Nanometer antibody storage device

Abstract

The utility model discloses a nanometer antibody preservation device which comprises a preservation box, a box cover, a visible window, a data display screen, a temperature sensor and a humidity sensor, a lifting device is arranged, a limiting block is pulled to cancel the limiting effect of the limiting block on a fixing rod, a second spring releases elastic potential energy to push an adjusting plate to move upwards, and therefore the nanometer antibody is preserved. When the adjusting plate moves, the fixing rod is pushed to move, when the fixing rod moves, the box cover moves, the box cover rotates, when the box cover rotates, the pressing rod is driven to rotate, when the pressing rod rotates, pressure on the movable plate is canceled, the first spring releases elastic potential energy to push the movable plate to move upwards, and when the movable plate moves, the fixing base is driven to move. When the fixed seat moves, the container is driven to ascend, so that the container can be conveniently and quickly taken out of the storage box, meanwhile, the container can be effectively prevented from shaking, and the activity and the quality of the nano antibody are ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of nano antibodies, in particular to a nano antibody storage device. Background Art

[0002] Nanobodies are antibodies that naturally lack light chains and exist in the peripheral blood of alpacas. The antibodies only contain one heavy chain variable region (VHH) and two conventional CH2 and CH3 regions. However, they are not as easy to stick to each other or even aggregate into clumps as artificially modified single-chain antibody fragments (scFv). More importantly, the individually cloned and expressed VHH structure has the same structural stability and antigen-binding activity as the original heavy chain antibody, and is the smallest unit known to bind to the target antigen.

[0003] For example, the "A Nano Antibody Low-Temperature Anti-Infection Storage Device" with publication number CN218318154U includes an incubator, a placement frame is fixedly connected to the lower end of the incubator, and limit strips are fixedly connected to the four corners of the placement frame. A storage box is arranged inside the incubator, and the storage box is snapped into the placement frame. A placement cylinder is fixedly connected to the storage box. The spring and the clamp are arranged to put the collected sample test tube from the top of the placement cylinder. The clamp is squeezed by the test tube to make the spring contract back, so that the test tube moves downward until the lower part of the test tube is placed in the limit circle, and then the elasticity of the spring drives the clamp to clamp and fix the upper part of the test tube, effectively preventing the bumps generated during the transportation of the incubator from causing the test tube to collide with the inside of the incubator, thereby causing the test tube to be damaged and the sample cannot be tested.

[0004] Although the above-mentioned storage device has certain advantages for test tube protection, it still has certain disadvantages:

[0005] When the above-mentioned storage device is used to store the test tube container with the nano-antibody, when the test tube needs to be taken out, it is not very convenient to take the test tube, and the range that can be grasped is small. At the same time, using a lot of force to shake the test tube easily causes the nano-antibody inside to shake, which is easy to affect the activity of the nano-antibody and thus affect its quality. Utility Model Content

[0006] 1. Technical issues to be resolved

[0007] In view of the deficiencies of the prior art, the utility model provides a nano antibody storage device to solve the above-mentioned problems.

[0008] (II) Technical solution

[0009] To achieve the above purpose, the utility model is implemented through the following technical solutions: a nano antibody storage device, including a storage box, a box cover, a visual window, a data display screen, a temperature sensor, a humidity sensor and a lifting device, the box cover is arranged at the top of the storage box, and the rear end bottom of the box cover is rotatably connected with the storage box through a rotating shaft, the visual window is arranged at the front end of the storage box, the data display screen is provided with two groups, and is respectively arranged on the left side and the right side of the top of the box cover, the temperature sensor is installed on the left side of the bottom end of the box cover, the humidity sensor is arranged on the right side of the bottom end of the box cover, and the lifting device is arranged inside the storage box, The lifting device includes a fixed plate, a support rod, a movable plate, an adjustment mechanism, a fixed seat and a spring. The fixed plate is fixed to the inner left end and the inner right end of the preservation box. The support rod is provided with two groups and is fixed to the bottom end of the fixed plate. The support rod passes through the movable plate and is fixed to the inner bottom end of the preservation box. The movable plate is arranged inside the preservation box, and the left end and the right end of the movable plate are arranged inside the adjustment mechanism. The adjustment mechanism is provided with two groups and is respectively arranged at the left end and the right end of the inner wall of the preservation box. The fixed seat is fixed to the top end of the movable plate. The spring is provided at the inner bottom end of the preservation box and is elastically connected to the bottom end of the movable plate.

[0010] Preferably, the adjustment mechanism includes a movable groove, a pressure rod, an adjustment rod, a sliding groove and a fixing mechanism, the movable groove is opened at the left end of the inner wall of the preservation box, the pressure rod is fixed to the bottom end of the box cover and extends downward to the interior of the movable groove, the adjustment rod is fixed to the bottom left end of the pressure rod, and the left end of the adjustment rod is arranged in the interior of the sliding groove, the sliding groove is opened at the left end of the movable groove, and the fixing mechanism is arranged at the front end of the inner wall of the preservation box.

[0011] Preferably, the fixing mechanism includes a fixing slot, a fixing rod, an adjusting plate, a second spring, a slot, a limit block, a fixing block, a limit slot and a third spring, the fixing slot being arranged at the front end of the inner wall of the preservation box, the fixing rod being fixed to the bottom end of the box cover, and the bottom end of the fixing rod being arranged inside the fixing slot, the adjusting plate being arranged inside the fixing slot, the second spring being fixed to the inner bottom end of the fixing slot, and the top end of the second spring being elastically connected to the bottom end of the adjusting plate, the slot being arranged at the front end of the fixing rod, the limit block being arranged at the front end of the preservation box and extending backward to the inside of the slot, the fixing block being provided with two groups, and being respectively fixed to the top and bottom ends of the limit block, the fixing block being arranged inside the limit slot, the limit slot being arranged at the front end of the inner wall of the preservation box, the third spring being fixed to the inner front end of the limit slot and being elastically connected to the front end of the fixing block.

[0012] Preferably, a notch is provided at the top of the fixing plate, and a rubber protective sleeve is provided in the notch, and this arrangement can protect the placed container.

[0013] Preferably, the bottom end of the pressure rod is arranged in a semicircular shape, through which the movable plate can be better adjusted.

[0014] Preferably, the sliding groove is arranged in an arc shape, thereby limiting the moving track of the pressure rod.

[0015] Preferably, the rear end surface of the limit block is inclined and tilted upward from back to front, and the fixing rod can be quickly fixed through this arrangement.

[0016] (III) Beneficial effects

[0017] The utility model provides a nano antibody storage device. It has the following beneficial effects: by setting a lifting device, by pulling the limit block, the limit block cancels the limiting effect on the fixed rod, the second spring releases elastic potential energy to push the adjustment plate to move upward, the adjustment plate pushes the fixed rod to move when it moves, the fixed rod moves when the box cover moves, so that the box cover rotates, the box cover drives the pressure rod to rotate when the box cover rotates, and the pressure on the movable plate is canceled when the pressure rod rotates, the first spring releases elastic potential energy to push the movable plate to move upward, the movable plate drives the fixed seat to move when it moves, and the fixed seat drives the container to rise when it moves. Through this setting, the container can be automatically ejected from the storage box for a distance quickly and conveniently, so as to achieve the effect of easy picking, which is convenient for the staff to pick up, and at the same time, it can effectively prevent the container from shaking, thereby ensuring the activity and quality of the nano antibody. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 It is a schematic diagram of the structure of the utility model;

[0019] Figure 2 This is a front view of the lifting device structure in the utility model;

[0020] Figure 3 This is a front view of the adjustment mechanism structure in the utility model;

[0021] Figure 4 It is a side view of the adjustment mechanism structure in the utility model;

[0022] Figure 5 It is a side view of the fixing mechanism structure in the utility model.

[0023] In the figure: preservation box-1, box cover-2, visual window-3, data display screen-4, temperature sensor-5, humidity sensor-6, lifting device-7, fixed plate-71, support rod-72, movable plate-73, adjustment mechanism-74, fixed seat-75, spring one-76, movable groove-741, pressure rod-742, adjustment rod-743, sliding groove-744, fixing mechanism-745, fixed groove-7451, fixed rod-7452, adjustment plate-7453, spring two-7454, slot-7455, limit block-7456, fixed block-7457, limit slot-7458, spring three-7459. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0025] See also Figure 1 and Figure 2 The utility model provides a technical solution for a nano antibody storage device: a nano antibody storage device, comprising a storage box 1, a box cover 2, a visual window 3, a data display screen 4, a temperature sensor 5, a humidity sensor 6 and a lifting device 7, the box cover 2 is arranged at the top of the storage box 1, and the rear end bottom of the box cover 2 is rotatably connected with the storage box 1 through a rotating shaft, the visual window 3 is arranged at the front end of the storage box 1, the data display screen 4 is provided with two groups, and is respectively arranged on the left side and the right side of the top of the box cover 2, the temperature sensor 5 is installed on the left side of the bottom end of the box cover 2, the humidity sensor 6 is arranged on the right side of the bottom end of the box cover 2, the lifting device 7 is arranged inside the storage box 1, and the lifting device 7 includes a fixed plate 71, a support rod 72, a movable plate 73, an adjustment mechanism 74, a fixed plate 75, a support rod 76, a movable plate 77, a fixed plate 78, a support rod 79, a movable plate 79, a fixed plate 71, a support rod 71, a movable plate 72, a movable plate 73, a regulating mechanism 74, a fixed plate 76, a movable plate 78, a movable plate 79 ... The fixed seat 75 and the spring 76, the fixed plate 71 is fixed to the inner left end and the inner right end of the preservation box 1, the support rod 72 is provided with two groups and is fixed to the bottom end of the fixed plate 71, the support rod 72 passes through the movable plate 73 and is fixed to the inner bottom end of the preservation box 1, the movable plate 73 is arranged inside the preservation box 1, and the left end and the right end of the movable plate 73 are arranged inside the adjustment mechanism 74, the adjustment mechanism 74 is provided with two groups and is respectively arranged at the left end and the right end of the inner wall of the preservation box 1, the fixed seat 75 is fixed to the top of the movable plate 73, the spring 76 is arranged at the inner bottom end of the preservation box 1, and is elastically connected to the bottom end of the movable plate 73, the top of the fixed plate 71 is provided with a notch, and a rubber protective sleeve is provided in the notch, through which the container placed in can be protected.

[0026] See also Figure 3-5The utility model provides a technical solution of a nano antibody storage device: a nano antibody storage device, comprising an adjustment mechanism 74 including a movable groove 741, a pressure rod 742, an adjustment rod 743, a sliding groove 744 and a fixing mechanism 745, wherein the movable groove 741 is opened at the left end of the inner wall of the storage box 1, the pressure rod 742 is fixed to the bottom end of the box cover 2 and extends downward to the inside of the movable groove 741, the adjustment rod 743 is fixed to the bottom of the left end of the pressure rod 742, and the left end of the adjustment rod 743 is arranged inside the sliding groove 744, and the sliding groove 74 4 is opened at the left end of the movable groove 741, the fixing mechanism 745 is arranged at the front end of the inner wall of the preservation box 1, and the fixing mechanism 745 includes a fixing groove 7451, a fixing rod 7452, an adjusting plate 7453, a second spring 7454, a clamping groove 7455, a limiting block 7456, a fixing block 7457, a limiting groove 7458 and a third spring 7459. The fixing groove 7451 is opened at the front end of the inner wall of the preservation box 1, the fixing rod 7452 is fixed to the bottom end of the box cover 2, and the bottom end of the fixing rod 7452 is arranged inside the fixing groove 7451, and the adjusting plate 7453 is provided with a fixing groove 7451, and the fixing rod 7452 is fixed to the bottom end of the box cover 2, and the bottom end of the fixing rod 7452 is arranged inside the fixing groove 7451. The section plate 7453 is arranged inside the fixing groove 7451, the second spring 7454 is fixed to the inner bottom end of the fixing groove 7451, and the top end of the second spring 7454 is elastically connected to the bottom end of the adjustment plate 7453, the slot 7455 is opened at the front end of the fixing rod 7452, the limit block 7456 is arranged at the front end of the preservation box 1, and extends backward to the inside of the slot 7455, the fixing block 7457 is provided with two groups, and is respectively fixed to the top and bottom ends of the limit block 7456, and the fixing block 7457 is arranged inside the limit groove 7458, The limiting groove 7458 is arranged at the front end of the inner wall of the preservation box 1, and the spring three 7459 is fixed to the inner front end of the limiting groove 7458 and is elastically connected to the front end of the fixing block 7457. The bottom end of the pressure rod 742 is arranged in a semicircular shape, and the movable plate 73 can be better adjusted through this arrangement. The sliding groove 744 is arranged in an arc shape, and the movable trajectory of the pressure rod 742 is limited through this arrangement. The rear end face of the limiting block 7456 is inclined and inclined upward from back to front, and the fixing rod 7452 can be quickly fixed through this arrangement.

[0027] Here’s how it works:

[0028] First, when in use, the container with the nanoantibody is placed on the fixing seat 75 along the notch of the fixing plate 71, and then the box cover 2 is closed for sealed storage. Later, it can be tested through the visual window 3, and the temperature and humidity in the storage box 1 can be observed through the data display screen 4;

[0029] Second, when it is necessary to take out the container of the nano antibody, pull the limit block 7456. When the limit block 7456 moves, it drives the fixed block 7457 to move. When the fixed block 7457 moves, it squeezes the spring three 7459. When the limit block 7456 moves, the restriction effect on the fixed rod 7452 is cancelled. After the spring two 7454 loses its force, it releases its elastic potential energy to push the adjustment plate 7453 to move. When the adjustment plate 7453 moves, it pushes the fixed rod 7452 to move, so that the fixed rod 7452 moves out of the fixed groove 7451. Then, the limit block 7456 is released. After the spring three 7459 loses its force, it releases its elastic potential energy to push the limit block 7456 back to its original position.

[0030] When the box cover 2 rotates, it drives the pressure rod 742 to move. When the pressure rod 742 moves, it drives the adjusting rod 743 to move, so that the adjusting rod 743 moves along the sliding groove 744. When the pressure rod 742 moves, the squeezing effect on the movable plate 73 is cancelled. After the spring 1 76 loses its force, it releases its elastic potential energy to push the movable plate 73 to move upward. When the movable plate 73 moves, it drives the fixed seat 72 to move. When the fixed seat 72 moves, it drives the container to move, so that the container is moved out of the fixed plate 71, so as to achieve the effect of facilitating the taking of the instrument.

[0031] The control method of the present invention is to control by manually starting and closing the switch. The wiring diagram of the power element and the provision of power supply are common knowledge in the field, and the present invention is mainly used to protect mechanical devices, so the present invention will not explain the control method and wiring arrangement in detail.

[0032] The control method of the present invention is automatic control through a controller. The control circuit of the controller can be realized by simple programming by technicians in this field. The provision of power is also common knowledge in this field. The present invention is mainly used to protect mechanical devices, so the present invention will no longer explain the control method and circuit connection in detail.

[0033] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A nano antibody storage device, comprising a storage box (1), a box cover (2), a visual window (3), a data display screen (4), a temperature sensor (5) and a humidity sensor (6), wherein the box cover (2) is arranged at the top of the storage box (1), and the bottom of the rear end of the box cover (2) is rotatably connected to the storage box (1) through a rotating shaft, the visual window (3) is arranged at the front end of the storage box (1), the data display screen (4) is provided with two groups, and is respectively arranged at the left side and the right side of the top end of the box cover (2), the temperature sensor (5) is installed at the left side of the bottom end of the box cover (2), and the humidity sensor (6) is arranged at the right side of the bottom end of the box cover (2); Features: The invention also comprises a lifting device (7), the lifting device (7) being arranged inside the storage box (1), the lifting device (7) comprising a fixed plate (71), a support rod (72), a movable plate (73), an adjustment mechanism (74), a fixed seat (75) and a spring (76), the fixed plate (71) being fixed to the left end and the right end of the interior of the storage box (1), the support rod (72) being provided with two groups and being fixed to the bottom end of the fixed plate (71), the support rod (72) penetrating the movable plate (73) The movable plate (73) is fixed to the inner bottom end of the preservation box (1), and the left end and the right end of the movable plate (73) are arranged inside the preservation box (1), and the left end and the right end of the movable plate (73) are arranged inside the adjustment mechanism (74). The adjustment mechanism (74) is provided with two groups, and is respectively arranged at the left end and the right end of the inner wall of the preservation box (1). The fixing seat (75) is fixed to the top end of the movable plate (73), and the spring (76) is arranged at the inner bottom end of the preservation box (1) and is elastically connected to the bottom end of the movable plate (73).

2. A nanoantibody storage device according to claim 1, characterized in that: The adjusting mechanism (74) comprises a movable groove (741), a pressure rod (742), an adjusting rod (743), a sliding groove (744) and a fixing mechanism (745); the movable groove (741) is opened at the left end of the inner wall of the preservation box (1); the pressure rod (742) is fixed to the bottom end of the box cover (2) and extends downward to the inside of the movable groove (741); the adjusting rod (743) is fixed to the bottom of the left end of the pressure rod (742), and the left end of the adjusting rod (743) is arranged inside the sliding groove (744); the sliding groove (744) is opened at the left end of the movable groove (741); and the fixing mechanism (745) is arranged at the front end of the inner wall of the preservation box (1).

3. A nanobody storage device according to claim 2, characterized in that: The fixing mechanism (745) comprises a fixing groove (7451), a fixing rod (7452), an adjusting plate (7453), a second spring (7454), a slot (7455), a limiting block (7456), a fixing block (7457), a limiting groove (7458) and a third spring (7459). The fixing groove (7451) is opened at the front end of the inner wall of the preservation box (1). The fixing rod (7452) is fixed to the bottom end of the box cover (2), and the bottom end of the fixing rod (7452) is arranged inside the fixing groove (7451). The adjusting plate (7453) is arranged inside the fixing groove (7451). The second spring (7454) is fixed to the bottom end of the inner wall of the fixing groove (7451). The top end of the second spring (7454) is elastically connected to the bottom end of the adjustment plate (7453); the slot (7455) is opened at the front end of the fixing rod (7452); the limit block (7456) is arranged at the front end of the storage box (1) and extends backward to the inside of the slot (7455); the fixing block (7457) is provided with two groups and is respectively fixed to the top and bottom ends of the limit block (7456); the fixing block (7457) is arranged inside the limit slot (7458); the limit slot (7458) is arranged at the front end of the inner wall of the storage box (1); the third spring (7459) is fixed to the front end of the inner part of the limit slot (7458) and is elastically connected to the front end of the fixing block (7457).

4. A nanoantibody storage device according to claim 1, characterized in that: The top of the fixing plate (71) is provided with a notch, and a rubber protective sleeve is provided in the notch.

5. A nanobody storage device according to claim 2, characterized in that: The bottom end of the pressure rod (742) is arranged in a semicircular shape.

6. A nanobody storage device according to claim 2, characterized in that: The sliding groove (744) is arranged in an arc shape.

7. A nanobody storage device according to claim 3, characterized in that: The rear end surface of the limit block (7456) is inclined and tilts upward from back to front.

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