Star-shaped polyamino acid nanoparticles with long circulation property and preparation method and application thereof

Abstract

The application discloses star-shaped polyamino acid nanoparticles with long circulation properties and a preparation method and application thereof, and belongs to the technical field of biological medicines.The nanoparticles are of a star-shaped structure with polyamide-amine dendrimers as a core and copolyamino acids as arms;the nanoparticles are prepared through random copolymerization reaction of polyamide-amine as an initiator, first N -carboxylic acid cyclic anhydride and second N -carboxylic acid cyclic anhydride monomers, and the reaction is carried out in an organic solvent; wherein the organic solvent is a mixed solvent of low-polarity halogenated alkane and high-polarity amide or cyclic ether, and the volume ratio of the two is 9:1, and the preparation method is simple and efficient.The application proves that the star-shaped topological structure and glutamic acid / lysine side chains play a key role in realizing long circulation by regulating the types of amino acids, the charge and the topological structure of the nanoparticles, and the nanoparticles have wide application prospects in the field of preparing tumor treatment drugs.

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