A xylooligosaccharide liquid composition for promoting digestion in children and a preparation method and application thereof

Abstract

The present application relates to the field of food technology, in particular to a xylo-oligosaccharide liquid composition for promoting digestion of children and a preparation method and application thereof.The xylo-oligosaccharide liquid composition comprises the following raw material components in parts by weight: 4-10 parts of xylo-oligosaccharide, 20-30 parts of poria cocos, 20-30 parts of phyllanthus emblica, 15-25 parts of hawthorn, 15-20 parts of roasted wheat germ, 8-15 parts of dried tangerine or orange peel and 10-20 parts of Chinese yam.The present application has the advantages of being suitable for children and having good effect on promoting digestion of children.

Description

Technical Field

[0001] This invention relates to the field of food technology, specifically to a xylooligosaccharide liquid composition that promotes digestion in children, its preparation method, and its application. Background Technology

[0002] Children have weaker digestive systems and their spleen and stomach functions are not fully developed, so they are prone to indigestion when they eat something unsuitable. Functional dyspepsia in children is a common and frequently occurring disease in pediatric clinics. It refers to a group of common clinical syndromes in children with symptoms such as recurrent upper abdominal pain, burning sensation in the upper abdomen, abdominal distension, early satiety, belching, loss of appetite, acid reflux, nausea, and vomiting, after various examinations have ruled out organic diseases.

[0003] The main causes of indigestion are emotional imbalance, improper diet, and medication damaging the spleen and stomach, leading to their weakness. Among these, emotional factors and diet are the primary causes. The key pathogenesis lies in the stagnation of liver qi, which fails to flow smoothly and invades the spleen and stomach, causing dysfunction in the ascending and descending functions of the spleen and stomach, thus triggering the disease. The location of the disease is in the stomach, and it is closely related to the liver and spleen. Functional dyspepsia is often a case of deficiency in the root and excess in the branch, with weakness in the middle jiao as the root cause. External pathogenic factors, improper diet, and emotional distress are the causes, while food stagnation, phlegm dampness, and blood stasis are the branch causes. The dysfunction of the ascending and descending functions of qi in the middle jiao is the main pathogenesis.

[0004] Indigestion can be categorized into several syndromes, including spleen deficiency and qi stagnation, liver-stomach disharmony, spleen-stomach damp-heat, spleen-stomach deficiency-cold, and mixed cold-heat syndrome. Commonly used treatments include Sijunzi Decoction, Xiangsha Zhishu Pill, Chaihu Shugan Powder, Lianpu Drink, Lizhong Pill, and Banxia Xiexin Decoction. Combining traditional Chinese medicine with Western medicine is also a common clinical approach, such as Zhishu Kuanzhong Capsules combined with erythromycin. However, for children, a product with fewer side effects and using both medicinal and edible ingredients is needed to promote digestion.

[0005] The prior art (Tan An, Wang Zhicheng, Yuan Ming, et al. Phyllanthus emblica extract and its compound to improve functional dyspepsia symptoms in rats [J]. Modern Food Science and Technology, 2024, 40(4):1-7.) disclosed the use of Phyllanthus emblica (single formula group), Phyllanthus emblica, hawthorn, Poria cocos and tangerine peel (compound group 1), Phyllanthus emblica, hawthorn, Atractylodes macrocephala and malt (compound group 2), Phyllanthus emblica, hawthorn, Poria cocos, Atractylodes macrocephala and tangerine peel (compound group 3), and Phyllanthus emblica, hawthorn, Poria cocos, Atractylodes macrocephala and tangerine peel (compound group 4) to improve functional dyspepsia symptoms in rats, among which compound group 4 showed better results.

[0006] Chinese Patent Publication No. CN102366087A discloses a health food product that promotes digestion and its preparation method. It is composed of Hericium erinaceus, Atractylodes macrocephala, hawthorn, yam, tangerine peel, and malt. The product is prepared by the following steps: raw material extraction and powdering, blending, metering and filling into capsules, and packaging. The product is safe to take and has a certain function of promoting digestion.

[0007] However, the digestive-promoting effects of the aforementioned products need further improvement, and their effectiveness in targeting children, a specific group, has not been examined.

[0008] Therefore, it is essential to develop a xylooligosaccharide liquid composition that can solve the above-mentioned technical problems and promote children's digestion, as well as its preparation method and application. Summary of the Invention

[0009] The purpose of this invention is to overcome the shortcomings of the prior art and provide a xylooligosaccharide liquid composition suitable for children to consume and with good digestive effects, as well as its preparation method and application.

[0010] This invention is achieved through the following technical solutions:

[0011] The first aspect of the present invention provides a xylooligosaccharide liquid composition that promotes digestion in children, comprising the following raw material components by weight: 4-10 parts xylooligosaccharide, 20-30 parts Poria cocos, 20-30 parts Phyllanthus emblica, 15-25 parts hawthorn, 15-20 parts roasted malt, 8-15 parts dried tangerine peel, and 10-20 parts yam.

[0012] Xylooligosaccharides selectively promote the proliferation of beneficial bacteria such as Bifidobacteria in the gut while inhibiting the growth of harmful bacteria, thereby optimizing the gut microbiota balance and improving symptoms such as indigestion and bloating in children. Simultaneously, xylooligosaccharides stimulate the secretion of digestive enzymes, enhancing the intestines' ability to absorb nutrients and alleviating problems such as decreased appetite and insufficient nutrient intake in children. Furthermore, by increasing the content of short-chain fatty acids (SCFAs) in the intestines, they soften stools and promote intestinal peristalsis, effectively preventing or alleviating functional constipation in children.

[0013] Poria cocos is the dried sclerotium of the fungus Poria cocos (Schw.) Wolf, belonging to the Polyporaceae family. It is sweet, bland, and neutral in nature. It enters the heart, lung, spleen, and kidney meridians. It promotes diuresis and eliminates dampness, strengthens the spleen, and calms the mind. It is used for edema with scanty urine, phlegm retention with dizziness and palpitations, spleen deficiency with poor appetite, loose stools and diarrhea, restlessness, palpitations, and insomnia.

[0014] Phyllanthus emblica L., a plant in the Euphorbiaceae family, is the dried, ripe fruit of the plant. It is sweet, sour, and astringent, and has a cooling effect. It enters the lung and stomach meridians. It clears heat and cools the blood, promotes digestion and strengthens the stomach, generates fluids and relieves cough. It is used for blood heat and blood stasis, indigestion, abdominal distension, cough, sore throat, and dry mouth.

[0015] Hawthorn is the dried, ripe fruit of *Crataegus pinnatifida* Bge. var. major NEBr. or *Crataegus pinnatifida* Bge., both belonging to the Rosaceae family. It is sour, sweet, and slightly warm in nature. It enters the spleen, stomach, and liver meridians. Its functions include aiding digestion, strengthening the stomach, promoting qi circulation, dispersing blood stasis, and reducing turbidity and lipids.

[0016] Malt is a processed product made from the germinated and dried mature fruit of barley (Hordeum vulgare L.), a plant belonging to the Poaceae family. It is sweet and neutral in nature. It enters the spleen and stomach meridians. It promotes digestion, strengthens the spleen and stomach, and relieves lactation and bloating. It is used for indigestion, abdominal distension and pain, poor appetite due to spleen deficiency, milk stasis, breast distension and pain, weaning in women, liver stagnation causing hypochondriac pain, and liver and stomach qi pain. Roasted malt promotes digestion, relieves lactation, and is used for indigestion and weaning in women.

[0017] Dried tangerine peel (Citrus reticulata Blanco) is the dried, mature peel of its cultivated varieties and other plants belonging to the Rutaceae family. It is bitter, pungent, and warm in nature. It enters the lung and spleen meridians. It regulates qi, strengthens the spleen, dries dampness, and resolves phlegm. It is used for abdominal distension, poor appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0018] Yam is the dried rhizome of *Dioscorea opposita* Thunb., a plant in the Dioscoreaceae family. It is sweet and neutral in nature. It enters the spleen, lung, and kidney meridians. It tonifies the spleen and stomach, promotes the production of body fluids and benefits the lungs, and tonifies the kidneys and astringes essence.

[0019] In a preferred embodiment of the present invention, the xylooligosaccharide liquid composition comprises, by weight, the following raw material components: 6-8 parts xylooligosaccharide, 22-28 parts Poria cocos, 23-27 parts Phyllanthus emblica, 17-23 parts hawthorn, 16-19 parts roasted malt, 10-13 parts dried tangerine peel, and 12-18 parts yam.

[0020] As a more preferred embodiment of the present invention, the xylooligosaccharide liquid composition comprises, by weight, the following raw material components: 7 parts xylooligosaccharide, 25 parts Poria cocos, 25 parts Phyllanthus emblica, 20 parts hawthorn, 18 parts roasted malt, 11 parts dried tangerine peel, and 15 parts yam.

[0021] In one embodiment of the present invention, the xylooligosaccharide includes at least xylobiose, xylotriose and xylotetraose, with a mass ratio of 1.5-2.5:1-2:1.

[0022] In one embodiment of the present invention, the total content of xylobiose, xylotriose and xylotetraose in the xylooligosaccharide is ≥80%.

[0023] In one embodiment of the present invention, the mass ratio of Poria cocos, Phyllanthus emblica and roasted malt is 1.5-1.8:1.5-1.8:1.

[0024] A second aspect of the present invention provides a method for preparing the above-mentioned xylooligosaccharide liquid composition, comprising the following steps: (1) Mix Poria cocos and Phyllanthus emblica, crush them, soak them in water, then decoct them, filter them, and obtain filtrate 1; (2) Mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, add water and reflux to extract, filter, and obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, add xylooligosaccharide, and you will get the product.

[0025] As one embodiment of the present invention, step (1) includes the following steps: mix Poria cocos and Phyllanthus emblica, crush them, pass them through a 40-60 mesh sieve, add 5-10 times the amount of water to soak for 0.5-1.5h, then decoct for 1-2h, filter, and obtain filtrate 1.

[0026] As one embodiment of the present invention, step (2) includes the following steps: mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, pass them through a 40-60 mesh sieve, add 5-10 times the amount of water and reflux extract 1-3 times, each time for 0.5-1.5h, filter, combine the filtrates to obtain filtrate 2.

[0027] A third aspect of the present invention provides the application of the above-described xylooligosaccharide liquid composition or the xylooligosaccharide liquid composition prepared by the above-described preparation method in the preparation of products that promote digestion.

[0028] As one embodiment of the present invention, the application is in the preparation of products that promote children's digestion.

[0029] As one embodiment of the present invention, the product includes food, health products, or medicines.

[0030] In one embodiment of the present invention, the product is a liquid formulation.

[0031] The beneficial effects of this invention are: This invention is based on traditional Chinese medicine theory and uses a compound of Poria cocos, Phyllanthus emblica, hawthorn, roasted malt, tangerine peel, and yam to invigorate qi and strengthen the spleen, promote digestion and relieve stagnation. The addition of xylooligosaccharides promotes digestive enzyme activity and maintains gastrointestinal motility. The synergistic effect among the components is significant, resulting in a remarkable improvement in digestion. In particular, the synergistic effect between xylooligosaccharides, Poria cocos, and Phyllanthus emblica in promoting digestion is evident.

[0032] This invention further optimizes the composition of xylooligosaccharides, significantly improving their digestive-promoting effects.

[0033] This invention further optimizes the dosage ratio of Poria cocos, Phyllanthus emblica, and roasted malt, thereby further improving its effect on promoting digestion.

[0034] The product of this invention contains hawthorn, roasted malt, dried tangerine peel and xylooligosaccharides. The product itself has a sweet and sour taste, is easy to take, does not require the addition of flavoring agents, and is suitable for children. Detailed Implementation

[0035] The present invention will be further described below with reference to specific embodiments, and the advantages and features of the present invention will become clearer as a result. However, these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. Those skilled in the art should understand that modifications or substitutions can be made to the details and form of the technical solutions of the present invention without departing from the spirit and scope of the present invention, but all such modifications and substitutions fall within the protection scope of the present invention.

[0036] Example 1 A liquid composition of xylooligosaccharides that promotes digestion in children, comprising the following raw material components by weight: 7 parts xylooligosaccharides, 25 parts Poria cocos, 25 parts Phyllanthus emblica, 20 parts hawthorn, 18 parts roasted malt, 11 parts dried tangerine peel, and 15 parts yam.

[0037] The xylooligosaccharide contains xylobiose, xylotriose, and xylotetraose in a mass ratio of 2:1.26:1; the total content of the three is 85%.

[0038] The preparation method of the xylooligosaccharide liquid composition is as follows: (1) Mix Poria cocos and Phyllanthus emblica, crush them, pass them through a 50-mesh sieve, add 8 times the amount of water to soak for 1 hour, then decoct for 1.5 hours, filter, and obtain filtrate 1; (2) Mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, pass them through a 50-mesh sieve, add 8 times the amount of water and reflux extract twice, 1 hour each time, filter, combine the filtrates to get filtrate 2; (3) Mix filtrate 1 and filtrate 2, add xylooligosaccharide, and you will get the product.

[0039] Example 2 A liquid composition of xylooligosaccharides that promotes digestion in children, comprising the following raw material components by weight: 10 parts xylooligosaccharides, 30 parts Poria cocos, 30 parts Phyllanthus emblica, 25 parts hawthorn, 20 parts roasted malt, 15 parts dried tangerine peel, and 20 parts yam.

[0040] The xylooligosaccharide contains xylobiose, xylotriose, and xylotetraose in a mass ratio of 2.5:2:1; the total content of the three is 81%.

[0041] The preparation method of the xylooligosaccharide liquid composition is as follows: (1) Mix Poria cocos and Phyllanthus emblica, crush them, pass them through a 60-mesh sieve, add 10 times the amount of water to soak for 0.5 hours, then decoct for 1 hour, filter, and obtain filtrate 1; (2) Mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, pass them through a 60-mesh sieve, add 10 times the amount of water and reflux extract 3 times, 0.5h each time, filter, combine the filtrates to get filtrate 2; (3) Mix filtrate 1 and filtrate 2, add xylooligosaccharide, and you will get the product.

[0042] Example 3 A liquid composition of xylooligosaccharides that promotes digestion in children, comprising the following raw material components by weight: 4 parts xylooligosaccharides, 20 parts Poria cocos, 20 parts Phyllanthus emblica, 15 parts hawthorn, 15 parts roasted malt, 8 parts dried tangerine peel, and 10 parts yam.

[0043] The xylooligosaccharide contains xylobiose, xylotriose, and xylotetraose in a mass ratio of 1.5:1:1; the total content of the three is 83%.

[0044] The preparation method of the xylooligosaccharide liquid composition is as follows: (1) Mix Poria cocos and Phyllanthus emblica, crush them, pass them through a 40-mesh sieve, add 5 times the amount of water to soak for 1.5 hours, then decoct for 2 hours, filter, and obtain filtrate 1; (2) Mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, pass them through a 40-mesh sieve, add 5 times the amount of water and reflux once for 1.5 hours, filter and get filtrate 2; (3) Mix filtrate 1 and filtrate 2, add xylooligosaccharide, and you will get the product.

[0045] Example 4 A xylooligosaccharide liquid composition that promotes children's digestion differs from Example 1 only in that the total amount of Poria cocos, Phyllanthus emblica and roasted malt remains the same, but the mass ratio is adjusted to 1.5:1.5:1, while all other conditions are the same.

[0046] Example 5 A xylooligosaccharide liquid composition that promotes children's digestion differs from Example 1 only in that the total amount of Poria cocos, Phyllanthus emblica and roasted malt remains the same, but the mass ratio is adjusted to 1.8:1.8:1, while all other conditions are the same.

[0047] Comparative Example 1 The only difference from Example 1 is that the mass ratio of xylobiose, xylotriose and xylotetraose in the xylooligosaccharide is different. The mass ratio of the three is 3:3:1 and the total content of the three is 85%. All other conditions are the same.

[0048] Comparative Example 2 The only difference from Example 1 is the mass ratio of xylobiose, xylotriose, and xylotetraose in the xylooligosaccharide. The mass ratio of the three is 1:0.7:1, and the total content of the three is 85%. All other conditions are the same.

[0049] Comparative Example 3 The only difference from Example 1 is the amount of xylooligosaccharide, Poria cocos, and Phyllanthus emblica. Specifically, the amount of xylooligosaccharide is 0 parts, the amount of Poria cocos is 28.5 parts, and the amount of Phyllanthus emblica is 28.5 parts. All other conditions are the same.

[0050] Comparative Example 4 The only difference from Example 1 is the amount of xylooligosaccharide, Poria cocos, and Phyllanthus emblica. Specifically, the amount of xylooligosaccharide is 12.47 parts, the amount of Poria cocos is 0 parts, and the amount of Phyllanthus emblica is 44.53 parts. All other conditions are the same.

[0051] Comparative Example 5 The only difference from Example 1 is the amount of xylooligosaccharide, Poria cocos, and Phyllanthus emblica. Specifically, the amount of xylooligosaccharide is 12.47 parts, the amount of Poria cocos is 44.53 parts, and the amount of Phyllanthus emblica is 0 parts. All other conditions are the same.

[0052] Test Example 1 The small bowel motility test was conducted in accordance with the "Methods for Functional Testing and Evaluation of Health Foods (2023 Edition)".

[0053] Experimental animals: Healthy SPF-grade male SD rats, 4 weeks old, weighing 85-105g. The animals were randomly divided into 12 groups of 8 rats each. One group served as a blank control group, one group as a model control group (modeled using loperamide 3mg / kg BW), and the remaining 10 groups served as the test sample groups. All animals were fed rat maintenance diet for one week of acclimatization.

[0054] Test samples: Liquid compositions prepared in Examples 1-5 and Comparative Examples 1-5. The amount of all raw materials in the composition was used as the sample amount, and the test sample amount was 5 g sample amount / kg. The samples were administered by gavage once daily for 4 consecutive weeks. The blank control group and the model control group were given the same volume of distilled water as in Example 1.

[0055] Experimental Methods: Animals were fasted for 16 hours prior to the end of the experiment, but water was allowed. On the day of measurement, each group was given the test sample again, while the blank control group and model control group were given distilled water. 30 minutes later, the test sample group and model control group were given loperamide (3 mg / kg BW), while the blank control group was given distilled water. 30 minutes later, each group was given ink (0.1 mL / 10 g). Animals were sacrificed 25 minutes later, and the ink propulsion rate was calculated. The results are shown in Table 1.

[0056] Table 1 Ink propulsion rate results (n=8, x±s)

[0057] If any two groups of numbers in the same column contain different letters, it indicates a significant difference (p < 0.05).

[0058] Test Example 2 Digestive enzyme tests were conducted in accordance with the "Methods for Functional Testing and Evaluation of Health Foods (2023 Edition)".

[0059] Experimental animals: Healthy SPF-grade male SD rats, 4 weeks old, weighing 85-105g. The animals were randomly divided into 11 groups of 8 rats each, with one group serving as a blank control and the remaining 10 groups as test sample groups. All animals were fed rat maintenance diet for one week to allow for acclimatization.

[0060] Test samples: Liquid compositions prepared in Examples 1-5 and Comparative Examples 1-5. The amount of all raw materials in the composition was used as the sample amount, and the test sample amount was 5 g sample amount / kg. The samples were administered by gavage once daily for 4 consecutive weeks. The blank control group received the same volume of distilled water as in Example 1.

[0061] Experimental Methods: Before the end of the experiment, all rats were fasted for 24 hours but allowed free access to water. Gastric fluid was collected within 3 hours after pyloric ligation by anesthetizing the rats with ether. 1 mL of gastric fluid was taken and 15 mL of 0.05 mol / L hydrochloric acid solution was added and mixed well. The mixture was then placed into two freshly prepared protein tubes. The tubes were sealed and incubated at 37℃ for 24 hours. The protein tubes were then removed, and the lengths (mm) of the transparent portions at both ends were measured. The average value of the four measurements was calculated. Pepsin activity was calculated, and the results are shown in Table 2.

[0062] Table 2. Pepsin activity (n=8, x±s)

[0063] If any two groups of numbers in the same column contain different letters, it indicates a significant difference (p < 0.05).

[0064] Test Example 3 Taste test Ten trained evaluators scored the samples of each embodiment sequentially, with scores ranging from 1 to 5. 1 indicates no sweetness or mild sweetness, 2 indicates mild sweetness, 3 indicates moderate sweetness, 4 indicates sweetness, and 5 indicates excessive sweetness. The scoring results are shown in Table 3.

[0065] Table 3. Taste Test Results

[0066] The above detailed description is a specific description of one of the feasible embodiments of the present invention. This embodiment is not intended to limit the patent scope of the present invention. All equivalent implementations or modifications that do not depart from the present invention should be included within the scope of the technical solution of the present invention.

Claims

1. A xylooligosaccharide liquid composition that promotes digestion in children, characterized in that, The ingredients, by weight, include the following components: xylooligosaccharides 4-10 parts, Poria cocos 20-30 parts, Phyllanthus emblica 20-30 parts, hawthorn 15-25 parts, roasted malt 15-20 parts, dried tangerine peel 8-15 parts, and yam 10-20 parts.

2. The xylooligosaccharide liquid composition according to claim 1, characterized in that, The ingredients, by weight, include the following components: xylooligosaccharides 6-8 parts, Poria cocos 22-28 parts, Phyllanthus emblica 23-27 parts, hawthorn 17-23 parts, roasted malt 16-19 parts, dried tangerine peel 10-13 parts, and yam 12-18 parts.

3. The xylooligosaccharide liquid composition according to claim 1, characterized in that, The ingredients, by weight, include the following components: 7 parts xylooligosaccharide, 25 parts Poria cocos, 25 parts Phyllanthus emblica, 20 parts hawthorn, 18 parts roasted malt, 11 parts dried tangerine peel, and 15 parts yam.

4. The xylooligosaccharide liquid composition according to claim 1, characterized in that, The xylooligosaccharide includes at least xylobiose, xylotriose, and xylotetraose, with a mass ratio of 1.5-2.5:1-2:

1.

5. The xylooligosaccharide liquid composition according to claim 4, characterized in that, The total content of xylobiose, xylotriose and xylotetraose in the xylooligosaccharide is ≥80%.

6. The xylooligosaccharide liquid composition according to claim 1, characterized in that, The mass ratio of Poria cocos, Phyllanthus emblica and roasted malt is 1.5-1.8:1.5-1.8:

1.

7. A method for preparing the xylooligosaccharide liquid composition according to any one of claims 1-6, characterized in that, Includes the following steps: (1) Mix Poria cocos and Phyllanthus emblica, crush them, soak them in water, then decoct them, filter them, and obtain filtrate 1; (2) Mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, add water and reflux to extract, filter, and obtain filtrate 2; (3) Mix filtrate 1 and filtrate 2, add xylooligosaccharide, and you will get the product.

8. The preparation method according to claim 7, characterized in that, Includes the following steps: (1) Mix Poria cocos and Phyllanthus emblica, crush them, pass them through a 40-60 mesh sieve, add 5-10 times the amount of water to soak for 0.5-1.5 hours, then decoct for 1-2 hours, filter, and obtain filtrate 1; (2) Mix hawthorn, roasted malt, dried tangerine peel and yam, crush them, pass them through a 40-60 mesh sieve, add 5-10 times the amount of water and reflux extract 1-3 times, each time for 0.5-1.5h, filter, combine the filtrates to get filtrate 2; (3) Mix filtrate 1 and filtrate 2, add xylooligosaccharide, and you will get the product.

9. The use of the xylooligosaccharide liquid composition according to any one of claims 1-6 or the xylooligosaccharide liquid composition prepared by any one of claims 7-8 in the preparation of products that promote children's digestion.

10. The application according to claim 9, characterized in that, The product is a liquid formulation.

11. The application according to claim 9, characterized in that, The products mentioned include food, health products, or medicines.

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