Heating device for chemiluminescence immunity analyzer

Abstract

The utility model provides a heating device for a chemiluminescence immunity analyzer. The heating device comprises a kit, a bearing jig and a heating block, a plurality of placing grooves are formed in the top of the bearing jig; the heating block comprises a heating sheet and a heating groove for accommodating the kit; a groove is formed in the bottom of the heating groove, the top of the heating piece is connected with the groove in an attached mode, and the bottom of the heating piece is connected with the containing groove in an attached mode. One side of the heating sheet is provided with a conductive wire used for being externally connected with a power supply; the bottom of the kit is attached to and connected with the heating groove; a temperature sensor is arranged between the placing groove and the heating sheet, and one end of the temperature sensor is connected with the bottom of the heating sheet; the placing groove is provided with a first opening, and the temperature sensor is embedded in the first opening; the heating speed is accelerated, so that the temperature fluctuation range is small, and the accuracy and the stability of a detection result are improved.

Description

Technical Field

[0001] The present application relates to the field of in vitro diagnostic (IVD) detectors, and in particular to a heating device for a chemiluminescent immunoassay analyzer. Background Art

[0002] In the field of medical diagnosis, chemiluminescent immunoassay analyzers have always been a key tool for in vitro diagnosis due to their highly sensitive and highly specific characteristics. The basic principle is to use the luminescent signal generated by chemical reactions to detect the presence of target molecules, thereby achieving quantitative analysis of specific components in biological samples. This instrument is widely used in clinical medicine, biological research, and drug development.

[0003] Although the development of traditional chemiluminescence analyzers has achieved remarkable results, it still faces a series of difficulties and shortcomings during the research and development process.

[0004] First, it is susceptible to contamination, which will directly affect the accuracy of the test results. Secondly, traditional chemiluminescence analyzers have certain limitations in sensitivity and accuracy, which is not superior enough in some high-demand detection scenarios. In addition, the loss of nanomagnetic beads during the cleaning process is also a difficult problem that needs to be solved urgently. Too little cleaning will cause the background signal to be too high and the contamination to be serious, while too much cleaning will cause serious loss of nanomagnetic beads, affecting the sensitivity and accuracy of the instrument; there are also problems with slow heating speed and large fluctuation range of heating temperature during the detection process. Utility Model Content

[0005] In view of the above problems, the present application is proposed to provide a heating device for a chemiluminescent immunoassay analyzer that overcomes the above problems or at least partially solves the above problems, comprising:

[0006] A heating device for a chemiluminescent immunoassay analyzer, comprising a reagent kit, a carrying fixture and a heating block;

[0007] The top of the carrying fixture is provided with a plurality of placement slots;

[0008] The heating block comprises a heating plate and a heating slot for accommodating the reagent kit; a groove is provided at the bottom of the heating slot, the top of the heating plate is fitted and connected to the groove, and the bottom of the heating plate is fitted and connected to the placement slot; a conductive wire for an external power supply is provided on one side of the heating plate;

[0009] The bottom of the reagent box is closely connected to the heating tank;

[0010] A temperature sensor is provided between the placement groove and the heating plate, and one end of the temperature sensor is connected to the bottom of the heating plate; the placement groove is provided with a first opening, and the temperature sensor is embedded in the first opening.

[0011] Furthermore, the reagent kit is composed of a plurality of reagent tubes connected to each other.

[0012] Furthermore, the reagent tube includes a through-rectangular parallelepiped and a test tube; the through-rectangular parallelepiped is arranged at the second opening of the test tube; and a plurality of the reagent tubes are connected through the side walls of the through-rectangular parallelepiped to form the reagent kit.

[0013] Furthermore, the supporting fixture is disc-shaped.

[0014] Furthermore, it also includes a power supply, which is electrically connected to the temperature sensor and the conductive wire respectively.

[0015] Furthermore, it also includes a power interface, which is electrically connected to the power supply, the temperature sensor and the conductive wire.

[0016] Furthermore, the reagent kit is arc-shaped.

[0017] Furthermore, it also includes a base, the top of which is connected to the bottom of the supporting fixture.

[0018] Furthermore, it also includes an upper shell, the bottom of which is connected to the side wall of the base.

[0019] Furthermore, it also includes a sliding door, which is arranged on the top of the upper shell.

[0020] This application has the following advantages:

[0021] In the embodiments of the present application, compared with the prior art that "is easily contaminated, and the contamination will directly affect the accuracy of the test results. Traditional chemiluminescence analyzers have certain limitations in sensitivity and accuracy, which are not superior enough in some high-demand detection scenarios. The problem of loss of nanomagnetic beads during the cleaning process is also a difficult problem that needs to be solved urgently. Too little cleaning will lead to excessive background signal and serious contamination, while too much cleaning will cause serious loss of nanomagnetic beads, affecting the sensitivity and accuracy of the instrument; and there are also problems of slow heating speed and large fluctuation range of heating temperature during the detection process", the present application provides a solution of "a heating device for a chemiluminescence immunoassay analyzer", specifically: "a method for The heating device of the chemiluminescent immunoassay analyzer comprises a reagent box, a carrying fixture and a heating block; the top of the carrying fixture is provided with a plurality of placement slots; the heating block comprises a heating plate and a heating slot for accommodating the reagent box; the bottom of the heating slot is provided with a groove, the top of the heating plate is fitted and connected to the groove, and the bottom of the heating plate is fitted and connected to the placement slot; a conductive wire for an external power supply is provided on one side of the heating plate; the bottom of the reagent box is fitted and connected to the heating slot; a temperature sensor is provided between the placement slot and the heating plate, one end of the temperature sensor is connected to the bottom of the heating plate; the placement slot is provided with a first opening, and the temperature sensor is embedded in the first opening. The "reagent box, the carrying fixture and the heating block" solve the problems of "the traditional chemiluminescent instrument has a complex design, the cleaning pipeline has a cumbersome procedure, the manufacturing and operation and maintenance costs are high, the heating efficiency is slow and the fluctuation range is large", and the effect of "fast heating speed, small temperature fluctuation range, and ensuring the accuracy and stability of the test results" is achieved. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] In order to more clearly illustrate the technical solution of the present application, the drawings required for use in the description of the present application will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0023] Figure 1 It is a structural schematic diagram of a heating device for a chemiluminescent immunoassay analyzer provided in one embodiment of the present application;

[0024] Figure 2 It is a detailed exploded diagram of a heating device for a chemiluminescent immunoassay analyzer provided in one embodiment of the present application;

[0025] Figure 3 It is a detailed exploded diagram of a heating device for a chemiluminescent immunoassay analyzer provided in one embodiment of the present application.

[0026] In the accompanying drawings: 1. reagent box; 2. carrying fixture; 3. placement slot; 4. heating plate; 5. heating slot; 6. groove; 7. conductive wire; 8. temperature sensor; 9. first opening. DETAILED DESCRIPTION

[0027] In order to make the objects, features and advantages of the present application more obvious and understandable, the present application is further described in detail below in conjunction with the accompanying drawings and specific implementation methods. Obviously, the described embodiments are part of the embodiments of the present application, rather than all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in the field without creative work are within the scope of protection of the present application.

[0028] The inventors have found through analysis of existing technologies that in the field of medical diagnosis, chemiluminescent immunoassay analyzers have always been a key tool for in vitro diagnosis due to their highly sensitive and highly specific characteristics. The basic principle is to use the luminescent signal generated by a chemical reaction to detect the presence of target molecules, thereby achieving quantitative analysis of specific components in biological samples. This instrument is widely used in clinical medicine, biological research, and drug development.

[0029] Although the development of traditional chemiluminescence analyzers has achieved remarkable results, it still faces a series of difficulties and shortcomings during the research and development process. First, it is susceptible to contamination, which will directly affect the accuracy of the test results. Secondly, traditional chemiluminescence analyzers have certain limitations in sensitivity and accuracy, which is not superior enough in some high-demand detection scenarios. In addition, the loss of nanomagnetic beads during the cleaning process is also a difficult problem that needs to be solved urgently. Too little cleaning will result in excessive background signals and serious contamination, while too much cleaning will cause serious loss of nanomagnetic beads, affecting the sensitivity and accuracy of the instrument.

[0030] Reference Figure 1-3 , showing a structural schematic diagram and detailed exploded diagram of a heating device based on the reagent kit 1 provided in one embodiment of the present application;

[0031] A heating device based on a reagent kit 1, comprising the reagent kit 1, a carrying fixture 2 and a heating block;

[0032] The top of the carrying fixture 2 is provided with a plurality of placement slots 3;

[0033] The heating block includes a heating sheet 4 and a heating slot 5 for accommodating the reagent kit 1; a groove 6 is provided at the bottom of the heating slot 5, the top of the heating sheet 4 is fitted and connected to the groove 6, and the bottom of the heating sheet 4 is fitted and connected to the placement slot 3; a conductive wire 7 for an external power supply is provided on one side of the heating sheet 4;

[0034] The bottom of the reagent box 1 is closely connected to the heating tank 5;

[0035] A temperature sensor 8 is provided between the placement groove 3 and the heating plate 4 , and one end of the temperature sensor 8 is connected to the bottom of the heating plate 4 ; the placement groove 3 is provided with a first opening 9 , and the temperature sensor 8 is embedded in the first opening 9 .

[0036] In the embodiments of the present application, compared with the prior art that "is easily contaminated, and the contamination will directly affect the accuracy of the test results. Traditional chemiluminescence instruments have certain limitations in sensitivity and accuracy, which are not superior in some high-demand detection scenarios. The problem of loss of nanomagnetic beads during the cleaning process is also a difficult problem that needs to be solved urgently. Too little cleaning will lead to excessive background signal and serious contamination, while too much cleaning will cause serious loss of nanomagnetic beads, affecting the sensitivity and accuracy of the instrument; and there are also problems of slow heating speed and large fluctuation range of heating temperature during the detection process", the present application provides a solution of "a heating device based on reagent kit 1", specifically: "A heating device based on reagent kit 1, comprising a reagent kit The reagent box 1, the carrying fixture 2 and the heating block; the top of the carrying fixture 2 is provided with a plurality of placement grooves 3; the heating block includes a heating plate 4 and a heating groove 5 for accommodating the reagent box 1; the bottom of the heating groove 5 is provided with a groove 6, the top of the heating plate 4 is fitted and connected to the groove 6, and the bottom of the heating plate 4 is fitted and connected to the placement groove 3; one side of the heating plate 4 is provided with a conductive wire 7 for an external power supply; the bottom of the reagent box 1 is fitted and connected to the heating groove 5; a temperature sensor 8 is provided between the placement groove 3 and the heating plate 4, and one end of the temperature sensor 8 is connected to the bottom of the heating plate 4; the placement groove 3 is provided with a first opening 9, and the temperature sensor 8 is embedded in the first opening 9". The "reagent box 1, the carrying fixture 2 and the heating block" solve the problems of "the traditional chemiluminescence instrument has a complex design, the cleaning procedure of the pipeline is cumbersome, the manufacturing and operation and maintenance costs are high, the heating efficiency is slow and the fluctuation range is large", and the effect of "fast heating speed, small temperature fluctuation range, ensuring the accuracy and stability of the test results" is achieved.

[0037] Next, a heating device based on the reagent kit 1 in this exemplary embodiment will be further described.

[0038] In one embodiment of the utility model, the reagent box 1 is placed in the heating tank 5. After the conductive wire 7 is powered on, the heating plate 4 generates heat, so that the temperature of the reagent box 1 in the heating tank 5 rises to a specified temperature, thereby completing the heating of the reagent box 1.

[0039] In one embodiment of the present invention, the temperature sensor 8 is used to detect the temperature; in a specific embodiment, the temperature sensor 8 is used to detect whether the heating temperature reaches a specified temperature.

[0040] In one embodiment of the present invention, the reagent kit 1 is formed by connecting a plurality of reagent tubes; in a specific embodiment, the reagent kit 1 is formed by connecting a plurality of reagent tubes.

[0041] In one embodiment of the utility model, the reagent tube includes a through-rectangular body and a test tube; the through-rectangular body is arranged at the second opening of the test tube; a plurality of the reagent tubes are connected through the side walls of the through-rectangular body to form the reagent kit 1; in a specific embodiment, the upper parts of the reagent tubes, i.e., the through-rectangular bodies, are connected to each other, and there are gaps between the lower parts of the reagent tubes, i.e., the test tubes.

[0042] In one embodiment of the present invention, the support fixture 2 is in the shape of a disk; in a specific embodiment, the placement groove 3 is arranged around the edge of the support fixture 2, and the placement groove 3 is in the shape of an arc.

[0043] In one embodiment of the utility model, a power supply is also included, and the power supply is electrically connected to the temperature sensor 8 and the conductive wire 7 respectively; in a specific embodiment, the power supply is used to supply power to the temperature sensor 8 and the conductive wire 7, and then the heating plate 4 is heated by the conductive wire 7; supplying power to the temperature sensor 8 enables the temperature sensor 8 to detect the temperature.

[0044] In one embodiment of the utility model, it also includes a power interface, which electrically connects the power supply, the temperature sensor 8 and the conductive wire 7; in a specific embodiment, the power interface can be used to supply AC power to the temperature sensor 8 and the conductive wire 7, and can also be used to charge the power supply through AC power.

[0045] In one embodiment of the present invention, the reagent kit 1 is arc-shaped; in a specific embodiment, the supporting fixture 2 is disc-shaped and the placement groove 3 is arc-shaped, and the reagent kit 1 is also arc-shaped accordingly.

[0046] In one embodiment of the utility model, a base is further included, and the top of the base is connected to the bottom of the supporting fixture 2; in a specific embodiment, the base plays a supporting role.

[0047] In one embodiment of the utility model, an upper shell is further included, and the bottom of the upper shell is connected to the side wall of the base; in a specific embodiment, the upper shell plays a shielding role.

[0048] In one embodiment of the utility model, a sliding door is further included, and the sliding door is arranged on the top of the upper shell; in a specific embodiment, the reagent box 1 can be placed in the heating tank 5 when the sliding door is opened, and heating can be performed when the sliding door is closed.

[0049] Beneficial effects of this application:

[0050] In order to solve the problems faced by traditional chemiluminescence instruments, we actively explore new technical paths. First of all, we deeply understand the problems of complex design, cumbersome cleaning pipelines and procedures of traditional chemiluminescence instruments. Therefore, by highly integrating the reagents required for chemistry on the reaction plate, we put the entire traditional chemiluminescence process into a small instrument, effectively reducing the difficulty of equipment cleaning. Unlike traditional instruments, we use a unique method to achieve cleaning by transferring magnetic beads, avoiding serious loss of magnetic beads and maintaining the high sensitivity and accuracy of the instrument.

[0051] The instrument has obvious advantages. First, it does not require regular maintenance and professional operation, which reduces the cost of R&D, manufacturing and operation, making it more suitable for places such as community health centers. Secondly, our instrument adopts a highly integrated design, which can realize single-person reagents and effectively avoid the problem of reagent expiration and waste. This innovative design not only improves the efficiency of reagent use, but also better meets the actual clinical needs, providing a more convenient and economical solution for medical testing.

[0052] In general, the new chemiluminescent immunoassay analyzer not only overcomes the various problems of traditional chemiluminescent analyzers in terms of pollution, sensitivity and accuracy, but is also simpler and more practical in design and has a wider range of applications. This technological breakthrough has injected new vitality into the development of the in vitro diagnostic field and has made a positive contribution to improving the accuracy and efficiency of medical testing.

[0053] As a key component of a novel chemiluminescent immunoassay analyzer, the present application is a key part in solving the above-mentioned problems, and also has the effects of fast heating speed, small temperature fluctuation range, and ensuring the accuracy and stability of the results.

[0054] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0055] Although the preferred embodiments of the present application have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the embodiments of the present application.

[0056] Finally, it should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or terminal device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or terminal device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or terminal device including the elements.

[0057] The above is a detailed introduction to a heating device based on the reagent kit 1 provided by the present application. Specific examples are used in this article to illustrate the principles and implementation methods of the present application. The description of the above embodiments is only used to help understand the method of the present application and its core idea; at the same time, for general technicians in this field, according to the idea of ​​the present application, there will be changes in the specific implementation method and application scope. In summary, the content of this specification should not be understood as a limitation on the present application.

Claims

1. A heating device for a chemiluminescent immunoassay analyzer, characterized in that: Includes test kit, carrier fixture and heating block; The top of the carrying fixture is provided with a plurality of placement slots; The heating block comprises a heating plate and a heating slot for accommodating the reagent kit; a groove is provided at the bottom of the heating slot, the top of the heating plate is fitted and connected to the groove, and the bottom of the heating plate is fitted and connected to the placement slot; a conductive wire for an external power supply is provided on one side of the heating plate; The bottom of the reagent box is closely connected to the heating tank; A temperature sensor is provided between the placement groove and the heating plate, and one end of the temperature sensor is connected to the bottom of the heating plate; the placement groove is provided with a first opening, and the temperature sensor is embedded in the first opening.

2. The heating device for chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The reagent kit is composed of a plurality of reagent tubes connected to each other.

3. The heating device for chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The reagent tube comprises a through-rectangular parallelepiped and a test tube; the through-rectangular parallelepiped is arranged at the second opening of the test tube; a plurality of the reagent tubes are connected through the side wall of the through-rectangular parallelepiped to form the reagent kit.

4. The heating device for chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The supporting fixture is in the shape of a disc.

5. The heating device for chemiluminescent immunoassay analyzer according to claim 1, characterized in that: A power source is also included, and the power source is electrically connected to the temperature sensor and the conductive wire respectively.

6. The heating device for chemiluminescent immunoassay analyzer according to claim 5, characterized in that: It also includes a power interface, which is electrically connected to the power source, the temperature sensor and the conductive wire.

7. The heating device for chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The reagent kit is in an arc shape.

8. The heating device for chemiluminescent immunoassay analyzer according to claim 1, characterized in that: It also includes a base, the top of which is connected to the bottom of the supporting fixture.

9. The heating device for chemiluminescent immunoassay analyzer according to claim 8, characterized in that: It also includes an upper shell, the bottom of which is connected to the side wall of the base.

10. The heating device for chemiluminescent immunoassay analyzer according to claim 9, characterized in that: It also includes a sliding door, which is arranged on the top of the upper shell.

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