Infinitely coupled polypeptide synthesis device

Abstract

The utility model discloses an infinitely coupled polypeptide synthesis device, which relates to the technical field of polypeptide synthesis and comprises a mounting table and a rotary mixing device, a servo motor is fixedly mounted at the top of the mounting table, and the output end of the servo motor is fixedly connected with a rotating shaft; the rotary mixing device comprises a polypeptide synthesis tank, a stirring rod, a bevel gear, an arc-shaped connecting plate, a circular ring and a bevel gear ring, the polypeptide synthesis tank is fixedly connected to the front end of the rotating shaft, the stirring rod is rotationally connected to the interior of the polypeptide synthesis tank, and the right end of the stirring rod extends to the exterior of the polypeptide synthesis tank and is fixedly connected with the bevel gear; the amino acid raw materials roll up and down and left and right in the polypeptide synthesis tank through rotation of the polypeptide synthesis tank, the amino acid raw materials with large density and the amino acid raw materials with small density are prevented from being separated from each other, the phenomenon that the amino acid raw materials are layered is avoided, and mixed reaction and infinite coupling of different amino acid molecules are better facilitated.

Description

Technical Field

[0001] The utility model relates to the technical field of polypeptide synthesis, in particular to an infinitely coupled polypeptide synthesis device. Background Art

[0002] Polypeptide is a compound formed by α-amino acids linked together by peptide bonds. It is an intermediate product of protein hydrolysis. The compound formed by the dehydration condensation of two amino acid molecules is called a dipeptide. Similarly, there are tripeptides, tetrapeptides, pentapeptides, etc. Polypeptides are usually formed by the dehydration condensation of 10 to 100 amino acid molecules. Polypeptide drugs have the advantages of small dosage, high efficacy, strong specificity and few side effects. They are widely used in the treatment of diabetes, tumors, cardiovascular, reproductive, immune and other diseases.

[0003] The currently published patent: CN219849539U discloses a polypeptide synthesis device. The utility model sets an annular water distribution row to spray water on the inner wall of the shell, and uses a motor, a stirring rod and a scraper to clean up the residue attached to the inner wall of the shell, so that the reactor has the function of automatically cleaning its interior.

[0004] Based on the above search, it is found that the above patent has the following problems when in use: when the polypeptide synthesis device is in use, the residues attached to the inner wall of the outer shell can be cleaned off by the stirring rod and the scraper, so that the reactor has the function of automatically cleaning its interior, but the stirring rod only has the function of stirring and mixing the raw materials. Since polypeptides are usually compounds formed by dehydration condensation of 10 to 100 amino acid molecules, different types of amino acid molecules have different densities, and polypeptide synthesis requires a variety of different amino acid molecules. Amino acid molecules with higher density are more likely to precipitate to the bottom side due to their own gravity, while amino acid molecules with lower density are more likely to move to the upper side, which causes the raw materials to be stratified, affecting the uniformity of mixing between different amino acid molecules, which is not conducive to the mixing reaction of different amino acid molecules. Utility Model Content

[0005] The purpose of the utility model is to solve at least one of the technical problems existing in the prior art and to provide an infinitely coupled polypeptide synthesis device, which can solve the problem that raw materials produce stratification, affect the uniformity of mixing between different amino acid molecules, and thus be unfavorable for the mixing reaction of different amino acid molecules.

[0006] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: an infinitely coupled polypeptide synthesis device, comprising a mounting platform and a rotating mixing device; a servo motor is fixedly mounted on the top of the mounting platform, and an output end of the servo motor is fixedly connected to a rotating shaft; the rotating mixing device comprises a polypeptide synthesis tank, a stirring stick, a bevel gear, an arc-shaped connecting plate, a circular ring and a bevel gear ring, the polypeptide synthesis tank is fixedly connected to the front end of the rotating shaft, the stirring stick is rotatably connected to the inside of the polypeptide synthesis tank, the right end of the stirring stick extends to the outside of the polypeptide synthesis tank and is fixedly connected to the bevel gear, the arc-shaped connecting plate is fixedly connected to the front side of the mounting platform, the circular ring is fixedly connected to the surface of the arc-shaped connecting plate, the bevel gear ring is fixedly connected to the inner wall of the circular ring, and the bevel gear is meshed with the bevel gear ring.

[0007] Preferably, an annular scraper is fixedly connected to the surface of the stirring rod, and the surface of the annular scraper is in contact with the inner wall of the polypeptide synthesis tank.

[0008] Preferably, a mixing stick is fixedly sleeved inside the stirring stick.

[0009] Preferably, a feed pipe is fixedly connected to the surface of the polypeptide synthesis tank, and a sealing disc is slidably connected to the inside of the feed pipe.

[0010] Preferably, an annular groove is provided on the surface of the sealing disc, and a rubber sealing ring is slidably connected inside the annular groove.

[0011] Preferably, a limiting groove is provided on the inner wall of the feed pipe, and the rubber sealing ring is slidably engaged in the limiting groove.

[0012] Compared with the prior art, the beneficial effects of the utility model are:

[0013] (1) In the infinitely coupled peptide synthesis device, the stirring rod rotates to drive the annular scraper to rotate and clean the inner wall of the peptide synthesis tank, thereby preventing the amino acid raw materials from adhering to the inner wall of the peptide synthesis tank. The rotation of the peptide synthesis tank itself causes the amino acid raw materials to roll up and down and left and right inside it, thereby preventing the amino acid raw materials with higher density from being separated from the amino acid raw materials with lower density, thereby avoiding the stratification of the amino acid raw materials, thereby improving the uniformity of mixing between different amino acid molecules, and being more conducive to the mixing reaction and infinite coupling of different amino acid molecules.

[0014] (2) In the infinitely coupled peptide synthesis device, the worker slides the sealing disc downward, and the sealing disc slides downward and drives the rubber sealing ring to slide out of the inner part of the limiting groove to complete the disassembly. The worker can then discharge the synthesized peptide through the feed pipe. Similarly, the worker rotates the feed pipe to the upper side and makes its opening face upward, and then the amino acid raw material can be added into the inner part of the peptide synthesis tank through the feed pipe, which is convenient for the worker to add the amino acid raw material into the inner part of the peptide synthesis tank. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The utility model is further described below in conjunction with the accompanying drawings and embodiments:

[0016] Figure 1 This is a schematic diagram of the overall structure of an infinitely coupled peptide synthesis device of the utility model;

[0017] Figure 2 This is a schematic diagram of the side structure of an infinitely coupled peptide synthesis device of the utility model;

[0018] Figure 3 This is a schematic diagram of the internal structure of the polypeptide synthesis tank of the utility model;

[0019] Figure 4 For this utility model Figure 3 Schematic diagram of the enlarged structure of A.

[0020] Figure numerals: 1, mounting table; 2, servo motor; 3, rotating shaft; 4, polypeptide synthesis tank; 5, stirring rod; 6, bevel gear; 7, arc-shaped connecting plate; 8, circular ring; 9, bevel gear ring; 10, annular scraper rod; 11, mixing rod; 12, feeding pipe; 13, sealing disc; 14, annular slot; 15, rubber sealing ring; 16, limiting groove. DETAILED DESCRIPTION

[0021] This section will describe in detail the specific embodiments of the utility model. The preferred embodiments of the utility model are shown in the accompanying drawings. The purpose of the accompanying drawings is to supplement the description of the text part of the specification with graphics, so that people can intuitively and vividly understand each technical feature and the overall technical solution of the utility model, but it cannot be understood as a limitation on the protection scope of the utility model.

[0022] In the description of the present invention, it should be understood that descriptions involving orientation, such as up, down, front, back, left, right, etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0023] In the description of the present utility model, "greater than", "less than", "exceed" etc. are understood as not including the number itself, and "above", "below", "within" etc. are understood as including the number itself. If there is a description of "first" or "second", it is only used for the purpose of distinguishing the technical features, and cannot be understood as indicating or implying the relative importance or implicitly indicating the number of the indicated technical features or implicitly indicating the order of the indicated technical features.

[0024] In the description of the present invention, unless otherwise clearly defined, terms such as setting, installing, connecting, etc. should be understood in a broad sense, and technicians in the relevant technical field can reasonably determine the specific meanings of the above terms in the present invention based on the specific content of the technical solution.

[0025] See also Figure 1-4 The utility model provides a technical solution: an infinitely coupled polypeptide synthesis device, comprising a mounting platform 1 and a rotating mixing device, a servo motor 2 is fixedly mounted on the top of the mounting platform 1, an output end of the servo motor 2 is fixedly connected to a rotating shaft 3, the rotating mixing device comprises a polypeptide synthesis tank 4, a stirring rod 5, a bevel gear 6, an arc-shaped connecting plate 7, a ring 8 and a bevel gear ring 9, the polypeptide synthesis tank 4 is fixedly connected to the front end of the rotating shaft 3, the stirring rod 5 is rotatably connected to the inside of the polypeptide synthesis tank 4, the right end of the stirring rod 5 extends to the outside of the polypeptide synthesis tank 4 and is fixedly connected to the bevel gear 6, the arc-shaped connecting plate 7 is fixedly connected to the front side of the mounting platform 1, the ring 8 is fixedly connected to the surface of the arc-shaped connecting plate 7, the bevel gear ring 9 is fixedly connected to the inner wall of the ring 8, the bevel gear 6 is meshed with the bevel gear ring 9, the surface of the stirring rod 5 is fixedly connected to an annular scraper 10, the surface of the annular scraper 10 contacts the inner wall of the polypeptide synthesis tank 4, and the inside of the stirring rod 5 is fixedly sleeved with a mixing rod 11;

[0026] When the infinitely coupled peptide synthesis device is in use, the staff starts the servo motor 2 and drives the rotating shaft 3 to rotate. The rotating shaft 3 rotates and drives the peptide synthesis tank 4 to rotate around the center of the ring 8 so that the amino acid raw materials inside it roll. The peptide synthesis tank 4 rotates and drives the bevel gear 6 to rotate in a circular shape on the surface of the bevel gear ring 9 through the stirring rod 5. At this time, the bevel gear 6 can drive the stirring rod 5 to rotate through the meshing action between the bevel gear ring 9. The rotation of the stirring rod 5 can drive the mixing rod 11 to rotate and stir the amino acid raw materials. At the same time, the rotation of the stirring rod 5 drives the annular scraper 10 to rotate and clean the inner wall of the peptide synthesis tank 4 to prevent the amino acid raw materials from adhering to the inner wall of the peptide synthesis tank 4. The rotation of the polypeptide synthesis tank 4 itself causes the amino acid raw materials to roll up and down and left and right inside it, preventing the amino acid raw materials with higher density and the amino acid raw materials with lower density from being separated from each other, thereby avoiding the phenomenon of stratification of the amino acid raw materials, thereby improving the uniformity of mixing between different amino acid molecules, which is more conducive to the mixing reaction and infinite coupling of different amino acid molecules.

[0027] A feed pipe 12 is fixedly connected to the surface of the polypeptide synthesis tank 4, a sealing disc 13 is slidably connected to the inside of the feed pipe 12, an annular groove 14 is provided on the surface of the sealing disc 13, a rubber sealing ring 15 is slidably connected to the inside of the annular groove 14, a limiting groove 16 is provided on the inner wall of the feed pipe 12, and the rubber sealing ring 15 is slidably engaged in the inside of the limiting groove 16.

[0028] After the amino acid raw materials are mixed and reacted inside the polypeptide synthesis tank 4, the staff can start the servo motor and drive the polypeptide synthesis tank 4 to a horizontal state, and make the opening of the feed pipe 12 face downward. The servo motor 2 is a new type of motor with a brake from Panasonic. It adds a brake on the basis of an ordinary servo motor, which can achieve more efficient control and safer operation. The brake can maintain the position of the motor through the braking torque when the servo motor 2 stops running, so that the polypeptide synthesis tank 4 can be kept in a horizontal position. The staff slides the sealing disc 13 downward, and the sealing disc 13 slides downward and drives the rubber sealing ring 15 to slide out of the limiting groove 16 to complete the disassembly. The staff can discharge the synthesized polypeptide through the feed pipe 12. Similarly, the staff rotates the feed pipe 12 to the upper side and makes its opening face upward, so that the amino acid raw material can be added to the inside of the polypeptide synthesis tank 4 through the feed pipe 12, which is convenient for the staff to add amino acid raw materials to the inside of the polypeptide synthesis tank 4.

[0029] Working principle: In the infinitely coupled peptide synthesis device, the staff starts the servo motor 2 and drives the rotating shaft 3 to rotate. The rotating shaft 3 drives the peptide synthesis tank 4 to rotate around the center of the ring 8 so that the amino acid raw materials inside it roll. The peptide synthesis tank 4 rotates and drives the bevel gear 6 to rotate in a circular shape on the surface of the bevel gear ring 9 through the stirring rod 5. At this time, the bevel gear 6 can drive the stirring rod 5 to rotate through the meshing action with the bevel gear ring 9. The rotation of the stirring rod 5 can drive the mixing rod 11 to rotate and stir the amino acid raw materials, and at the same time drive the annular scraper 10 to rotate to clean the inner wall of the peptide synthesis tank 4. The rotation of the body makes the amino acid raw materials roll up and down and left and right inside it, preventing the amino acid raw materials with higher density from being separated from the amino acid raw materials with lower density. The staff starts the servo motor and drives the polypeptide synthesis tank 4 to a horizontal state, and makes the opening of the feeding pipe 12 face downward. The staff slides the sealing disc 13 to the lower side and drives the rubber sealing ring 15 to slide out of the limiting groove 16 to complete the disassembly. The staff can discharge the synthesized polypeptide through the feeding pipe 12. Similarly, the staff rotates the feeding pipe 12 to the upper side and makes its opening face upward, so as to add the amino acid raw materials into the interior of the polypeptide synthesis tank 4.

[0030] The embodiments of the present invention are described in detail above in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the technical field without departing from the purpose of the present invention.

Claims

1. An infinitely coupled peptide synthesis device, characterized in that: include: A mounting platform (1) and a rotating mixing device; A servo motor (2) is fixedly mounted on the top of the mounting platform (1), and a rotating shaft (3) is fixedly connected to the output end of the servo motor (2); The rotary mixing device comprises a polypeptide synthesis tank (4), a stirring rod (5), a bevel gear (6), an arc-shaped connecting plate (7), a circular ring (8) and a bevel gear ring (9); the polypeptide synthesis tank (4) is fixedly connected to the front end of a rotating shaft (3); the stirring rod (5) is rotatably connected to the inside of the polypeptide synthesis tank (4); the right end of the stirring rod (5) extends to the outside of the polypeptide synthesis tank (4) and is fixedly connected to the bevel gear (6); the arc-shaped connecting plate (7) is fixedly connected to the front side of the mounting platform (1); the circular ring (8) is fixedly connected to the surface of the arc-shaped connecting plate (7); the bevel gear ring (9) is fixedly connected to the inner wall of the circular ring (8); and the bevel gear (6) is meshingly connected to the bevel gear ring (9).

2. An infinitely coupled peptide synthesis device according to claim 1, characterized in that: The surface of the stirring rod (5) is fixedly connected to an annular scraper (10), and the surface of the annular scraper (10) is in contact with the inner wall of the polypeptide synthesis tank (4).

3. The infinitely coupled peptide synthesis device according to claim 1, characterized in that: A mixing stick (11) is fixedly sleeved inside the stirring stick (5).

4. The infinitely coupled peptide synthesis device according to claim 1, characterized in that: A feed pipe (12) is fixedly connected to the surface of the polypeptide synthesis tank (4), and a sealing disc (13) is slidably connected to the inside of the feed pipe (12).

5. An infinitely coupled peptide synthesis device according to claim 4, characterized in that: An annular groove (14) is provided on the surface of the sealing disc (13), and a rubber sealing ring (15) is slidably connected inside the annular groove (14).

6. An infinitely coupled peptide synthesis device according to claim 5, characterized in that: The inner wall of the feed pipe (12) is provided with a limiting groove (16), and the rubber sealing ring (15) is slidably engaged in the limiting groove (16).

Images