Preparation method and application of mass spectrometry ionization element modified by boric acid functionalization
By constructing a boric acid-functionalized covalent organic framework on a stainless steel substrate through ultrasonic acidification and Schiff base condensation, the problems of complex preparation and insufficient selectivity of existing mass spectrometry ionization elements are solved, enabling efficient and sensitive detection of macrolide antibiotics.
Patent Information
- Application Number
- CN202610504227.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2026-04-16
- Publication Date
- 2026-07-17
AI Technical Summary
Existing mass spectrometry ionization elements have complex fabrication processes, poor safety, and insufficient enrichment selectivity, making it difficult to achieve efficient and sensitive detection of macrolide antibiotics.
By employing ultrasonic acidification to activate a stainless steel substrate, a boric acid-functionalized covalent organic framework is constructed on the stainless steel surface through Schiff base condensation and mercapto-alkene click chemistry, avoiding hazardous chemical reagents and cumbersome steps, and achieving highly selective enrichment.
The simplified preparation process improves safety and reproducibility, significantly enhances the enrichment efficiency and detection sensitivity of macrolide antibiotics, lowers the detection limit, and strengthens the resistance to matrix interference.
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Abstract
Citation Information
Patent Citations
Mass spectrum ionization element for macrolide antibiotic detection and preparation method thereof
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