Intelligent wet granulation equipment for preparing sustained-release chewable tablets

Abstract

The application relates to the technical field of pharmaceutical equipment, and discloses an intelligent wet granulation equipment for preparing sustained-release chewable tablets, which comprises a base frame, a kettle body is installed on the base frame, a temperature control detection assembly and a cutting assembly are arranged on the kettle body; the upper cover assembly comprises a cover body and an upper cover connected to the cover body, a stirring piece is installed on the cover body; the stirring piece comprises a stirring rod and stirring blades connected to the stirring rod, and a scraping plate is arranged at the outer end of the stirring blades; the temperature control detection assembly comprises a mounting ring, a temperature control ring and a detection piece which are evenly arranged on the inner side of the mounting ring; the cutting assembly comprises a base piece and a mounting seat piece connected to the inside of the base piece; the problems that the existing wet granulation equipment is prone to cause local over-wetting and caking, the particle uniformity is poor, the kettle body temperature control precision is insufficient and the stability of lipid sustained-release materials is easily damaged, the granulation endpoint depends on manual experience, and the cutting assembly is inconvenient to disassemble and clean and maintain is high in difficulty are solved.

Description

Technical Field

[0001] This invention relates to the field of pharmaceutical equipment technology, specifically to an intelligent wet granulation equipment for preparing sustained-release chewable tablets. Background Technology

[0002] Wet granulation is a core process in the preparation of sustained-release chewable tablets. It involves mixing the drug and excipient powders, spraying in a binder, and then stirring and cutting the mixture to create granules with a specific particle size and hardness. The quality of these granules directly determines the formability of the subsequent tableting process, as well as the drug release rate and sustained-release effect of the final product. Currently, the high-speed mixing wet granulation equipment commonly used in the pharmaceutical industry still has the following shortcomings when applied to the production of sustained-release chewable tablets: The methods for adding binders are often limited, primarily employing a single-pipe constant-speed spray structure, which cannot match the phased progression of wet granulation: nucleation, growth, and compaction. Excessive spray volume in the initial stages of granulation can cause localized over-wetting and agglomeration of powder, resulting in large particle clumps. Insufficient spray intensity in the later stages of granulation leads to uneven particle growth and poor compaction, ultimately resulting in a wide particle size distribution and low roundness in the finished product. This directly causes batch-to-batch fluctuations in the release rate of sustained-release chewable tablets, making it difficult to meet the requirements for consistent formulation quality.

[0003] The temperature control precision of the granulation pot is insufficient. Sustained-release chewable tablets generally use lipid-based matrix materials as the sustained-release carrier. These materials are highly sensitive to temperature; excessively high ambient temperatures can cause melting and denaturation, damaging the sustained-release matrix structure; while excessively low temperatures can cause the material to adhere to the pot wall, resulting in residue. Existing equipment struggles to achieve precise temperature control within a narrow range, failing to guarantee the structural stability of the sustained-release material and the smoothness of the granulation process.

[0004] The methods for determining the granulation endpoint are outdated, often relying on fixed time control or operator visual and tactile judgment. This is significantly affected by batch differences in raw materials and fluctuations in ambient temperature and humidity, easily leading to over-granulation or under-granulation. This results in large batch-to-batch differences in key indicators such as particle moisture, hardness, and particle size, making it difficult to ensure the quality uniformity of sustained-release formulations.

[0005] Side-mounted cutting mechanisms are mostly fixed installations, and the disassembly and assembly process is complex. Pharmaceutical production requires strict adherence to GMP cleaning standards, and the fixed structure has many blind spots for cleaning, which can easily lead to drug residues and cross-contamination risks. At the same time, the horizontally set cutting mechanism will block the internal space of the pot and also hinder the disassembly, cleaning and maintenance of the stirring components, resulting in low equipment maintenance efficiency.

[0006] The equipment has a low overall level of intelligence, process parameters need to be set manually one by one, the production process is highly dependent on the operator's experience, the production efficiency is low, and it is difficult to achieve large-scale, standardized and unmanned production of sustained-release chewable tablets. Summary of the Invention

[0007] To address the problems in the prior art, this invention provides an intelligent wet granulation device for preparing sustained-release chewable tablets. This invention is achieved through the following technical solution.

[0008] An intelligent wet granulation device for preparing sustained-release chewable tablets includes a base frame, a pot body mounted on the base frame, a top cover assembly mounted on the upper end of the pot body, and a temperature control detection assembly and a cutting assembly provided on the pot body. The upper cover assembly includes a cover body and an upper cover connected to the cover body. A stirring component is installed on the cover body, and a stepped spray component is provided inside the cover body. The stirring component includes a stirring rod and stirring blades connected to the stirring rod, and a pushing inclined surface is provided on one side of the stirring blades. A scraping plate is provided at the outer end of the stirring blades. The stepped spray component includes a first spray pipe, a second spray pipe and a third spray pipe, and a nozzle is connected to the lower side of the first spray pipe, the second spray pipe and the third spray pipe, and a liquid inlet pipe is connected to the upper side of each of them. The temperature control and detection assembly includes a mounting ring and temperature control rings and detection elements evenly arranged inside the mounting ring; The cutting assembly includes a base and a mounting bracket connected inside the base. The cutting component is installed inside the mounting bracket, and a fixing component is installed at the outer end of the mounting bracket.

[0009] Preferably, the base component includes a fixed seat and a threaded seat opened at one end of the fixed seat, and a positioning pin is provided on the outer side of the threaded seat, and a sealing seat is provided inside the fixed seat.

[0010] Preferably, the mounting base includes a mounting body and a sealing ring disposed on the mounting body, wherein one end of the mounting body is provided with a positioning hole and a limit groove is provided on the outer side.

[0011] Preferably, the cutting component includes a drive shaft and a limiting shaft and a cutting blade respectively disposed at both ends of the drive shaft, and the other end of the limiting shaft is connected to a drive motor.

[0012] Preferably, the fastener includes a mounting sleeve and a threaded ring formed on the mounting sleeve, and a limit ring is provided on the inner side of the mounting sleeve.

[0013] Preferably, the bottom of the pot is provided with a discharge pipe, which is controlled by an electrically controlled valve and connected to the drying equipment.

[0014] Preferably, the first nozzle, the second nozzle, and the third nozzle are evenly distributed along the circumference inside the cover and are independently controlled. The nozzle is a two-fluid atomizing nozzle with an atomization angle of 120° and an adjustable atomization particle size range of 20-100μm.

[0015] Preferably, the inlet pipe is connected to a high-precision peristaltic metering pump, the flow rate of which is adjustable from 0.1 to 5 L / min and the control accuracy is ±1%.

[0016] Preferably, the temperature control ring is used to precisely control the temperature of the pot wall at 30-60℃; the detection device consists of a near-infrared moisture probe, a laser particle size analyzer, a temperature sensor and a pressure sensor, which can monitor the moisture content, particle size distribution, material temperature and pressure inside the pot in real time.

[0017] Preferably, it also includes an intelligent control system, which is electrically connected to the drive motor of the stirring component, the drive motor of the cutting component, the metering pump, the temperature control ring, the detection component, and the electrically controlled valve of the discharge pipe. The control system has a built-in multi-dimensional granulation endpoint determination model, which combines the moisture, particle size, and temperature data collected by the detection component with the stirring drive torque data to make a comprehensive determination. When the three core parameters fall into the preset target range at the same time, the granulation is automatically terminated and the electrically controlled valve is opened to discharge the material.

[0018] The present invention has the following beneficial effects: 1. Through the coordinated operation of the stepped spray component, mixing component, and cutting component, the adhesive is added in a three-stage gradient atomization process. During the nucleation stage, a small flow of fine mist slowly wets and forms particle nuclei. During the growth stage, a medium flow of spray promotes uniform particle growth. During the compaction stage, a large flow of spray completes the compaction of the particle surface. The mixing blades with pusher slopes form an up-and-down circulating material flow pattern, and the high-speed rotating cutting blades simultaneously break up agglomerated materials, avoiding the problem of local over-wetting and clumping, and improving the particle size uniformity and roundness.

[0019] 2. By combining the temperature control detection component with the intelligent control system, the pot wall temperature can be precisely controlled within the suitable range of 30-60℃, avoiding melting and denaturation of lipid-based sustained-release materials due to high temperatures, while also preventing materials from sticking to the wall at low temperatures, ensuring temperature stability throughout the granulation process; at the same time, by combining multiple parameters such as particle moisture, particle size distribution and stirring torque for comprehensive judgment, the granulation is automatically terminated, replacing the traditional manual experience judgment and timed control mode, offsetting the impact of raw material batch differences and environmental fluctuations, ensuring a high degree of consistency in the quality of each batch of granules, and improving the batch-to-batch uniformity of sustained-release formulation production.

[0020] 3. Through the quick-release cutting component structure design, the threaded engagement of the threaded seat and threaded ring, combined with the rotation limiting structure of the limiting ring and limiting groove, allows the mounting base and cutting component to be quickly pulled out from the side wall of the pot body. There are no dead corners for cleaning, which facilitates thorough cleaning of the equipment and reduces the risk of cross-contamination of drugs. At the same time, after the cutting component is removed, there are no horizontal parts obstructing the interior of the pot body, which also makes it easy to remove the stirring component from the top for cleaning and maintenance, thus improving the efficiency of equipment disassembly, assembly, cleaning and maintenance. Attached Figure Description

[0021] To more clearly illustrate the technical solution of the present invention, the accompanying drawings used in the description of the specific embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0022] Figure 1 : A schematic diagram of the overall structure of this invention; Figure 2 : A schematic diagram of the overall cross-sectional structure in this invention; Figure 3 : A cross-sectional structural diagram of the upper cover assembly in this invention; Figure 4 : A schematic diagram of the structure of the stepped spray component in this invention; Figure 5 : A schematic diagram of the temperature control detection component in this invention; Figure 6 : A schematic diagram of the structure of the stirring component in this invention; Figure 7 : A cross-sectional structural diagram of the cutting component in this invention; Figure 8 This invention Figure 7 Enlarged structural diagram at point A; Figure 9 : Schematic diagram of the connection structure between the mounting base and the fixing component in this invention.

[0023] The attached figures are labeled as follows: 1. Base frame; 2. Pot body; 21. Discharge pipe; 3. Top cover assembly; 31. Cover body; 32. Top cover; 33. Stirring component; 331. Stirring rod; 332. Stirring blade; 333. Pushing inclined surface; 334. Scraper; 34. Stepped spray component; 341. First spray nozzle; 342. Second spray nozzle; 343. Third spray nozzle; 344. Nozzle; 345. Liquid inlet pipe; 4. Temperature control detection assembly; 41. Mounting ring; 42. Temperature control ring; 43. Detection component; 5. Cutting assembly; 51. Base component; 511. Fixing seat; 512. Threaded seat; 513. Locating pin; 514. Sealing seat; 52. Mounting component; 521. Mounting body; 522. Sealing ring; 523. Limiting groove; 524. Locating hole; 53. Cutting component; 531. Drive shaft; 532. Limiting shaft; 533. Cutting blade; 54. Fixing component; 541. Mounting sleeve; 542. Threaded ring; 543. Limiting ring. Detailed Implementation

[0024] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0025] Example 1

[0026] Reference Figures 1-9 As shown in the first embodiment of the present invention, an intelligent wet granulation device for preparing sustained-release chewable tablets is provided. The device includes a base frame 1 as the overall supporting foundation, a pot body 2 fixedly mounted on the upper part of the base frame 1, and a cylindrical cavity structure with an open upper end. The upper opening is detachably and sealed to the upper cover assembly 3 via a flange structure. The cover 31 of the upper cover assembly 3 is fastened and fixed to the upper opening of the pot body 2, and the upper cover 32 is hinged to the top of the cover 31, allowing it to open and close around the hinge axis for easy feeding, observation, and internal maintenance.

[0027] The stirring element 33 is vertically installed at the center of the cover 31. The upper end of the stirring rod 331 protrudes from the top surface of the cover 31 and is connected to the output end of the external stirring drive motor. The lower end of the stirring rod 331 extends downward into the internal cavity of the pot body 2. The stirring blade 332 is fixedly connected to the lower part of the stirring rod 331. The pushing inclined surface 333 is opened on the material-facing side of the stirring blade 332 and is inclined upward. When the stirring blade rotates with the stirring rod, the pushing inclined surface can drive the material to turn upward. Then, the material falls naturally under the action of gravity, forming an up-and-down circulating material flow, which enhances the powder mixing effect. The scraper 334 is fixedly installed on the outer end of the stirring blade 332. Its outer edge is closely attached to the inner wall of the pot body 2. It can scrape off the material adhering to the pot wall synchronously with the stirring rotation, avoiding the material from remaining on the wall and clumping for a long time.

[0028] The stepped spray component 34 is fixedly installed inside the cover 31, located on the outer periphery of the agitator 33; the first spray pipe 341, the second spray pipe 342, and the third spray pipe 343 are evenly distributed along the circumference of the cover 31, and each spray pipe has a uniformly arranged nozzle 344 fixedly installed at its lower end, with the spray direction of the nozzle 344 facing the material area inside the pot 2; each spray pipe has an inlet pipe 345 connected to its upper end, and after the inlet pipe 345 extends upward through the cover 31, it is connected to three high-precision peristaltic metering pumps on the outside, realizing independent control of the three spray paths.

[0029] The temperature control detection component 4 is fixedly installed on the upper part of the inner wall of the pot body 2 by the mounting ring 41. The temperature control ring 42 and the detection element 43 are alternately and evenly arranged on the inner ring surface of the mounting ring 41. The outer side of the temperature control ring 42 is set to fit against the inner wall of the pot body 2, which can heat and control the pot wall. The detection end of the detection element 43 faces the central cavity of the pot body 2, and is used to collect material parameters and environmental parameters in the cavity in real time.

[0030] The cutting assembly 5 is horizontally mounted on the lower side wall of the pot body 2. The fixing seat 511 of the base component 51 is sealed and fixed at the mounting opening on the side wall of the pot body 2. The threaded seat 512 extends horizontally toward the outside of the pot body 2. The mounting seat 52 is inserted into the internal channel of the base component 51 from the outside. The cutting component 53 passes through the central through hole of the mounting seat 521. The drive shaft 531 is supported inside the mounting seat 521 by a sealed bearing. The cutting blade 533 is located in the internal cavity of the pot body 2, facing the material flow area. The limiting shaft 532 extends toward the outside of the pot body 2 for connecting and transmitting power to the output end of the external cutting drive motor. The fixing component 54 is sleeved on the outer end of the mounting seat 52 and screwed onto the threaded seat 512 through a threaded engagement, thereby achieving axial positioning and fixing of the mounting seat 52.

[0031] A discharge pipe 21 is provided at the bottom center of the pot body 2. An electrically controlled valve is installed on the discharge pipe 21. The outlet end of the discharge pipe 21 is sealed and connected to the feed inlet of the downstream drying equipment. After granulation, the wet granules can be discharged through the electrically controlled valve and enter the next process.

[0032] Cutting component 5 adopts a quick-release design, which facilitates cleaning, maintenance, and component replacement. The specific disassembly steps are as follows: After the equipment is shut down and the power is cut off, disconnect the transmission connection between the cutting drive motor and the limit shaft 532; rotate the fixing part 54 to gradually disengage the threaded engagement between the threaded ring 542 and the threaded seat 512, and screw the fixing part 54 outward. Since the limit ring 543 is fitted into the limit groove 523, the fixing part 54 only rotates circumferentially relative to the mounting body 521 when it rotates, and will not drive the mounting body 521 to rotate synchronously.

[0033] After the fixing part 54 is completely unscrewed, pull the mounting base 52 outward, causing the mounting body 521 to be pulled outward along the channel of the base part 51. At the same time, the cutting part 53 installed inside it is also taken out of the pot body 2, so that the cutting blade 533, the mounting base 52 and the channel of the base part 51 can be thoroughly cleaned and maintained.

[0034] After the cutting part 53 is removed, there are no horizontal parts obstructing the interior of the pot body 2. The connection between the stirring rod 331 and the stirring drive motor can be disconnected, the stirring part 33 can be removed from the cover 31 and taken out from the top of the pot body 2, and the stirring blade 332, the scraper 334 and the inner wall of the pot body 2 can be thoroughly cleaned.

[0035] During installation and reset, the mounting base 52 is aligned with the channel of the base 51 and inserted, so that the positioning pin 513 is inserted into the positioning hole 524, restricting the circumferential rotation of the mounting base 521 and ensuring the docking accuracy between the drive shaft 531 and the drive motor; then the fixing part 54 is tightened, and the mounting base 52 is axially pressed and fixed through the threaded engagement; the sealing seat 514 and the sealing ring 522 fit tightly to each other to achieve a seal at the installation channel and prevent material and liquid leakage during the granulation process.

[0036] Example 2

[0037] Combination Figures 1-9 As shown, this is the second embodiment of the present invention, which, based on embodiment 1, details the granulation process and material handling procedure of the equipment, as follows: Open the top cover 32 and add the raw and auxiliary powders for the sustained-release chewable tablets into the pot body 2 according to the formula ratio. Close the top cover 32 to complete the equipment sealing. The operator selects the corresponding sustained-release chewable tablet product formula in the human-machine interface of the control system. The system automatically loads the preset process parameters for the formula, such as stirring speed, cutting blade speed, three-stage spray flow rate and duration, pot wall set temperature, and granulation endpoint parameter range.

[0038] When the equipment is started, the stirring drive motor drives the stirring blades 332 to rotate at a constant speed inside the pot 2 via the stirring rod 331, mixing the powder inside. During the stirring process, the pushing inclined surface 333 continuously pushes the material upward and then falls naturally, forming an up-and-down circulating flow, so that the powders of different components are fully and evenly mixed; the scraper 334 rotates synchronously with the stirring blades, continuously scraping off the material adhering to the pot wall, preventing local material retention and clumping. At the same time, the cutting drive motor starts, and drives the cutting blade 533 to rotate at high speed through the limit shaft 532 and the transmission shaft 531, cutting and breaking the agglomerated powder that is stirred up, ensuring that the material is always in a uniformly dispersed state.

[0039] The control system controls three high-precision peristaltic metering pumps to deliver the adhesive in three stages according to a preset program. The adhesive enters the corresponding spray pipe through the inlet pipe 345 and is finally atomized and sprayed into the material through the nozzle 344. The metering pump outputs the adhesive at a small flow rate of 0.5-1L / min, and the nozzle 344 atomizes the adhesive into fine droplets, slowly wetting the powder surface and gradually forming uniform particle nuclei, avoiding local over-wetting and clumping caused by excessive spray volume in the initial stage. After the particle nuclei are formed, the metering pump automatically adjusts to a medium flow rate of 1.5-3L / min to continuously replenish the binder in the material, promote uniform particle growth, and gradually approach the target particle size range. When the particle size is close to the target value, the metering pump is adjusted to a high flow rate of 2-5L / min to quickly wet and compact the particle surface, thereby improving the mechanical strength and roundness of the particles.

[0040] The spray duration for each of the three stages can be set independently according to different formulation requirements, enabling precise, gradient-based addition of the adhesive.

[0041] Throughout the granulation process, the temperature control ring 42 works continuously to precisely control the temperature of the pot wall 2 within the range of 30-60℃, preventing the lipid-based sustained-release materials in the sustained-release chewable tablets from melting and denaturing due to excessively high temperatures, while also preventing the materials from sticking to the pot wall due to excessively low temperatures, thus ensuring that the temperature during the granulation process is stable and controllable.

[0042] When granulation reaches its endpoint, the control system automatically stops the operation of the metering pump, stirring drive motor and cutting drive motor, and then controls the opening of the electrically controlled valve on the discharge pipe 21. The prepared wet granules are discharged into the downstream drying equipment through the discharge pipe 21 under the action of gravity and enter the drying process.

[0043] Example 3

[0044] Reference Figures 1-9 As shown, this is the third embodiment of the present invention. Based on embodiments 1 and 2, this embodiment further explains the intelligent control process of the device: The intelligent control system configured for the equipment includes a formula storage module, a data acquisition module, an endpoint determination module, and an execution control module. The fully automated control logic is as follows: S1: Recipe Loading Operators select the corresponding product formula through a human-machine interface, and the control system automatically calls up the stored process parameter package. There is no need to manually set parameters one by one, which reduces the reliance on the operator's experience and ensures the consistency of the process between batches.

[0045] S2: Automatic process control After the equipment is started, the execution control module synchronously controls the stirring drive motor, the cutting drive motor, and the temperature control loop 42 to start, so that the equipment can quickly enter a steady-state operation. During the granulation process, the system strictly switches the output flow of the metering pump according to the preset time nodes, and automatically completes the three stages of step spraying in the nucleation period, growth period and compaction period without manual intervention.

[0046] S3: Real-time acquisition of multiple parameters The detection component 43 collects data on the moisture content, particle size distribution, material temperature, and chamber pressure of the particles in the pot 2 in real time. At the same time, the control system collects the running torque data of the stirring drive motor in real time. All data are transmitted synchronously to the endpoint determination module at a fixed frequency to realize real-time monitoring of all parameters of the granulation process.

[0047] S4: Multi-dimensional endpoint determination The endpoint determination module, based on a built-in multi-dimensional granulation endpoint determination model, compares the three core parameters—moisture, particle size, and torque—collected in real time with preset target ranges. When all three parameters fall within the target range simultaneously, the granulation process is determined to have reached its endpoint, and a termination command is immediately sent to the execution control module. This determination method replaces traditional timed control, avoiding over- or under-granulation due to batch variations in raw materials, and ensuring a high degree of consistency in particle quality for each batch.

[0048] S5: Automatic stop and material unloading After receiving the endpoint command, the execution control module automatically stops the operation of the metering pump, the stirring drive motor and the cutting drive motor. After a delay until the material stabilizes, it opens the electrically controlled valve of the discharge pipe 21 to automatically discharge the material. After the material is discharged, the valve is automatically closed, completing the fully automated operation.

[0049] The preferred embodiments of the present invention disclosed above are merely illustrative of the invention. These preferred embodiments do not exhaustively describe all details, nor do they limit the invention to any specific implementation. Clearly, many modifications and variations can be made based on the content of this specification. This specification selects and specifically describes these embodiments to better explain the principles and practical applications of the invention, thereby enabling those skilled in the art to better understand and utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims

1. An intelligent wet granulation device for preparing sustained-release chewable tablets, comprising a base frame (1), characterized in that, The base frame (1) is equipped with a pot body (2), and the upper end of the pot body (2) is equipped with a cover assembly (3). The pot body (2) is equipped with a temperature control detection assembly (4) and a cutting assembly (5). The upper cover assembly (3) includes a cover body (31) and an upper cover (32) connected to the cover body (31). A stirring component (33) is installed on the cover body (31), and a stepped spray component (34) is provided inside the cover body (31). The stirring component (33) includes a stirring rod (331) and a stirring blade (332) connected to the stirring rod (331). A pushing slope (333) is provided on one side of the stirring blade (332), and a scraping plate (334) is provided at the outer end of the stirring blade (332). The stepped spray component (34) includes a first spray pipe (341), a second spray pipe (342), and a third spray pipe (343). A nozzle (344) is connected to the lower side of the first spray pipe (341), the second spray pipe (342), and the third spray pipe (343), and an inlet pipe (345) is connected to the upper side of each of them. The temperature control detection component (4) includes a mounting ring (41) and a temperature control ring (42) and a detection element (43) evenly arranged inside the mounting ring (41). The cutting assembly (5) includes a base (51) and a mounting bracket (52) connected inside the base (51), and a cutting component (53) is installed inside the mounting bracket (52), and a fixing component (54) is installed at the outer end of the mounting bracket (52).

2. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The base component (51) includes a fixed seat (511) and a threaded seat (512) opened at one end of the fixed seat (511), and a positioning pin (513) is provided on the outside of the threaded seat (512), and a sealing seat (514) is provided inside the fixed seat (511).

3. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The mounting base (52) includes a mounting body (521) and a sealing ring (522) disposed on the mounting body (521). One end of the mounting body (521) is provided with a positioning hole (524) and a limiting groove (523) is provided on the outer side.

4. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The cutting component (53) includes a drive shaft (531) and a limiting shaft (532) and a cutting blade (533) respectively disposed at both ends of the drive shaft (531), and the other end of the limiting shaft (532) is connected to the drive motor.

5. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The fastener (54) includes a mounting sleeve (541) and a threaded ring (542) formed on the mounting sleeve (541), and a limit ring (543) is provided on the inner side of the mounting sleeve (541).

6. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The bottom of the pot body (2) is provided with a discharge pipe (21), which is controlled by an electric valve and connected to the drying equipment.

7. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The first nozzle (341), the second nozzle (342) and the third nozzle (343) are evenly distributed along the circumference inside the cover (31) and are independently controlled. The nozzle (344) adopts a two-fluid atomizing nozzle with an atomization angle of 120° and an adjustable atomization particle size range of 20-100μm.

8. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The inlet pipe (345) is connected to a high-precision peristaltic metering pump. The flow rate of the metering pump is adjustable from 0.1 to 5 L / min, and the control accuracy is ±1%.

9. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, The temperature control ring (42) is used to precisely control the temperature of the pot wall of the pot body (2) at 30-60℃; the detection component (43) consists of a near-infrared moisture probe, a laser particle size analyzer, a temperature sensor and a pressure sensor, which can monitor the moisture content, particle size distribution, material temperature and pressure inside the pot body (2) in real time.

10. The intelligent wet granulation equipment for preparing sustained-release chewable tablets according to claim 1, characterized in that, It also includes an intelligent control system, which is electrically connected to the drive motor of the stirring component (33), the drive motor of the cutting component (53), the metering pump, the temperature control ring (42), the detection component (43), and the electric control valve of the discharge pipe (21). The control system has a built-in multi-dimensional granulation endpoint determination model, which combines the moisture, particle size, temperature data collected by the detection component (43) with the stirring drive torque data to make a comprehensive determination. When the three core parameters fall into the preset target range at the same time, the granulation is automatically terminated and the electric control valve is opened to discharge the material.

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