A peptidoglycan-labeled magnetic bead probe, a preparation method and application thereof

By labeling peptidoglycan onto carboxyl magnetic beads to prepare peptidoglycan-labeled magnetic bead probes, the problem of low removal efficiency of tetrodotoxin in existing technologies is solved, achieving rapid and stable tetrodotoxin separation, which is suitable for the enrichment and separation of tetrodotoxin in aquatic products and biological samples.

CN122399757APending Publication Date: 2026-07-17SHANGHAI OCEAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI OCEAN UNIV
Filing Date
2026-06-04
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing technologies are insufficient for efficiently, quickly, and safely removing tetrodotoxins. Traditional methods are inefficient, costly, or pose a risk of chemical pollution.

Method used

By labeling peptidoglycan onto carboxyl magnetic beads to form peptidoglycan-labeled magnetic bead probes, the specific adsorption properties of peptidoglycan and the magnetic separation properties of magnetic beads can be utilized to achieve rapid and efficient separation of tetrodotoxin.

Benefits of technology

It enables rapid and stable separation of tetrodotoxin in complex biological matrices, featuring high efficiency and low cost, and is suitable for the enrichment and separation of tetrodotoxin in aquatic products and biological samples.

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Abstract

本发明涉及生物吸附材料技术领域，尤其涉及一种肽聚糖标记磁珠探针及其制备方法和应用。所述探针由肽聚糖的氨基与羧基磁珠的羧基通过酰胺键结合而成，用于快速分离溶液中的河豚毒素。本发明提供了一种高效的河豚毒素去除方法，通过将肽聚糖标记在羧基磁珠探针上，利用磁珠的磁分离特性，实现快速高效地分离溶液中的河豚毒素。本发明的探针对河豚毒素的吸附率高达96%，比单独的肽聚糖吸附效率提高约1.5倍，而且操作简便，可以循环使用5次以上；具有高效、快速、稳定的特点，可广泛应用于河豚毒素的富集与分离领域，具备开发为TTX吸附剂的应用潜力。
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