High-activity exogenous cell maintenance preparation from natural macrocell sources and global applications

Abstract

This invention discloses a highly active exogenous cell care preparation derived from natural biological macrocells and its applications, belonging to the fields of biomedicine and cell care technology. This invention uses natural biological macrocells from algae, woody plants, herbaceous plants, fungi, and animals as raw materials, employing a low-temperature, mild purification process to retain the original active substances, and then compounding them with medical excipients to produce oral or sterile intravenous infusion preparations. The active ingredients of the preparation are natural, native components, mild and safe, with no obvious toxic side effects. At conventional doses, they are essentially metabolized within 24 hours, and at high doses, they are completely excreted within 1-2 days, without long-term accumulation in the body. This invention achieves cell activity repair, microenvironment regulation, and cell homeostasis maintenance through an exogenous, non-invasive method, without involving invasive cell modification. It has a wide range of applications, high safety, and a clearly defined scope of protection, possessing significant scientific research and industrial application value.

Description

Technical Field

[0001] This invention belongs to the field of biomedicine, cell care and bioactive preparation technology. Specifically, it relates to a preparation and its method of use that uses algae, woody plants, herbaceous plants, fungi and animal-derived natural biological macrocells as raw materials, which are purified at low temperature to retain the original active substances, and is administered orally or by peripheral intravenous infusion to achieve exogenous supplementation, thereby achieving human cell activity repair, microenvironment regulation and cell homeostasis maintenance. Background Technology

[0002] Currently, most commercially available nutritional supplements primarily consist of static nutrients such as carbohydrates, basic vitamins, minerals, and conventional amino acids. These only meet the body's basic nutritional and energy needs and are insufficient for targeted repair of cell damage or effective maintenance of cellular physiological activity. Conventional biological extracts often undergo high-temperature drying, high-temperature sterilization, and strong chemical treatments, resulting in a significant loss of naturally occurring active substances within cells. These extracts typically possess only ordinary nutritional value and lack targeted cell-specific nourishment functions. Some existing active products suffer from unclear metabolic pathways, are prone to accumulation in the body, and are highly irritating; long-term use may increase the body's metabolic burden. Furthermore, existing cell intervention technologies often involve invasive methods such as gene editing, stem cell transplantation, and endogenous cell modification, posing high operational risks, strict ethical restrictions, and limitations on widespread civilian application. Currently, a complete cell activity maintenance technology system has not yet been established, utilizing multiple types of natural biological large cells as a unified raw material source, employing low-temperature preservation extraction, exogenous non-invasive supplementation, and controllable metabolic cycles. Technological gaps remain in this field.

[0003] This invention aims to overcome the shortcomings of existing conventional nutritional supplements, such as lack of cell activity repair, easy inactivation of active raw materials due to processing, uncontrollable metabolic residues, and high risks of invasive cell maintenance technology. It provides a natural, mild, highly bioactive, safe, and controllable metabolic cycle exogenous cell maintenance technology solution with no long-term accumulation in the body.

[0004] The natural biological macrocell raw materials used in this invention include one or more combinations of algal macrocells, woody plant macrocells, herbaceous plant macrocells, fungal macrocells, and animal-derived macrocells. Natural intact macrocells are used as the extraction substrate, which is different from conventional small molecule extracts, inactivated powders, and chemically synthesized additives.

[0005] The highly active substances described in this invention are all natural, endogenous components of biological macrocells, free from chemical irritants, hormones, and toxic or harmful ingredients. At appropriate dosages, the active components are mild and do not cause significant damage to normal human cells, mucous membranes, or organs. They exhibit no significant acute or chronic cumulative toxicity, making them suitable for long-term, gentle maintenance.

[0006] The highly active ingredients derived from natural macrocells in the formulation of this invention can be normally decomposed, utilized, and metabolized and excreted by the human body: at conventional doses, most active substances can be metabolized and utilized within 24 hours; under high concentration and high dose supplementation conditions, the overall complete metabolic excretion cycle is 1 to 2 days due to the influence of the body's metabolic load; the active ingredients do not accumulate in the body for a long time, do not remain persistently in tissues and organs, and the safety boundary is controllable. Technical solution (1) Extraction and preparation process

[0007] It adopts a low-temperature and gentle cell wall breaking, ultrafiltration purification, and room-temperature aseptic preparation process, without high-temperature inactivation, high-temperature baking, or strong acid and strong alkali modification treatment, so as to preserve the original activity of natural biological cells to the maximum extent. (2) Formulation composition

[0008] It uses highly active complexes derived from natural biological macrocells as its core functional components; it is compounded with medical isotonic regulators, pH buffers, and sterile solvents; it does not contain common static nutrients such as glucose, single inorganic salts, and basic multivitamins, thus clearly distinguishing it from conventional nutritional supplements. (3) Administration method

[0009] The formulations of this invention include two exogenous non-invasive delivery methods: an oral formulation, absorbed through the digestive tract, suitable for daily long-term cell maintenance; and a sterile intravenous infusion formulation, administered via peripheral veins, suitable for rapid cellular microenvironment repair and conditioning. The entire process is non-invasive, does not involve human gene editing, exogenous cell implantation, or endogenous cell modification, and carries no related ethical risks.

[0010] Beneficial effects The raw material sources are widely covered, and various natural biological large cells such as algae, plants, fungi, and animals can be used. The selection of raw materials is flexible and not easily avoided. It employs a low-temperature preservation process to retain the maximum amount of natural, original activity, which distinguishes it from nutritional supplements that are processed at conventional high temperatures. The active ingredients are natural and mild, with good safety profile and no obvious toxic side effects, making them suitable for long-term use. The metabolic cycle is well-defined and controllable, and it can be almost completely metabolized and excreted within 1 to 2 days, with no risk of long-term accumulation in the body. It adopts a dual-pathway exogenous supplementation of oral and intravenous infusion, which is applicable to a wide range of scenarios and has both daily maintenance and rapid conditioning functions; The technical solution is non-invasive and easy to operate, with low risk, and is easy to popularize in civilian use and clinical application.

[0011] Example 1: Oral preparations derived from algal macrocells Using intact large cells of natural algae as raw material, a highly active complex containing active polysaccharides, small molecule active peptides, and natural antioxidants is obtained through low-temperature gentle cell disruption and ultrafiltration purification. A food-grade buffer matrix is ​​added, and the mixture is aseptically mixed and filled at low temperature to produce an oral formulation. Usage: Oral administration for daily cell activity maintenance and care. At the usual dose, it is largely metabolized within 24 hours.

[0012] Example 2: Woody / Herbal / Fungal Large Cell Derivative Intravenous Infusion Formulation Using woody plants, herbaceous plants, and fungal macrocells as raw materials, the original highly active components are obtained through low-temperature extraction; medical isotonic buffer and sterile water for injection are added, and the mixture is prepared in a Class 10,000 cleanroom, ultrafiltered to remove pyrogens, and aseptically filled to obtain an intravenous infusion formulation. Usage: Peripheral intravenous infusion for rapid conditioning of the cellular microenvironment; at high doses, it is completely metabolized and excreted within 1-2 days without significant accumulation.

[0013] Example 3 Animal-derived large cell preparation Using compliant animal-derived large cells as raw materials, active proteins and active polypeptides are extracted at low temperatures and prepared into finished products according to oral or infusion formulation processes. The metabolic characteristics are consistent with plant-derived preparations; they are completely decomposed and metabolized within 1-2 days, with no obvious rejection reactions or long-term residues.

Claims

1. A natural biological macrocellular source of highly active exogenous cell care preparation, characterized in that: The product is prepared from one or more of the following raw materials: algal macrocells, woody plant macrocells, herbaceous plant macrocells, fungal macrocells, and animal-derived macrocells. The raw material is then purified at low temperature to obtain a native, highly active complex. This complex is then compounded with a medical isotonic adjuster, pH buffer, and sterile solvent. The preparation does not contain conventional sugars, basic vitamins, or single inorganic salts as static nutrients. The highly active component is a natural, native ingredient that causes no significant damage to the human body at conventional doses. Its metabolic cycle is controllable; at conventional doses, it is essentially metabolized within 24 hours, and at high doses, it is completely excreted within 1-2 days, without long-term accumulation in the body.

2. The formulation according to claim 1, characterized in that: The preparation process uses a low-temperature process, without high-temperature inactivation, high-temperature drying or strong chemical modification, thus preserving the original activity of natural biological macrocells.

3. The formulation according to claim 1, characterized in that: The formulation is available in oral form or aseptic peripheral intravenous infusion form, both of which are exogenous noninvasive replenishment methods.

4. A method for preserving highly active exogenous cells from natural biological macrocell sources, characterized by: The preparations described in any one of claims 1 to 5 are administered exogenously via oral or peripheral intravenous infusion; used to supplement cell activity, repair the extracellular microenvironment, maintain cell homeostasis, and delay the decline of cell activity; the entire process does not involve invasive operations such as gene editing, cell implantation, or endogenous cell modification.

5. The use of the formulation according to any one of claims 1 to 3 in the preparation of non-invasive human cell care products, characterized in that: With natural biological macrocellular highly active extracts as its core, and characterized by exogenous supplementation and controllable metabolism within 1-2 days, it is used for the active repair and homeostasis maintenance of human cells.