Reaction tank for clarithromycin methylation

Abstract

The utility model discloses a reaction tank for clarithromycin methylation. The reaction tank comprises a tank body, a pressure relief mechanism and a stirring mechanism, uniformly distributed feed ports are formed in the upper left side of the outer cambered surface of the tank body, the feed ports are externally connected with external feeding equipment respectively, a discharge pipe is arranged in the middle of the lower side of the outer cambered surface of the tank body, the front ends of the discharge ports are externally connected with external collecting equipment, and reinforcing ribs are arranged on the outer cambered surface of the tank body; the pressure relief mechanism is arranged in the middle of the upper side of the outer arc surface of the tank body; the stirring mechanism is arranged in the tank body; the reaction tank for clarithromycin methylation further comprises supporting legs, the supporting legs are fixedly connected to the lower side of the outer cambered surface of the tank body in a bilateral symmetry mode, the reaction tank for clarithromycin methylation further comprises a single chip microcomputer, the single chip microcomputer is arranged on the left side face of the tank body, and the input end of the single chip microcomputer is electrically connected with an external power source. And the problem that the reaction tank cannot automatically discharge high-pressure toxic gas is solved by manually debugging the internal air pressure.

Description

Technical Field

[0001] The utility model relates to the technical field of clarithromycin, in particular to a reaction tank for clarithromycin methylation. Background Art

[0002] Clarithromycin, also known as 6-0-methylerythromycin A, is a derivative of erythromycin, which is obtained by selectively methylating the 6-hydroxyl group of erythromycin A. The antibacterial activity of clarithromycin in vitro is similar to that of erythromycin, but its antibacterial activity in vivo against some bacteria such as Staphylococcus aureus, Streptococcus, Haemophilus influenzae, etc. is stronger than erythromycin. It has poor drug resistance to erythromycin, and also has certain antibacterial activity against induced erythromycin-resistant strains. Since its discovery in 1980, clarithromycin has gone through a long process of synthesis and development. So far, a relatively mature and universal industrial synthesis route has been formed, that is, erythromycin or erythromycin thiocyanate is firstly subjected to oximation reaction of the 9-hydroxyl group with hydroxylammonium to form erythromycin oxime, and then the hydroxyl group at the oxime position is protected by 2-ethoxypropylene, and the hydroxyl groups at the 2′ and 4" positions are protected by trimethylchlorosilane. The methylated product is then reacted with a methylating agent such as methyl iodide, methyl bromide or methyl p-toluenesulfonate in a mixed solvent formed by a fat-soluble solvent such as ethers or aromatic hydrocarbons and a super solvent such as dimethyl alkali, under the catalysis of sodium hydroxide or potassium hydroxide, to achieve methylation of the hydroxyl group at the 6th position. The methylated product obtained after the treatment is then added to water and acetic acid and sodium bisulfite are added at the same time. Ethanol is then added for solubilization and the temperature is raised to 60-70°C for insulation reaction. The ethoxypropyl group and trimethylsilane are removed by hydrolysis and reduction to obtain clarithromycin:

[0003] When the existing clarithromycin methylation reaction device performs methylation reaction on clarithromycin, workers are usually required to watch the clarithromycin methylation reaction device to prevent excessive internal pressure. When the internal pressure of the clarithromycin methylation reaction device is too high, the workers release the pressure through the pressure relief valve of the clarithromycin methylation reaction device.

[0004] There are some problems. It is necessary to keep an eye on the reaction device manually, which is time-consuming and laborious. The high-pressure poisonous gas cannot be discharged automatically. For this reason, we propose a reaction tank for clarithromycin methylation. Utility Model Content

[0005] The technical problem to be solved by the utility model is to overcome the existing defects and provide a reaction tank for clarithromycin methylation, which can realize the function of automatic pressure relief and effectively solve the problems in the background technology.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a reaction tank for clarithromycin methylation, comprising a tank body, a pressure relief mechanism and a stirring mechanism;

[0007] Tank body: The upper left side of its outer arc surface is provided with evenly distributed feed ports, which are respectively connected to external feeding equipment. A discharge pipe is provided in the middle of the lower side of the outer arc surface of the tank body, and the front end of the discharge port is connected to the external collection equipment. The outer arc surface of the tank body is provided with reinforcing ribs;

[0008] Pressure relief mechanism: It is arranged in the middle of the upper side of the outer arc surface of the tank body;

[0009] Stirring mechanism: it is arranged inside the tank;

[0010] Among them: it also includes supporting feet, which are symmetrically fixed to the lower side of the outer arc surface of the tank body. When the reaction tank is working, there is no need for manual inspection of the reaction tank in real time and manual adjustment of the internal air pressure, so as to solve the problem that the reaction tank cannot automatically discharge high-pressure toxic gas.

[0011] Furthermore, it also includes a single-chip microcomputer, which is arranged on the left side of the tank body. The input end of the single-chip microcomputer is electrically connected to an external power supply to regulate the normal operation of the electrical appliance.

[0012] Furthermore, the pressure relief mechanism includes a pressure relief guide bucket, a lower mounting flange, an upper pressure relief pipe, a limit rod, a telescopic rod, a displacement plate, a return spring, a sealing plate and a pressure discharge port. The pressure relief guide bucket is arranged at the middle part of the upper side of the outer arc surface of the tank body, the upper surface of the pressure relief guide bucket is provided with a lower mounting flange, the upper surface of the lower mounting flange is provided with an upper mounting flange, the upper surface of the upper mounting flange is provided with an upper pressure relief pipe, the upper end of the upper pressure relief pipe is fixedly connected with a sealing plate, a front-and-rear symmetrical limit rod is fixedly connected between the lower surface of the sealing plate and the upper surface of the upper mounting flange, a telescopic rod is fixedly connected with the middle part of the lower surface of the sealing plate, the telescopic end of the telescopic rod is fixedly connected with the displacement plate, a rubber pad is provided on the lower surface of the displacement plate, two telescopic rods are both slidably connected with a displacement plate, a return spring is fixedly connected between the lower surface of the sealing plate and the displacement plate, the return spring is movably sleeved on the outer arc surface of the telescopic rod, and a pressure discharge port is provided in the middle part of the right side of the outer arc surface of the upper pressure relief pipe to realize the pressure relief function.

[0013] Furthermore, it also includes a condenser, which is arranged on the upper right side of the outer curved surface of the tank body. The air inlet of the condenser is connected to the pressure exhaust port through an air pipe. The condensation air inlet of the condenser is connected to an external compressor. The water outlet of the condenser is connected to an external wastewater treatment equipment to treat the toxic gas released from the pressure.

[0014] Furthermore, the stirring mechanism includes a motor, a rotating rod, a connecting rod and a stirring plate. The rotating rod is rotatably connected between the left inner wall and the right inner wall of the tank body. The outer arc surface of the rotating rod is provided with evenly distributed connecting rods. The end of each connecting rod is fixedly connected to the stirring plate. The middle of the left side surface of the tank body is fixedly connected to the motor. The output shaft of the motor is fixedly connected to the left end of the rotating rod. The input end of the motor is electrically connected to the output end of the single-chip microcomputer to realize the function of accelerating the reaction of stirring.

[0015] Furthermore, it also includes heaters, which are evenly arranged on the outer arc surface of the tank body, and the heating ends of the heaters extend into the interior of the tank body. The heating ends of the heaters are staggered with the stirring plates. A temperature sensor is provided on the right side of the tank body. The input ends of the heaters are electrically connected to the output ends of the single-chip microcomputer. The temperature sensor is electrically connected to the single-chip microcomputer in both directions to achieve temperature control inside the reaction tank.

[0016] Furthermore, it also includes a pressure gauge, which is arranged in the middle of the right side of the tank body, and the measuring end of the pressure gauge extends to the inside of the tank body to achieve real-time measurement of the pressure inside the reaction tank.

[0017] Compared with the prior art, the utility model has the following beneficial effects: the reaction tank for clarithromycin methylation has the following advantages:

[0018] When the reaction produces a large amount of toxic high-pressure gas, the pressure gauge detects the pressure inside the tank in real time. When the pressure reaches the specified critical point, the high-pressure toxic gas will lift the sealing plate, the sealing plate will move upward, and the telescopic rod will contract. At this time, the toxic gas will be guided through the pressure discharge port. At this time, the external compressor is regulated and the condenser is operated to condense the toxic gas into water, which is then discharged into the interior of the treatment equipment. When the air pressure inside the tank is restored to stability, the reset spring lifts the displacement plate downward. During this process, the telescopic rod is extended, and the limit rod provides horizontal stability for the movement of the displacement plate. There is no need for manual work in the reaction tank. The reaction tank can be detected in real time and the internal air pressure can be manually adjusted to solve the problem that the reaction tank cannot automatically discharge high-pressure toxic gas. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the cross-sectional structure of the stirring mechanism of the utility model;

[0021] Figure 3 This is a schematic diagram of the cross-sectional structure of the pressure relief mechanism of the utility model;

[0022] Figure 4 This is an enlarged structural diagram of point A of the utility model.

[0023] In the figure: 1 tank body, 2 pressure relief mechanism, 21 pressure relief guide bucket, 22 lower mounting flange, 23 upper pressure relief pipe, 24 limit rod, 25 telescopic rod, 26 displacement plate, 27 return spring, 28 sealing plate, 29 pressure discharge port, 3 temperature sensor, 4 feed port, 5 condenser, 6 stirring mechanism, 61 motor, 62 rotating rod, 63 connecting rod, 64 stirring plate, 7 support feet, 8 reinforcing ribs, 9 discharge pipe, 10 single chip microcomputer, 11 pressure gauge, 12 heater. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] See also Figure 1-4 , this embodiment provides a technical solution: a reaction tank for clarithromycin methylation, comprising a tank body 1, a pressure relief mechanism 2 and a stirring mechanism 6;

[0026] Tank body 1: The upper left side of its outer arc surface is provided with evenly distributed feed ports 4, which are respectively connected to external feeding equipment, a discharge pipe 9 is provided in the middle of the lower side of the outer arc surface of the tank body 1, and the front end of the discharge port 9 is externally connected to an external material collection device, and the outer arc surface of the tank body 1 is provided with reinforcing ribs 8, and also includes a single-chip microcomputer 10, which is arranged on the left side of the tank body 1, and the input end of the single-chip microcomputer 10 is electrically connected to an external power supply;

[0027] Pressure relief mechanism 2: It is arranged at the middle of the upper side of the outer arc surface of the tank body 1. The pressure relief mechanism 2 includes a pressure relief guide bucket 21, a lower mounting flange 22, an upper pressure relief pipe 23, a limit rod 24, a telescopic rod 25, a displacement plate 26, a reset spring 27, a sealing plate 28 and a pressure discharge port 29. The pressure relief guide bucket 21 is arranged at the middle of the upper side of the outer arc surface of the tank body 1. The upper surface of the pressure relief guide bucket 21 is provided with a lower mounting flange 22, the upper surface of the lower mounting flange 22 is provided with an upper mounting flange, the upper surface of the upper mounting flange is provided with an upper pressure relief pipe 23, and the upper pressure relief The upper end of the tube 23 is fixedly connected with a sealing plate 28, and a front-to-rear symmetrical limiting rod 24 is fixedly connected between the lower surface of the sealing plate 28 and the upper surface of the upper mounting flange. A telescopic rod 25 is fixedly connected to the middle of the lower surface of the sealing plate 28, and a displacement plate 26 is fixedly connected to the telescopic end of the telescopic rod 25. A rubber pad is provided on the lower surface of the displacement plate 26. The two telescopic rods 25 are slidably connected to one displacement plate 26. A reset spring 27 is fixedly connected between the lower surface of the sealing plate 28 and the displacement plate 26. The reset spring 27 is fixedly connected to the telescopic rod 25. The outer arc surface of the tank body 1 is movably sleeved, and a pressure relief port 29 is provided in the middle of the right side of the outer arc surface of the upper pressure relief pipe 23. It also includes a condenser 5. The condenser 5 is arranged on the upper right side of the outer arc surface of the tank body 1. The air inlet of the condenser 5 is connected to the pressure relief port 29 through an air pipe. The condensation air inlet of the condenser 5 is externally connected to an external compressor, and the water outlet of the condenser 5 is externally connected to an external wastewater treatment device. During the reaction, a large amount of high-pressure toxic gas will be generated. The pressure gauge 11 detects the pressure inside the tank body 1 in real time. When the pressure reaches the specified critical point, these high-pressure toxic gases The toxic gas lifts the sealing plate 28, and the sealing plate 28 moves upward, and the telescopic rod 25 contracts. At this time, the toxic gas is guided by the pressure discharge port 29. At this time, the external compressor 10 is regulated, and the condenser 5 is operated to condense the toxic gas into water, and then the toxic water is discharged into the interior of the treatment equipment. When the air pressure inside the tank body 1 is restored to stability, the reset spring 27 lifts the displacement plate 26 downward to move downward. During this process, the telescopic rod 25 is extended, and the limit rod 24 provides horizontal stability for the movement of the displacement plate 26.

[0028] Stirring mechanism 6: It is arranged inside the tank body 1, and the stirring mechanism 6 includes a motor 61, a rotating rod 62, a connecting rod 63 and a stirring plate 64. The rotating rod 62 is rotatably connected between the left inner wall and the right inner wall of the tank body 1. The outer arc surface of the rotating rod 62 is provided with evenly distributed connecting rods 63, and the end of each connecting rod 63 is fixedly connected to the stirring plate 64. The middle of the left side of the tank body 1 is fixedly connected to the motor 61, and the output shaft of the motor 61 is fixedly connected to the left end of the rotating rod 62. The input end of the motor 61 is electrically connected to the output end of the single-chip microcomputer 10. It also includes a heater 12 for heating The heaters 12 are evenly arranged on the outer arc surface of the tank body 1, and the heating ends of the heaters 12 extend to the inside of the tank body 1. The heating ends of the heaters 12 are staggered with the stirring plates 64. The right side of the tank body 1 is provided with a temperature sensor 3. The input ends of the heaters 12 are electrically connected to the output ends of the single-chip microcomputer 10. The temperature sensor 3 is bidirectionally electrically connected to the single-chip microcomputer 10. It also includes a pressure gauge 11. The pressure gauge 11 is arranged in the middle of the right side of the tank body 1. The measuring end of the pressure gauge 11 extends to the inside of the tank body 1. At this time, the clarithromycin raw material is discharged into the tank body 1 through the feed port 4. At this time, the single chip microcomputer 10 is regulated, the heater 12 is operated, and the heating port of the heater 12 heats the clarithromycin raw material inside the tank body 1. During the reaction, the single chip microcomputer 10 is regulated, the motor 61 is operated, and the output shaft of the motor 61 is operated, thereby driving the rotating rod 62 to rotate, and then driving the stirring plate 64 through the connecting rod 63, thereby continuously stirring and accelerating the reaction rate. At this time, the single chip microcomputer 10 is regulated, the temperature sensor 3 is operated, and the temperature sensor 3 measures the temperature inside the tank body 1 in real time. When the temperature inside the tank body 1 reaches the reaction temperature, the feed port 4. Add water to the inside to hydrolyze and remove a methyl group on the amino group. At this time, add the benzyl chloroformate reaction raw material to the inside of the tank body 1 through the feed port 4 to protect the hydroxyl group and amino group on the five-position side chain tetrahydropyran ring, and then add the corresponding catalyst, and then react with methyl iodide in dimethyl sulfoxide and tetrahydrofuran to methylate the hydroxyl group on the six-position, and then catalytically hydrogenate to remove the protecting group, and react with formaldehyde to hydroxymethylate the amino group, and finally reduce it to a methyl group. The clarithromycin that has completed the reaction passes through the external material collection equipment, and the clarithromycin inside the tank body 1 is discharged to complete the operation;

[0029] Among them, it also includes supporting feet 7, which are fixedly connected to the lower side of the outer arc surface of the tank body 1 symmetrically on the left and right, and the reaction tank is placed on the designated work station through the supporting feet 7.

[0030] The working principle of a reaction tank for methylation of clarithromycin provided by the utility model is as follows: the reaction tank is placed on a designated work station through a support leg 7, and the clarithromycin raw material is discharged into the interior of the tank body 1 through a feed port 4. At this time, the single chip microcomputer 10 is regulated, the heater 12 is operated, and the heating port of the heater 12 heats the clarithromycin raw material in the tank body 1. At this time, the single chip microcomputer 10 is regulated, the temperature sensor 3 is operated, and the temperature sensor 3 measures the temperature inside the tank body 1 in real time. When the temperature inside the tank body 1 reaches the reaction temperature, water is added to the interior through the feed port 4 to hydrolyze and remove a methyl group on the amino group. At this time, the benzyl chloroformate reaction raw material is added to the interior of the tank body 1 through the feed port 4, and the hydroxyl group and the amino group on the five-position side chain tetrahydropyran ring are protected, and then the corresponding catalyst is added, and then the reaction is carried out with methyl iodide in dimethyl sulfoxide and tetrahydrofuran to methylate the hydroxyl group on the six-position, and then the protective group is removed by catalytic hydrogenation, and the amino group is reacted with formaldehyde to hydroxymethylate, and finally reduced to a methyl group. The reaction process In the process, the single chip microcomputer 10 is regulated, the motor 61 is operated, and the output shaft of the motor 61 is operated, thereby driving the rotating rod 62 to rotate, and then driving the stirring plate 64 through the connecting rod 63, thereby continuously stirring and accelerating the reaction rate, which will produce a large amount of high-pressure toxic gas. The pressure gauge 11 detects the pressure inside the tank body 1 in real time. When the pressure reaches the specified critical point, these high-pressure toxic gases will lift the sealing plate 28, and the sealing plate 28 will move upward, and the telescopic rod 25 will shrink. At this time, the toxic gas passes through the guide of the pressure discharge port 29. At this time, the external compressor 10 is regulated, and the condenser 5 is operated to condense these toxic gases into water, and then the toxic water is discharged into the interior of the treatment equipment. When the air pressure inside the tank body 1 is restored to stability, the reset spring 27 lifts the displacement plate 26 downward, and in this process, the telescopic rod 25 is extended, and the limit rod 24 provides horizontal stability for the movement of the displacement plate 26. The clarithromycin that has completed the reaction passes through the external aggregate equipment, and the clarithromycin inside the tank body 1 is discharged to complete the operation.

[0031] It is worth noting that the single chip microcomputer 10 disclosed in the above embodiment is specifically model S7-200, and the temperature sensor 3, condenser 5, motor 61, pressure gauge 11 and heater 12 can be freely configured according to the actual application scenario. It is recommended to use ds 18b20 temperature sensor for temperature sensor 3, TY / LNQ201905 pure steam sampling condenser for condenser 5, YK1000-D Chinese electric stirrer for motor 61, THLL352 ceramic capacitor pressure transmitter for pressure gauge 11, and JGS-201 water jacket heater for heater 12. The single chip microcomputer 10 controls the operation of temperature sensor 3, condenser 5, motor 61 and heater 12 using methods commonly used in the prior art.

[0032] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A reaction tank for clarithromycin methylation, characterized in that: It comprises a tank body (1), a pressure relief mechanism (2) and a stirring mechanism (6); The tank body (1) is provided with evenly distributed feed ports (4) on the upper left side of its outer arc surface, and the feed ports (4) are respectively connected to external feeding equipment. A discharge pipe (9) is provided in the middle of the lower side of the outer arc surface of the tank body (1), and the front end of the discharge pipe (9) is connected to external material collection equipment. The outer arc surface of the tank body (1) is provided with reinforcing ribs (8); A pressure relief mechanism (2): the pressure relief mechanism (2) is arranged at the middle part of the upper side of the outer curved surface of the tank body (1); A stirring mechanism (6): which is arranged inside the tank body (1); Among them, it also includes supporting feet (7), and the supporting feet (7) are fixedly connected to the lower side of the outer curved surface of the tank body (1) in a left-right symmetrical manner.

2. A reaction tank for clarithromycin methylation according to claim 1, characterized in that: It also comprises a single-chip microcomputer (10), which is arranged on the left side of the tank body (1), and an input end of the single-chip microcomputer (10) is electrically connected to an external power supply.

3. A reaction tank for clarithromycin methylation according to claim 2, characterized in that: The pressure relief mechanism (2) comprises a pressure relief guide bucket (21), a lower mounting flange (22), an upper pressure relief pipe (23), a limit rod (24), a telescopic rod (25), a displacement plate (26), a return spring (27), a sealing plate (28) and a pressure relief port (29); the pressure relief guide bucket (21) is arranged at the middle part of the upper side of the outer arc surface of the tank body (1); the upper surface of the pressure relief guide bucket (21) is provided with a lower mounting flange (22); the upper surface of the lower mounting flange (22) is provided with an upper mounting flange; the upper surface of the upper mounting flange is provided with an upper pressure relief pipe (23); the upper end of the upper pressure relief pipe (23) is fixedly connected with a sealing plate (28); the sealing plate (28) ) is fixedly connected between the lower surface of the sealing plate (28) and the upper surface of the upper mounting flange with a front-to-rear symmetrical limiting rod (24); a telescopic rod (25) is fixedly connected to the middle of the lower surface of the sealing plate (28); a displacement plate (26) is fixedly connected to the telescopic end of the telescopic rod (25); a rubber pad is provided on the lower surface of the displacement plate (26); two telescopic rods (25) are slidably connected to one displacement plate (26); a reset spring (27) is fixedly connected between the lower surface of the sealing plate (28) and the displacement plate (26); the reset spring (27) is movably sleeved with the outer arc surface of the telescopic rod (25); and a pressure discharge port (29) is provided in the middle of the right side of the outer arc surface of the upper pressure relief pipe (23).

4. A reaction tank for clarithromycin methylation according to claim 3, characterized in that: It also includes a condenser (5), which is arranged on the upper right side of the outer curved surface of the tank body (1), the air inlet of the condenser (5) is connected to the pressure discharge port (29) through an air pipe, the condensation air inlet of the condenser (5) is externally connected to an external compressor, and the water outlet of the condenser (5) is externally connected to an external wastewater treatment device.

5. The reaction tank for clarithromycin methylation according to claim 2, characterized in that: The stirring mechanism (6) comprises a motor (61), a rotating rod (62), a connecting rod (63) and a stirring plate (64); the rotating rod (62) is rotatably connected between the left inner wall and the right inner wall of the tank body (1); the outer arc surface of the rotating rod (62) is provided with evenly distributed connecting rods (63); the end of each connecting rod (63) is fixedly connected to the stirring plate (64); the middle part of the left side surface of the tank body (1) is fixedly connected to the motor (61); the output shaft of the motor (61) is fixedly connected to the left end of the rotating rod (62); and the input end of the motor (61) is electrically connected to the output end of the single-chip computer (10).

6. A reaction tank for clarithromycin methylation according to claim 5, characterized in that: The tank body (1) further comprises a heater (12), wherein the heaters (12) are evenly arranged on the outer arc surface of the tank body (1), the heating ends of the heaters (12) extend into the interior of the tank body (1), the heating ends of the heaters (12) are staggered with the stirring plates (64), a temperature sensor (3) is arranged on the right side of the tank body (1), the input ends of the heaters (12) are electrically connected to the output ends of the single-chip microcomputer (10), and the temperature sensor (3) is bidirectionally electrically connected to the single-chip microcomputer (10).

7. The reaction tank for clarithromycin methylation according to claim 1, characterized in that: It also comprises a pressure gauge (11), which is arranged in the middle of the right side of the tank body (1), and the measuring end of the pressure gauge (11) extends to the interior of the tank body (1).

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