A method for industrial hemp metabolite separation based on reversible boronate ester reaction

By combining a core-shell mesoporous functional adsorbent with a clamp-type double boron recognition cavity, the contradiction between selectivity and throughput in the separation of industrial hemp metabolites is resolved, achieving separation effects with high selectivity, high throughput and long cycle life, which is suitable for the large-scale separation of industrial hemp metabolites.

CN121338390BActive Publication Date: 2026-07-21ECONOMIC CROP RES INST OF HEILONGJIANG ACAD OF AGRI SCI
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Patent Information

Application Number
CN202511520196.1
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-10-23
Publication Date
2026-07-21
Estimated Expiration
2045-10-23

AI Technical Summary

Technical Problem

Existing technologies for separating industrial hemp metabolites suffer from problems such as insufficient selectivity, high energy consumption, large solvent consumption, and poor cycle stability. In particular, it is difficult to balance selectivity and throughput in complex systems, and the regeneration process poses a risk of chemical degradation of boric acid sites.

Method used

Employing a core-shell mesoporous functional adsorbent, consisting of a mesoporous silica core and an organic shell, and featuring a clamp-type dual-boron recognition cavity design, it selectively adsorbs adsorbents in an ethanol-water mixed solvent via reversible borate ester bonds, and achieves mild regeneration by utilizing a graded desorption strategy with competing CO2 and diol agents.

Benefits of technology

It achieves high selectivity (selectivity coefficient ≥100), high throughput, low leaching (boron leaching amount ≤1ppm) and long cycle life (activity retention rate ≥90% after 100-200 cycles), reduces energy consumption and solvent consumption, and is suitable for large-scale separation of industrial hemp metabolites.

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Abstract

The application belongs to the field of chemical separation and functional materials, and provides an industrial hemp metabolite extraction method based on dynamic borate reversible reaction. The application adopts a core-shell mesoporous functional adsorbent design. The adsorbent comprises a mesoporous silica core and an organic shell layer containing a pincer-type double-boron recognition cavity. The distance from boron to the boron center is 0.32-0.50 nm. The selective adsorption of ortho-diphenol type industrial hemp metabolites is realized under the condition that the volume fraction of ethanol is 85-96 vol%, and the temperature is 30-40 DEG C. The borate bond is reversibly broken by reducing the acidity and / or introducing a glycol competitive agent to complete mild desorption, realizing the performance of a selectivity coefficient of greater than or equal to 100, a recovery rate of greater than or equal to 95%, an activity retention rate of greater than or equal to 90% after 100-200 cycles, and a boron leaching amount of less than or equal to 1 ppm. The triple contradiction between the shell layer cross-linking and recognition cavity accessibility, high liquid hourly space velocity and ethanol-water microenvironment regulation, mild regeneration and site chemical integrity is solved, and the application has wide application value.
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