A formula and preparation process for improving metabolic reduction of triglyceride

Abstract

The application relates to the technical field of functional food, in particular to a formula and preparation process for improving metabolism and reducing three high values, which comprises scientific proportioning and a preparation method of mulberry leaf, radix puerariae, medlar, hawthorn, tuckahoe, dried orange peel and licorice extract granules. Through optimization of an extraction process and proportioning of auxiliary materials, the extraction efficiency of active ingredients and the stability of products are remarkably improved, and the taste and solubility are also improved. The formula is based on modern nutrition research, and the components synergize to comprehensively regulate blood sugar, blood fat and blood pressure, has a wide application range, meets individualized needs, and provides new ideas and technical support for functional food research and development.

Description

Technical Field

[0001] This invention belongs to the field of health food and biomedicine technology, specifically a formula and preparation process for improving metabolism and lowering blood pressure, blood sugar, and cholesterol. Background Technology

[0002] In recent years, solutions for improving "three highs" (hypertension, hyperglycemia, and hyperlipidemia) and related metabolic syndromes have become a research hotspot. Currently, there are several technical solutions for lowering the three highs through natural plant extracts or functional foods; however, these solutions still have certain limitations in terms of formulation design, preparation processes, and overall effects, making it difficult to fully meet market demands.

[0003] Among existing patents, patent CN104431135B discloses a solid instant black tea beverage with lipid-lowering, blood sugar-lowering, and weight-loss effects, as well as its preparation method, published on July 7, 2017. This patent uses cassia seed, honeysuckle, mesona chinensis, bletilla striata, black tea, and sweeteners as main raw materials. It extracts the essence of each component to produce solid granules or powder, offering benefits such as lowering blood pressure, blood sugar, and cholesterol, health maintenance, and beauty enhancement. However, its formula primarily focuses on traditional Chinese medicinal materials, lacking a deep integration with modern nutrition and metabolic mechanisms. This may result in a relatively singular mechanism of action and limited ability to regulate complex metabolic issues. Furthermore, its preparation process relies on traditional extraction and drying techniques, potentially leading to significant loss of active ingredients and requiring improvement in product stability, thus affecting actual efficacy and user experience.

[0004] Among existing patents, patent CN102907521B discloses a health tea and its preparation method, published on March 26, 2014. This patent uses green tea as the main ingredient, supplemented with buckwheat, black beans, chrysanthemum, and other components, aiming to reduce fat accumulation and lower blood sugar, blood pressure, and blood lipids through synergistic effects. However, its formula design is relatively simple and fails to fully consider the metabolic differences and individualized needs of different populations, potentially limiting its applicability. Furthermore, its preparation method does not involve deep extraction and protection measures for active ingredients, which may affect the bioavailability and long-term preservation performance of the effective components, thus restricting its market competitiveness.

[0005] The aforementioned issues indicate that existing formulas and preparation processes for improving metabolism and lowering blood pressure, blood sugar, and cholesterol still have room for improvement in terms of the scientific nature of ingredient selection, the refinement of preparation processes, and the comprehensiveness of overall effects. Therefore, this invention aims to enhance the overall effectiveness and stability of the product by optimizing formula design and introducing advanced preparation technologies and protective measures, in order to better meet the needs of modern consumers for efficient, safe, and convenient health products. Summary of the Invention

[0006] The purpose of this invention is to provide a formula and preparation process for improving metabolism and lowering blood pressure, blood sugar, and cholesterol, so as to solve the problems mentioned in the background art.

[0007] To achieve the above objectives, the present invention provides the following technical solution: a method for preparing a formula to improve metabolism and lower blood pressure, blood sugar, and cholesterol, comprising the following steps: Weigh out 15 to 30 parts of mulberry leaf extract granules, 20 to 40 parts of kudzu root extract granules, 10 to 25 parts of wolfberry extract granules, 15 to 35 parts of hawthorn extract granules, 5 to 15 parts of poria extract granules, 5 to 20 parts of tangerine peel extract granules, and 5 to 15 parts of licorice extract granules. The above-mentioned extract particles are mixed evenly to obtain the formulated product; The preparation method of the mulberry leaf extract granules includes the following steps: taking mulberry leaf slices, adding water and decocting twice, adding six to eight times the weight of the mulberry leaf slices of water in the first decoction and four to six times the weight of the mulberry leaf slices of water in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding lactose as an excipient, mixing well, granulating to obtain mulberry leaf extract granules, wherein the mass ratio of mulberry leaf extract granules to mulberry leaf slices is one to three to five.

[0008] Preferably, the preparation method of the kudzu root extract granules includes the following steps: taking kudzu root slices, adding water and decocting twice, adding eight to ten times the weight of the kudzu root slices of water in the first decoction and six to eight times the weight of the kudzu root slices of water in the second decoction, decocting for 1.5 to 2 hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding microcrystalline cellulose as an excipient, mixing well, granulating, and obtaining kudzu root extract granules, wherein the mass ratio of kudzu root extract granules to kudzu root slices is 1:2 to 4.

[0009] Preferably, the preparation method of the wolfberry extract granules includes the following steps: taking wolfberry slices, adding water and decocting twice. For the first decoction, add 10 to 12 times the weight of the wolfberry slices of water, soak for 20 to 30 minutes, and decoct for 1 to 1.5 hours. For the second decoction, add 8 to 10 times the weight of the wolfberry slices of water, and decoct for 1 to 1.5 hours. Filter, combine the two filtrates, concentrate to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add maltodextrin as an excipient, mix well, and granulate to obtain wolfberry extract granules. The mass ratio of wolfberry extract granules to wolfberry slices is 1:4 to 6.

[0010] Preferably, the preparation method of the hawthorn extract granules includes the following steps: taking hawthorn slices, adding water and decocting twice, adding eight to ten times the weight of the hawthorn slices of water in the first decoction and six to eight times the weight of the hawthorn slices of water in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding starch as an excipient, mixing well, granulating to obtain hawthorn extract granules, wherein the mass ratio of hawthorn extract granules to hawthorn slices is one to three to five.

[0011] Preferably, the preparation method of the Poria cocos extract granules includes the following steps: taking Poria cocos slices, adding water and decocting twice, adding six to eight times the mass of water of the Poria cocos slices in the first decoction, and adding four to six times the mass of water of the Poria cocos slices in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding lactose as an excipient, mixing well, granulating, and thus obtaining Poria cocos extract granules, wherein the mass ratio of Poria cocos extract granules to Poria cocos slices is one to four to six.

[0012] Preferably, the preparation method of the tangerine peel extract granules includes the following steps: taking tangerine peel slices, adding water and decocting twice, adding eight to ten times the weight of the tangerine peel slices of water in the first decoction and six to eight times the weight of the tangerine peel slices of water in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding microcrystalline cellulose as an excipient, mixing well, granulating, and thus obtaining tangerine peel extract granules, wherein the mass ratio of tangerine peel extract granules to tangerine peel slices is one to two to four.

[0013] Preferably, the method for preparing the licorice extract granules includes the following steps: taking licorice slices, adding water and decocting twice, adding 10 to 12 times the weight of the licorice slices of water in the first decoction and 8 to 10 times the weight of the licorice slices of water in the second decoction, decocting for 1.5 to 2 hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding maltodextrin as an excipient, mixing well, granulating to obtain licorice extract granules, wherein the mass ratio of licorice extract granules to licorice slices is 1:3 to 5.

[0014] Preferably, the operating conditions for the spray drying include: an inlet air temperature of 180 to 220 degrees Celsius, an outlet air temperature of 80 to 100 degrees Celsius, and a spray pressure of 0.2 to 0.4 MPa.

[0015] Preferably, the process of achieving uniform mixing includes placing each extract particle in a three-dimensional mixer and mixing at a speed of 10 to 20 revolutions per minute for 30 to 60 minutes.

[0016] Preferably, when the formulated product is used to prepare functional foods, it can be mixed with protein powder, dietary fiber, vitamins or minerals to form meal replacement powder; or the formulated product can be combined with natural sweeteners, acidulants or flavorings to form solid beverages; or the formulated product can be filled into hard capsule shells to form capsule dosage forms.

[0017] Compared with the prior art, the beneficial effects of the present invention are: the formula and preparation process for improving metabolism and lowering blood pressure, blood sugar, and cholesterol are as follows: This application presents a formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol, and its application. Through scientific screening and optimization of the composition and content of each component in the compound formula, combined with research findings in modern nutrition and metabolic mechanisms, it achieves comprehensive regulation of complex metabolic problems. Mulberry leaf extract granules and kudzu root extract granules work synergistically to significantly lower blood sugar and blood lipids, serving as the principal ingredients. Goji berry extract granules and hawthorn extract granules work together to exert antioxidant and lipid metabolism-promoting effects, serving as the assistant ingredients. Poria cocos extract granules and tangerine peel extract granules assist in regulating dampness and digestive function in the body, avoiding side effects caused by metabolic disorders, serving as the adjuvant ingredients. Licorice extract granules harmonize the various ingredients, enhancing the overall stability and synergistic effect of the formula, serving as the guiding ingredient. The entire formula addresses both the symptoms and the root cause, with all ingredients working together to achieve the effect of regulating blood sugar, blood lipids, and blood pressure.

[0018] Furthermore, by introducing advanced spray drying technology and a reasonable ratio of excipients, this application effectively improves the extraction efficiency of active ingredients and the stability of the product, extends its shelf life, and enhances its taste and solubility, thereby improving the user experience. In addition, this formula fully considers the metabolic differences and individualized needs of different population groups, making it widely applicable and providing new ideas and technical support for the research and development of functional foods. Attached Figure Description

[0019] Figure 1 This is a flowchart for the application of the formulated product. Detailed Implementation

[0020] The technical solutions in the embodiments of the present invention have been clearly and completely described. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0021] Please see Figure 1 This invention provides a technical solution: a method for preparing a formula to improve metabolism and lower blood pressure, blood sugar, and cholesterol, comprising the following steps: Weigh out 15 to 30 parts of mulberry leaf extract granules, 20 to 40 parts of kudzu root extract granules, 10 to 25 parts of wolfberry extract granules, 15 to 35 parts of hawthorn extract granules, 5 to 15 parts of poria extract granules, 5 to 20 parts of tangerine peel extract granules, and 5 to 15 parts of licorice extract granules. The above-mentioned extract particles are mixed evenly to obtain the formulated product; The preparation method of the mulberry leaf extract granules includes the following steps: taking mulberry leaf slices, adding water and decocting twice, adding six to eight times the weight of the mulberry leaf slices of water in the first decoction and four to six times the weight of the mulberry leaf slices of water in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding lactose as an excipient, mixing well, granulating to obtain mulberry leaf extract granules, wherein the mass ratio of mulberry leaf extract granules to mulberry leaf slices is one to three to five.

[0022] Furthermore, the preparation method of the kudzu root extract granules includes the following steps: take kudzu root slices, add water and decoct twice. The first time, add eight to ten times the weight of the kudzu root slices of water, and the second time, add six to eight times the weight of the kudzu root slices of water. Each decoction lasts for 1.5 to 2 hours. Filter the decoction, combine the two filtrates, concentrate to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add microcrystalline cellulose as an excipient, mix well, and granulate to obtain kudzu root extract granules. The mass ratio of kudzu root extract granules to kudzu root slices is 1:2 to 4.

[0023] Furthermore, the preparation method of the wolfberry extract granules includes the following steps: take wolfberry slices, add water and decoct twice. For the first decoction, add 10 to 12 times the weight of the wolfberry slices of water, soak for 20 to 30 minutes, and decoct for 1 to 1.5 hours. For the second decoction, add 8 to 10 times the weight of the wolfberry slices of water, and decoct for 1 to 1.5 hours. Filter, combine the two filtrates, concentrate to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add maltodextrin as an excipient, mix well, and granulate to obtain wolfberry extract granules. The mass ratio of wolfberry extract granules to wolfberry slices is 1:4 to 6.

[0024] Furthermore, the preparation method of the hawthorn extract granules includes the following steps: take hawthorn slices, add water and decoct twice. The first time, add eight to ten times the weight of the hawthorn slices of water, and the second time, add six to eight times the weight of the hawthorn slices of water. Each decoction lasts for one to one and a half hours. Filter, combine the two filtrates, concentrate to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add starch as an excipient, mix well, and granulate to obtain hawthorn extract granules. The mass ratio of hawthorn extract granules to hawthorn slices is one to three to five.

[0025] Furthermore, the preparation method of the Poria cocos extract granules includes the following steps: taking Poria cocos slices, adding water and decocting twice, adding six to eight times the mass of water of the Poria cocos slices in the first decoction, and adding four to six times the mass of water of the Poria cocos slices in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding lactose as an excipient, mixing well, granulating, and obtaining Poria cocos extract granules, wherein the mass ratio of Poria cocos extract granules to Poria cocos slices is one to four to six.

[0026] Furthermore, the preparation method of the tangerine peel extract granules includes the following steps: take tangerine peel slices, add water and decoct twice. The first time, add eight to ten times the weight of the tangerine peel slices of water, and the second time, add six to eight times the weight of the tangerine peel slices of water. Each decoction lasts for one to one and a half hours. Filter, combine the two filtrates, concentrate to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add microcrystalline cellulose as an excipient, mix well, and granulate to obtain tangerine peel extract granules. The mass ratio of tangerine peel extract granules to tangerine peel slices is one to two to four.

[0027] Furthermore, the preparation method of the licorice extract granules includes the following steps: take licorice slices, add water and decoct twice. The first time, add 10 to 12 times the weight of the licorice slices of water, and the second time, add 8 to 10 times the weight of the licorice slices of water. Each decoction lasts for 1.5 to 2 hours. Filter, combine the two filtrates, concentrate to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add maltodextrin as an excipient, mix well, and granulate to obtain licorice extract granules. The mass ratio of licorice extract granules to licorice slices is 1:3 to 5.

[0028] Furthermore, the operating conditions for the spray drying include: an inlet air temperature of 180 to 220 degrees Celsius, an outlet air temperature of 80 to 100 degrees Celsius, and a spray pressure of 0.2 to 0.4 MPa.

[0029] Furthermore, the process of achieving uniform mixing includes placing each extract particle in a three-dimensional mixer and mixing it at a speed of 10 to 20 revolutions per minute for 30 to 60 minutes.

[0030] Furthermore, when the formulated product is used to prepare functional foods, it can be mixed with protein powder, dietary fiber, vitamins or minerals to form meal replacement powder; or the formulated product can be combined with natural sweeteners, acidulants or flavorings to form solid beverages; or the formulated product can be filled into hard capsule shells to form capsule dosage forms.

[0031] Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present invention should be included within the protection scope of the present invention.

Claims

1. A method for preparing a formula to improve metabolism and lower blood pressure, blood sugar, and cholesterol, characterized in that: Includes the following steps: Weigh out 15 to 30 parts of mulberry leaf extract granules, 20 to 40 parts of kudzu root extract granules, 10 to 25 parts of wolfberry extract granules, 15 to 35 parts of hawthorn extract granules, 5 to 15 parts of poria extract granules, 5 to 20 parts of tangerine peel extract granules, and 5 to 15 parts of licorice extract granules. The above-mentioned extract particles are mixed evenly to obtain the formulated product; The preparation method of the mulberry leaf extract granules includes the following steps: taking mulberry leaf slices, adding water and decocting twice, adding six to eight times the weight of the mulberry leaf slices of water in the first decoction and four to six times the weight of the mulberry leaf slices of water in the second decoction, decocting for one to one and a half hours each time, filtering, combining the two filtrates, concentrating to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray drying, collecting the dried powder, adding lactose as an excipient, mixing well, granulating to obtain mulberry leaf extract granules, wherein the mass ratio of mulberry leaf extract granules to mulberry leaf slices is one to three to five.

2. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The preparation method of the kudzu root extract granules includes the following steps: Take kudzu root slices, add water and decoct twice. The first time, add eight to ten times the weight of the kudzu root slices of water, and the second time, add six to eight times the weight of the kudzu root slices of water. Each decoction lasts for 1.5 to 2 hours. Filter the decoction, combine the two filtrates, concentrate to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add microcrystalline cellulose as an excipient, mix well, and granulate to obtain kudzu root extract granules. The mass ratio of kudzu root extract granules to kudzu root slices is 1:2 to 4.

3. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The preparation method of the wolfberry extract granules includes the following steps: take wolfberry slices, add water and decoct twice. For the first decoction, add 10 to 12 times the weight of the wolfberry slices of water, soak for 20 to 30 minutes, and decoct for 1 to 1.5 hours. For the second decoction, add 8 to 10 times the weight of the wolfberry slices of water, and decoct for 1 to 1.5 hours. Filter, combine the two filtrates, concentrate to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add maltodextrin as an excipient, mix well, and granulate to obtain wolfberry extract granules. The mass ratio of wolfberry extract granules to wolfberry slices is 1:4 to 6.

4. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The preparation method of the hawthorn extract granules includes the following steps: take hawthorn slices, add water and decoct twice. The first time, add eight to ten times the weight of the hawthorn slices of water, and the second time, add six to eight times the weight of the hawthorn slices of water. Each decoction lasts for one to one and a half hours. Filter, combine the two filtrates, concentrate to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add starch as an excipient, mix well, and granulate to obtain hawthorn extract granules. The mass ratio of hawthorn extract granules to hawthorn slices is one to three to five.

5. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The preparation method of the Poria cocos extract granules includes the following steps: take Poria cocos slices, add water and decoct twice. The first time, add six to eight times the weight of the Poria cocos slices of water, and the second time, add four to six times the weight of the Poria cocos slices of water. Each decoction lasts for one to one and a half hours. Filter, combine the two filtrates, concentrate to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add lactose as an excipient, mix well, and granulate to obtain Poria cocos extract granules. The mass ratio of Poria cocos extract granules to Poria cocos slices is one to four to six.

6. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The preparation method of the tangerine peel extract granules includes the following steps: take tangerine peel slices, add water and decoct twice. The first time, add eight to ten times the weight of the tangerine peel slices of water, and the second time, add six to eight times the weight of the tangerine peel slices of water. Each decoction lasts for one to one and a half hours. Filter, combine the two filtrates, concentrate to a relative density of 1.15 to 1.25 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add microcrystalline cellulose as an excipient, mix well, and granulate to obtain tangerine peel extract granules. The mass ratio of tangerine peel extract granules to tangerine peel slices is one to two to four.

7. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The preparation method of the licorice extract granules includes the following steps: take licorice slices, add water and decoct twice. The first time, add 10 to 12 times the weight of the licorice slices of water, and the second time, add 8 to 10 times the weight of the licorice slices of water. Each decoction lasts for 1.5 to 2 hours. Filter, combine the two filtrates, concentrate to a relative density of 1.10 to 1.20 (measured at 60 degrees Celsius), spray dry, collect the dried powder, add maltodextrin as an excipient, mix well, and granulate to obtain licorice extract granules. The mass ratio of licorice extract granules to licorice slices is 1:3 to 5.

8. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The operating conditions for spray drying include: an inlet air temperature of 180 to 220 degrees Celsius, an outlet air temperature of 80 to 100 degrees Celsius, and a spray pressure of 0.2 to 0.4 MPa.

9. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: The process of achieving uniform mixing includes placing each extract particle in a three-dimensional mixer and mixing it at a speed of 10 to 20 revolutions per minute for 30 to 60 minutes.

10. The preparation method of the formula for improving metabolism and lowering blood pressure, blood sugar, and cholesterol according to claim 1, characterized in that: When the formulated product is used to prepare functional foods, it can be mixed with protein powder, dietary fiber, vitamins or minerals to form meal replacement powder; or the formulated product can be combined with natural sweeteners, acidulants or flavorings to form solid beverages; or the formulated product can be filled into hard capsule shells to form capsule dosage forms.

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