Data acquisition control system based on organ chip microflow

By introducing a rhythm-locked loop module, a phase-controlled acquisition module, an impedance detection module, and a data compensation module into the organ-on-a-chip microfluidic system, the problems of signal distortion caused by fluid pulse noise and sensor contamination were solved, the signal-to-noise ratio of data acquisition and the usable life of the sensor were improved, and the stability of closed-loop control was achieved.

CN122306922APending Publication Date: 2026-06-30SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG FIRST MEDICAL UNIVERSITY (SHANDONG PROVINCIAL HOSPITAL)
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Patent Information

Application Number
CN202610608175.3
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2026-05-06
Publication Date
2026-06-30

AI Technical Summary

Technical Problem

In existing organ-on-a-chip microfluidic data acquisition systems, signal distortion is caused by deep coupling between fluid pulse noise and biofouling of sensors. Furthermore, single-variable closed-loop control is prone to divergence under complex operating conditions, affecting the signal-to-noise ratio of data acquisition and the usable lifespan of sensors.

Method used

A rhythmic phase-locked loop (PLL) module is used to analyze the timing data of the pumping drive current and chamber pressure of the microfluidic pump to obtain the phase-locked clock. Combined with the phase control acquisition module, the signal is acquired within the steady-state window of the fluid laminar flow. The electrode contamination is monitored in real time by the impedance detection module, and the calibration is performed by the data compensation module. Finally, the closed-loop control module performs adaptive microfluidic closed-loop control.

Benefits of technology

This approach achieves temporal decoupling between fluid dynamics noise and biological signals, improves the signal-to-noise ratio, eliminates the impact of sensor contamination, extends the usable lifespan of the sensor array, and enhances the accuracy and stability of closed-loop control.

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Abstract

The invention relates to the technical field of microfluidic biosensing, and discloses a data acquisition control system based on organ chip microflow, which comprises a rhythm phase locking module, a phase control acquisition module, an impedance detection module, a data compensation module and a closed-loop control module. According to the system, pulse rhythm analysis and time domain lock alignment are carried out on microflow pump pumping driving current and chamber pressure time sequence data to generate a phase locking clock, and phase control synchronous acquisition is carried out on a sensor array in a fluid laminar flow steady-state window period to obtain an original biochemical data set; and performing electrochemical impedance spectroscopy detection in a clock low-level interval period to obtain a fouling compensation factor, performing compensation calibration on each modal data based on the factor to obtain a biological phenotypic characteristic matrix, and inputting the biological phenotypic characteristic matrix into a model prediction controller to realize self-adaptive microflow closed-loop control. According to the invention, the signal-to-noise ratio of data acquisition and the robustness of microenvironment control in long-period operation of the organ chip are effectively improved.
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