Drops and devices therefor

Abstract

This application relates to drops and devices thereof. The dropper device includes a bottle body having a cavity; a nozzle disposed on the container, including a nozzle opening and a discharge port for discharging a liquid composition; and a vent tube including a vent hole for balancing internal pressure. The dropper device is capable of dispensing drops at a desired rate. The drops contain 1-5 parts by weight of glyceryl monostearate, 80-95 parts by weight of medium-chain triglycerides or sunflower seed oil, and 1-15 parts by weight of probiotic powder or zinc oxide; wherein the viscosity η of the drops is 40-400 mPa·s.

Description

[0001] This application is a divisional application of Chinese Patent Application No. 202511902555.X, filed on December 17, 2025, entitled "A Dropping Device and Method of Use". Technical Field

[0002] This application relates to drops, specifically to a drop, a drop device, and a method of use. Background Technology

[0003] Drops are a dosage form in which nutrients are ingested through a dropping method. Oil-powder drops are characterized by their convenience and relative cleanliness. For oil-powder drops, achieving uniform dosage is a key challenge. For drops containing active ingredients, the key lies in achieving precise dosage of the active ingredient or nutrient. Precise dosage can be achieved through controllable dripping speed and controllable concentration of the functional substance. For different oil-powder mixtures, precise control of the dripping speed can be achieved.

[0004] For precise concentration of functional substance drops, most current technologies focus on improving the dispersion performance of the functional substance in the system. For example, adding suspending agents can extend the dispersion time, but in practice, it has been found that the suspending agents combine with the powder to form large clumps, resulting in a large amount of lumpy residue in the final product, which cannot be dispensed evenly.

[0005] Chinese patent application CN116649575A uses a compound of three liquid oils to slow down the sedimentation rate of probiotic powder, but its effect is short-lived and cannot maintain uniform dispersion for more than 6 months. Traditional suspension soft capsules may form a stable system by adding a large amount of suspending agent, but the product form is paste-like with high viscosity. At room temperature, it tends to become more viscous with prolonged storage time, with a viscosity range of generally 500-6000 cp, and some products have even higher viscosity. Such products cannot be dispensed using dropper nozzles with dropper diameters.

[0006] There is still a need in the art for dropper devices for liquid compositions. Summary of the Invention

[0007] Current technology lacks a reliable solution for controlling the dripping rate of liquids with different viscosities. Blindly adding suspending agents to improve dispersion often results in excessively high viscosity, increasing the difficulty of dripping and causing a large deviation between the dripping rate and the dripping dosage, or large-area clumping, which in turn makes dispersion difficult.

[0008] This application reveals that, when the viscosity is within a certain range, by clarifying the relationship between the liquid composition, especially the oil-powder two-phase composition, and the nozzle design, a product with controllable dripping speed, easy dispersion, and uniform dispersion can be developed. The product of this application is a dripping device for an oil-powder two-phase composition, which is used by limiting the number of drops taken through the nozzle to achieve quantitative administration. The number of drops required varies depending on the effective dose of different functional substances; considering daily use, the typical daily dose is between 2 and 10 drops.

[0009] In one aspect, a dropper is provided, characterized in that it comprises:

[0010] A bottle with a cavity for containing a liquid composition;

[0011] A liquid composition encapsulated within the cavity of the bottle, the viscosity η of the liquid composition being 40-400 mPa·s (e.g., 40, 50, 60, 70, 80, 90, 10, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200, 210, 220, 230, 240, 250, 260, 270, 280, 290, 300, 310, 320, 330, 340, 350, 360, 370, 380, 390, 400 mPa·s).

[0012] The bottle stopper is located at the opening of the bottle body and includes a dropper head, a dropper liquid channel connected to the dropper head, a droplet outlet connected to the dropper liquid channel, and a dropper air channel connected to the bottle cavity; wherein the dropper air channel has a dropper vent hole at the end away from the opening of the bottle body.

[0013] Wherein, the radius of the discharge port is R1, the radius of the vent hole is R2, and the viscosity η, R1, and R2 satisfy the following relationship:

[0014] R1=K1 x η 1 / 4 ;

[0015] When 40 ≤ η ≤ 120, the value is 0.0005 m / (Pa·s). 4 ≤K1≤0.0015 m / (Pa·s) 4 ;

[0016] When 120 < η ≤ 200, 0.0005 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4 ;

[0017] When 200 < η ≤ 300, 0.0008 m / (Pa·s) 4<K1≤0.002 m / (Pa·s) 4 ;

[0018] When 300 < η ≤ 400, 0.001 m / (Pa·s) 4 <K1≤0.0026 m / (Pa·s) 4 ;and

[0019] R2 = K2 x R1, and 0.5 ≤ K2 ≤ 1.5;

[0020] Where K1 is a constant; K2 is the ratio of the radii of the vent to the discharge port.

[0021] In one embodiment, the bottle stopper is provided with an annular groove, and the dropper head is located at the center of the annular groove; when the bottle opening is vertically downward, the drops in the bottle cavity flow from the droplet outlet into the dropper channel, and flow out from the dropper head in the form of droplets through the dropper channel; the annular groove is configured to receive the return fluid flowing out of the dropper after use; the bottom of the annular groove is provided with a dropper air channel communicating with the bottle cavity.

[0022] In one embodiment, the diameter of the dropper channel is designed to be segmented and variable. In another embodiment, the cross-section of the dropper channel is tapered.

[0023] In one embodiment, the liquid composition is an oil-powder two-phase composition. In another embodiment, the liquid composition is in the form of a liquid, suspension, emulsion, or a flowable semi-solid fluid.

[0024] In one embodiment, the liquid composition comprises grease and powder, wherein the grease aggregates have a size of 25-100 μm and the powder particles have a size of 10 μm-200 μm (e.g., 10, 20, 30, 40, 50, 60, 70, 80, 90, 10, 110, 120, 130, 140, 150, 160, 170, 180, 190, 200 μm).

[0025] In one embodiment, the powder is one or more of flavoring powder and functional powder.

[0026] In one embodiment, the liquid composition comprises 0.01-30 parts by weight of powder and 70-99.99 parts by weight of oil phase.

[0027] In one embodiment, the flavoring powder is one or more of fruit and vegetable powders, flavorings, sweetness modifiers, oil-soluble flavoring agents, and acidity modifiers, and the functional powder is one or more of plant extract nutrients, animal extract nutrients, protein nutrients, amino acid nutrients, probiotic nutrients, vitamin nutrients, fermented nutrients, chemically synthesized nutrients, functional sugars, food and medicine homologous substances, oil-soluble functional materials, and minerals.

[0028] In one implementation, the oil is one or more of vegetable oils, animal oils, and processed oils.

[0029] In one implementation, the fruit and vegetable powder is one or more of apple powder, blueberry powder, strawberry powder, mango powder, and purple sweet potato powder.

[0030] In one implementation, the spice is rosemary extract.

[0031] In one embodiment, oil-soluble flavoring agents include neotame, menthol, cooling agents, and oil-soluble flavorings.

[0032] In one implementation, the sweetness modifier is one or more of powdered sugar, sucralose, aspartame, and mogroside.

[0033] In one embodiment, the acidity regulator is one or more of citric acid, malic acid, and lactic acid.

[0034] In one implementation scheme, the plant extract nutrients are one or more of the following: blueberry anthocyanins, Dunaliella salina and its extract, inulin, Haematococcus pluvialis powder, Haematococcus pluvialis oil, earthworm protein, mushroom concentrate powder, lychee enzyme, brown algae powder, Acanthopanax senticosus, Gynostemma pentaphyllum, citrus fruit powder, dried tangerine peel powder, white kidney bean powder, green tea powder, cherry fruit powder, vine tea powder, Platycodon grandiflorus powder, corn oligopeptide powder, epigallocatechin gallate, wheat oligopeptide, snow lotus culture, maca powder, ginseng extract, Chlorella vulgaris powder, Cordyceps powder, Euglena rubescens powder, Ampelopsis japonica leaf, Paeonia suffruticosa flower, chia seed powder, Plantago asiatica husk powder, Cordyceps militaris powder, tea theanine, bamboo leaf flavonoids, loquat leaf powder, Pleurotus ostreatus powder, broccoli seed water extract, Nostoc commune powder, Ashitaba juice powder, Loquat flower powder, and Gynostemma pentaphyllum. Powder, quercetin, potato extract, Kanzan cherry blossom powder, Chlamydomonas reinhardtii powder, sugarcane polyphenols, rye pollen, Xanthoceras sorbifolium kernel powder, Xanthoceras sorbifolium leaf powder, Gynostemma pentaphyllum, catechin, phosphatidylserine, broken-cell wall Ganoderma lucidum spore powder, spirulina powder, Isatis indigotica root powder, Viola yedoensis powder, guarana extract, Chinese cinnamon bark tincture extract, bergamot extract, Alpinia officinarum root extract, seaweed extract, yellow mustard extract, alfalfa extract, basil extract, celery seed extract, bay leaf extract, lemon extract, sweet orange peel extract, elderberry flower extract, bay leaf extract, laurel leaf extract, enzyme-treated isoquercitrin, grape seed extract, spearmint extract, Zanthoxylum bungeanum extract, catechin powder, wormwood extract, Juniperus chinensis extract, licorice extract, annatto extract, ginger extract, kola nut extract, and Rhodiola rosea extract.

[0035] In one implementation, the animal extract nutrients are one or more of the following: hydrolyzed egg yolk powder, whey powder, pearl peptide powder, yeast powder containing SOD, and clam polysaccharide.

[0036] In one implementation, the protein nutrient is one or more of the following: colostrum basic protein, milk basic protein, lactoferrin, casein, whey protein isolate, yeast protein, collagen powder, and collagen peptides.

[0037] In one embodiment, the amino acid nutrient is one or more of the following: glycine, alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, arginine, histidine, selenocysteine, and lysine.

[0038] In one implementation, the probiotics are one or more of the following: Bifidobacterium species, Lactobacillus species, Lactobacillus species, Lactobacillus species, Lactobacillus species, Lactobacillus species, Lactobacillus species, Lactobacillus species, Streptococcus species, Lactococcus species, Propionibacterium species, Propionibacterium species, Leuconostoc species, Pediococcus species, Weizmannella species, Zoococcus species, Staphylococcus species, and Kluyveromyces species.

[0039] In one embodiment, the vitamin nutrient is one or more of the following: vitamin B1, vitamin B2, vitamin B3 and its derivatives, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin K1, vitamin K2, folic acid, biotin, and inositol.

[0040] In one implementation, the fermentable nutrient is one or more of the following: coenzyme Q10, sodium hyaluronate, gamma-aminobutyric acid (GABA), and human milk oligosaccharides.

[0041] In one embodiment, the chemically synthesized nutrient is one or more of the following: melatonin, N-acetylneuraminic acid, cis-15-tetracosenoic acid, disodium pyrroloquinoline quinone, choline, and para-aminobenzoic acid.

[0042] In one embodiment, the functional sugar is one or more of the following: galactooligosaccharides, fructooligosaccharides, cottonseed oligosaccharides, yeast glucan, mannose oligosaccharides, chitosan oligosaccharides, and L-arabinose.

[0043] In one implementation scheme, the food-medicine homologous substance is one or more of the following ground into powder: sea buckthorn, amla, mulberry leaf, chicken gizzard lining, Solomon's seal, licorice, angelica, ginkgo, yam, hawthorn, cassia seed, lily, kelp, monk fruit, honeysuckle, houttuynia cordata, Japanese raisin tree fruit, wolfberry, gardenia, amomum villosum, sterculia lychnophora, poria cocos, citron, lotus seed, dandelion, jujube seed, chrysanthemum, chicory, perilla, perilla seed, kudzu root, black sesame, tangerine peel, mint, raspberry, patchouli, angelica sinensis, galangal, saffron, cardamom, turmeric, long pepper, codonopsis, cistanche, dendrobium officinale, American ginseng, astragalus, ganoderma lucidum, cornus officinalis, gastrodia elata, and eucommia ulmoides leaf.

[0044] In one implementation, the oil-soluble active ingredient is an oil-soluble vitamin.

[0045] In one implementation, the mineral is one or more of the following: calcium, magnesium, potassium, manganese, iron, zinc, selenium, and copper.

[0046] In one implementation, the vegetable oil is one or more of the following: rice bran wax, soybean oil, corn oil, sunflower seed oil, peanut oil, flaxseed oil, safflower seed oil, perilla oil, maple seed oil, walnut oil, rapeseed oil, wheat germ oil, pumpkin seed oil, coconut oil, cocoa butter, sea buckthorn fruit oil, grape seed oil, rice bran oil, borage oil, hemp seed oil, palm oil, olive oil, camellia seed oil, goji berry oil, palm kernel oil algae oil, and DHA algae oil.

[0047] In one implementation, the animal fat is one or more of fish oil, cod liver oil, and beeswax.

[0048] In one embodiment, the processed oil is one or more of the following: glyceryl monostearate, glyceryl distearate, medium-chain triglycerides, palm oil fractions, concentrated fish oil, ethyl ester fish oil, rTG fish oil, edible hydrogenated oil, margarine, shortening, cocoa butter substitute, vegetable fat butter, and powdered oil.

[0049] In one implementation, the species of Bifidobacterium is one or more of Bifidobacterium adolescentis, Bifidobacterium animalis subspecies, Bifidobacterium animalis subspecies, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum subspecies, and Bifidobacterium longum subspecies.

[0050] In one implementation, the Lactobacillus species is one or more of Lactobacillus acidophilus, Lactobacillus curvaturei, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. lactis, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus johnsonii, and Lactobacillus maltii subsp. maltii.

[0051] In one implementation, the species of Lactobacillus is one or more of Lactobacillus casei, Lactobacillus paracasei, and Lactobacillus rhamnosus.

[0052] In one embodiment, *Lactobacillus* is one or more of *Lactobacillus fermentatus* and *Lactobacillus reuteri*.

[0053] In one implementation, the species of the genus *Lactobacillus* is *Lactobacillus plantarum*.

[0054] In one implementation, the species of *Lactobacillus* is *Lactobacillus salivarius*.

[0055] In one implementation, the species of *Lactobacillus* is one or more of *Lactobacillus curvatureus* and *Lactobacillus sakei*; or the species of *Streptococcus* is *Streptococcus thermophilus* subsp. *salivaryis*.

[0056] In one embodiment, the *Lactococcus* species is one or more of *Lactococcus lactis* subsp. *lactococcus*, *Lactococcus lactis* diacetyl type, and *Lactococcus fat*.

[0057] In one embodiment, the *Propionibacterium* species is *Propionibacterium fischeri* subsp. *she*. In one embodiment, the *Propionibacterium* species is propionate-producing *Propionibacterium*. In one embodiment, the *Leuconostoc* species is *Leuconostoc mesenteroides* subsp. *mesenteroides*. In one embodiment, the *Pediococcus* species is one or more of *Pediococcus lactis* and *Pediococcus pentosaceus*. In one embodiment, the *Weizmannella* species is *Weizmannella coagulans*. In one embodiment, the *Zoococcus* species is *Zoococcus calf*. In one embodiment, the *Staphylococcus* species is one or more of *Staphylococcus xylose* and *Staphylococcus carinatum*. In one embodiment, the *Kluyveromyces* species is *Kluyveromyces marsupialis*. In one embodiment, the calcium is one or more of calcium carbonate, calcium citrate, and calcium chloride. In one embodiment, the magnesium is one or more of magnesium carbonate, magnesium sulfate, and magnesium oxide. In one embodiment, the potassium is one or more of potassium dihydrogen phosphate, potassium chloride, and potassium citrate. In one embodiment, the manganese is one or more of manganese sulfate and manganese gluconate. In one embodiment, the iron is one or more of ferrous sulfate and ferrous fumarate. In one embodiment, the zinc compound is one or more of zinc oxide, zinc sulfate, and zinc citrate. In one embodiment, the selenium compound is one or more of selenium-enriched yeast and sodium selenite. In one embodiment, the copper compound is one or more of copper sulfate and copper gluconate.

[0058] In one embodiment, glyceryl monostearate and glyceryl distearate are each independently obtained by reacting one or more fatty acids selected from oleic acid, linoleic acid, linolenic acid, palmitic acid, behenic acid, stearic acid, and lauric acid with glycerol.

[0059] In one embodiment, the liquid composition is an oil-powder two-phase composition. In one embodiment, the oil-powder two-phase composition may comprise 1-5 parts by weight (e.g., 1, 2, 3, 4, 5 parts by weight) of glyceryl monostearate, 80-95 parts by weight (e.g., 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95 parts by weight) of medium-chain triglycerides or sunflower oil, and 1-15 parts by weight (e.g., 1, 2, 3, 4, 5 parts by weight) of probiotic powder or zinc oxide. In one embodiment, the oil-powder two-phase composition comprises glyceryl monostearate, medium-chain triglycerides or sunflower oil, and probiotic powder or zinc oxide to form oil crystal aggregates with a size of 25-100 μm. The sizes of the lipid crystal aggregates are, for example, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, and 100 μm. The size of oil crystal aggregates can be determined using methods or software commonly used in the field (such as LISSCAPTURE software).

[0060] In another aspect, a dripping method is provided, which includes using the dripping device described herein to drip the first drop within 1-6 seconds, and then dripping each drop at a rate of 0.8-1 second / drop.

[0061] In another aspect, a kit is provided for forming the dropper device described herein, the kit comprising a bottle having a cavity, a liquid composition, and a stopper, wherein the bottle having a cavity, the liquid composition, and the stopper are separate from each other or integrally formed. The liquid composition is separate from the bottle or encapsulated within the cavity.

[0062] In another aspect, a drop is provided, formulated as the drop device described herein, and comprising 1-5 parts by weight of glyceryl monostearate, 80-95 parts by weight of medium-chain triglycerides or sunflower seed oil, and 1-15 parts by weight of probiotic powder or zinc oxide, and the drop has a viscosity η of 40-400 mPa·s. In one embodiment, the drop contains oil crystal aggregates with a size of 25-100 μm. The various embodiments described above for the liquid composition are equally applicable to the drops described herein.

[0063] The beneficial effects of this application include: (1) the device of this application can achieve controllable dripping rate of oil-powder composition; (2) the composition formulation maintains good dispersion effect and ensures accurate dosage; (3) the composition may contain a small amount of suspending agent or no suspending agent. Attached Figure Description

[0064] Figure 1 An exemplary dispensing device of this application is shown. 1. Dropper reflux port; 2. Bottle body; 3. Bottle cavity; 4. Dropper head; 5. Dropper liquid channel; 6. Dropper outlet (R1); 7. Dropper air channel; 8. Dropper vent (R2).

[0065] Figure 2 A photograph of the dropper device of this application is shown. Detailed Implementation

[0066] To make the objectives, technical solutions, and advantages of this invention clearer, the technical solutions in the embodiments of this invention will be clearly and completely described below in conjunction with the embodiments of this invention. Obviously, the described embodiments are only some embodiments of this invention, not all embodiments. Based on the embodiments of this invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this invention.

[0067] As used in this article, when referring to a range of values, any integer or fraction within that range is included. For example, referring to “1-5 parts by weight” includes 1, 2, 3, 4, 5 parts by weight, as well as fractions such as 1.1, 1.2, 1.3, 1.4, 1.5, 1.6, 1.7, 1.8, 1.9, 2.1, and so on, and any range between these values.

[0068] As used herein, "liquid composition" refers to a multi-component system in which the components are uniformly mixed and the overall composition is in a liquid state, particularly possessing the characteristic of being flowable. Liquid compositions can encompass various liquid forms, such as liquids, suspensions, emulsions, or semi-solid fluids with flowability. Liquid compositions can also include two-phase compositions of oil and powder.

[0069] As used herein, "oil-powder two-phase composition" refers to a multiphase system formed by physical mixing or dispersion stabilization techniques of an oily dispersed phase and a powdered dispersed phase. The oily dispersed phase (oil phase) is typically a water-insoluble fat-soluble component (such as vegetable oil, mineral oil, synthetic fats, fat-soluble active substances, etc.), existing in the form of droplets, films, or gels; the powdered dispersed phase (powder phase) is a solid particulate matter (such as inorganic powders, organic powders, active powders, carrier powders, etc.), with a particle size typically in the nanometer to micrometer range. The preparation process of the oil-powder two-phase composition may include melting and mixing and ultrasonic treatment. The melting and mixing process involves fully melting the oil at 60–85°C, mixing and stirring until homogeneous, cooling to room temperature, and then adding the powder. Ultrasonic treatment involves further ultrasonication of the melt-mixed composition, with a residence time of 0.1–60 min, a power of 100–1000 W, and a temperature of 4–50°C. The oil-powder two-phase composition may contain oil or an oil composition and powder or a powder composition.

[0070] Oils or oil compositions typically include one or more of the following: vegetable oils, animal oils, processed oils (edible oil products, glycerides), oil-soluble functional ingredients, and oil-soluble flavoring agents. Processed oils include glyceryl monostearate, glyceryl distearate, and mixtures thereof obtained by reacting fatty acids such as oleic acid, linoleic acid, linolenic acid, palmitic acid, behenic acid, stearic acid, and lauric acid with glycerol. Further processed oils or edible oil products obtained from animal and vegetable oils through processes such as extraction, concentration, refining, esterification, and hydrogenation include medium-chain triglycerides (caprylic / capric triglyceride, MCT), palm oil extracts, concentrated fish oil, ethyl ester-type fish oil, rTG fish oil, edible hydrogenated oils, margarine, shortening, cocoa butter substitutes (including cocoa butter substitutes), vegetable fat cream, and powdered oils. Glyceryl esters are food additives made from the reaction of saturated or unsaturated fatty acids or oils with glycerol, and are obtained through processing such as separation and purification, including mono- and diglyceride fatty acid esters (oleic acid, linoleic acid, linolenic acid, palmitic acid, behenic acid, stearic acid, and lauric acid). Edible oil products are single or mixed animal or vegetable oils processed through one or more methods such as refining, hydrogenation, transesterification, and fractionation, with or without water and other excipients, and manufactured as solid, semi-solid, or fluid oil products with certain properties through emulsification, rapid cooling, and kneading. These include edible hydrogenated oils, margarine, shortening, cocoa butter substitutes (including cocoa butter-like substances), vegetable fat cream, and powdered oils. When oils or oil compositions are melted and then allowed to stand at room temperature (e.g., 25-35°C) for 1 hour, oil crystal aggregates will form. Oil crystal aggregates are aggregates with different structural levels formed by the aggregation of structural factors (such as long-chain fatty acids and natural waxes) in the oil through intermolecular forces during the crystallization process. Oil crystal aggregates were spread on a glass slide and stabilized for 30 seconds. They were then observed using an optical microscope at 5 x 10 magnification. Simultaneously, measurements were performed using LISSCAPTURE software. At least 20 oil crystal aggregates were taken from each sample for measurement, and the average value was used to determine the size range of the oil crystal aggregates.

[0071] The powder or powder composition can be any suitable flavoring powder and functional powder (or powdered active ingredient). For example, flavoring powders are one or more of fruit and vegetable powders, flavorings, sweetness modifiers, oil-soluble flavoring agents, and acidity modifiers. Functional powders are one or more of plant-derived nutrients, animal-derived nutrients, protein nutrients, amino acid nutrients, probiotic nutrients, vitamin nutrients, fermented nutrients, chemically synthesized nutrients, functional sugars, food-medicine homologous substances, oil-soluble active ingredients, and minerals.

[0072] The primary technical effect achieved by this invention is the control of the dripping speed: the first drop can be dripped within 1-6 seconds, and the subsequent dripping speed of each drop is 0.8-1 seconds, thereby meeting consumer demand. This is achieved by controlling the viscosity of the oil-powder composition to be between 40 and 400 mPa·s.

[0073] And R1=K1 x η 1 / 4 ,at the same time

[0074] When 40 ≤ η ≤ 120, 0.0005 m / (Pa·s) 4 ≤K1≤0.0015 m / (Pa·s) 4

[0075] When 120 < η ≤ 200, 0.0005 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4

[0076] When 200 < η ≤ 300, 0.0008 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4

[0077] When 300 < η ≤ 400, 0.001 m / (Pa·s) 4 <K1≤0.0026 m / (Pa·s) 4

[0078] R2 = K2 x R1, and 0.5 ≤ K2 ≤ 1.5.

[0079] In one implementation, the first droplet ejaculation time is 0.6 to 14 seconds, preferably 0.6 to 12 seconds, 0.6 to 10 seconds, 0.6 to 8 seconds, or 1 to 6 seconds. For example, the first droplet ejaculation time is 0.6, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, or 14 seconds.

[0080] In one implementation, the dripping time interval is 0.4-1.8 seconds, 0.4-1.6 seconds, 0.4-1.2 seconds, or 0.4-1 second. For example, the dripping time interval is 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, 1.5, or 1.6 seconds.

[0081] When the viscosity is <40 mPa·s, the composition at this viscosity is generally a single-phase liquid of oil. At this time, the viscosity of the composition is low, and the dripping of the liquid is mainly affected by its own gravity. That is, the resistance caused by the surface tension of the liquid at the outlet is small, and it is in a rapid dripping state. The dripping speed of each drop is <0.8s, which is too fast.

[0082] When the viscosity is >400 mPa·s, the composition is quite viscous, and the resistance encountered during the dripping process has a huge impact. This problem cannot be solved by the synergistic relationship between the discharge port and the vent hole alone, and the dripping speed of each drop is >1s.

[0083] When the composition is in the range of 40-400 mPa·s, its viscosity is strongly correlated with the design of the discharge port and vent, as shown in the formula above. For example, when 40 ≤ η ≤ 120, K1 > 0.0015 m / (Pa·s). 4 At this time, the corresponding discharge port and vent are designed to be too large, resulting in excessively fast dripping of moisture, with each drop dripping at a rate of <0.8s; conversely, when K1 <0.0005m / (Pa·s) 4 At this point, both the outlet and vent are designed to be too small, resulting in a slow dripping speed, with each drop exceeding 1 second. When K1 is within the specified range and K2 > 2, the vent is designed to be too large, which may cause the composition to flow out of the vent. Conversely, when K2 < 0.2, the vent is designed to be too small, which may prevent the gas pressure inside the bottle from being balanced smoothly, thus preventing the composition from dripping out.

[0084] In one implementation, when 40 ≤ η ≤ 120, 0.0005 m / (Pa·s) 4 ≤K1≤0.0015 m / (Pa·s) 4 In this embodiment, η can be 40, 45, 50, 55, 60, 65, 70, 75, 80, 85, 90, 95, 100, 105, 110, 115, or 200 mPa·s, or any range therebetween. In this embodiment, K1 can be 0.0005, 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.0011, 0.0012, 0.0013, 0.0014, or 0.0015 m / (Pa·s). 4 Or any range therein.

[0085] In one implementation, when 120 < η ≤ 200, 0.0005 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4In this embodiment, η can be any range of 121, 125, 130, 135, 140, 145, 150, 155, 160, 165, 170, 175, 180, 195, or 200 mPa·s. In this embodiment, K1 can be 0.0006, 0.0007, 0.0008, 0.0009, 0.001, 0.0011, 0.0012, 0.0013, 0.0014, 0.0015, 0.0016, 0.0017, 0.0018, 0.0019, or 0.002 m / (Pa·s). 4 or any range thereof.

[0086] In one implementation, when 200 < η ≤ 300, 0.0008 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4 In this embodiment, η can be any range of 201, 205, 210, 215, 220, 230, 235, 240, 245, 250, 255, 260, 265, 270, 275, 280, 295, or 300 mPa·s. In this embodiment, K1 can be 0.0009, 0.001, 0.0011, 0.0012, 0.0013, 0.0014, 0.0015, 0.0016, 0.0017, 0.0018, 0.0019, or 0.002 m / (Pa·s). 4 or any range thereof.

[0087] In one implementation, when 300 < η ≤ 400, 0.001 m / (Pa·s) 4 <K1≤0.0026 m / (Pa·s) 4 In this embodiment, η can be any range of 301, 305, 310, 315, 320, 330, 335, 340, 345, 350, 355, 360, 365, 370, 375, 380, 395, or 400 mPa·s. In this embodiment, K1 can be 0.001, 0.0011, 0.0012, 0.0013, 0.0014, 0.0015, 0.0016, 0.0017, 0.0018, 0.0019, 0.002, 0.0021, 0.0022, 0.0023, 0.0024, 0.0025, or 0.0026 m / (Pa·s). 4 or any range thereof.

[0088] In one implementation, K2 can be 0.5, 0.6, 0.7, 0.8, 0.9, 1, 1.1, 1.2, 1.3, 1.4, or 1.5 or any range thereof.

[0089] Dropping device

[0090] like Figure 1 As shown, the dropper includes a bottle body (made of a rigid material such as glass) with a cavity and a stopper. The stopper is located at the opening of the bottle body, which has a threaded opening. The stopper can be fixed to the opening of the bottle body by a threaded connection. The stopper has an annular groove, and a dropper head (such as a dropper tip) is located at the center of the annular groove. Figure 1 (As shown in the small diagram on the right). The bottle stopper includes a dropper channel that communicates with the dropper head. When the bottle opening is vertically downward (no pressure is applied to the bottle due to gravity), the drops in the bottle cavity flow from the droplet outlet into the dropper channel and flow out from the dropper head in the form of droplets. The annular groove is configured to receive backflow liquid from the dropper when the used dropper bottle is placed on a table. The bottom of the annular groove has a dropper vent channel that communicates with the bottle cavity. The dropper vent channel has a dropper vent hole at the end away from the bottle opening, which is further away from the bottle opening than the droplet outlet. In one embodiment, the diameter of the dropper channel can be designed as a segmented variable diameter (e.g., Figure 1 (As shown in the small diagram on the left). In another embodiment, the cross-section of the dropper channel is tapered (as shown in the small diagram on the left). Figure 1 (As shown in the middle small figure). The dropper can be used as a dispensing bottle, for example, a bottle with graduations on its body. In one embodiment, the diameter of the dropper vent is constant.

[0091] Fluid dynamics analysis and formula fitting of key parameters (R1, R2, η) in dropper nozzle design

[0092] 1. Theoretical basis: The working process of the dripper involves liquid outflow and air inflow. The entire system can be regarded as a micro fluid system driven by gravity and subjected to the combined effects of viscous force, pressure and surface tension.

[0093] 1.1 Liquid outflow governing equation: Application of Poiseuille's law

[0094] The liquid flows out from the outlet R1, which can be approximated as flow through a narrow tube under the influence of a pressure gradient. For viscous fluids (such as the liquid in this application), the Navier-Stokes equations are used to describe the flow. Under laminar flow conditions at low velocities (i.e., low Reynolds numbers), the Navier-Stokes equations can be simplified to the more practical Hagen-Poiseuille's law. This law clearly states the relationship between the volumetric flow rate (Q) in the pipe and the pipe radius (R), fluid viscosity (η), pipe length (L), and the pressure difference (ΔP) between the two ends:

[0095] This relationship is known in the art.

[0096] In dropper systems

[0097] Q (Q_out): Represents the dripping rate (volume / time) of the liquid. A good nozzle design should maintain a relatively stable and acceptable dripping rate at different viscosities.

[0098] R (R1): Represents the radius of the discharge port.

[0099] η: represents the viscosity of the liquid.

[0100] L (L2): Represents the effective length of the liquid column driving the liquid outflow. The distance L2 from the outlet to the bottom of the bottle determines the main hydrostatic head.

[0101] ΔP (ΔP out The effective pressure difference driving the liquid outflow is represented by ρgL², which is mainly determined by the hydrostatic pressure generated by the liquid column (ρgL², where ρ is the liquid density and g is the acceleration due to gravity) and the pressure difference between the inside and outside of the bottle.

[0102] ;

[0103] 1.2 Gas inflow and pressure balance: Function of vent R2;

[0104] When the liquid flows out, the volume of liquid inside the bottle decreases. If there is no air supply, the pressure P inside the bottle will... bottle The pressure will drop, creating a negative pressure. This negative pressure will prevent the liquid from continuing to flow out. The function of the vent R2 is to provide a channel for outside air (at pressure P) to flow out. atm The liquid can flow into the bottle to compensate for the volume loss caused by the outflow of liquid, thereby maintaining the relative balance of pressure inside and outside the bottle.

[0105] The process of air flowing in through R2 can also be seen as the gas moving through a pressure difference ( Driven by an airflow through a channel, the liquid must drip continuously and stably. To ensure a steady flow of air, the volume of air flowing in per unit time (Q¿) must be approximately equal to the volume of liquid flowing out (Q). out If the vent R2 is too small, the resistance to air inflow will be very high. To drive sufficient air inflow, a significant negative pressure needs to be created inside the bottle (i.e., ΔP¿ increases). This results in an effective pressure difference ΔP driving the liquid outflow. out A sharp decrease, or even a negative value, can prevent liquid from flowing out. This is a case of vacuum lock or gas lock. Therefore, the size of R2 must be matched with R1 and the properties of the liquid to ensure smooth gas-liquid exchange.

[0106] 2. Derivation of key parameters

[0107] 2.1 Derivation of the relationship between the outlet radius R1 and the liquid viscosity η;

[0108] The derivation is based on Poiseuille's law. When using a dropper, it is desirable for the dripping rate Q to remain constant regardless of the liquid viscosity. Therefore, the dripping rate Q can be assumed to be a design target constant. From Poiseuille's law... Starting from here, we can obtain:

[0109]

[0110] The driving pressure difference ΔP mainly comes from the hydrostatic head ρgL². Under steady-fall conditions, the negative pressure inside the bottle remains at a small, stable value, so ΔP can be approximated as being proportional to ρgL². To simplify the model, we initially assume that ΔP does not change significantly with viscosity (this will be corrected later based on results from the example for R2).

[0111] This is simplified as follows.

[0112]

[0113] K1 includes the desired flow velocity Q, liquid density ρ, gravity g, and other pressure-related system parameters. Based on the complete form of Poiseuille's law, it can be deduced that... .

[0114] 2.2 Derivation of the relationship between the vent radius R2 and the discharge port radius R1

[0115] The condition for stable dripping is that the air inflow rate is approximately equal to the liquid outflow rate (Q ≈ Q). out A simplified flow model can also be applied to airflow. The viscosity of air, η... air It is much smaller than the liquid viscosity η, and is essentially a constant.

[0116] Let the effective pressure difference for air flow be ΔP¿, and the effective pressure difference for liquid outflow be ΔP. outLet there be: ;

[0117] (This model is sufficient to simulate the actual situation)

[0118] Let Qout = Q¿, then we get: ,

[0119] Place R1 and R2 on one side. .

[0120] The relationship shows that the R2 / R1 ratio is related to viscosity η and pressure distribution. In practice, as η increases, R2 increases with R1; R2 tends to be less than or equal to R1; if R2 is too small, flow stops. Based on this, the formula simplifies to a linear relationship with a constant.

[0121] R2 = k·R1;

[0122] Where k is a dimensionless proportionality coefficient, representing the ratio of the radius of the vent to the radius of the discharge port.

[0123] 2.3 Influence of distance parameter L2

[0124] L2 (distance from outlet to bottom of bottle): This determines the main driving force propelling the liquid outflow—the hydrostatic head (ρgL2). In the formula... In this context, the effect of L2 is included in the constant K1. If L2 increases, the driving force is enhanced, and for the same viscosity η and flow rate Q, the required R1 can be smaller.

[0125] 3. Final Formula

[0126]

[0127] Where R1 is the design radius of the discharge port.

[0128] η: Dynamic viscosity of the target liquid.

[0129] K1: System design constant. It is a lumped parameter whose physical meaning is mainly determined by the desired dripping rate Q, liquid density ρ, and gravitational acceleration g. .

[0130] R2: Design radius of the vent.

[0131] K2: Dimensionless, gas-liquid balance coefficient, representing the ratio of the radii of the vent to the discharge port.

[0132] 4. Experimental process;

[0133] By designing multiple droppers with different R1 and R2 values, commissioning dropper suppliers to manufacture the droppers, and evaluating the dispensing effect under different liquid viscosities, the ranges of K1 and K2 were summarized (as shown in the data of the example).

[0134] Based on the above fluid dynamics analysis and formula fitting, the following formula is derived:

[0135] R1=K1 x η 1 / 4

[0136] When 40 ≤ η ≤ 120, the value is 0.0005 m / (Pa·s). 4 ≤K1≤0.0015 m / (Pa·s) 4 ;

[0137] When 120 < η ≤ 200, 0.0005 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4 ;

[0138] When 200 < η ≤ 300, 0.0008 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4 ;

[0139] When 300 < η ≤ 400, 0.001 m / (Pa·s) 4 <K1≤0.0026 m / (Pa·s) 4 And R2 = K2 x R1, and 0.5 ≤ K2 ≤ 1.5.

[0140] Example

[0141] The following embodiments are provided to illustrate the present invention. Those skilled in the art should understand that the embodiments are merely illustrative and not restrictive. The invention is limited only by the scope of the appended claims.

[0142] The preparation process of the oil-powder two-phase composition includes melting and mixing and ultrasonic treatment. The melting and mixing process involves fully melting the oil (such as glyceryl monostearate or MCT) at 60–85°C, mixing and stirring until homogeneous, cooling to room temperature, and then adding the powder (such as probiotic powder or zinc oxide). The ultrasonic treatment involves further sonicating the melt-mixed composition for a residence time of 0.1–60 min, a power of 100–1000 W, and a temperature of 4–50°C.

[0143] In this embodiment, the dropper nozzle of the dropper device was manufactured by a supplier. Schematic diagrams and photographs of the dropper device are shown below. Figure 1 and Figure 2 As shown.

[0144] The dropper device was evaluated using the following measurement methods and scoring criteria.

[0145] Dispensing interval: Open the cap of the dispensing device, invert the dispensing device, and point the nozzle vertically downwards. Simultaneously, use a stopwatch to record the interval between each drop. Detect 6 sets of interval data, in seconds. If the dispensing speed is too fast, it will be impossible to accurately quantify the dispensing speed. If the dispensing speed is too slow, it will result in a long waiting time, affecting the actual experience. The optimal score is a dispensing speed of 0.8~1s per drop.

[0146] First drop time: Open the cap of the dropper, invert the dropper, with the nozzle pointing vertically downwards, and use a stopwatch to record the time it takes for the first drop to be dispensed from the moment it is inverted. A first drop that is too fast or too slow will affect the actual user experience. The optimal score is a first drop time of 1-6 seconds.

[0147] Table 1: Scoring Criteria for Dropper Devices

[0148]

[0149] Example 1: Determining the range of K1 for the dropper

[0150] The oil-powder two-phase composition was prepared according to the material formulation in Table 2. The oil-powder two-phase composition was then loaded into a dispensing device. A schematic diagram and photograph of the dispensing device are shown below. Figure 1 and Figure 2 As shown in the diagram. Invert the dropper so that the tip is pointing vertically downwards. Calculate the dispensing time interval and the time of the first drop. The results are shown in Table 2.

[0151] Table 2: Determine the range of K1 while fixing K2.

[0152]

[0153] Table 2 continued:

[0154]

[0155] As shown in Table 2, with fixed composition viscosity and K2, when both K1 and K2 are within suitable ranges, the sample dripping time interval and the first dripping time are significantly improved, reflected in a high comprehensive score >3. This means that when the viscosity is 80 and 250, K1 within the corresponding limited ranges of 0.0005 <= K1 <= 0.0015 and 0.0008 < K1 <= 0.002, a suitable discharge port can be prepared, and the dripping speed is suitable and controllable. When K2 is within a suitable range, the air pressure can be effectively replenished through a reasonable vent R2 size to ensure that the liquid in the bottle can drip out smoothly and continuously and evenly.

[0156] Compared with Examples 1-4, when K1 is not in the optimal range of K1 (0.0005 <= K1 <= 0.0015) for viscosity 80 or 250, and when K1 is not in the optimal range of K1 (0.0008 < K1 <= 0.002) for viscosity 250, the obtained discharge port R1 is too small (Comparative Examples 1 and 3) or too large (Comparative Examples 2 and 4). Even if K2 is in a reasonable range, the combination of R1 and R2 obtained based on this cannot ultimately meet the requirements of the first droplet dispensing time and the dispensing time interval, resulting in a low overall score.

[0157] Example 2: Determining the range of K2 for the dropper

[0158] An oil-powder two-phase composition was prepared according to the material formulation in Table 3. The oil-powder two-phase composition was loaded into a dropping device, which was then inverted with the nozzle pointing vertically downwards. The dropping time interval and the time of the first drop were calculated. The results are shown in Table 3.

[0159] Table 3: Determine the range of K2 while fixing K1.

[0160]

[0161] Table 3 (continued)

[0162]

[0163] As shown in Table 3, when the viscosity of the composition is fixed and its corresponding K1 is used to obtain a suitable outlet R1, and a reasonable vent R2 is obtained within the range of K2, it can be ensured that the first drop time and the drop interval are within a suitable range, which is reflected in a high comprehensive score >3. It can be considered that when K2 is 0.5 to 1.5, the corresponding vent size is appropriate, which can ensure that the dripping process is appropriate and controllable.

[0164] In Comparative Examples 5-8, K1 achieved R1 within a suitable range. However, in Comparative Examples 5 and 7, K2=0.3, resulting in a smaller R2 at the corresponding vent, which failed to adequately replenish the pressure inside the bottle. This led to the composition failing to drip smoothly and stably in the later stages, resulting in a low overall score. In Comparative Examples 6 and 8, K2=2.2, indicating a larger R2 at the corresponding vent. This resulted in an excessively fast dripping rate that could not be controlled, and even caused the composition to flow out of the vent, also resulting in a low overall score.

[0165] Example 3: Determining the relationship between K1 and different viscosity ranges of the composition

[0166] An oil-powder two-phase composition was prepared according to the material formulation in Table 4. The oil-powder two-phase composition was loaded into a dropping device, which was then inverted with the nozzle pointing vertically downwards. The dropping time interval and the time of the first drop were calculated. The results are shown in Table 4.

[0167] Table 4: Relationship between K1 and different viscosity ranges of the composition:

[0168]

[0169] Table 4 (continued)

[0170]

[0171] As shown in Table 4, among the compositions in Table 4, as the viscosity of the composition increases, when the corresponding viscosity is within the optimal K1 range of the corresponding viscosity range, and K2 is also within the appropriate range, the sample dripping time interval and the first dripping time are significantly improved, resulting in a higher overall score (>3). This means that when the composition viscosity is 40-400, K1 and K2 are within the optimal range, and a suitable size outlet R1 and a suitable size vent R2 can be obtained, ensuring that the first dripping time and dripping time interval are controllable. In Comparative Example 9, the composition viscosity is 20. At this time, the corresponding composition is almost a single-phase liquid of pure oil, and the surface tension resistance formed at the outlet is small. Under the R value range calculated within the K1 and K2 ranges specified in this application, it still has an excessively fast dripping speed, and even when inverted, it is in a continuous dripping state, resulting in a low overall score.

[0172] Compared with Examples 10 and 11, when the viscosity of the composition is 200 and 300, the R1 value calculated by K1 in other viscosity ranges but not in the corresponding optimal K1 range still cannot obtain a good score, and the overall score is <3. Compared with Examples 12 and 13, the corresponding compositions are more viscous, and the frictional resistance of the wall during the dripping process is large, and the composition cannot drip smoothly. Even if the discharge port R1 is enlarged, the first dripping time and the dripping time interval cannot meet the requirements, and the overall score is low.

[0173] Example 4: Determination of dispersion efficiency and dripping accuracy of the mixture.

[0174] The following measurement methods and scoring methods were used for evaluation in the examples:

[0175] Dispersion efficiency: The sample was left to stand for 24 hours, and then rotated and shaken using a 6cm robotic arm at a speed of 40rpm / min. The time it took for the sample to become evenly dispersed without layering or sedimentation was recorded by visual observation, with the unit being seconds. The faster the speed, the higher the score.

[0176] Droplet accuracy: The weight repeatability test of the dispensed samples was conducted using groups of four drops. The relative standard deviation (RSD) was calculated for the weight results of 30 parallel samples, expressed as a percentage (%). RSD indicates the dispersion of a dataset relative to its mean, calculated by dividing the standard deviation of the data by its mean. A smaller RSD value indicates more concentrated data, higher accuracy, and a higher score.

[0177] The oil-powder two-phase composition prepared according to the formulation in Table 6 was allowed to stand at 25-35°C for 1 hour to stabilize the oil crystal aggregates in the product. Then, it was spread on a glass slide and stabilized for 30 seconds. It was then observed using an optical microscope at 5 x 10x magnification, and measurements were performed using LISSCAPTURE software. At least 20 oil crystal aggregates were measured for each sample, and the average value was taken to determine the size range of the oil crystal aggregates in the composition.

[0178] The mixture was prepared according to the material formulation in Table 6. The dispersion efficiency and dripping accuracy of the mixture were determined.

[0179] Table 5

[0180]

[0181] Table 6:

[0182]

[0183] Table 6 (continued)

[0184]

[0185] As shown in Table 6, for each composition, as the size of the oil crystal aggregates decreases, the viscosity of the composition gradually increases. After standing for 24 hours, the sample does not separate into layers and does not require redispersing, or it separates slightly while the dispersion efficiency is appropriate. By selecting appropriate K1 and K2 for different viscosities, suitable sizes of outlet R1 and vent R2 can be obtained. At this time, the dripping accuracy is significantly improved, which is reflected in a high comprehensive score >3. That is, when the size of the oil crystal aggregates in the composition is 25-100μm, the corresponding composition viscosity is 40-400mPa·s. By adjusting the size of K1 and K2 and selecting appropriate sizes of outlet and vent, the dripping speed is appropriate and controllable, and the dripping accuracy is high.

[0186] Compared with Example 15, the size of the oil crystal aggregates in the composition is 20 μm. At this time, the oil crystal aggregates cannot effectively support the functional factor powder. After standing for 24 hours, obvious stratification occurs. Furthermore, due to the high viscosity of the composition at this time, dispersion is difficult, resulting in low dispersion efficiency and droplet accuracy, which is reflected in the low overall score.

[0187] Compared with Example 14, the size of the oil crystal aggregates in the composition is 120 μm. At this time, the oil crystal aggregates are loose and separate into layers after standing for 24 hours. Although the composition has low viscosity and is easy to disperse, the accuracy of dripping is poor, which is reflected in the low overall score.

[0188] When the liquid composition is an oil-powder two-phase composition, if the size of the oil crystal aggregates in the composition is 25~100μm, there is no stratification and no need to shake it when it is reused after standing for ≤24h; if it is <25μm, the oil crystal aggregates cannot effectively support the functional factor powder and cannot meet the requirement of no stratification within 24h; if it is >100μm, it cannot meet the requirement of rapid shaking after standing for more than 3 months, the shaking time will be >1min, and the accuracy of dripping may be affected due to insufficient shaking.

[0189] The above embodiments are preferred embodiments of the present invention, but the embodiments of the present invention are not limited to the above embodiments. Any changes, modifications, substitutions, combinations, or simplifications made without departing from the spirit and principle of the present invention shall be considered equivalent substitutions and shall be included within the protection scope of the present invention.

Claims

1. A liquid composition having a viscosity η of 40-400 mPa·s, comprising grease and powder, and having grease crystal aggregates with a size of 25-100 μm.

2. The liquid composition according to claim 1, wherein the oil is one or more of vegetable oil, animal oil and processed oil, and / or the powder is one or more of flavoring powder and functional powder.

3. The liquid composition according to claim 1 or 2, wherein the liquid composition comprises 0.01-30 parts by weight of powder and 70-99.99 parts by weight of oil phase.

4. The liquid composition according to claim 2, wherein the vegetable oil is one or more of the following: rice bran wax, soybean oil, corn oil, sunflower seed oil, peanut oil, flaxseed oil, safflower seed oil, perilla oil, maple seed oil, walnut oil, rapeseed oil, wheat germ oil, pumpkin seed oil, coconut oil, cocoa butter, sea buckthorn fruit oil, grape seed oil, rice bran oil, borage oil, hemp seed oil, palm oil, olive oil, camellia seed oil, wolfberry oil, palm kernel oil algae oil, and DHA algae oil; Animal fats are one or more of fish oil, cod liver oil, and beeswax; Processed oils are one or more of the following: glyceryl monostearate, glyceryl distearate, medium-chain triglycerides, palm oil extracts, concentrated fish oil, ethyl ester fish oil, rTG fish oil, edible hydrogenated oil, margarine, shortening, cocoa butter substitute, vegetable fat cream, and powdered oils. Flavoring powders are one or more of the following: fruit and vegetable powders, flavorings, sweetness regulators, oil-soluble flavoring agents, and acidity regulators. Functional powders are one or more of the following: plant extract nutrients, animal extract nutrients, protein nutrients, amino acid nutrients, probiotic nutrients, vitamin nutrients, fermented nutrients, functional sugars, food and medicine homologous substances, oil-soluble functional materials, and minerals.

5. The liquid composition according to claim 4, wherein the fruit and vegetable powder is one or more selected from apple powder, blueberry powder, strawberry powder, mango powder, and purple sweet potato powder; or The spice is rosemary extract; or Oil-soluble flavoring agents include neotame, menthol, cooling agents, and oil-soluble flavorings; or Sweetness modifiers are one or more of powdered sugar, sucralose, aspartame, and mogrosides; or Acidity regulators are one or more of citric acid, malic acid, and lactic acid; or Plant extract nutrients include one or more of the following: blueberry anthocyanins, Dunaliella salina and its extract, inulin, Haematococcus pluvialis powder, Haematococcus pluvialis oil, earthworm protein, mushroom concentrate powder, lychee enzyme, brown algae powder, Acanthopanax senticosus, Gynostemma pentaphyllum, citrus fruit powder, dried tangerine peel powder, white kidney bean powder, green tea powder, cherry fruit powder, vine tea powder, Platycodon grandiflorus powder, corn oligopeptide powder, epigallocatechin gallate, wheat oligopeptide, snow lotus culture, maca powder, ginseng extract, Chlorella vulgaris powder, Cordyceps powder, Euglena rubrum powder, Ampelopsis japonica leaf, Paeonia suffruticosa flower, chia seed powder, Plantago asiatica husk powder, Cordyceps militaris powder, tea theanine, bamboo leaf flavonoids, loquat leaf powder, Pleurotus ostreatus powder, broccoli seed water extract, Nostoc commune powder, Ashitaba juice powder, Loquat flower powder, Gynostemma pentaphyllum powder, quercetin. Potato extract, cherry blossom powder, Chlamydomonas reinhardtii powder, sugarcane polyphenols, rye pollen, Xanthoceras sorbifolium seed kernel powder, Xanthoceras sorbifolium leaf powder, Gynostemma pentaphyllum, catechins, phosphatidylserine, broken-cell wall Ganoderma lucidum spore powder, spirulina powder, Isatis indigotica root powder, Viola yedoensis powder, guarana extract, Chinese cinnamon bark tincture extract, bergamot extract, Alpinia galanga root extract, seaweed extract, yellow mustard extract, alfalfa extract, basil extract, celery seed extract, bay leaf extract, lemon extract, sweet orange peel extract, elderberry flower extract, bay leaf extract, enzyme-treated isoquercitrin, grape seed extract, spearmint extract, Zanthoxylum bungeanum extract, catechin powder, wormwood extract, Juniperus chinensis extract, licorice extract, annatto extract, ginger extract, kola nut extract, and Rhodiola rosea extract; or Animal-derived nutrients include one or more of the following: hydrolyzed egg yolk powder, whey powder, pearl peptide powder, yeast powder containing SOD, and mussel polysaccharides; or The protein nutrients include one or more of the following: colostrum basic protein, milk basic protein, lactoferrin, casein, whey protein isolate, yeast protein, collagen powder, and collagen peptides; or The amino acid nutrients are one or more of the following: glycine, alanine, valine, leucine, isoleucine, methionine, proline, tryptophan, serine, tyrosine, cysteine, phenylalanine, asparagine, glutamine, threonine, aspartic acid, glutamic acid, arginine, histidine, selenocysteine, and lysine; or Probiotics include one or more of the following: *Bifidobacterium*, *Lactobacillus*, *C. casei*, *Lactobacillus mucinus*, *Lactobacillus lactis*, *Lactobacillus assemblica*, *Lactobacillus spp.*, *Streptococcus*, *Lactococcus*, *Propionibacterium*, *Leuconostoc*, *Pediococcus*, *Weizmannella*, *Azoococcus*, *Staphylococcus*, and *Kluyveromyces*; or Vitamins are one or more of the following: vitamin B1, vitamin B2, vitamin B3 and its derivatives, vitamin B5, vitamin B6, vitamin B12, vitamin C, vitamin K1, vitamin K2, folic acid, biotin, and inositol; or Fermented nutrients include one or more of the following: coenzyme Q10, sodium hyaluronate, gamma-aminobutyric acid (GABA), and human milk oligosaccharides; or Functional sugars are one or more of the following: galacto-oligosaccharides, fructo-oligosaccharides, cottonseed oligosaccharides, yeast glucan, mannose oligosaccharides, chitosan oligosaccharides, and L-arabinose; or Food and medicine homology substances are one or more of the following ground into powder: sea buckthorn, amla, mulberry leaf, chicken gizzard lining, Solomon's seal, licorice, angelica, ginkgo, yam, hawthorn, cassia seed, lily, kelp, monk fruit, honeysuckle, houttuynia cordata, Japanese raisin tree fruit, wolfberry, gardenia, amomum villosum, sterculia lychnophora, poria cocos, citron, lotus seed, dandelion, jujube seed, chrysanthemum, chicory, perilla, perilla seed, kudzu root, black sesame, tangerine peel, mint, raspberry, patchouli, angelica sinensis, galangal, saffron, cardamom, turmeric, long pepper, codonopsis, cistanche, dendrobium officinale, American ginseng, astragalus, ganoderma lucidum, cornus officinalis, gastrodia elata, and eucommia ulmoides leaf; or Oil-soluble active ingredients are oil-soluble vitamins; or The minerals are one or more of the following: calcium, magnesium, potassium, manganese, iron, zinc, selenium, and copper.

6. The liquid composition according to claim 5, wherein the Bifidobacterium species is one or more selected from Bifidobacterium adolescentis, Bifidobacterium animalis subsp. animalis, Bifidobacterium animalis subsp. lactis, Bifidobacterium bifidum, Bifidobacterium breve, Bifidobacterium longum subsp. longis, and Bifidobacterium longum subsp. infantis. The species of Lactobacillus include one or more of the following: Lactobacillus acidophilus, Lactobacillus curvaturei, Lactobacillus delbrueckii subsp. bulgaricus, Lactobacillus delbrueckii subsp. lactis, Lactobacillus gasseri, Lactobacillus helveticus, Lactobacillus johnsonii, and Lactobacillus maltii subsp. maltii. The genus *Lactobacillus* includes one or more of the following: *Lactobacillus casei*, *Lactobacillus paracasei*, and *Lactobacillus rhamnosus*. The genus *Lactobacillus* includes one or more of *Lactobacillus fermentatus* and *Lactobacillus reuteri*. The species of the genus *Lactobacillus* is *Lactobacillus plantarum*. The species of the genus *Lactobacillus* is *Lactobacillus salivarii*. The species of the genus *Lactobacillus* are one or more of *Lactobacillus curvaturei* and *Lactobacillus sakei*; or the species of the genus *Streptococcus* is *Streptococcus thermophilus*. Lactococcus species include one or more of Lactococcus lactis subsp. lactis, Lactococcus lactis subsp. diacetate, and Lactococcus fat-type. Propionibacterium species is Propionibacterium fischeri subsp. Scheres; Propionibacterium species are propionic acid-producing bacteria; Leuconostoc species are the Leuconostoc mesenteroides subspecies. The species of the genus *Pediococcus* include one or more of *Pediococcus lactis* and *Pediococcus pentosaceus*. The species of the genus *Weizmannia* is *Weizmannia coagulans*. The species of the genus *Zoococcus* is *Zoococcus calf*. Staphylococcus species include one or more of Staphylococcus xylosus and Staphylococcus carminatus. The species of Kluyveromyces is Kluyveromyces marx. Calcium compounds include one or more of calcium carbonate, calcium citrate, and calcium chloride. Magnesium compounds are one or more of magnesium carbonate, magnesium sulfate, and magnesium oxide; Potassium compounds are one or more of potassium dihydrogen phosphate, potassium chloride, and potassium citrate; Manganese compounds are one or more of manganese sulfate and manganese gluconate; The iron compounds are one or more of ferrous sulfate and ferrous fumarate; Zinc compounds include one or more of zinc oxide, zinc sulfate, and zinc citrate. Selenium compounds include one or more of selenium-enriched yeast and sodium selenite; Copper compounds are one or more of copper sulfate and copper gluconate.

7. The liquid composition according to claim 4, wherein the glyceryl monostearate and the glyceryl distearate are each independently obtained by reacting one or more fatty acids selected from oleic acid, linoleic acid, linolenic acid, palmitic acid, behenic acid, stearic acid, and lauric acid with glycerol to obtain glyceryl monostearate and glyceryl distearate.

8. The liquid composition according to claim 1, wherein the liquid composition comprises 1-5 parts by weight of glyceryl monostearate, 80-95 parts by weight of medium-chain triglycerides or sunflower seed oil, and 1-15 parts by weight of probiotic powder or zinc oxide.

9. The liquid composition according to claim 2, wherein the functional powder is one or more of the following: Bifidobacterium, Lactobacillus, melatonin, N-acetylneuraminic acid, cis-15-tetracosenoic acid, disodium pyrroloquinoline quinone, choline, and para-aminobenzoic acid.

10. A method for dispensing a liquid composition according to any one of claims 1-9, comprising dispensing the liquid composition using a dispensing device, the dispensing device comprising the liquid composition encapsulated within the cavity of the bottle; The bottle stopper is located at the opening of the bottle body and includes a dropper head, a dropper liquid channel connected to the dropper head, a droplet outlet connected to the dropper liquid channel, and a dropper air channel connected to the bottle cavity; wherein the dropper air channel has a dropper vent hole at the end away from the opening of the bottle body. in, The radius of the discharge port is R1, the radius of the vent is R2, and the viscosity η, R1, and R2 satisfy the following relationship: R1=K1 x η 1 / 4 Where 0.0005 m / (Pa·s) is the value when 40≤η≤120. 4 ≤K1≤0.0015 m / (Pa·s) 4 ; When 120 < η ≤ 200, 0.0005 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4 ; When 200 < η ≤ 300, 0.0008 m / (Pa·s) 4 <K1≤0.002 m / (Pa·s) 4 ; When 300 < η ≤ 400, 0.001 m / (Pa·s) 4 <K1≤0.0026 m / (Pa·s) 4 ;and R2 = K2 x R1, and 0.5 ≤ K2 ≤ 1.5; Where K1 is a constant; K2 is the ratio of the radii of the vent to the discharge port.

11. The method according to claim 10, wherein in the dropper, the stopper is provided with an annular groove, and the dropper head is disposed at the center of the annular groove; when the opening of the bottle is vertically downward, the dropper in the bottle cavity flows from the dropper outlet into the dropper channel, and flows out from the dropper head in the form of a droplet through the dropper channel; the annular groove is configured to receive the return fluid flowing out of the dropper after use; the bottom of the annular groove is provided with a dropper air channel communicating with the bottle cavity.

12. The method according to claim 10, wherein in the dropper device, the diameter of the dropper channel is designed to be segmented and / or the cross-section of the dropper channel is tapered.

13. The method of claim 12, wherein the first drop of liquid composition is dispensed within 1-6 seconds, and the subsequent dispensing rate is 0.8-1 second / drop, with a dispensing time interval of 0.4-1.6 seconds.

14. The method according to any one of claims 10-13, wherein K1 is (8Q / πρg) 1 / 4 Q is the desired flow velocity, ρ is the liquid density, and g is gravity.

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