Yintang acupoint cantharides powder plaster for treating rhinitis and preparation method thereof

Abstract

This invention discloses a method for applying blister beetle powder to the Yintang acupoint for treating rhinitis, belonging to the field of traditional Chinese medicine technology. The preparation method of the blister beetle powder is as follows: Take an appropriate amount of blister beetles, remove the head and feet, add an appropriate amount of glutinous rice, and stir-fry over low heat until the glutinous rice turns yellow. Remove the blister beetles, let them cool, and then grind them into a fine powder. When using, apply a therapeutically effective amount of the blister beetle powder to the Yintang acupoint, causing blistering of the skin at that point to treat rhinitis. This invention comprehensively addresses four key aspects: reducing toxicity through stir-frying with glutinous rice, controlling dosage, controlling application time, and post-application skin repair. This ensures the efficacy of clearing nasal passages while achieving the technical effect of leaving absolutely no marks on the skin after one course of treatment. Clinical statistics of over 1000 patients show a cure rate of 60% and an effective rate of 90%, applicable to acute rhinitis, chronic rhinitis, allergic rhinitis, and sinusitis.

Description

Technical Field

[0001] This invention relates to the field of traditional Chinese medicine formulation technology, specifically to a blister beetle powder patch applied to the Yintang acupoint for treating rhinitis and its preparation method. Background Technology

[0002] Allergic rhinitis, chronic rhinitis, acute rhinitis, and sinusitis are common nasal diseases in clinical practice. Patients often experience symptoms such as nasal congestion, runny nose, nasal itching, sneezing, dizziness, and headaches, which seriously affect their daily lives and work. Current conventional treatments in modern medicine mainly include the use of antihistamines, nasal corticosteroids, decongestants, and surgical treatments for structural abnormalities such as turbinate hypertrophy and deviated nasal septum. However, drug treatment often requires long-term maintenance, symptoms are prone to recurrence after discontinuation, and some patients do not respond ideally to the medication.

[0003] In traditional Chinese medicine, blistering therapy is a distinctive external treatment method. Cantharides, a commonly used herb in this therapy, is the dried body of the southern large cantharides or the yellow-black small cantharides, both belonging to the family Cladosporidae. It is pungent, hot, and highly toxic, and enters the liver, stomach, and kidney meridians. The cantharidin contained in cantharides has a strong stimulating effect on the skin and mucous membranes, causing local redness, burning, blistering, and even erosion, thereby stimulating the flow of Qi in the meridians to achieve the effects of unblocking the meridians, opening the orifices, and clearing the channels. The Yintang acupoint, located in the depression between the eyebrows on the head, is an extra acupoint. Its name comes from the *Bian Que Shen Ying Zhen Jiu Yu Long Jing* (The Divine Response Acupuncture and Moxibustion Classic of Bian Que). It is a very important acupoint in traditional Chinese medicine meridian theory, connected to the Du meridian. Stimulating the Yintang acupoint has the effects of clearing the nasal passages, regulating lung Qi, and regulating the Qi of the twelve meridians. It can not only prevent and assist in the treatment of nasal diseases and headaches, but also has a holistic regulatory effect on the whole body. Therefore, combining the vesicating effect of blister beetles with the acupoint effects of the Yintang point theoretically constitutes a feasible approach for treating rhinitis.

[0004] However, blister beetles are highly toxic. Excessive absorption of their toxic component, cantharidin, through the skin can damage the kidneys and digestive tract, leading to hematuria, vomiting, and in severe cases, death. During topical treatment, excessive dosage or prolonged application can easily cause excessive burns to the local skin, secondary infections, and pigmentation or even scarring after healing. Summary of the Invention

[0005] To address the aforementioned technical deficiencies, the present invention aims to provide a blister beetle powder patch for treating rhinitis at the Yintang acupoint and its preparation method, thereby resolving the problems mentioned in the background art.

[0006] To solve the above-mentioned technical problems, the present invention adopts the following technical solution: A method for preparing cantharides powder for treating rhinitis, the formula of which consists of cantharides and glutinous rice. The preparation method includes the following steps: taking an appropriate amount of cantharides, removing the head and feet, adding an appropriate amount of glutinous rice, and stir-frying over low heat until the glutinous rice turns yellow. Then, removing the cantharides, letting it cool, and grinding it into a fine powder to obtain the cantharides powder. The ratio of cantharides to glutinous rice should be such that the glutinous rice can fully absorb the toxic components released by the cantharides during the stir-frying process, and that the color change of the glutinous rice accurately reflects the end point of the stir-frying process.

[0007] In the above formula and processing method, the co-frying of glutinous rice and blister beetle plays a crucial role. On the one hand, as a solid excipient, glutinous rice can absorb some of the volatile toxic components released by blister beetle during the gentle heating process, thereby effectively reducing the toxicity of the blister beetle powder. On the other hand, using the intuitive color change of "glutinous rice turning yellow" as the criterion for judging the end of frying, the operator can distinguish whether the blister beetle has reached the appropriate processing temperature without relying on complex instruments, thus ensuring the consistency of the processing technology and the stability of the powder quality.

[0008] This invention further provides the application of the cantharides powder prepared by the above-described formula and method in the treatment of rhinitis. The specific method of application is as follows: A therapeutically effective amount of the cantharides powder is taken and applied to the acupoint between the eyebrows (Yintang point) of the patient. Blistering of the skin at the Yintang point induces nasal congestion and promotes nasal patency. After application, local redness and blistering begin, and the medicinal effect is produced. For adults, the application should continue until a sufficient therapeutic effect is achieved, after which the medication is removed. For children, the application time should be shortened accordingly. After the prescribed time, the medication should be removed. It is strictly forbidden to puncture the blisters; only cover the wound with sterile gauze to protect it, allowing the blisters to be naturally absorbed, dried, scab over, and fall off on their own.

[0009] The formula and treatment method of this invention are suitable for acute rhinitis, chronic rhinitis, allergic rhinitis, and sinusitis. However, they are not very effective for patients with nasal turbinate hypertrophy and deviated nasal septum.

[0010] Compared with the prior art, the beneficial effects of the present invention are as follows: First, by using the processing technique of stir-frying glutinous rice and blister beetle together in the formula, the glutinous rice absorbs some of the volatile toxic components of blister beetle, effectively reducing the toxicity of blister beetle powder and improving the safety of clinical use; at the same time, using the yellowing of glutinous rice as the criterion for judging the end point of stir-frying makes the processing process standardized and repeatable.

[0011] Secondly, by controlling the amount of medication applied in a single application to a therapeutically effective amount, the total dosage of cantharidin is precisely controlled from the source, making the blistering effect gentle and controllable, avoiding damage to deep skin tissues due to excessive dosage, and laying a dosage foundation for preventing pigmentation.

[0012] Third, by controlling the application time for adults and children, the stimulation of the drug on the skin is stopped in time after the drug has fully exerted its effect, which not only ensures the therapeutic effect of clearing the nasal passages, but also prevents skin damage caused by excessive stimulation.

[0013] Fourth, by strictly prohibiting the breaking of blisters after application, covering and protecting them with sterile gauze, and allowing them to heal naturally, the skin repair method effectively prevents secondary infections and pigmentation caused by improper wound treatment.

[0014] Through the combined effects of the above four key steps—formula preparation, dosage control, application time control, and skin repair treatment—this invention achieves the technical effect of leaving absolutely no marks on the skin after one course of treatment. Clinical observation of over 1000 patients with various types of rhinitis showed a cure rate of up to 60% and an effectiveness rate of up to 90%. Detailed Implementation

[0015] The technical solutions in the embodiments of the present invention will be clearly and completely described below. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention. Example

[0016] This embodiment illustrates a preferred processing method for blister beetle powder. Take 10 dried blister beetles (small yellow-black blister beetles from the south), and remove their heads and legs one by one with scissors. Weigh two ounces of glutinous rice and place it in a wok along with the headless and legless blister beetles. Heat slowly over a low flame, stirring constantly with a spatula to ensure even heating of the blister beetles and glutinous rice. Closely observe the color change of the glutinous rice during the frying process. When the surface of the glutinous rice turns completely from white to a uniform yellow and a fragrant, slightly burnt aroma is detected, the frying is considered complete. At this point, remove the wok from the heat and immediately separate the blister beetles from the glutinous rice using a sieve. Place the fried blister beetles in a clean container and allow them to cool naturally to room temperature. Then, grind them into a fine powder using a grinder, pass the powder through a 100-200 mesh sieve, and collect the fine powder to obtain the blister beetle powder of this invention. Accurately weigh the prepared blister beetle powder in a clean, dry environment, divide it into 0.01-gram portions, and seal them for later use. In this embodiment, the ratio of 10 blister beetles to 2 ounces of glutinous rice has been verified through multiple practices. This ratio allows the glutinous rice to fully absorb the toxic components of the blister beetles, and the color change of the glutinous rice is obvious and easily distinguishable, making it a relatively ideal ratio. It should be understood that appropriate adjustments can be made to this ratio based on factors such as the size of the blister beetles and the variety of glutinous rice, and these adjustments still fall within the scope of protection of this invention. Example

[0017] This embodiment illustrates a preferred method of using blister beetle powder applied to the Yintang acupoint for treating rhinitis. The patient lies supine with their head slightly lowered and without a pillow, ensuring the Yintang acupoint area faces upwards. The skin at the Yintang acupoint is cleaned with sterile saline solution, followed by drying with a sterile cotton swab. The physician takes one portion (0.01 g) of the blister beetle powder prepared in Example 1 and applies it evenly to the patient's Yintang acupoint. The powder is then covered and secured with breathable medical tape, ensuring a tight fit to the acupoint skin. Approximately 5 hours after application, the patient will feel warmth and redness at the Yintang acupoint, accompanied by a slight tingling sensation, followed by the appearance of small blisters; this is a normal reaction to the medication's effectiveness. Adults should continue applying the patch for two days, while children should continue for one day. After the prescribed time, carefully remove the tape, being careful not to remove any residual powder, allowing it to continue exerting its medicinal properties. Blisters will be visible at the application site. During subsequent treatment, it is strictly forbidden to puncture the blisters with a needle or to break them in any other way. Cover the wound with two layers of sterile dry gauze and secure it with adhesive tape. Change the clean, sterile gauze daily until the fluid inside the blister is completely absorbed, the blister dries up, and a scab forms, which then falls off naturally. The entire process takes approximately 5 days, constituting one course of treatment. After the scab falls off, the skin around the Yintang acupoint will be smooth and even, without leaving any pigmentation or scars. Example

[0018] The cantharides powder of Example 1 and the treatment method of Example 2 were used to treat and observe various types of rhinitis patients in clinical practice. The following are some typical cases.

[0019] Case 1: Li Huan, female, 25 years old, from Bijie, Guizhou Province, suffered from allergic rhinitis for 3 years. In October 2024, she received treatment with cantharides powder applied to the Yintang acupoint. After 3 courses of treatment, her allergic rhinitis symptoms completely disappeared, and she was clinically cured. The skin at the application site returned to normal, with no pigmentation marks.

[0020] Case 2: Li Qin, female, 27 years old, from Tongren City, Guizhou Province, suffered from allergic rhinitis for 15 years. She had long-term nasal congestion accompanied by nasal and eye itching and had to breathe through her mouth every night. She received this treatment in December 2024. After applying the patch 3 times, all symptoms of nasal congestion, nasal itching and eye itching disappeared. She was able to breathe normally through her mouth at night and was clinically cured. She has not relapsed since then.

[0021] Case 3: Chen Guilan, female, 62 years old, from Guiyang City, suffered from chronic rhinitis for 2 years. She received this treatment plan on May 10, 2026. After one application, her symptoms completely disappeared and she was clinically cured.

[0022] Case 4: Dai Bochuan, male, 7 years old, living in Xiaohe, Guiyang, had recurrent sinusitis for 4 years. He received this treatment plan on May 13, 2026 and was cured after one application.

[0023] Case 5: Wang Zhengen, male, 12 years old, had sinusitis for 1 year, with symptoms of purulent nasal discharge, nasal congestion, and dizziness. He received this treatment plan on May 17, 2026, and all his sinusitis symptoms disappeared after one application.

[0024] Case 6: Luo Zhiqiang, male, 27 years old, suffered from allergic sinusitis for 3 years, with recurrent nasal itching and runny nose. He received this treatment plan on May 24, 2026. After 2 applications, all symptoms disappeared and he was clinically cured.

[0025] Of the more than 1,000 rhinitis patients treated with this regimen, the overall effective rate reached 90%, and the cure rate reached 60%. All patients strictly followed the post-application care requirements, and the skin at the Yintang acupoint recovered smoothly after the scabs fell off. After one course of treatment, absolutely no pigmentation marks remained.

[0026] Obviously, those skilled in the art can make various modifications and variations to this invention without departing from its spirit and scope. Therefore, if these modifications and variations fall within the scope of the claims of this invention and their equivalents, this invention also intends to include these modifications and variations.

Claims

1. A Yintang acupoint cantharides powder patch for treating rhinitis, characterized in that, Including blister beetles and glutinous rice.

2. A preparation method of the Yintang acupoint cantharides powder patch for treating rhinitis, characterized in that, The process includes the following steps: Take an appropriate amount of blister beetles, remove their heads and feet, add an appropriate amount of glutinous rice, stir-fry over low heat until the glutinous rice turns yellow, remove the blister beetles, let them cool, and then grind them into a fine powder to obtain the blister beetle powder.

3. The preparation method of the forehead spot canichthocolla powder patch for treating rhinitis according to claim 2, characterized in that, The ratio of blister beetles to glutinous rice is 10 blister beetles to 2 ounces of glutinous rice.

4. The cantharides powder patch applied to the Yintang acupoint for treating rhinitis as described in claim 1, characterized in that, It is used in the preparation of drugs for treating rhinitis.