecting normal production and improving work efficiency.

[0052] Please see Figure 6 As shown, in some embodiments, a 30G metal-tipped needle is selected as the syringe to release the diffusion phase liquid. The operating voltage U is set to 30V; the operating frequency f1 is 7.2kHz; and the pump flow rate q is set to a range of 10μL / min-500μL / min, causing the diffusion phase to be sprayed in a mist-like manner. The diffusion phase liquid generates droplets with a spherical radiation range centered on the needle tip, and the droplet volume of the diffusion phase is smaller. Applied in the pharmaceutical field, it uniformly covers the target area (such as skin and mucous membranes), avoids concentration gradient differences, improves drug permeability and utilization, and reduces waste.

[0053] Please see Figure 7 As shown, in some embodiments, a 30G metal-tipped needle is selected as the syringe to release the diffuse phase liquid. The operating voltage U is set to 30V; the operating frequency f1 is 7.2kHz; and the pump flow rate q is set to 1000μL / min, causing the diffuse phase to be sprayed in a jet-like manner. The jet-like diffuse phase liquid has a fan-shaped radiation range pointing downwards from the needle tip. The radiation range is relatively concentrated, and the distribution of droplets has a certain directionality and aggregation. Moreover, the liquid volume is larger, and the delivery volume of the diffuse phase per unit time is greater, allowing a large amount of diffuse phase liquid to quickly reach the target area in a short time, thus improving the efficiency of liquid spraying.

[0054] Please see Figure 8 As shown, under the same operating frequency f1 and operating voltage U, as the pump flow rate q increases from 10 μL / min to 500 μL / min, the size of the liquid droplets ejected gradually increases; when q reaches 1000 μL / min, the diffused phase liquid ejected from the needle 11 is jet-shaped; as q increases from 1000 μL / min to 2000 μL / min, the length of the jet ejected by the liquid becomes longer.

[0055] Please see Figure 9As shown, in some embodiments, a mixture of paraffin oil and 5% emulsifying stabilizer is used as the receiving phase, and the receiving phase is placed in a petri dish 3 to receive droplets ejected from a metal-tipped needle. The petri dish 3 is then placed on a shaker and continuously rotated at 90 rpm for 20 minutes to prevent droplet aggregation and fusion, thus aiding in droplet formation. 90 rpm is a gentle yet effective stirring rate, sufficient to generate adequate liquid flow without being too vigorous to damage the newly formed fragile gel microspheres. The 20-minute duration is sufficient for most droplets to complete the transformation from a liquid to a gel state, ensuring microsphere structural stability and preventing the fusion of different droplets. Without stirring or rotation, droplets tend to deposit at the bottom of the coagulation bath, resulting in excessively high local concentrations, microsphere aggregation, and adhesion, affecting overall quality. Rotation keeps the droplets suspended or uniformly distributed in three-dimensional space, preventing stacking and ensuring that each microsphere receives the same forming conditions. This achieves the effect of producing microdroplets using the spray jetting device of the present invention, improving the applicability of the invention.

[0056] In some embodiments, a 0.5% w / v sodium alginate solution prepared with pure water is selected as the diffusion phase, and a calcium chloride solution containing 1% w / v is selected as the receiving phase. The pump flow rate q of the diffusion phase is set to 50 μL / min, the voltage U is set to 20 V, and the operating frequency f1 is set to 8.9 kHz. After the sodium alginate solution as the diffusion phase is sprayed from syringe 11, it enters the calcium chloride solution receiving phase in culture dish 3, where sodium alginate reacts with Ca²⁺. + An ionic cross-linking reaction occurs, forming calcium alginate gel microspheres. The culture dish is fixed on a shaker and continuously rotated at 90 rpm for 20 minutes to stabilize the calcium alginate gel microspheres.

[0057] The technical means disclosed in this invention are not limited to those disclosed in the above embodiments, but also include technical solutions composed of any combination of the above technical features. It should be noted that those skilled in the art can make various improvements and modifications without departing from the principles of this invention, and these improvements and modifications are also considered within the scope of protection of this invention.

Claims

1. A solution spraying device, characterized in that, include: A diffusion phase output mechanism includes a needle tube, one end of which is provided with a conical tip nozzle for releasing the diffusion phase, and the other end for replenishing the diffusion phase; The actuation mechanism includes a mounting bracket and a Luer connector, the Luer connector being fixedly connected to the mounting bracket, and the needle tube communicating with the Luer connector; the mounting bracket is provided with an actuator, the direction of the output vibration of the actuator being perpendicular to the length direction of the needle tube.

2. The solution jetting device according to claim 1, characterized in that, The diffusion phase output mechanism further includes a syringe and an injection pump; the syringe is used to store the diffusion phase; one end of the syringe is equipped with the injection pump, and the other end is connected to the Luer connector via a hose.

3. The solution jetting device according to claim 1, characterized in that, The mounting bracket has a cavity that mates with the Luer connector. The cavity has a locking block for positioning the Luer connector and a reinforcing opening for securing the Luer connector. The reinforcing opening has fasteners for fixing the Luer connector to the mounting bracket.

4. The solution jetting device according to claim 1, characterized in that, The mounting bracket is provided with a positioning hole, the normal of which is perpendicular to the length direction of the needle tube, and the positioning hole is used to fix the actuator.

5. The solution spraying device according to any one of claims 1-4, characterized in that, The diameter of the syringe is selected from 18G to 34G, and the length is ≥6.5mm.

6. A method of using a solution spraying device, characterized in that, The solution spraying device according to any one of claims 1-5 comprises: S1. Using pure water as a solvent, prepare a 1% lecithin solution as the diffusion phase; S2. Use a syringe to draw in the diffusion phase, and select a 30G metal ground-tipped needle as the syringe tube; connect the syringe to the injection pump, and connect the injection pump to the metal ground-tipped needle through a tubing; S3. Set the operating parameters of the device, including the pumping flow rate q of the injection pump being in the range of 10μL / min, the operating voltage U, operating frequency f1, and stopping frequency f2 of the actuator when it is working; wherein, the operating voltage U is in the range of 20V-120V, the operating frequency f1 is in the range of 7kHz-9.2kHz, and the stopping frequency f2 is in the range of 2Hz-100Hz.

7. The method of using the solution jetting device according to claim 6, characterized in that... The metal-tipped needle is selected as the needle tube, and the working voltage U is set to 30V; the working frequency f1 is set to 7.2kHz; the pump flow rate q is set to 10μL / min, so that the diffused phase is sprayed in a mist.

8. The method of using the solution spraying device according to claim 6, characterized in that, The metal-tipped needle is selected as the needle tube, and the working voltage U is set to 30V; the working frequency f1 is set to 7.2kHz; the pump flow rate q is set to 1000μL / min, so that the diffused phase is sprayed in a jet shape.

9. The method of using the solution jetting device according to claim 6, characterized in that, A mixture of paraffin oil and 5% emulsion stabilizer was used as the receiving phase, and the receiving phase was placed in a petri dish to receive droplets ejected from the metal tipped needle; the petri dish was then continuously rotated at 90 rpm for 20 minutes.

10. The method of using the solution jetting device according to claim 9, characterized in that, A 0.5% w / v sodium alginate solution prepared with pure water was selected as the diffusion phase, and a 1% w / v calcium chloride solution was selected as the receiving phase. The receiving phase was placed in a petri dish. The pump flow rate q of the diffusion phase was set to 50 μL / min, the voltage U was set to 20 V, and the operating frequency f1 was set to 8.9 kHz.

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