Heating device for nucleic acid extractor

Abstract

The utility model relates to a heating device for a nucleic acid extractor. According to the heating device for the nucleic acid extraction instrument, the upper motor and the lower motor are used for controlling the main part, namely the clamping hand assembly, in the whole kit grabbing mechanical hand to move up and down, so that the clamped kit can move up and down. By controlling the clamping size of the clamping hand assembly, automatic clamping and loosening of the kit are completed, and automatic picking and placing are completed; and by controlling the rotating motor, the clamped kit is controlled to rotate at different angles in the horizontal direction, so that the multi-angle placement of the kit is achieved. Manual extraction is replaced by automatic work through overall design, and efficiency is improved; the cost can be effectively reduced, and the popularity rate of equipment is favorably realized; and through the autonomously designed automatic mechanical arm, the quality is improved, and the extraction accuracy is improved.

Description

Technical Field

[0001] The present application relates to the technical field of nucleic acid extraction instruments, and in particular to a heating device for nucleic acid extraction instruments. Background Art

[0002] The nucleic acid extractor is an instrument that uses matching nucleic acid extraction reagents to automatically complete the sample nucleic acid extraction work. It is widely used in various fields such as disease control centers, clinical disease diagnosis, blood transfusion safety, forensic identification, environmental microbiology testing, food safety testing, animal husbandry and molecular biology research.

[0003] The traditional methods of nucleic acid extraction and heating include the following three methods: manual extraction, large-scale automated nucleic acid extraction instrument extraction, and small-scale automated nucleic acid extraction instrument extraction, followed by moving to a heating and mixing device for heating and mixing. The three methods have the following defects:

[0004] (1) Foreign automatic robotic arms: high equipment cost and high operating cost;

[0005] (2) Domestic automatic robotic arms: less research and lower precision;

[0006] (3) Manual extraction: The workload is extremely large and the work is tedious. Summary of the invention

[0007] Based on this, it is necessary to provide a heating device for a nucleic acid extractor.

[0008] The present application is implemented through the following scheme. The present application provides a heating device for a nucleic acid extractor, comprising:

[0009] A reagent kit grabbing manipulator and a heating and mixing component, wherein the reagent kit grabbing manipulator is used to grab the reagent kit to the heating and mixing component;

[0010] The reagent kit grabbing manipulator comprises a vertically arranged bottom plate, and upper and lower motors, a lifting screw, a vertical guide rail, a connecting seat, a rotating motor, a coupling, a mechanical finger mounting seat, a mechanical finger and a gripping hand assembly installed on the bottom plate;

[0011] The lifting screw is vertically arranged and connected to the upper and lower motors, and a lifting nut is sleeved on the lifting screw;

[0012] The connecting seat is slidably connected to the vertical guide rail via a slider, and the lifting nut is fixedly connected to the connecting seat;

[0013] The rotating motor is installed on the connecting seat, the rotating shaft of the rotating motor extends downward, the robotic finger mounting seat is connected to the rotating shaft of the rotating motor through the coupling, the robotic finger is installed on the robotic finger mounting seat, and the clamping hand assembly is installed on the robotic finger; the robotic finger is used to control the opening and closing distance of the clamping hand assembly according to the size of the nucleic acid test kit to achieve clamping and placement of the nucleic acid test kit.

[0014] In one of the embodiments, the upper and lower motors are mounted on the base plate via upper and lower motor mounting seats;

[0015] The upper and lower motors are provided with a first positioning sensor, the connecting seat is provided with a first limiting piece, and the first positioning sensor is used to detect whether the first limiting piece rises to a specified position.

[0016] In one of the embodiments, a second positioning sensor is disposed on the mechanical finger mounting seat, and a second limiting plate is disposed on the coupling, and the second positioning sensor is used to detect whether the second limiting plate is rotated to a specified position.

[0017] In one of the embodiments, it further includes a rotating motor mounting seat, which is arranged below the connecting seat and fixedly connected to the connecting seat via a first connecting rod; the rotating motor is mounted on the rotating motor mounting seat.

[0018] In one embodiment, the mechanical finger mounting seat is arranged below the rotating motor mounting seat and is fixedly connected to the connecting seat via a second connecting rod;

[0019] The mechanical finger mounting seat includes a seat body, on which a connecting shaft, an upper rolling bearing and a lower rolling bearing are arranged; the connecting shaft sleeve is arranged in the upper rolling bearing and the lower rolling bearing, the upper end of the connecting shaft is connected to the coupling, and the lower end of the connecting shaft is connected to the mechanical finger.

[0020] In one embodiment, the reagent kit grabbing robot further includes an outer shell, an inner shell, an inner bottom plate and a lower bottom plate;

[0021] The inner bottom plate is fixed to the inner side of the bottom plate, the lower bottom plate is fixed below the bottom plate, the inner shell cover is arranged on the inner bottom plate, and together with the inner bottom plate and the lower bottom plate, encloses the rotating motor, the coupling, the mechanical finger mounting seat and the mechanical finger; the clamping hand assembly includes a driving part and a clamping part, and the clamping part passes through the lower bottom plate and is arranged downward;

[0022] The outer shell cover is arranged on the bottom plate.

[0023] In one embodiment, the heating and mixing assembly includes a mounting base, a vibration motor, an eccentric bearing, a vibration member and a heating base;

[0024] The vibration motor is mounted on the mounting base, and its rotating shaft is arranged vertically upward; the eccentric bearing is sleeved on the rotating shaft; the vibration member is sleeved on the eccentric bearing to generate vibration on a horizontal plane under the drive of the vibration member; the heating base is mounted above the vibration member and is fixedly connected to the vibration member.

[0025] In one of the embodiments, an eccentric flyweight is eccentrically sleeved on the eccentric bearing.

[0026] In one of the embodiments, counterweights are provided on both sides of the vibration member.

[0027] In one of the embodiments, a heat sink and a fan are further included, wherein the heat sink is arranged below the heating base, and the fan is arranged on the side of the heat sink.

[0028] The heating device for the nucleic acid extractor of this embodiment controls the up and down movement of the clamping hand assembly, the main component of the entire reagent kit grabbing manipulator, through the up and down motors to complete the up and down movement of the clamped reagent kit. By controlling the clamping size of the clamping hand assembly, the reagent kit is automatically clamped and released, and automatic picking and placement is completed; by controlling the rotating motor, the clamped reagent kit is rotated at different angles in the horizontal direction to achieve multi-angle placement of the reagent kit. Through the overall design, automation can replace manual extraction and improve efficiency; it can effectively reduce costs and help achieve the popularization rate of equipment; through the independently designed automatic mechanical arm, the quality is improved and the extraction accuracy is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is a schematic structural diagram of a heating device for a nucleic acid extractor in one embodiment of the present application;

[0030] Figure 2 This is a schematic structural diagram of a heating device for a nucleic acid extractor in one embodiment of the present application with the outer shell removed;

[0031] Figure 3 This is a schematic structural diagram of a heating device for a nucleic acid extractor in one embodiment of the present application without an outer shell and an inner shell;

[0032] Figure 4 for Figure 3 A schematic diagram of a local structure of a

[0033] Figure 5 for Figure 3 A schematic diagram of a local structure of a

[0034] Figure 6 This is a schematic diagram of the structure of a mechanical finger mounting base in an embodiment of the present application;

[0035] Figure 7 for Figure 6 sectional view of;

[0036] Figure 8 and Fig. 9 This is a schematic diagram of the structure of a heating and mixing component in one embodiment of the present application;

[0037] Fig.10 It is a cross-sectional view of a heating and mixing component in one embodiment of the present application.

[0038] Description of Figure Numbers:

[0039] 1000, heating device for nucleic acid extractor; 100, reagent kit grabbing manipulator; 101, bottom plate; 102, upper and lower motors; 103, lifting screw; 104, vertical guide rail; 105, connecting seat; 106, rotating motor; 107, coupling; 108, mechanical finger mounting seat; 1081, seat body; 1082, upper rolling bearing; 1083, lower rolling bearing; 1084, connecting shaft; 109, mechanical finger; 110, clamping hand assembly; 1101, driving part; 1102, clamping part; 111, lifting nut; 112, upper and lower motor mounting Mounting seat; 113, first positioning sensor; 114, first limiting plate; 115, second positioning sensor; 116, second limiting plate; 117, rotating motor mounting seat; 118, first connecting rod; 119, second connecting rod; 120, outer shell; 121, inner shell; 122, inner bottom plate; 123, lower bottom plate; 200, heating and mixing component; 201, mounting base; 202, vibration motor; 203, eccentric bearing; 204, vibration element; 205, heating base; 206, heat sink; 207, fan; 208, eccentric flyweight; 209, counterweight. DETAILED DESCRIPTION

[0040] In order to make the above-mentioned purposes, features and advantages of the present application more obvious and easy to understand, the specific implementation methods of the present application are described in detail below in conjunction with the accompanying drawings. In the following description, many specific details are set forth to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways different from those described herein, and those skilled in the art can make similar improvements without violating the connotation of the present application, so the present application is not limited by the specific embodiments disclosed below.

[0041] In the description of the present application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing the present application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present application.

[0042] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, a feature defined as "first" or "second" may explicitly or implicitly include at least one of the features. In the description of this application, if the term "plurality" appears, the meaning of "plurality" is at least two, such as two, three, etc., unless otherwise clearly and specifically defined.

[0043] In this application, unless otherwise clearly specified and limited, if the terms "installed", "connected", "connected", "fixed" and the like appear, these terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly defined. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0044] In the present application, unless otherwise clearly specified and limited, if there is a description that a first feature is "above" or "below" a second feature, etc., or similar descriptions appear, it may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Moreover, the first feature being "above", "above" and "above" the second feature may mean that the first feature is directly above or obliquely above the second feature, or simply means that the first feature is higher in level than the second feature. The first feature being "below", "below" and "below" the second feature may mean that the first feature is directly below or obliquely below the second feature, or simply means that the first feature is lower in level than the second feature.

[0045] See also Figures 1 to 3The embodiment of the present application provides a heating device for a nucleic acid extractor, including a reagent kit grabbing robot 100 and a heating and mixing component 200. The reagent kit grabbing robot 100 is used to grab the reagent kit to the heating and mixing component 200, and the heating and mixing component 200 is used to heat the reagent tube in the reagent kit.

[0046] The reagent kit grabbing manipulator 100 includes a vertically arranged bottom plate 101, and an upper and lower motor 102, a lifting screw 103, a vertical guide rail 104, a connecting seat 105, a rotating motor 106, a coupling 107, a mounting seat 108 for a mechanical finger 109, a mechanical finger 109, and a clamping hand assembly 110 installed on the bottom plate 101. Specifically, the lifting screw 103 is arranged vertically and connected to the motor shaft of the upper and lower motors 102, and a lifting nut 111 is sleeved on the lifting screw 103; the connecting seat 105 is slidably connected to the vertical guide rail 104 through a slider, and the lifting nut 111 is fixedly connected to the connecting seat 105; thus, the upper and lower motors 102 drive the lifting screw 103 to rotate, so that the lifting nut 111 rises or falls, and the connecting seat 105 moves up and down along the vertical guide rail 104 driven by the lifting nut 111.

[0047] The rotating motor 106 is installed on the connecting seat 105, and the rotating shaft of the rotating motor 106 extends downward. The mechanical finger mounting seat 108 is connected to the rotating shaft of the rotating motor 106 through the coupling 107. The mechanical finger 109 is installed on the mechanical finger mounting seat 108, and the clamping hand assembly 110 is installed on the mechanical finger 109.

[0048] In this embodiment, the rotary motor 106, the robotic finger 109 and the clamping hand assembly 110 are arranged from top to bottom, and the robotic finger 109 is used to control the opening and closing distance of the clamping hand assembly 110 according to the size of the nucleic acid reagent kit to achieve clamping and placement of the nucleic acid reagent kit.

[0049] Specifically, the reagent kit held in this embodiment is a 96-well plate, which can hold multiple reagent tubes in an array.

[0050] The heating device for the nucleic acid extractor of this embodiment controls the up and down movement of the clamping hand assembly, the main component of the entire reagent kit grabbing manipulator, through the up and down motors to complete the up and down movement of the clamped reagent kit. By controlling the clamping size of the clamping hand assembly, the reagent kit is automatically clamped and released, and automatic picking and placement is completed; by controlling the rotating motor, the clamped reagent kit is rotated at different angles in the horizontal direction to achieve multi-angle placement of the reagent kit. Through the overall design, automation can replace manual extraction and improve efficiency; it can effectively reduce costs and help achieve the popularization rate of equipment; through the independently designed automatic mechanical arm, the quality is improved and the extraction accuracy is improved.

[0051] like Figures 3 to 5 As shown, in one embodiment, the upper and lower motors 102 are installed on the base plate 101 through the upper and lower motor mounting seats 112; a first positioning sensor 113 is provided on the upper and lower motors 102, and a first limiting plate 114 is provided on the connecting seat 105. The first positioning sensor 113 is used to detect whether the first limiting plate 114 rises to the specified position.

[0052] A second positioning sensor 115 is disposed on the mounting base 108 of the robot finger 109 , and a second limiting piece 116 is disposed on the coupling 107 . The second positioning sensor 115 is used to detect whether the second limiting piece 116 rotates to a specified position.

[0053] Specifically, the first positioning sensor 113 includes a horizontally arranged transmitter and receiver. When the first limiting plate 114 rises to a set height driven by the rotating motor mounting seat 117, it is used to cut off the signal of the first positioning sensor 113, thereby realizing the detection and limitation of the height of the rotating motor mounting seat 117.

[0054] The principle of the second positioning sensor 115 is similar to that of the first positioning sensor 113, and it also includes a transmitter and a receiver arranged in the vertical direction. When the second limit plate 116 is driven by the coupling 107 and rotates to a set angle, it is used to cut off the signal of the second positioning sensor 115, thereby realizing the detection and limitation of the rotation angle of the coupling 107, and then realizing the detection and limitation of the rotation angle of the rotating motor 106.

[0055] like Figure 3 As shown, in one embodiment, the heating device 1000 for the nucleic acid extractor also includes a rotating motor mounting seat 117, which is arranged below the connecting seat 105 and fixedly connected to the connecting seat 105 through a first connecting rod 118; the rotating motor 106 is installed on the rotating motor mounting seat 117.

[0056] like Figure 3 , Figure 6 and Figure 7 As shown, the mechanical finger mounting seat 108 is arranged below the rotating motor mounting seat 117 and is fixedly connected to the connecting seat 105 via a second connecting rod 119;

[0057] The robot finger mounting seat 108 includes a seat body 1081, on which a connecting shaft 1084, an upper rolling bearing 1082 and a lower rolling bearing 1083 are provided; the connecting shaft 1084 is sleeved in the upper rolling bearing 1082 and the lower rolling bearing 1083, the upper end of the connecting shaft 1084 is connected to the coupling 107, and the lower end of the connecting shaft 1084 is connected to the robot finger 109.

[0058] In this embodiment, the coupling 107 and the connecting shaft are used to transmit the power of the rotating motor 106 to the robot finger 109 , and the upper rolling bearing 1082 and the lower rolling bearing 1083 are used to assist the rotation of the robot finger 109 .

[0059] like Figure 1-3 As shown, in one embodiment, the reagent kit grasping robot 100 also includes an outer shell 120, an inner shell 121, an inner bottom plate 122 and a lower bottom plate 123; the inner bottom plate 122 is fixed to the inner side of the bottom plate 101, the lower bottom plate 123 is fixed below the bottom plate 101, the inner shell 121 is covered on the inner bottom plate 122, and together with the inner bottom plate 122 and the lower bottom plate 123, encloses the rotating motor 106, the coupling 107, the robot finger 109 mounting seat 108 and the robot finger 109; the clamping hand assembly 110 includes a driving part 1101 and a clamping part 1102, and the clamping part 1102 is arranged downward through the lower bottom plate 123; the outer shell 120 is covered on the bottom plate 101.

[0060] In one embodiment, if Figures 8 to 10 As shown, the heating and mixing component 200 includes a mounting base 201, a vibration motor 202, an eccentric bearing 203, a vibrating member 204 and a heating base 205; the vibration motor 202 is mounted on the mounting base 201, and its rotating shaft is vertically arranged upward; the eccentric bearing 203 is sleeved on the rotating shaft of the vibration motor 202; the vibrating member 204 is sleeved on the eccentric bearing 203 to generate vibration in a horizontal plane under the drive of the eccentric bearing 203; the heating base 205 is mounted above the vibrating member 204 and fixedly connected to the vibrating member 204, so that the heating base 205 can also generate vibration in a horizontal plane to mix the reagents in the reagent kit on the heating base 205.

[0061] like Figures 8 to 10 As shown, in one embodiment, an eccentric flyweight 208 is eccentrically sleeved on the eccentric bearing 203 . The eccentric flyweight 208 generates eccentric swing under the drive of the eccentric bearing 203 , thereby driving the vibration member 204 to swing.

[0062] In one embodiment, weight blocks 209 are further disposed on both sides of the vibration member 204 to control the vibration amplitude of the vibration member 204 .

[0063] In one embodiment, if Figures 8 to 10 As shown, a heat sink 206 and a fan 207 are also included. The heat sink 206 is arranged below the heating base 205 , and the fan 207 is arranged on the side of the heat sink 206 .

[0064] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0065] The above-described embodiments only express several implementation methods of the present application, and the descriptions thereof are relatively specific and detailed, but they cannot be construed as limiting the scope of the patent application. It should be pointed out that, for a person of ordinary skill in the art, several variations and improvements can be made without departing from the concept of the present application, and these all belong to the protection scope of the present application. Therefore, the protection scope of the patent application shall be subject to the attached claims.

Claims

1. A heating device for a nucleic acid extractor, characterized in that: include: A reagent kit grabbing manipulator and a heating and mixing component, wherein the reagent kit grabbing manipulator is used to grab the reagent kit to the heating and mixing component; The reagent kit grabbing manipulator comprises a vertically arranged bottom plate, and upper and lower motors, a lifting screw, a vertical guide rail, a connecting seat, a rotating motor, a coupling, a mechanical finger mounting seat, a mechanical finger and a gripping hand assembly installed on the bottom plate; The lifting screw is vertically arranged and connected to the upper and lower motors, and a lifting nut is sleeved on the lifting screw; The connecting seat is slidably connected to the vertical guide rail via a slider, and the lifting nut is fixedly connected to the connecting seat; The rotating motor is installed on the connecting seat, the rotating shaft of the rotating motor extends downward, the robotic finger mounting seat is connected to the rotating shaft of the rotating motor through the coupling, the robotic finger is installed on the robotic finger mounting seat, and the clamping hand assembly is installed on the robotic finger; the robotic finger is used to control the opening and closing distance of the clamping hand assembly according to the size of the nucleic acid test kit to achieve clamping and placement of the nucleic acid test kit.

2. A heating device for a nucleic acid extractor according to claim 1, characterized in that: The upper and lower motors are mounted on the bottom plate via upper and lower motor mounting seats; The upper and lower motors are provided with a first positioning sensor, the connecting seat is provided with a first limiting piece, and the first positioning sensor is used to detect whether the first limiting piece rises to a specified position.

3. A heating device for a nucleic acid extractor according to claim 2, characterized in that: A second positioning sensor is arranged on the mechanical finger mounting seat, and a second limiting plate is arranged on the coupling. The second positioning sensor is used to detect whether the second limiting plate is rotated to a specified position.

4. A heating device for a nucleic acid extractor according to claim 1, characterized in that: It also includes a rotating motor mounting seat, which is arranged below the connecting seat and fixedly connected to the connecting seat via a first connecting rod; the rotating motor is mounted on the rotating motor mounting seat.

5. A heating device for a nucleic acid extractor according to claim 4, characterized in that: The mechanical finger mounting seat is arranged below the rotating motor mounting seat and is fixedly connected to the connecting seat via a second connecting rod; The mechanical finger mounting seat includes a seat body, on which a connecting shaft, an upper rolling bearing and a lower rolling bearing are arranged; the connecting shaft sleeve is arranged in the upper rolling bearing and the lower rolling bearing, the upper end of the connecting shaft is connected to the coupling, and the lower end of the connecting shaft is connected to the mechanical finger.

6. A heating device for a nucleic acid extractor according to claim 1, characterized in that: The reagent kit grabbing manipulator also includes an outer shell, an inner shell, an inner bottom plate and a lower bottom plate; The inner bottom plate is fixed to the inner side of the bottom plate, the lower bottom plate is fixed below the bottom plate, the inner shell cover is arranged on the inner bottom plate, and together with the inner bottom plate and the lower bottom plate, encloses the rotating motor, the coupling, the mechanical finger mounting seat and the mechanical finger; the clamping hand assembly includes a driving part and a clamping part, and the clamping part passes through the lower bottom plate and is arranged downward; The outer shell cover is arranged on the bottom plate.

7. A heating device for a nucleic acid extractor according to claim 1, characterized in that: The heating and mixing assembly comprises a mounting base, a vibration motor, an eccentric bearing, a vibration member and a heating base; The vibration motor is mounted on the mounting base, and its rotating shaft is arranged vertically upward; the eccentric bearing is sleeved on the rotating shaft; the vibration member is sleeved on the eccentric bearing to generate vibration on a horizontal plane under the drive of the vibration member; the heating base is mounted above the vibration member and is fixedly connected to the vibration member.

8. A heating device for a nucleic acid extractor according to claim 7, characterized in that: An eccentric flying weight is eccentrically sleeved on the eccentric bearing.

9. A heating device for a nucleic acid extractor according to claim 8, characterized in that: Counterweight blocks are also arranged on both sides of the vibration member.

10. A heating device for a nucleic acid extractor according to claim 7, characterized in that: It also includes a heat sink and a fan. The heat sink is arranged below the heating base, and the fan is arranged on the side of the heat sink.

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