Gingival repair membrane and its preparation method and application

Abstract

The present application relates to a kind of gum repair membranes and its preparation method and application, the gum repair membrane is composed of two outer layers and one inner layer, the inner layer is clamped between two outer layers, form outer-inner-outer three-layer composite structure;The outer layer includes electrospinning fiber membrane and microsphere, the microsphere is loaded on the electrospinning fiber membrane, and the preparation raw material of the electrospinning fiber membrane includes collagen and polycaprolactone;The microsphere includes shell and core, the shell includes temperature-sensitive biodegradable polymer material, the core includes acoustic heat responsive nanoparticle and proangiogenic active polypeptide, and the proangiogenic active polypeptide is neurointermediate U;The core is enclosed in the shell;The inner layer includes polyester electrospinning fiber membrane.The gum repair membrane has ultrasonic response, can time sequence synergistic release acoustic heat nanoparticle and proangiogenic active polypeptide-neurointermediate U, realizes the multiple synergistic treatment of anti-infection, proangiogenic and accelerates tissue regeneration.

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