Physiological age prediction model based on urine proteins and metabolites and applications thereof

By constructing a physiological age prediction model based on urinary proteins and metabolites, the problem of non-invasively assessing an individual's aging status and health risks has been solved, enabling accurate physiological age prediction and early disease identification, and supporting self-health management.

CN122361818APending Publication Date: 2026-07-10BEIJING HOSPITAL +1

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIJING HOSPITAL
Filing Date
2025-01-09
Publication Date
2026-07-10

AI Technical Summary

Technical Problem

Current technologies lack stable, non-invasive aging clock models, making it impossible to effectively assess an individual's physiological age and health status, predict health risks, or enable self-health monitoring and early identification of age-related diseases.

Method used

By identifying urinary aging biomarkers through non-targeted metabolomics and proteomics, a physiological age prediction model based on urinary proteins and metabolites was constructed. Using indicators such as cartilage intermediate layer protein, collagen Alpha 1 chain, myristic acid, and 12-methyltridecanoic acid, combined with machine learning algorithms, a simplified comprehensive clock was constructed to achieve accurate prediction of physiological age.

Benefits of technology

It provides an accurate, convenient, and non-invasive method for assessing an individual's aging status and health risks, enabling early identification of age-related diseases, discovery of anti-aging targets, and support for self-health monitoring.

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Abstract

This invention provides a physiological age prediction model that predicts the physiological age of a subject by detecting urinary proteins and metabolites in a urine sample. The aforementioned urinary proteins and metabolites are those that change significantly with age, including one or more selected from the following: cartilage intermediate layer protein (CILP2), collagen Alpha 1 chain (COFA1), myristic acid, 12-methyltridecanoic acid, CN family member 5 (CCN5), Sushi domain-containing protein 5 (SUSD5), procollagen C endopeptidase enhancer 1 (PCOLCE), and L-lactate oxidase (LOX), preferably including all of the aforementioned urinary proteins and metabolites.
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