A sleep aid composition based on biotransformation technology and its preparation method

By using microbial enzymatic transformation technology and a symbiotic fermentation system of Lactobacillus plantarum and Saccharomyces cerevisiae, macromolecular glycosides are degraded in a targeted manner to form small molecule aglycones that can easily cross the blood-brain barrier. This solves the problem of low absorption rate of natural plant extracts and achieves highly effective sleep aid and nerve repair.

CN122297576APending Publication Date: 2026-06-30TAIHAOLE BIOTECHNOLOGY CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
TAIHAOLE BIOTECHNOLOGY CO LTD
Filing Date
2026-06-02
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

Existing natural plant extracts have problems such as low absorption rate and difficulty in crossing the blood-brain barrier in improving sleep, and traditional drug treatments for insomnia have problems such as drug resistance and difficulty in repairing neuronal damage.

Method used

Using microbial enzymatic transformation technology, a symbiotic fermentation system of Lactobacillus plantarum and Saccharomyces cerevisiae is used to directionally degrade macromolecular glycosides. Extracts of jujube seed, sea buckthorn, and raspberry are combined with GABA through biological matrix recombination to form small molecule aglycones that can easily cross the blood-brain barrier, thus synergistically exerting the drug effect.

Benefits of technology

It significantly improves the biopermeability and efficacy of active ingredients, promotes the biotransformation of central nervous system nutrients in the preparation of sleep-aiding compositions by prolonging the quality of slow-wave deep sleep, repairing central nervous system synaptic damage, extending the duration of slow-wave deep sleep, and improving sleep quality.

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Abstract

This invention discloses a sleep-aid composition based on biotransformation technology, its preparation method, and its applications. The composition comprises jujube seed extract, sea buckthorn compound extract, γ-aminobutyric acid (GABA), and raspberry anthocyanin extract. Through a dual biotransformation process of "directional fiber-pectin dual-enzyme degradation" and "Lactobacillus plantarum-Saccharomyces cerevisiae symbiotic fermentation," the sugar chains of large molecular weight glycosides in the raw materials are broken down, efficiently enriching free small molecular weight jujube seed saponin A and isorhamnetin aglycone with high brain permeability, and achieving matrix synergy with GABA. The composition of this invention is safe and non-addictive, and can be used to prepare drugs or functional foods for sedation and hypnosis, prolonging slow-wave deep sleep, and promoting neural synapse regeneration and repair.
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