Blood purification equipment with respiratory support function

Abstract

The utility model provides blood purification equipment with a respiratory support function, an oxygenator is arranged on a blood path of the blood purification equipment, and the oxygenator is arranged on a blood path output pipeline or a blood path input pipeline. According to the blood purification equipment, in-vitro oxygenation of blood can be carried out through the oxygenator while blood purification is carried out, carbon dioxide in the blood is removed, and a partial respiration support function is provided for a patient.

Description

Technical Field

[0001] The utility model relates to the technical field of medical machinery, in particular to a blood purification device with a respiratory support function. Background Art

[0002] Extracorporeal carbon dioxide removal (ECCO2R) is one of the extracorporeal life support technologies. It drains blood to an artificial membrane lung (membrane oxygenator) for oxygenation and removal of CO2, and then returns it to the human body, thereby achieving gas exchange to replace lung ventilation function. Extracorporeal carbon dioxide removal (ECCO2R) is mainly used to remove carbon dioxide from patients with acute hypoxia or acute hypercapnia respiratory failure to minimize respiratory acidosis and allow more lung protective ventilator settings, which can reduce ventilator-induced lung damage. The blood flow of extracorporeal carbon dioxide removal (ECCO2R) is relatively low (200-1500ml / min), which can completely remove the CO2 metabolized by the human body. While removing CO2, it can also provide patients with partial oxygenation capacity and achieve partial respiratory function support for patients.

[0003] Currently, ECMO devices are mostly used clinically to reduce blood flow and use smaller catheters than ECMO for ECCO2R treatment. ECMO equipment is expensive, has high consumable costs, usually requires a medical team to operate, is complex to use, and requires very high technical skills from operators. In addition, the reduced efficiency of the centrifugal pump in the ECMO system can lead to blood stagnation and increased recirculation, which may lead to increased hemolysis. At the same time, lower blood flow may also lead to uneven blood flow distribution. Blood will stagnate when passing through a large membrane lung, requiring the use of higher doses of anticoagulants to avoid thrombosis, which will increase the risk of severe bleeding in patients.

[0004] Usually, patients with respiratory failure have concurrent organ failure and need continuous blood purification equipment (CRRT) to remove toxins and water from the patient's body and correct the internal environment disorder. Therefore, the patient needs to be treated with CRRT equipment and ECMO equipment at the same time to achieve functional support treatment for multiple organs. However, the combined use of the two devices is complicated to operate, has high treatment costs, and poses safety risks. Utility Model Content

[0005] In order to overcome the defects existing in the above-mentioned prior art, the purpose of the utility model is to provide a blood purification device with a respiratory support function.

[0006] In order to achieve the above-mentioned purpose of the utility model, the utility model provides a blood purification device with a respiratory support function, an oxygenator is arranged on the blood path of the blood purification device, and the oxygenator is arranged on the blood path output pipeline or the blood path input pipeline;

[0007] A first blood oxygen monitor is arranged on the pipeline before the blood inlet end of the oxygenator, and a second blood oxygen monitor is arranged on the pipeline after the blood outlet end of the oxygenator, and the blood oxygen signal output ends of the first blood oxygen monitor and the second blood oxygen monitor are respectively connected to the control module of the blood purification device;

[0008] Also includes replacement fluid lines and / or dialysate lines;

[0009] One end of the replacement fluid pipeline is used to input the replacement fluid, and the other end is connected to the blood circuit;

[0010] One end of the dialysate pipeline is used to input the replacement fluid, and the other end is connected to the dialysate inlet end of the blood filter of the blood purification device;

[0011] The replacement fluid pipeline includes a front replacement fluid pipeline and / or a rear replacement fluid pipeline;

[0012] One end of the front replacement fluid pipeline is used to input replacement fluid, and the other end is connected to the blood output pipeline. The front replacement fluid pipeline is provided with a front replacement pump;

[0013] One end of the post-substitution fluid pipeline is used to input substitution fluid, and the other end is connected to the blood circuit input pipeline. The post-substitution fluid pipeline is provided with a post-substitution pump;

[0014] The front displacement pump and the rear displacement pump are respectively control-connected to the control module.

[0015] The blood purification device can use an oxygenator to perform extracorporeal oxygenation of the blood and remove carbon dioxide from the blood while purifying the blood. The control module can understand the blood oxygenation status in real time based on the information fed back by the first blood oxygen monitor and the second blood oxygen monitor sensor. The blood purification device can select pre-dilution, post-dilution, and pre- and post-dilution (mixed dilution) according to clinical needs. At the same time, the pre-dilution and post-dilution replacement fluid flow rates can be flexibly adjusted according to needs, while increasing the service life of the blood filter and ensuring the patient's treatment dosage, reducing coagulation problems caused by excessive blood concentration.

[0016] In an optional solution of the blood purification device with respiratory support function, it also includes a transcutaneous carbon dioxide monitor, and the carbon dioxide partial pressure signal output end of the transcutaneous carbon dioxide monitor is connected to the control module of the blood purification device.

[0017] The information fed back by the first blood oxygen monitor, the second blood oxygen monitor sensor, and the transcutaneous carbon dioxide monitor in this optional solution can be used by the control module to evaluate the therapeutic effect in order to achieve the best treatment effect; it can also be used to determine whether some components in the blood purification equipment are working properly, such as whether the membrane pores of the oxygenator are blocked.

[0018] In an optional solution of the blood purification device with respiratory support function, the other end of the front replacement fluid pipeline is connected to the blood inlet end of the blood filter.

[0019] In an optional solution of the blood purification device with respiratory support function, it also includes an alarm module connected to the control module.

[0020] In an optional solution of the blood purification device with respiratory support function, the air inlet of the oxygenator is connected to the oxygen outlet of the oxygen supply device, and the oxygen supply device is communicatively connected to the control module.

[0021] The beneficial effects of the utility model are:

[0022] During the blood purification process, the utility model exchanges gas between the blood and externally input oxygen, removes a large amount of carbon dioxide in the blood, and realizes the supporting or replacing effect of lung function.

[0023] The utility model can simultaneously remove toxins such as creatinine, urea nitrogen, inflammatory mediators, cytokines, etc. in patients with renal failure and respiratory failure, and perform gas exchange of oxygen and carbon dioxide in the blood in vitro, while achieving replacement of kidney and lung functions. Compared with traditional ECMO, the utility model simplifies the treatment plan, reduces the treatment cost, is simple to operate, and the treatment process is safe and reliable.

[0024] Additional aspects and advantages of the present invention will be given in part in the following description, and in part will become apparent from the following description, or will be learned through the practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0026] Figure 1 It is a principle block diagram of the utility model;

[0027] Figure 2 It is an assembly schematic diagram of the utility model. DETAILED DESCRIPTION

[0028] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals throughout represent the same or similar elements or elements having the same or similar functions. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain the present invention, and cannot be understood as limiting the present invention.

[0029] In the description of the present utility model, unless otherwise specified and limited, it should be noted that the terms "installation", "connection" and "connection" should be understood in a broad sense. For example, it can be a mechanical connection or an electrical connection, or it can be the internal connection of two components. It can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms can be understood according to the specific circumstances.

[0030] like Figure 1 and Figure 2 As shown, the utility model provides a blood purification device with a respiratory support function, and an oxygenator 4 is arranged on the blood path of the blood purification device. In this embodiment, the oxygenator 4 can be a membrane oxygenator, which can be arranged in the blood path output pipeline, such as Figure 1 As shown, it can also be set on the blood input pipeline, which refers to the pipeline that returns blood to the patient end, such as Figure 2 As shown, extracorporeal oxygenation of blood and removal of carbon dioxide are simultaneously performed during the blood purification process.

[0031] The blood purification device is also provided with a replacement fluid pipeline and a dialysate pipeline 14. One end of the replacement fluid pipeline is input with replacement fluid and the other end is connected to the blood circuit. One end of the dialysate pipeline 14 is input with replacement fluid and the other end is connected to the dialysate inlet of the blood filter 6 of the blood purification device. The replacement fluid pipeline may include a front replacement fluid pipeline 21 and may also include a rear replacement fluid pipeline 12. Figure 2 As shown, Figure 2 The case where the oxygenator 4 is arranged on the blood input pipeline and only the rear replacement fluid pipeline 12 is arranged is shown. Figure 2 In the figure, the blood purification device includes a display screen 1 and a host 2, and a blood pump 3, a dialysate pump 16, a post-replacement fluid pump 13, a waste fluid pump 15, a replacement fluid meter 18, and a waste fluid meter 10 are arranged on the front of the host 2.

[0032] The blood pump 3 is installed on the arterial pipeline 8, the inlet of the arterial pipeline 8 is connected to the outlet of the patient's blood channel pair, the outlet of the arterial pipeline 8 is connected to the inlet of the blood filter 6, the blood filter 6 is fixed on the host 2 through the clamp 7, the outlet of the blood filter 6 is connected to the blood inlet of the oxygenator 4 through the pipeline, the oxygenator 4 is fixed on the host 2 through the clamp 5, the air inlet of the oxygenator 4 is connected to oxygen, the blood outlet of the oxygenator 4 is connected to the venous pipeline 9, the venous pot is arranged on the venous pipeline 9, and the other end of the venous pipeline 9 is connected to the outlet of the patient's central venous catheter.

[0033] The replacement fluid bag 19 is hung on the replacement fluid meter 18, the liquid interface of the replacement fluid bag 19 is connected to the inlet of the rear replacement fluid pipeline 12, the rear replacement fluid pump 13 is installed on the rear replacement fluid pipeline 12, and the outlet of the rear replacement fluid pipeline 12 is connected to the venous pot branch of the venous pipeline 9.

[0034] The pipeline between the inlet of the post-replacement fluid pipeline 12 and the post-replacement fluid pump 13 is provided with a branch pipe, which is connected to the inlet of the dialysate pipeline 14. The dialysate pump 16 is installed on the dialysate pipeline 14. The outlet of the dialysate pipeline 14 is connected to the first connector outside the membrane of the blood filter 6.

[0035] The second connector outside the membrane of the blood filter 6 is connected to the inlet of the waste liquid pipeline 17, and a waste liquid pump 15 is provided on the waste liquid pipeline 17. The outlet of the waste liquid pipeline 17 is connected to the connector of the waste liquid bag 11, and the waste liquid bag 11 is hung on the waste liquid meter 10.

[0036] The blood purification device draws the patient's blood from the outlet of the central venous catheter through the blood pump 3, and the blood passes through the blood filter 6 and the oxygenator 4 in turn. The blood after substance exchange and gas exchange respectively is finally returned to the human body through the inlet of the central venous catheter, forming a continuous extracorporeal blood circulation.

[0037] The rear replacement fluid pump 13 uses power to transfer the liquid in the replacement fluid bag 19 from the branch pipe on the venous pot to the venous blood and enter the human body; the dialysate pump 16 uses power to transfer the liquid in the replacement fluid bag 19 to the outside of the membrane of the blood filter 6; the waste liquid pump 15 uses power to discharge the input dialysate into the waste liquid bag 11, and also discharges part of the water in the blood in the hollow fiber membrane of the blood filter 6 across the membrane into the waste liquid bag 11. In this process, the speeds of the rear replacement fluid pump 13, the dialysate pump 16 and the waste liquid pump 15 are adjusted by continuous measurement by the replacement fluid meter 18 and the waste liquid meter 10, so that the liquid output from the replacement fluid bag 19 and the liquid discharged into the waste liquid bag 11 are balanced. According to the clinical treatment prescription, if dehydration is required from the body of a patient with renal failure, the speeds of the rear replacement fluid pump 13, the dialysate pump 16 and the waste liquid pump 15 are adjusted so that the amount of liquid entering the waste liquid bag 11 per unit time is greater than the amount of liquid discharged from the replacement fluid bag 19, and the difference is the amount of dehydration from the human body per unit time. The replacement fluid mainly contains ions that are close to the human body's components, including potassium, sodium, calcium, chloride, magnesium, glucose, bicarbonate and other ion components. When passing through the blood filter 6, it can continuously remove a large number of small and medium-molecule toxins in the human blood by utilizing the principles of diffusion and convection, and achieve the removal of creatinine, urea nitrogen, inflammatory mediators, cytokines and other substances in patients with renal failure and respiratory failure.

[0038] During extracorporeal circulation, venous blood exchanges gas with externally input oxygen when passing through the oxygenator 4, thereby removing a large amount of carbon dioxide from the blood and achieving a supporting or replacing effect on lung function.

[0039] In this embodiment, Figure 1As shown, a first blood oxygen monitor 22 is arranged on the pipeline before the blood inlet end of the oxygenator 4, and a second blood oxygen monitor 23 is arranged on the pipeline after the blood outlet end of the oxygenator 4, and the blood oxygen signal output ends of the first blood oxygen monitor 22 and the second blood oxygen monitor 23 are respectively connected to the control module of the blood purification device. The control module can control the blood purification work while evaluating the oxygenation of the blood through the blood oxygen saturation fed back by the first blood oxygen monitor 22 and the second blood oxygen monitor 23. The control module can be a control module of an existing blood purification device.

[0040] like Figure 1 As shown, a transcutaneous carbon dioxide monitor 24 can also be set, and the transcutaneous carbon dioxide monitor 24 is attached to the patient, and the carbon dioxide partial pressure PaCO2 in the patient's blood is measured in real time through the transcutaneous carbon dioxide monitor 24. The carbon dioxide partial pressure signal output end of the transcutaneous carbon dioxide monitor 24 is connected to the control module of the blood purification device. The control module can evaluate the therapeutic effect according to the information fed back by the first blood oxygen monitor 22, the second blood oxygen monitor sensor 23, and the transcutaneous carbon dioxide monitor 24, and feedback and adjust the parameters such as blood flow and oxygen flow to achieve the best treatment effect; at the same time, according to the information fed back by the first blood oxygen monitor 22, the second blood oxygen monitor sensor 23, and the transcutaneous carbon dioxide monitor 24, it can analyze whether the oxygenator 4 has a decreased gas exchange efficiency due to the blockage of the membrane pores of the oxygenator, and prompt the operator to replace the corresponding consumables in time. When prompting, an alarm module can be set to prompt, such as a voice alarm module, or text or graphics can be used on the display screen 1 to alarm.

[0041] In this embodiment, the air inlet of the oxygenator 4 is connected to the oxygen outlet of the oxygen supply device, and the oxygen supply device can be connected to the control module for communication. The control module can control the oxygen supply of the oxygen supply device according to the information fed back by the first blood oxygen monitor 22, the second blood oxygen monitor sensor 23, and the transcutaneous carbon dioxide monitor 24, so that the oxygen supply is always accurate; or the control module sends the information fed back by the first blood oxygen monitor 22, the second blood oxygen monitor sensor 23, and the transcutaneous carbon dioxide monitor 24 to the oxygen supply device, and the oxygen supply device autonomously adjusts the oxygen supply.

[0042] In the specific implementation of this embodiment, if a front replacement fluid pipeline 21 is required, one end of the front replacement fluid pipeline 21 is input with replacement fluid, and the other end is connected to the blood output pipeline, such as the blood inlet end of the blood filter 6. Figure 1As shown, the front replacement fluid pipeline 21 is provided with a front replacement pump 20. The front replacement pump 20 and the rear replacement pump 12 are respectively connected to the control module for control. When the front replacement fluid pipeline 21 and the rear replacement fluid pipeline 12 exist at the same time, the front replacement fluid pump 20 and the rear replacement fluid pump 13 can be turned on at the same time, or only one can be turned on, and the control module can control them to be turned on or off according to actual needs, and control the rotation speed of the front replacement fluid pump 20 and the rear replacement fluid pump 13.

[0043] In this embodiment, in order to prevent blood clotting, an anticoagulant 25 is added to the blood circuit.

[0044] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0045] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A blood purification device with respiratory support function, characterized in that: An oxygenator is arranged on the blood circuit of the blood purification device, wherein the oxygenator is arranged on the blood circuit output pipeline or the blood circuit input pipeline; A first blood oxygen monitor is provided on the pipeline before the blood inlet end of the oxygenator, and a second blood oxygen monitor is provided on the pipeline after the blood outlet end of the oxygenator, and the blood oxygen signal output ends of the first blood oxygen monitor and the second blood oxygen monitor are respectively connected to the control module of the blood purification device; Also includes replacement fluid lines and / or dialysate lines; One end of the replacement fluid pipeline is used to input the replacement fluid, and the other end is connected to the blood circuit; One end of the dialysate pipeline is used to input the replacement fluid, and the other end is connected to the dialysate inlet end of the blood filter of the blood purification device; The replacement fluid pipeline includes a front replacement fluid pipeline and / or a rear replacement fluid pipeline; One end of the front replacement fluid pipeline is used to input replacement fluid, and the other end is connected to the blood output pipeline. The front replacement fluid pipeline is provided with a front replacement pump; One end of the post-substitution fluid pipeline is used to input substitution fluid, and the other end is connected to the blood circuit input pipeline. The post-substitution fluid pipeline is provided with a post-substitution pump; The front displacement pump and the rear displacement pump are respectively control-connected to the control module.

2. The blood purification device with respiratory support function according to claim 1, characterized in that: It also includes a transcutaneous carbon dioxide monitor, and the carbon dioxide partial pressure signal output end of the transcutaneous carbon dioxide monitor is connected to the control module of the blood purification device.

3. The blood purification device with respiratory support function according to claim 1, characterized in that: The other end of the front replacement fluid pipeline is connected to the blood inlet end of the blood filter.

4. The blood purification device with respiratory support function according to claim 1 or 2, characterized in that: Also included is an alarm module connected to the control module.

5. The blood purification device with respiratory support function according to claim 1, characterized in that: The air inlet of the oxygenator is connected to the oxygen outlet of the oxygen supply device, and the oxygen supply device is communicatively connected to the control module.

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