A traditional Chinese medicine formula for treating hypertension and a preparation method thereof
By using a high-pressure, high-temperature decoction and boiling packaging technology containing Chinese medicinal herbs such as rhubarb and dried ginger, a Chinese medicine preparation suitable for long-term use has been prepared. This solves the problems of large side effects of Western and traditional Chinese medicines in the treatment of hypertension and poor portability of traditional Chinese medicine, and achieves stable blood pressure reduction and low-cost production.
Patent Information
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- HENAN TRADITIONAL HOSPITAL CO LTD
- Filing Date
- 2026-05-19
- Publication Date
- 2026-07-03
AI Technical Summary
Existing treatments for hypertension suffer from problems such as significant side effects, high costs, and difficulty in long-term use of Western medicine, while traditional Chinese medicine treatments lack systematicity and portability, making mass production difficult.
Using a traditional Chinese medicine formula, including 17 kinds of Chinese medicinal materials such as rhubarb, dried ginger, and dragon bone, a stable and effective traditional Chinese medicine preparation was prepared through high-pressure and high-temperature decoction and boiling packaging technology, which is suitable for long-term use.
It achieves stable blood pressure regulation, reduces side effects, lowers production costs, and increases the extraction rate of active ingredients, making it suitable for long-term use and mass production.
Smart Images
Figure CN122321091A_ABST
Abstract
Description
Technical Field
[0001] This invention belongs to the field of hypertension prescription preparation technology, specifically a traditional Chinese medicine prescription for treating hypertension and its preparation method. Background Technology
[0002] Hypertension, a common chronic cardiovascular disease, is treated primarily through two major systems: Western medicine and Traditional Chinese Medicine (TCM). Western medicine often relies on chemical antihypertensive drugs, aiming to rapidly lower blood pressure through pharmacological effects. However, in TCM theory, hypertension is considered a complex holistic pathological state, typically involving a "deficiency of the root and excess of the branch" pathogenesis. This involves multiple factors intertwined, such as imbalance of Yin and Yang, Qi and Blood, hyperactivity of Liver Yang, deficiency of Kidney Essence, and blood stasis and phlegm obstruction. Therefore, an ideal treatment plan not only needs to lower blood pressure but also to regulate the body's Yin-Yang balance holistically and restore the coordination of organ functions to achieve a comprehensive cure.
[0003] Although existing technologies have been applied to the treatment of hypertension, significant limitations and shortcomings remain. First, while Western medicines for lowering blood pressure act quickly, they have short-lasting effects and require long-term, regular use. Long-term use can easily lead to side effects such as liver and kidney damage, electrolyte imbalances, and coughing, and they cannot fundamentally improve the body's pathological environment. Second, current traditional Chinese medicine treatments are mostly limited to simple modifications of single classical formulas, lacking a systematic coverage of the complex pathogenesis of hypertension, which involves both deficiency and excess, resulting in limited diagnosis and unstable efficacy. Finally, in terms of preparation technology and application, traditional decoctions are inconvenient to carry and store, while existing pills and concentrated pastes are often expensive to prepare and have complicated processes that make it difficult to achieve mass production and accessibility, thus limiting patients' adherence to long-term medication and its availability. Summary of the Invention
[0004] The purpose of this invention is to provide a traditional Chinese medicine formula for treating hypertension and its preparation method, so as to solve the problems mentioned in the background art.
[0005] To achieve the above objectives, the present invention provides the following technical solution: a traditional Chinese medicine formula for treating hypertension and its preparation method, comprising the following raw materials in parts by weight: rhubarb 5-15 parts, dried ginger 5-15 parts, dragon bone 5-15 parts, oyster shell 5-15 parts, cinnamon twig 5-15 parts, white peony root 5-15 parts, prepared rehmannia root 5-15 parts, yam kernel 5-15 parts, Chinese yam 5-15 parts, poria cocos 5-15 parts, alisma rhizome 5-15 parts, peony bark 5-15 parts, angelica root 5-15 parts. -15 parts, Red peony root 5-15 parts, Ligusticum chuanxiong 5-15 parts, Rehmannia glutinosa 5-15 parts, Peach kernel 5-15 parts, Safflower 5-15 parts, Coptis chinensis 5-15 parts, Scutellaria baicalensis 5-15 parts, Phellodendron chinense 5-15 parts, Gardenia jasminoides 5-15 parts, Isatis indigotica 5-15 parts, Imperata cylindrica 5-15 parts, Phragmites communis 5-15 parts, Viola yedoensis 5-15 parts, Taraxacum mongolicum 5-15 parts, Chrysanthemum morifolium 5-15 parts, Fructus Hordei Fructus, Fructus Hordei Germinatus ...
[0006] As a further preferred embodiment of this technical solution, the following raw materials are included in parts by weight: 8 parts rhubarb, 8 parts dried ginger, 8 parts dragon bone, 8 parts oyster shell, 8 parts cinnamon twig, 8 parts white peony root, 8 parts prepared rehmannia root, 8 parts yam kernel, 8 parts Chinese yam, 9 parts Poria cocos, 9 parts Alisma plantago-aquatica, 9 parts peony bark, 9 parts Angelica sinensis, 9 parts red peony root, 9 parts Ligusticum chuanxiong, 9 parts raw rehmannia root, 10 parts peach kernel, 10 parts safflower, 10 parts Coptis chinensis, 10 parts Scutellaria baicalensis, 10 parts Phellodendron chinense, 10 parts gardenia, 10 parts Isatis indigotica leaf, 10 parts Isatis tinctoria root, 10 parts Imperata cylindrica root, 10 parts Phragmites communis root, 10 parts Viola yedoensis, 10 parts dandelion, 10 parts chrysanthemum, 10 parts charred hawthorn fruit, 10 parts roasted malt, 10 parts roasted barley sprout, and 10 parts licorice root.
[0007] As a further preferred embodiment of this technical solution, the following steps are included:
[0008] S1: Select Chinese medicinal materials that meet the requirements of the formula, clean and remove impurities, and remove mud and impurities from the surface of the medicinal materials;
[0009] S2: Using Beijing Donghuayuan Pharmaceutical Equipment, add 20-50L of water, pressure 0.1MPa, temperature 120℃, decoct for 1-3 hours, filter and collect the decoction, repeat the decoction twice, and combine the three decoctions;
[0010] S3: Concentrate the combined medicinal juice to a relative density of 1.20-1.30 (measured at 60℃), and add purified water to adjust to the specified concentration;
[0011] S4: The boiling packaging process is adopted, and the medicine is aseptically and tightly sealed while the medicine is boiling to prevent air residue inside the bag.
[0012] S5: Test pH value, microbial limit, and active ingredient content; after passing the test, the product is put into storage.
[0013] As a further preferred embodiment of this technical solution: the concentration range of the herbal juice in S3 is 30-200 ml;
[0014] As a further preferred embodiment of this technical solution: the capacity of a single bag in S4 is 150-200ml, the first and last bags are removed, and the middle section is retained for uninterrupted high-temperature aseptic packaging.
[0015] Compared with the prior art, the beneficial effects of the present invention are:
[0016] 1. This invention integrates the core formulas of Fengyin Decoction, Liuwei Dihuang Decoction, Taohong Siwu Decoction, and Huanglian Jiedu Decoction, taking into account the five major effects of "calming the liver and suppressing yang, nourishing yin and tonifying the kidney, promoting blood circulation and removing blood stasis, clearing heat and detoxifying, and strengthening the spleen and stomach". It regulates the pathogenesis of hypertension as a whole, which is "deficiency in the root and excess in the branch". Compared with existing Western medicines, this drug has a stable and long-lasting effect. It can not only effectively lower blood pressure, but also significantly improve accompanying symptoms such as dizziness, headache, and chest tightness. It reduces patients' dependence on chemical antihypertensive drugs and the side effects such as liver and kidney damage and electrolyte imbalance caused by them. It is especially suitable for middle-aged and elderly patients and patients with underlying diseases to take for a long time.
[0017] 2. In this invention, by adopting a high-pressure and high-temperature (120℃, 0.1MPa) decoction process, the extraction rate of medicinal components is greatly improved. Combined with aseptic packaging technology under boiling conditions, the medicinal liquid can be stored for a long time at room temperature (below 40℃) (shelf life of 12 months). This completely solves the problems of traditional decoctions being inconvenient to carry and difficult to mass-produce. This process is simple to operate, saves labor, has no environmental pollution, and significantly reduces production costs, enabling patients to obtain effective drugs with a lower economic burden. Attached Figure Description
[0018] Figure 1 This is a flowchart illustrating a traditional Chinese medicine formula for treating hypertension and its preparation method according to the present invention. Detailed Implementation
[0019] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.
[0020] Example 1:
[0021] Please see Figure 1As shown, the present invention provides a technical solution: a traditional Chinese medicine formula for treating hypertension and its preparation method, comprising the following raw materials in parts by weight: rhubarb 5-15 parts, dried ginger 5-15 parts, dragon bone 5-15 parts, oyster shell 5-15 parts, cinnamon twig 5-15 parts, white peony root 5-15 parts, prepared rehmannia root 5-15 parts, yam kernel 5-15 parts, Chinese yam 5-15 parts, poria cocos 5-15 parts, alisma rhizome 5-15 parts, peony bark 5-15 parts, angelica root 5-15 parts. 5-15 parts of Paeonia lactiflora, 5-15 parts of Ligusticum chuanxiong, 5-15 parts of Rehmannia glutinosa, 5-15 parts of Prunus persica, 5-15 parts of Carthamus tinctorius, 5-15 parts of Coptis chinensis, 5-15 parts of Scutellaria baicalensis, 5-15 parts of Phellodendron chinense, 5-15 parts of Gardenia jasminoides, 5-15 parts of Isatis indigotica, 5-15 parts of Isatis tinctoria, 5-15 parts of Imperata cylindrica, 5-15 parts of Phragmites communis, 5-15 parts of Viola yedoensis, 5-15 parts of Taraxacum mongolicum, 5-15 parts of Chrysanthemum morifolium, 5-15 parts of the three roasted herbs (Horse, Fructus Hordei Fructus, and Fructus Hordei Fructus), and 5-15 parts of Glycyrrhiza uralensis.
[0022] Further: Includes the following ingredients by weight: 8 parts rhubarb, 8 parts dried ginger, 8 parts dragon bone, 8 parts oyster shell, 8 parts cinnamon twig, 8 parts white peony root, 8 parts prepared rehmannia root, 8 parts yam kernel, 8 parts Chinese yam, 9 parts Poria cocos, 9 parts Alisma plantago-aquatica, 9 parts peony bark, 9 parts Angelica sinensis, 9 parts red peony root, 9 parts Ligusticum chuanxiong, 9 parts raw rehmannia root, 10 parts peach kernel, 10 parts safflower, 10 parts Coptis chinensis, 10 parts Scutellaria baicalensis, 10 parts Phellodendron chinense, 10 parts gardenia, 10 parts Isatis indigotica leaf, 10 parts Isatis tinctoria root, 10 parts Imperata cylindrica root, 10 parts Phragmites communis root, 10 parts Viola yedoensis, 10 parts dandelion, 10 parts chrysanthemum, 10 parts charred hawthorn fruit, 10 parts roasted malt, 10 parts licorice root.
[0023] Example 2:
[0024] A traditional Chinese medicine formula for treating hypertension and its preparation method, comprising the following raw materials in parts by weight: rhubarb 5-15 parts, dried ginger 5-15 parts, dragon bone 5-15 parts, oyster shell 5-15 parts, cinnamon twig 5-15 parts, white peony root 5-15 parts, prepared rehmannia root 5-15 parts, yam kernel 5-15 parts, Chinese yam 5-15 parts, poria cocos 5-15 parts, alisma rhizome 5-15 parts, peony bark 5-15 parts, angelica root 5-15 parts, red peony root 5-15 parts. 5 parts, Ligusticum chuanxiong 5-15 parts, Rehmannia glutinosa 5-15 parts, Prunus persica 5-15 parts, Carthamus tinctorius 5-15 parts, Coptis chinensis 5-15 parts, Scutellaria baicalensis 5-15 parts, Phellodendron chinense 5-15 parts, Gardenia jasminoides 5-15 parts, Isatis indigotica 5-15 parts, Imperata cylindrica 5-15 parts, Phragmites communis 5-15 parts, Viola yedoensis 5-15 parts, Taraxacum mongolicum 5-15 parts, Chrysanthemum morifolium 5-15 parts, Fructus Hordei Fructus, Fructus Hordei Germinatus ...
[0025] Further: Includes the following ingredients by weight: 7 parts rhubarb, 7 parts dried ginger, 7 parts dragon bone, 7 parts oyster shell, 7 parts cinnamon twig, 7 parts white peony root, 7 parts prepared rehmannia root, 7 parts yam kernel, 7 parts Chinese yam, 8 parts Poria cocos, 8 parts Alisma plantago-aquatica, 8 parts peony bark, 8 parts angelica sinensis, 8 parts red peony root, 8 parts Ligusticum chuanxiong, 8 parts raw rehmannia root, 9 parts peach kernel, 9 parts safflower, 9 parts Coptis chinensis, 9 parts Scutellaria baicalensis, 9 parts Phellodendron chinense, 9 parts gardenia, 9 parts Isatis indigotica leaf, 9 parts Isatis tinctoria root, 9 parts Imperata cylindrica root, 9 parts Phragmites communis root, 9 parts Viola yedoensis, 9 parts dandelion, 9 parts chrysanthemum, 9 parts charred hawthorn, malt, and barley sprouts, 9 parts licorice root.
[0026] Example 3:
[0027] A traditional Chinese medicine formula for treating hypertension and its preparation method, comprising the following raw materials in parts by weight: rhubarb 5-15 parts, dried ginger 5-15 parts, dragon bone 5-15 parts, oyster shell 5-15 parts, cinnamon twig 5-15 parts, white peony root 5-15 parts, prepared rehmannia root 5-15 parts, yam kernel 5-15 parts, Chinese yam 5-15 parts, poria cocos 5-15 parts, alisma rhizome 5-15 parts, peony bark 5-15 parts, angelica root 5-15 parts, red peony root 5-15 parts. 5 parts, Ligusticum chuanxiong 5-15 parts, Rehmannia glutinosa 5-15 parts, Prunus persica 5-15 parts, Carthamus tinctorius 5-15 parts, Coptis chinensis 5-15 parts, Scutellaria baicalensis 5-15 parts, Phellodendron chinense 5-15 parts, Gardenia jasminoides 5-15 parts, Isatis indigotica 5-15 parts, Imperata cylindrica 5-15 parts, Phragmites communis 5-15 parts, Viola yedoensis 5-15 parts, Taraxacum mongolicum 5-15 parts, Chrysanthemum morifolium 5-15 parts, Fructus Hordei Fructus, Fructus Hordei Germinatus ...
[0028] Further: Includes the following ingredients by weight: 10 parts rhubarb, 10 parts dried ginger, 10 parts dragon bone, 10 parts oyster shell, 10 parts cinnamon twig, 10 parts white peony root, 10 parts prepared rehmannia root, 10 parts yam kernel, 10 parts Chinese yam, 11 parts Poria cocos, 11 parts Alisma plantago-aquatica, 11 parts peony bark, 11 parts angelica sinensis, 11 parts red peony root, 11 parts Ligusticum chuanxiong, 8 parts raw rehmannia root, 12 parts peach kernel, 12 parts safflower, 12 parts Coptis chinensis, 12 parts Scutellaria baicalensis, 12 parts Phellodendron chinense, 12 parts gardenia, 12 parts Isatis indigotica leaf, 12 parts Isatis tinctoria root, 12 parts Imperata cylindrica root, 12 parts reed rhizome, 12 parts Viola yedoensis, 12 parts dandelion, 12 parts chrysanthemum, 12 parts charred hawthorn fruit, 12 parts roasted malt, 12 parts licorice root.
[0029] The formula experiment table is as follows:
[0030]
[0031] Clinical observation experiment:
[0032] First, 120 patients with essential hypertension were recruited, and the treatment course was 8 weeks. Second, the main efficacy indicators were the decrease in systolic blood pressure (SBP) and diastolic blood pressure (DBP).
[0033] Example 1: Among 120 subjects, 3 (2.5%) experienced mild diarrhea and 2 (1.7%) experienced stomach discomfort, all of which were relieved after dose reduction or administration after meals. Liver and kidney function tests showed no abnormalities, and no serious adverse events occurred.
[0034] This formula embodies the comprehensive treatment principle of "calming the liver and suppressing yang, clearing heat and purging fire, promoting blood circulation and removing blood stasis, and strengthening the spleen and benefiting the kidneys." In this formula, rhubarb, coptis, scutellaria, phellodendron, and gardenia are bitter and cold, clearing heat and purging fire, directly suppressing the hyperactivity of liver yang; dragon bone and oyster shell heavily suppress yang; peach kernel, safflower, angelica, and chuanxiong promote blood circulation and remove blood stasis; prepared rehmannia, yam, and Chinese yam nourish the liver and kidneys; and poria and alisma strengthen the spleen and promote diuresis. The proportions of each component are balanced, combining both tonifying and purging methods, resulting in a significant and stable antihypertensive effect and marked improvement in symptoms.
[0035] Example 2: The dosage of each herb was reduced by 1-2 parts compared to Example 1, resulting in a slightly weaker effect in clearing heat and purging fire, and a reduction in blood pressure of approximately 26% compared to Example 1. It still has a good effect on patients with mild to moderate hypertension, but its heat-clearing effect is slightly insufficient for those with obvious liver yang hyperactivity.
[0036] Example 3: The dosage of heat-clearing herbs (Coptis chinensis, Scutellaria baicalensis, Phellodendron chinense, Gardenia jasminoides) and blood-activating herbs (Prunus persica, Carthamus tinctorius) was increased to 12 parts, which enhanced the effects of clearing heat and purging fire and activating blood and removing blood stasis. However, the formula contained too many cold herbs, which led to 8.3% of the subjects experiencing symptoms of spleen and stomach deficiency such as diarrhea and stomach cold. Although the antihypertensive effect was acceptable, the tolerability was not as good as in Example 1.
[0037] Conclusion: The formulation of Example 1 ensures the effects of clearing heat and purging fire, calming the liver and suppressing yang, while also taking into account the spleen and stomach protection, achieving the best balance between efficacy and safety. It is recommended as the preferred clinical formulation.
[0038] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.
Claims
1. A Chinese medicine formula for treating hypertension and a preparation method thereof, characterized in that, The ingredients include the following by weight: rhubarb 5-15 parts, dried ginger 5-15 parts, dragon bone 5-15 parts, oyster shell 5-15 parts, cinnamon twig 5-15 parts, white peony root 5-15 parts, prepared rehmannia root 5-15 parts, yam kernel 5-15 parts, Chinese yam 5-15 parts, poria cocos 5-15 parts, alisma rhizome 5-15 parts, peony bark 5-15 parts, angelica root 5-15 parts, red peony root 5-15 parts, and chuanxiong rhizome 5-15 parts. 5-15 parts Rehmannia glutinosa, 5-15 parts Prunus persica, 5-15 parts Carthamus tinctorius, 5-15 parts Coptis chinensis, 5-15 parts Scutellaria baicalensis, 5-15 parts Phellodendron chinense, 5-15 parts Gardenia jasminoides, 5-15 parts Isatis indigotica, 5-15 parts Imperata cylindrica, 5-15 parts Phragmites communis, 5-15 parts Viola yedoensis, 5-15 parts Taraxacum mongolicum, 5-15 parts Chrysanthemum morifolium, 5-15 parts Fructus Hordei Fructus, Fructus Hordei Germinatus, Fructus Hordei Germinatus, and Fructus Hordei Germinatus, 5-15 parts Glycyrrhiza uralensis.
2. The traditional Chinese medicine formula for treating hypertension and its preparation method according to claim 1, characterized in that: The ingredients include the following by weight: 8 parts rhubarb, 8 parts dried ginger, 8 parts dragon bone, 8 parts oyster shell, 8 parts cinnamon twig, 8 parts white peony root, 8 parts prepared rehmannia root, 8 parts yam kernel, 8 parts Chinese yam, 9 parts Poria cocos, 9 parts Alisma plantago-aquatica, 9 parts peony bark, 9 parts Angelica sinensis, 9 parts red peony root, 9 parts Ligusticum chuanxiong, 9 parts raw rehmannia root, 10 parts peach kernel, 10 parts safflower, 10 parts Coptis chinensis, 10 parts Scutellaria baicalensis, 10 parts Phellodendron chinense, 10 parts gardenia, 10 parts Isatis indigotica leaf, 10 parts Isatis tinctoria root, 10 parts Imperata cylindrica root, 10 parts Phragmites communis root, 10 parts Viola yedoensis, 10 parts dandelion, 10 parts chrysanthemum, 10 parts charred hawthorn fruit, 10 parts roasted malt, 10 parts roasted barley sprout, and 10 parts licorice root.
3. The traditional Chinese medicine formula for treating hypertension and its preparation method according to claim 2, characterized in that: Includes the following steps: S1: Select Chinese medicinal materials that meet the requirements of the formula, clean and remove impurities, and remove mud and impurities from the surface of the medicinal materials; S2: Using Beijing Donghuayuan Pharmaceutical Equipment, add 20-50L of water, pressure 0.1MPa, temperature 120℃, decoct for 1-3 hours, filter and collect the decoction, repeat the decoction twice, and combine the three decoctions; S3: Concentrate the combined medicinal juice to a relative density of 1.20-1.30 (measured at 60℃), and add purified water to adjust to the specified concentration; S4: The boiling packaging process is adopted, and the medicine is aseptically and tightly sealed while the medicine is boiling to prevent air residue inside the bag. S5: Test pH value, microbial limit, and active ingredient content; products are put into storage after passing the test.
4. The traditional Chinese medicine formula for treating hypertension and its preparation method according to claim 3, characterized in that: The concentration range of the herbal juice in S3 is 30-200 ml.
5. The traditional Chinese medicine formula for treating hypertension and its preparation method according to claim 4, characterized in that: The capacity of a single bag in S4 is 150-200ml. The first and last bags are removed, and the middle section is kept in continuous high-temperature aseptic packaging.