Chromosome dispersion instrument

By combining humidification and dehumidification components in the chromosome disperser, using constant temperature water circulation unit and semiconductor refrigeration sheet, the problem of inaccurate temperature and humidity control in the prior art is solved, a stable and easy-to-maintain chromosome dispersion environment is achieved, and chromosomes is improved Consistency of preparation and stability of equipment.

CN222232153UActive Publication Date: 2024-12-24SHANGHAI LECHEN BIOLOGICAL SCI & TECH
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Patent Information

Application Number
CN202420579975.3
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-03-25
Publication Date
2024-12-24
Estimated Expiration
2034-03-25

AI Technical Summary

Technical Problem

The existing chromosome preparation system has inaccuracy and poor stability in temperature and humidity control, resulting in inconsistent chromosome dispersion, complex maintenance and low accuracy.

Method used

The combination of humidification components and dehumidification components is adopted to improve the control accuracy of humidity and temperature through constant temperature water circulation unit and semiconductor refrigeration sheet, avoid direct contact between the condenser and corrosive gas, and design an optimized structure for easy maintenance.

Benefits of technology

A stable temperature and humidity environment is achieved, the repetition and consistency of chromosome dispersion is improved, the operation difficulty is reduced, and the stability and maintenance convenience of the equipment are improved.

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Abstract

The utility model relates to the technical field of biological detection. A chromosome dispersion instrument comprises an operation box and an operation platform located in the operation box, and further comprises a humidification assembly and a dehumidification assembly. The humidifying assembly is mounted in the operation box; the dehumidification assembly comprises a constant-temperature water circulation unit located outside the operation box and further comprises an in-box dehumidification assembly located in the operation box, and the in-box dehumidification assembly comprises a water cooling head, a condensation channel, a condensate water collecting tank, a first circulation fan and a semiconductor chilling plate. A water outlet of the constant-temperature water circulation unit is connected with an inlet of the water cooling head, and an outlet of the water cooling head is connected with a water inlet of the constant-temperature water circulation unit; a semiconductor chilling plate is clamped between the water cooling head and the condensation channel, and the refrigeration face of the semiconductor chilling plate is tightly attached to the condensation channel. The condensation channel is obliquely arranged, the high position of the condensation channel is in butt joint with the first circulating fan, and the low position of the condensation channel is in butt joint with the condensate water collecting tank. Through the combination of the constant-temperature water circulation unit and the semiconductor chilling plate, the dehumidification efficiency is greatly improved, and the corrosion of acetic acid and methanol volatilized in the chromosome dispersion process to dehumidification parts is avoided.
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Description

Technical Field

[0001] The utility model relates to the technical field of biological detection, in particular to a chromosome dispersion instrument with internal temperature and humidity controlled. Background Art

[0002] According to classical cytogenetics, chromosomes prepared from cells can be analyzed under a microscope to diagnose possible defects. Chromosome preparation requires the harvested cells to be treated with hypotonicity, fixation, drying, aging, trypsin digestion, and staining. Only after these treatments can the chromosomes of the cells be analyzed under a microscope to determine whether there are chromosomal abnormalities. This classic method has been used since its inception.

[0003] In the past few decades, cytogenetics has achieved major breakthroughs in many aspects, such as cell synchronization culture technology, chromosome high resolution technology and in situ amniotic fluid cell chromosome analysis technology. Despite these major breakthroughs in cytogenetics, it is still a very difficult problem to achieve the best degree of chromosome dispersion and its high consistency and repeatability. It is difficult to ensure the consistency and repeatability of chromosome dispersion of each sample used for cytogenetic analysis.

[0004] According to the principle of chromosome dispersion dynamics, in the conventional chromosome preparation process, the temperature and humidity of the environment have a great impact on the quality of chromosome preparation. In order to solve the problem of environmental factors on chromosome dispersion, cytogenetics experts have adopted many methods, such as: passing the glass slide of the titrated cell suspension through the flame of an alcohol lamp or using a wet glass slide for drop placement; raising the height of the drop placement or using steam fumigation, etc. These methods are difficult to achieve accurate control of the conditions, so there is not only randomness in the operation process, but these methods are still not ideal in ensuring the consistency of chromosome dispersion and the optimal dispersion.

[0005] The existing constant temperature and humidity system for chromosome preparation mainly uses a compressor refrigeration unit to directly control the humidity and temperature of the air inside the machine. This type of system has the following main disadvantages: the condenser of the compressor refrigeration unit is located inside the box, and directly contacts the gas inside the disperser for cooling and dehumidification. The methanol and acetic acid gases generated during the chromosome preparation process corrode the copper tubes and heat sinks of the condenser. Long-term use of the capacity leads to leakage of the refrigerant, resulting in poor stability of the instrument; maintenance requires the dismantling of the entire structure, which is very complicated and difficult; the use of a compressor refrigeration unit alone for humidity control has low precision and slow response speed. Utility Model Content

[0006] In view of the problems existing in the prior art, the utility model provides a chromosome dispersion instrument, which has solved at least one of the above technical problems.

[0007] The technical solution of the utility model is: a chromosome dispersion instrument, comprising an operation box and an operation platform located in the operation box, characterized in that it also comprises a humidification component and a dehumidification component;

[0008] The humidifying component is installed in the operation box;

[0009] The dehumidification component includes a constant temperature water circulation unit located outside the operation box, and the dehumidification component also includes an in-box dehumidification component located inside the operation box, and the in-box dehumidification component includes a water cooling head, a condensation channel, a condensation water collection tank, a first circulation fan and a semiconductor refrigeration sheet;

[0010] The water outlet of the constant temperature water circulation unit is connected to the inlet of the water cooling head, and the outlet of the water cooling head is connected to the water inlet of the constant temperature water circulation unit;

[0011] The semiconductor refrigeration sheet is sandwiched between the water cooling head and the condensation channel, and the cooling surface of the semiconductor refrigeration sheet is in close contact with the condensation channel;

[0012] The condensation channel is arranged obliquely, the high position of the condensation channel is connected to the first circulation fan, and the low position of the condensation channel is connected to the condensation water collecting tank.

[0013] The utility model optimizes the structure of the chromosome dispersion instrument and combines the humidification component and the dehumidification component to facilitate the adjustment of the humidity of the inner cavity environment. By optimizing the structure of the dehumidification component and combining the constant temperature water circulation unit and the semiconductor refrigeration sheet, the dehumidification efficiency is greatly improved.

[0014] Further preferably, the humidification component includes a water tank, a water pump, a first heating element, a second fan, a first temperature sensor and a liquid level sensor;

[0015] The liquid level sensor is installed in the water tank;

[0016] The water pump is used to connect to the inner cavity of the water tank;

[0017] The water tank is provided with an air inlet and an air outlet, and the air inlet is equipped with the second fan;

[0018] The first heating element is installed at the bottom of the water tank, and the first temperature sensor for detecting the temperature of the liquid in the water tank is installed on the water tank.

[0019] The second fan blows air across the surface of the liquid in the water tank to humidify the air. The heating element and the temperature sensor are used to control the heating of the water in the water tank, and the water pump and the liquid level sensor are used to adjust the water level in the water tank. The water pump is used to realize the circulation of water, introduce water into the water tank or discharge water.

[0020] Further preferably, the operating platform comprises a table top, a second temperature sensor and a second heating element, the table top is located at the bottom of the operating box, and the second heating element and the second temperature sensor are located on the back of the table top.

[0021] Further preferably, the humidification component and the in-box dehumidification component are arranged side by side.

[0022] Further preferably, the operation box comprises an upper part, a middle part and a lower part arranged from top to bottom;

[0023] The upper part is provided with the humidifying component and the in-box dehumidifying component;

[0024] The operating platform is installed on the lower part.

[0025] Further preferably, the upper portion is divided into front and rear airflow channels arranged side by side by a partition, and both ends of the airflow channel are connected to the middle portion respectively;

[0026] The humidification component and the dehumidification component in the box are respectively installed in the air flow channels arranged side by side in the front and back.

[0027] Further preferably, a top cover is detachably connected to the top of the operation box, and the top cover serves as a top plate of the airflow channel.

[0028] It is convenient to repair the humidification component and the dehumidification component in the box by opening the top cover.

[0029] Further preferably, it also includes a control system, and the control system controls the connection between the humidification component and the dehumidification component.

[0030] Further preferably, a switch door is installed on the front side of the operation box, and an operation window is installed on the switch door.

[0031] Easy to operate through the operation window.

[0032] Further preferably, an operating glove is installed on the operating window.

[0033] Beneficial effects:

[0034] The utility model can provide stable temperature and humidity environment conditions, and the chromosome drop slice operation is performed inside the box, which reduces the technical requirements for operators, ensures the repeatability and consistency of chromosome dispersion, and ensures the quality of chromosome preparation.

[0035] The utility model optimizes the structure of the dehumidification component to ensure that corrosive gases such as methanol and acetic acid generated in the chromosome drop process have no direct contact with the condenser of the constant temperature water circulation unit, thereby ensuring the stability of the chromosome dispersion instrument and making operation and maintenance more convenient. BRIEF DESCRIPTION OF THE DRAWINGS

[0036] Figure 1 This is a structural schematic diagram of a specific embodiment 1 of the utility model;

[0037] Figure 2 This is a structural schematic diagram of a dehumidification component of a specific embodiment 1 of the utility model;

[0038] Figure 3 This is a structural schematic diagram of a humidification component of a specific embodiment 1 of the utility model;

[0039] Figure 4 This is a schematic diagram of a specific embodiment 1 of the present utility model.

[0040] In the figure: 1 is an operating platform, 2 is a dehumidification component, 3 is a humidification component, 4 is a control system, 5 is an operating box, 11 is a table, 12 is a second heating element, 21 is a constant temperature water circulation unit, 22 is a first circulation fan, 23 is a condensed water collection tank, 24 is a condensation channel, 25 is a semiconductor refrigeration plate, 26 is a water cooling head, 31 is a water pump, 32 is a first heating element, 33 is a first temperature sensor, 34 is a second fan, 35 is a liquid level sensor, 36 is a water tank, 51 is an operating window, and 52 is an upper part. DETAILED DESCRIPTION

[0041] See also Figures 1 to 4, Specific embodiment 1, a chromosome dispersion instrument, including an operation box 5 and an operation platform 1 located in the operation box 5, and also including a humidification component 3 and a dehumidification component 2; the humidification component 3 is installed in the operation box 5; the dehumidification component 2 includes a constant temperature water circulation unit 21 located outside the operation box 5, and the dehumidification component 2 also includes an in-box dehumidification component 2 located in the operation box 5, and the in-box dehumidification component 2 includes a water cooling head 26, a condensation channel 24, a condensation water collecting tank 23, a first circulation fan 22 and a semiconductor refrigeration sheet 25; the water outlet of the constant temperature water circulation unit 21 is connected to the inlet of the water cooling head 26, and the outlet of the water cooling head 26 is connected to the water inlet of the constant temperature water circulation unit 21; a semiconductor refrigeration sheet 25 is sandwiched between the water cooling head 26 and the condensation channel 24, and the cooling surface of the semiconductor refrigeration sheet 25 is close to the condensation channel 24; the condensation channel 24 is inclined, and the high position of the condensation channel 24 is connected to the first circulation fan 22, and the low position of the condensation channel 24 is connected to the condensation water collecting tank 23. The utility model optimizes the structure of the chromosome dispersion instrument, and facilitates the adjustment of the humidity of the inner cavity environment through the combination of the humidification component 3 and the dehumidification component 2. By optimizing the structure of the dehumidification component 2, and combining the constant temperature water circulation unit 21 and the semiconductor refrigeration sheet 25, the dehumidification efficiency is greatly improved. The first circulation fan 22 is connected to the inner cavity of the operating box. The heating surface of the semiconductor refrigeration sheet 25 is close to the water cooling head. Both ends of the condensation channel are open.

[0042] A base is installed at the bottom of the condensation channel, and a condensation water collecting tank is installed on one side of the base.

[0043] The water cooling head 26 is a rectangular parallelepiped structure. At least two semiconductor cooling sheets 25 arranged along the condensing channel 24 are sandwiched between the water cooling head 26 and the condensing channel 24. The water cooling head includes a front water cooling head and a rear water cooling head located at the front and rear sides of the condensing channel. The water outlet of the constant temperature water circulation unit is connected to the inlet of the front water cooling head, the outlet of the front water cooling head is connected to the inlet of the rear water cooling head, and the outlet of the rear water cooling head is connected to the water inlet of the constant temperature water circulation unit.

[0044] The inner wall of the condensation channel is fixed with a heat sink, which is arranged tilted, and the tilt direction of the heat sink is parallel to the tilt direction of the condensation channel.

[0045] The constant temperature water circulation unit 21 includes a cold water tank. The constant temperature water circulation unit 21 includes a compressor refrigeration unit, and the condenser of the compressor refrigeration unit is immersed in the cold water tank. The water inlet of the cold water tank is the water inlet of the constant temperature water circulation unit 21. The water outlet of the cold water tank is the water outlet of the constant temperature water circulation unit 21.

[0046] The humidification component 3 includes a water tank 36, a water pump 31, a first heating element 32, a second fan 34, a first temperature sensor 33 and a liquid level sensor 35; the liquid level sensor 35 is installed in the water tank 36; the water pump 31 is used to connect to the inner cavity of the water tank 36; the water tank 36 is provided with an air inlet and an air outlet, and the air inlet is provided with a second fan 34; the first heating element 32 is installed at the bottom of the water tank 36, and the water tank 36 is provided with a first temperature sensor 33 for detecting the temperature of the liquid in the water tank 36. It is convenient to blow air over the surface of the liquid in the water tank 36 through the second fan 34 to humidify the air. The heating element and the temperature sensor are used to heat and control the water in the water tank 36, and the water pump 31 and the liquid level sensor 35 are used to adjust the water level in the water tank 36.

[0047] The operating platform 1 comprises a table top 11 , a second temperature sensor and a second heating element 12 . The table top 11 is located at the bottom of the operating box 5 , and the second heating element 12 and the second temperature sensor are located at the back of the table top.

[0048] The humidifying component 3 and the in-box dehumidifying component 2 are arranged side by side.

[0049] The operation box 5 includes an upper part, a middle part and a lower part arranged from top to bottom; the upper part is equipped with a humidification component 3 and an in-box dehumidification component 2; the lower part is equipped with an operation platform 1. The upper part is divided into airflow channels arranged side by side in front and back by a partition, and the two ends of the airflow channel are connected to the middle part respectively; the humidification component 3 and the in-box dehumidification component 2 are respectively installed in the airflow channels arranged side by side in front and back. A display rack is installed in the middle part.

[0050] The top of the operation box 5 is detachably connected with a top cover, which serves as the top plate of the airflow channel, so as to facilitate maintenance of the humidification assembly 3 and the dehumidification assembly 2 in the box by opening the top cover.

[0051] It also includes a control system 4, which controls the connection between the humidification component 3 and the dehumidification component 2.

[0052] A switch door is installed on the front side of the operation box 5, and an operation window 51 is installed on the switch door. It is convenient to operate through the operation window 51. An operation glove is installed on the operation window 51.

[0053] The above are only preferred implementations of the present invention. It should be pointed out that ordinary technicians in this technical field can make several improvements and modifications without departing from the principles of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A chromosome dispersion instrument, comprising an operating box and an operating platform located in the operating box, characterized in that: It also includes a humidification component and a dehumidification component; The humidifying component is installed in the operation box; The dehumidification component includes a constant temperature water circulation unit located outside the operation box, and the dehumidification component also includes an in-box dehumidification component located inside the operation box, and the in-box dehumidification component includes a water cooling head, a condensation channel, a condensation water collection tank, a first circulation fan and a semiconductor refrigeration sheet; The water outlet of the constant temperature water circulation unit is connected to the inlet of the water cooling head, and the outlet of the water cooling head is connected to the water inlet of the constant temperature water circulation unit; The semiconductor refrigeration sheet is sandwiched between the water cooling head and the condensation channel, and the cooling surface of the semiconductor refrigeration sheet is in close contact with the condensation channel; The condensation channel is arranged obliquely, the high position of the condensation channel is connected to the first circulation fan, and the low position of the condensation channel is connected to the condensation water collecting tank.

2. A chromosome dispersion instrument according to claim 1, characterized in that: The humidification assembly includes a water tank, a water pump, a first heating element, a second fan, a first temperature sensor and a liquid level sensor; The liquid level sensor is installed in the water tank; The water pump is used to connect to the inner cavity of the water tank; The water tank is provided with an air inlet and an air outlet, and the air inlet is equipped with the second fan; The first heating element is installed at the bottom of the water tank, and the first temperature sensor is installed on the water tank.

3. A chromosome dispersion instrument according to claim 1, characterized in that: The operating platform comprises a table top, a second temperature sensor and a second heating element. The table top is located at the bottom of the operating box, and the second heating element and the second temperature sensor are located at the back of the table top.

4. A chromosome dispersion instrument according to claim 1, characterized in that: The humidifying component and the in-box dehumidifying component are arranged side by side.

5. A chromosome dispersion instrument according to claim 1, characterized in that: The operation box includes an upper part, a middle part and a lower part arranged from top to bottom; The upper part is provided with the humidifying component and the in-box dehumidifying component; The operating platform is installed on the lower part.

6. A chromosome dispersion instrument according to claim 5, characterized in that: The upper part is divided into front and rear airflow channels arranged side by side by a partition, and the two ends of the airflow channel are connected to the middle part respectively; The humidification component and the dehumidification component in the box are respectively installed in the air flow channels arranged side by side in the front and back.

7. A chromosome dispersion instrument according to claim 6, characterized in that: A top cover is detachably connected to the top of the operation box, and the top cover serves as the top plate of the airflow channel.

8. A chromosome dispersion instrument according to claim 1, characterized in that: It also includes a control system, which controls the connection between the humidification component and the dehumidification component.

9. A chromosome dispersion instrument according to claim 1, characterized in that: A switch door is installed on the front side of the operation box, and an operation window is installed on the switch door.

10. A chromosome dispersion instrument according to claim 9, characterized in that: An operating glove is installed on the operating window.