A magnetic nanoparticle imaging reconstruction method based on a cascaded neural network

The magnetic nanoparticle imaging method using a two-stage cascaded neural network and a dual-loss training strategy solves the problems of insufficient high spatial resolution and quantitative capability in existing technologies, and achieves high-resolution, low-artifact magnetic nanoparticle imaging reconstruction.

CN122409446APending Publication Date: 2026-07-17BEIHANG UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
BEIHANG UNIV
Filing Date
2026-05-15
Publication Date
2026-07-17

AI Technical Summary

Technical Problem

Existing magnetic nanoparticle imaging technology struggles to balance high spatial resolution with good quantitative capabilities during image reconstruction and is sensitive to noise, resulting in insufficient quantitative accuracy and stability.

Method used

A two-stage cascaded neural network and a dual-loss training strategy are adopted. The global and local features of magnetic nanoparticles are processed by feature extraction subnetwork and feature enhancement subnetwork, respectively. By utilizing the nonlinear magnetization response information of magnetic nanoparticles, combined with the encoder-decoder U-Net structure and spatial attention module, the staged reconstruction of images is achieved.

Benefits of technology

It improves the spatial resolution and quantitative accuracy of magnetic nanoparticle imaging, reduces artifacts, achieves a balance between high resolution and good quantitative capability, and enhances the visual effect and reliability of reconstructed images.

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Abstract

本发明属于磁纳米粒子成像技术领域,涉及一种基于级联神经网络的磁纳米粒子成像重建方法,包括:获取目标体积的磁纳米粒子样品和水样品,将磁纳米粒子样品和水样品放置于磁纳米粒子成像系统的中心位置,并按照目标激励条件对磁纳米粒子样品和水样品进行激励,生成系统矩阵和系统噪声;基于系统矩阵和系统噪声,获取电压向量,以构建电压向量数据集,用于训练级联神经网络模型;在训练过程中,采用双损失函数协同训练策略约束模型输出;利用训练后的级联神经网络模型对待测磁纳米粒子样品进行成像重建,获得待测样品粒子浓度分布的重建图像。本发明能够平衡高空间分辨率与良好定量能力,对于推动MPI在精准医学影像中的应用具有重要意义。
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