Novel uracil DNA glycosylase bph and its application in base editing
By recognizing and removing hypoxanthine produced by the deamination of the A base using a novel uracil DNA glycosylase, and constructing a novel base editor in conjunction with the Cas protein, the problem of low editing efficiency of existing tools in rice breeding is solved, and precise base replacement is achieved, promoting the industrial application of rice breeding.
CN122277758APending Publication Date: 2026-06-26SANYA NATIONAL INSTITUTE OF SOUTHERN BREEDING CHINESE ACADEMY OF AGRICULTURAL SCIENCES +1
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Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SANYA NATIONAL INSTITUTE OF SOUTHERN BREEDING CHINESE ACADEMY OF AGRICULTURAL SCIENCES
- Filing Date
- 2026-05-26
- Publication Date
- 2026-06-26
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Figure CN122277758A_ABST
Abstract
This invention provides a novel DNA glycosylase Bph and its application in base editing. Specifically, it provides a novel DNA glycosylase Bph and a novel base editor containing this novel DNA glycosylase. This novel base editor can achieve adenine-based base transversions. The novel DNA glycosylase of this invention can be applied to precise genome editing and has promising application prospects.
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