A medical sponge for sterilization, anti-fouling and healing promotion and a preparation method thereof

CN122399083APending Publication Date: 2026-07-17SHAANXI NORMAL UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHAANXI NORMAL UNIV
Filing Date
2026-05-13
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing medical sponges present a contradiction in achieving both antibacterial and antifouling functions, and are difficult to meet the needs of individualized treatment, especially the need to promote healing of chronic, difficult-to-heal wounds.

Method used

A "core-shell" bilayer protein nanocoating was constructed on the surface of a medical sponge. The inner layer was loaded with antimicrobial peptides and growth factors, while the outer layer was grafted with antifouling functional components to form an antifouling layer. Functional separation was achieved by utilizing protein self-assembly.

Benefits of technology

It achieves highly efficient sterilization, anti-fouling and healing-promoting functions, reduces dressing adhesion to wounds, promotes fibroblast migration and healing, is suitable for various medical sponge surfaces, has good biocompatibility, and allows for controllable drug release.

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Abstract

本发明提供了一种用于杀菌抗污促愈合的医用海绵及其制备方法,属于医用材料技术领域。本发明通过在海绵表面依次修饰负载生长因子的相转变蛋白质纳米薄膜、负载杀菌肽的相转变蛋白质纳米薄膜、接枝抗污功能组分的相转变蛋白质纳米薄膜,制得兼具杀菌、抗污、促愈合作用的医用海绵。该方法利用分层界面设计,制备方法简单,涂层黏附稳定、柔韧和生物安全。该医用海绵在保留涂层极佳抗污性能的同时具有极高杀菌率和促愈合作用,同时还具有抗污性能(包括抵抗蛋白质、细菌、成纤维细胞和血细胞的黏附)和促进血液吸附与洗脱性能,可防止和治疗伤口感染、防止敷料与伤口的粘连,减少更换敷料时对伤口的二次伤害。
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