Sample analyzer

Abstract

The utility model provides a sample analyzer. The sample analyzer comprises a reagent bin, a reaction cup dispatching assembly, a reagent loading assembly, a reagent separate injection assembly, an incubation assembly and a detection assembly, the reagent bin is used for cold storage and scheduling of reagents and quality control products; the reaction cup scheduling assembly is used for loading and scheduling reaction cups; the reagent loading assembly is used for automatically loading and taking a reagent and a quality control product and selecting a corresponding quality control container to open or close the sealing cover; the reagent separate injection assembly is used for sucking a reagent or a quality control product and injecting the reagent or the quality control product into the reaction cup; the incubation assembly is used for providing a temperature returning environment and an incubation environment for an object in the reaction cup; the detection assembly is used for analyzing and determining the solution. Based on the technical scheme of the utility model, the standard quality control container can be directly adopted to contain the quality control product without replacing a special container, the duration of opening and closing the cover and the duration of opening the quality control container can be shortened, and the influence of cover opening on the quality control product is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of sample analysis equipment, in particular to a sample analyzer. Background Art

[0002] During the use of sample analysis instruments, quality control tests are required every day. During the quality control test, users are required to take the quality control products out of the refrigerated container in advance and warm them up, that is, the quality control products need to be balanced to room temperature (18℃-26℃), and then placed on the sample rack and sent to the instrument for testing. Before the quality control results of this project are out, related tests for this project cannot be performed. The storage time and opening time of the quality control products at room temperature will affect the stability of the quality control products, which will not only waste user time and reduce user work efficiency, but may also lead to abnormal quality control results.

[0003] At present, the prior art "quality control / calibration test method, sample analyzer and computer-readable storage medium" proposes a technical solution for the preservation and testing of quality control products. In this solution, the mouth of the container for storing quality control / calibration products is provided with a rubber film with a cross cut, but this film cannot achieve a completely sealed effect, and there will still be volatilization problems, and the container is placed in the reagent compartment for a long time, and the volatilization amount will be very large. At the same time, the reagent needle will produce friction with the film when passing through the film, which will affect the service life of the needle. In addition, the containers of third-party quality control products on the market are not provided with this film, but are just standard quality control product bottles (sealed with threaded or non-threaded lids), which cannot be directly used in the above technical solution. The quality control products need to be transferred to special quality control bottles with a film first. Utility Model Content

[0004] In order to solve the above-mentioned problems existing in the prior art, the utility model proposes a sample analyzer.

[0005] The utility model provides a sample analyzer, comprising:

[0006] A reagent warehouse, which is used for refrigerated storage and dispatch of reagents and quality control products, wherein the quality control products are contained in quality control containers with sealed lids;

[0007] A reaction cup scheduling component, which is used for loading and scheduling reaction cups;

[0008] A reagent dispensing component, which is used to draw the reagent or the quality control product from the quality control container in the reagent compartment and inject it into the reaction cup;

[0009] An incubation component, wherein a temperature return zone and an incubation zone are formed on an incubation plate of a rectangular fixed structure, wherein the temperature return zone is used to provide a temperature return environment at a set temperature for the quality control product in the reaction cup, and the incubation zone is used to provide an incubation environment at a set temperature for the object in the reaction cup, wherein the object includes a mixed solution formed by mixing reagents with quality control products or samples;

[0010] A detection component, which is used to analyze and measure the mixed solution after the incubation; and

[0011] The reagent loading component is used to load the reagent from outside the instrument into the reagent chamber, or to dispatch and take out the reagent kit in the reagent chamber; the reagent loading component is also used to move the sealing cover of the quality control container upward or downward relative to the quality control container.

[0012] In one embodiment, the temperature return zone is provided with a plurality of temperature return positions, each of which is provided with a placement hole, and the placement hole is used to place a reaction cup containing a quality control product.

[0013] In one embodiment, a temperature control unit for providing a set temperature is provided in the reheat zone, and the temperature control unit includes at least one temperature control unit, and each of the temperature control units corresponds to at least one reheat position of the reheat zone;

[0014] The temperature control unit can provide a set temperature of a corresponding value for the corresponding temperature return position, and the temperatures of different temperature control units are independently controlled.

[0015] In one embodiment, a heat preservation unit is provided in the temperature recovery zone, and the heat preservation unit is coated at other positions of the temperature control unit except the position corresponding to the temperature recovery position, so as to prevent heat dissipation and keep the temperature control unit warm.

[0016] In one embodiment, the reagent loading component can extend into the reagent compartment to directly open or close the sealing cover of the corresponding quality control container; or the reagent loading component can grab the corresponding quality control container from the reagent compartment to open or close the sealing cover, and can put the quality control container with the cover opened or closed back into the reagent compartment.

[0017] In one embodiment, the sealing cover is a sealing plug cover that is interference-fitted on the mouth of the quality control container;

[0018] The reagent loading assembly includes a liftable loading gripper disposed above the reagent chamber, and the loading gripper can pass through the inlet and outlet of the reagent chamber and enter the reagent chamber to clamp and pull out the sealing plug cover of the corresponding quality control container or press the pulled out sealing plug cover into the quality control container.

[0019] In one embodiment, the sealing cover is a sealing plug cover that is interference-fitted on the mouth of the quality control container or a sealing screw cover that is threadably fitted on the mouth of the quality control container;

[0020] The reagent loading assembly includes a bearing seat and a lifting and lowering loading gripper both disposed above the reagent compartment, the loading gripper can pass through the inlet and outlet of the reagent compartment and enter the reagent compartment to grab the corresponding quality control container, and the bearing seat is provided with a bearing slot for placing an adapter for carrying the quality control container;

[0021] Among them, the loading gripper can clamp the sealing plug cover or the sealing screw cap of the quality control container after placing the adapter in the carrying groove; the bottom of the carrying groove is provided with a second rotating drive component that can drive the quality control container to rotate, so that the sealing screw cap and the quality control container rotate relative to each other.

[0022] In one embodiment, a cover storage groove adjacent to the bearing groove is provided on the bearing seat, and the cover storage groove is used for the loading gripper to place the sealing cover removed from the quality control container.

[0023] In one embodiment, a relatively protruding support portion is configured on the groove wall of the cover storage groove, a plurality of the support portions are spaced apart along the circumferential direction, and the tops of the plurality of the support portions form a support step for supporting the sealing cover, and the height of the support step is lower than the notch of the cover storage groove;

[0024] Wherein, a drainage groove extending along the depth direction of the cover storage groove is formed between two adjacent support parts, and the drainage groove is used to guide the residual liquid on the sealing cover to flow to the bottom of the cover storage groove.

[0025] In one embodiment, the reagent loading assembly further comprises a linear translation mechanism, and the supporting seat is movably disposed on the linear translation mechanism so as to be moved to correspond to or stagger with the loading gripper under the drive of the linear translation mechanism.

[0026] In one embodiment, for the adapter carrying the quality control container, the adapter and the storage slot in the reagent compartment for placing the adapter and / or the adapter and the carrying slot on the reagent loading assembly for placing the adapter are relatively fixed by a snap.

[0027] In one embodiment, the quality control container is carried on an adapter, and a placement groove is configured on the adapter, and the quality control container can be at least partially accommodated in the placement groove and the portion where the sealing cover is located is located outside the placement groove;

[0028] Wherein, a limiting member for fixing the quality control container relative to the placement slot is detachably provided at the slot opening of the placement slot.

[0029] In one embodiment, a rotatable drum is embedded in the adapter, and the internal space of the drum is configured as the placement slot. The bottom of the drum passes through the adapter and the bottom of the drum is closed and provided with a card slot. The card slot can cooperate with a corresponding rotating drive member to drive the drum to rotate, thereby driving the quality control container to rotate.

[0030] In one embodiment, the stopper is constructed as an annular structure with a central hole, and the outer peripheral surface of the stopper is threadedly matched with the inner wall of the placement groove;

[0031] For the quality control container accommodated in the placement groove, the portion where the sealing cover is located passes through the central hole, and the limiting step constructed on the upper end of the quality control container abuts against the bottom of the limiting member.

[0032] In one embodiment, the reagent dispensing assembly includes a reagent arm and a dispensing needle disposed on the reagent arm, and the reagent arm can drive the dispensing needle to move into the reagent chamber to absorb the reagent or the quality control product and can drive the dispensing needle to inject the reagent or the quality control product into the reaction cup.

[0033] Compared with the prior art, the sample analyzer provided by the utility model has at least the following beneficial effects:

[0034] The utility model provides a sample analyzer, based on the loading and retrieving function and the opening function of the reagent loading component, which can realize automatic loading and retrieving of objects such as reagents and quality control products, and can directly use standard quality control containers to contain quality control products, without the need to use special containers, thereby eliminating the process of transferring quality control products; combined with a reagent warehouse for low-temperature refrigeration of reagents and quality control products, the reagent loading component can directly interact with the reagent warehouse to select the corresponding quality control container that needs to be opened or closed, so as to realize on-demand use, shorten the opening and closing process and the time when the quality control container is in the open state, and reduce the impact of opening the cover on the quality control product; and the quality control container after opening the cover is also placed in the reagent warehouse for circulation, and the low temperature environment in the reagent warehouse can reduce the possibility of volatilization of the quality control product, thereby ensuring the stability of the quality control product. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] The present invention will be described in more detail below based on embodiments and with reference to the accompanying drawings.

[0036] Figure 1 A top view showing the overall structure of the sample analyzer of the present invention formed by various components;

[0037] Figure 2 A schematic diagram showing the structure of the reagent loading assembly and the reagent compartment of the sample analyzer of the present invention is shown;

[0038] Figure 3 A partial top view of the reagent compartment of the utility model is shown;

[0039] Figure 4 A three-dimensional diagram showing a part of the reagent compartment of the present invention;

[0040] Figure 5 A partial structural schematic diagram of the supporting seat portion of the reagent loading assembly of the utility model is shown;

[0041] Figure 6 The schematic diagram of the structure of the quality control container and the adapter of the utility model is shown;

[0042] Figure 7 A schematic diagram showing two types of area divisions of the temperature recovery zone of the sample analyzer of the present invention is shown;

[0043] Figure 8 A schematic diagram showing another area division of the sample analyzer of the utility model for the temperature recovery zone;

[0044] Fig. 9 A schematic diagram showing another area division of the temperature recovery zone of the sample analyzer of the present invention based on an incubation component of another structure;

[0045] Fig.10 The process of returning the temperature of the quality control product in the sample analysis control method of the utility model is shown;

[0046] Fig.11 The diagram shows a partially overlapping process when the quality control product test and the sample test in the sample analysis control method of the utility model are performed simultaneously.

[0047] In the drawings, like reference numerals are used for like parts. The drawings are not necessarily to scale.

[0048] Reference numerals:

[0049] 1-reagent bin, 101-storage position, 102-bin body, 103-reagent turntable, 104-storage slot, 105-fixed gear;

[0050] 2-cup scheduling component, 201-sample filling position, 202-first reagent filling position, 203-cup placement position, 204-cup loading position;

[0051] 3- sample injection assembly, 4- reagent dispensing assembly;

[0052] 5-incubation assembly, 501-incubation plate, 502-first incubation well, 503-second incubation well, 504-third incubation well, 505-fourth incubation well, 506-fifth incubation well;

[0053] 6-Detection components;

[0054] 7-reagent loading assembly, 701-opening gripper, 702-carrying seat, 703-carrying slot, 704-linear translation mechanism, 705-cap storage slot, 706-supporting part, 707-drainage slot, 708-rotational power unit;

[0055] 8-second reagent filling assembly, 801-transfer position, 802-second reagent filling position;

[0056] 9-first magnetic separation cleaning component, 10-second magnetic separation cleaning component, 11-first dispatching gripper, 12-second dispatching gripper, 13-third dispatching gripper;

[0057] 14-quality control container, 141-sealing cover, 142-limiting step, 15-adapter, 151-placing slot, 152-rotating cylinder, 153-limiting member;

[0058] 16-first rotating driving member, 161-transmission gear, 17-temperature recovery zone, 18-incubation zone, 19-second rotating driving member. DETAILED DESCRIPTION

[0059] The utility model will be further described below in conjunction with the accompanying drawings.

[0060] Quality control testing usually refers to one or more rounds of testing using quality control products (also called standard products) before sample testing and analysis. The main purpose is to judge the test accuracy of the sample analyzer based on the quality control test results and calibrate the sample analyzer to ensure the accuracy of subsequent sample testing.

[0061] The embodiment of the utility model provides a sample analyzer, comprising:

[0062] A reagent warehouse 1, which is used for refrigerated storage and dispatch of reagents and quality control products, the quality control products are contained in a quality control container 14 with a sealing cover 141;

[0063] A reaction cup scheduling component 2, which is used for loading and scheduling reaction cups;

[0064] The reagent dispensing component 4 is used to draw reagents or quality control products from the quality control container 14 in the reagent compartment 1 and inject them into the reaction cup;

[0065] The incubation component 5 has an incubation tray 501 of a rectangular fixed structure on which a temperature return zone 17 and an incubation zone 18 are formed. The temperature return zone 17 is used to provide a temperature return environment at a set temperature for the quality control product in the reaction cup, and the incubation zone 18 is used to provide an incubation environment at a set temperature for the object in the reaction cup, and the object includes a mixed solution formed by mixing the reagent and the quality control product or the sample;

[0066] A detection component 6, which is used to analyze and measure the mixed solution after the incubation; and

[0067] The reagent loading component 7 is used to load the reagent from outside the instrument into the reagent chamber 1, or to dispatch and take out the reagent reagent chamber 1; the reagent loading component 7 is also used to move the sealing cover 141 of the quality control container 14 upward or downward relative to the quality control container 14.

[0068] Specifically, the overall layout structure of each component in the sample analyzer is shown in the attached figure Figure 1 As shown, each component is arranged around the reagent compartment 1, and each component will be described below:

[0069] The reagent compartment 1 is mainly used to store containers for reagents or quality control products. For quality control products, the container here can be a container provided by a third-party quality control product, that is, a standard quality control container 14 with a removable sealing cover 141. The reagent compartment 1 provides a low-temperature refrigerated environment (for example, a low-temperature environment of 2-8°C) for reagents and quality control products, which can achieve stable low-temperature storage of quality control products.

[0070] The cuvette scheduling component 2 mainly includes a scheduling plate for loading cuvettes. The scheduling plate has corresponding functional positions with different functions, and the scheduling plate can be rotated to allow the cuvettes to flow between multiple functional positions.

[0071] The reagent loading component 7 is mainly used for loading and retrieving reagents and even quality control products, and opening and closing the cover of the quality control container 14, that is, opening or closing the sealing cover 141 of the quality control container 14. Based on the loading and retrieving functions of the reagent loading component 7, the corresponding reagents and quality control products can be automatically placed in the reagent compartment 1 or other corresponding positions of the instrument from the outside of the instrument to achieve loading; the reagent box or quality control container 14 in the reagent compartment 1 can also be retrieved as needed. Based on the opening and closing cover function of the reagent loading component 7, that is, the reagent loading component 7 is also used to move the sealing cover 141 of the quality control container 14 upward (opening the cover) or downward (closing the cover) relative to the quality control container 14, it is possible to directly perform quality control testing based on the standard quality control container 14. For the loading and retrieving of the reagent box and the quality control container 14 of the reagent loading component 7 and the opening and closing cover function of the quality control container 14, the reagent onboard component 7 is not only for opening and closing the cover of the quality control container 14 with the sealing cover 141, but also for some special reagent boxes with sealing covers, the reagent loading component 7 of the present application can also be used to open and close the cover.

[0072] At the same time, the reagent loading component 7 can be adapted to different sealing covers 141 (including sealing plug covers and sealing screw covers) at the same time. Based on the different types of sealing covers 141, the specific operation of opening the cover is different, that is: optionally, the reagent loading component 7 can extend into the reagent compartment 1 to directly open or close the sealing cover 141 of the corresponding quality control container 14; or the reagent loading component 7 can grab the corresponding quality control container 14 from the reagent compartment 1 to open or close the sealing cover 141, and can put the opened or closed quality control container 14 back into the reagent compartment 1. Specifically, the reagent loading component 7 can extend into the reagent compartment 1 to directly open or close the sealing cover 141 of the corresponding quality control container 14; or the reagent loading component 7 can grab the corresponding quality control container 14 from the reagent compartment 1, open or close the sealing cover 141 outside the reagent compartment 1, and can put the opened or closed quality control container 14 back into the reagent compartment 1. But in general, the reagent loading component 7 can eventually make the quality control container 14 after opening or closing the lid be in the reagent compartment 1, so that the reagent compartment 1 can be mainly used to refrigerate the quality control container 14 after opening the lid to avoid volatilization in the room temperature environment and to drive the quality control container 14 to circulate.

[0073] The reagent dispensing component 4 is mainly used to absorb the quality control product from the quality control container 14 after the cover is opened, or absorb the reagent from the container of the corresponding reagent, and then inject the reagent into the reaction cup. The reagent here mainly refers to the reagent required for quality control testing and subsequent sample testing. The container where the reagent is located can be opened according to the specific situation (for example, a standard container with a sealing cover 141 is used for volatile reagents) or directly absorbed (for example, an open container is used for low-volatility reagents).

[0074] The incubation component 5 includes an incubation tray 501 with a rectangular fixed structure, which mainly provides a corresponding temperature environment for quality control testing and sample testing; for example, in quality control testing, the quality control product needs to be warmed up before testing. At this time, it can be placed in the warming zone 17 of the incubation component 5 for warming up at a set temperature and a set time (there is only a quality control product solution in the reaction cup), and after warming up, it can be incubated at a set temperature and a set time in the subsequent process through the incubation zone 18 of the incubation component 5 (the reaction cup contains a mixture of the quality control product and the reagent); and in the subsequent sample testing process, the sample usually does not need a warming process, because the incubation component 5 can provide an incubation environment with a set temperature and a set time directly for the sample (the reaction cup contains a mixture of the sample and the reagent).

[0075] The detection component 6 is mainly used to detect the mixed solution of the quality control product and the reagent or the mixed solution of the sample and the reagent after the incubation is completed, so as to obtain the quality control test results and the sample test results.

[0076] The sample analyzer proposed in the utility model, based on the loading and retrieving function and the opening function of the reagent loading component 7, can realize the automatic loading and retrieving of objects such as reagents and quality control products, and can directly use standard quality control containers 14 to contain quality control products, without the need to use special containers, thereby eliminating the process of transferring quality control products; combined with the reagent warehouse 1 for low-temperature refrigeration of reagents and quality control products, the reagent loading component 7 can directly interact with the reagent warehouse 1 to select the corresponding quality control container 14 that needs to be opened or closed, so as to realize on-demand use, shorten the opening and closing process and the time when the quality control container 14 is in the open state, and reduce the impact of opening the cover on the quality control product; and the quality control container 14 after opening the cover is also placed in the reagent warehouse 1 for circulation, and the low temperature environment in the reagent warehouse 1 can reduce the possibility of volatilization of the quality control product, thereby ensuring the stability of the quality control product.

[0077] In one embodiment, a plurality of reheating positions are provided in the reheating zone 17, each of which is provided with a placement hole (that is, the original hole position of the incubation component 5), and the placement hole is used to place a reaction cup containing a quality control product. In this embodiment, the plurality of reheating positions are arranged in an array.

[0078] In one embodiment, a temperature control unit for providing a set temperature is provided in the temperature return zone 17, and the temperature control unit includes at least one temperature control unit, and each temperature control unit corresponds to at least one temperature return position of the temperature return zone 17; wherein the temperature control unit can provide a set temperature of a corresponding value for the temperature return position corresponding to it, and the temperatures of different temperature control units are independently controlled.

[0079] Specifically, the temperature of the corresponding temperature return position is controlled by the temperature control unit, and multiple temperature control units can be set in the temperature return zone 17, and the temperature of each temperature control unit is independently controlled, so the temperature return zone 17 can provide set temperatures of different temperature values ​​at the same time to meet the temperature requirements of different quality control products or different quality control schemes. Of course, the incubation zone 18 of the incubation component 5 is also provided with a temperature control unit, and its function is to provide an incubation environment at a set temperature.

[0080] In one embodiment, a heat preservation unit is provided in the temperature return zone 17 , and the heat preservation unit covers other positions of the temperature control unit except the position corresponding to the temperature return position, so as to prevent heat dissipation and keep the temperature control unit warm. The heat preservation unit can also be provided in the incubation zone 18 .

[0081] In one embodiment, the sealing cover 141 is a sealing plug cover that is interference fit at the mouth of the quality control container 14; the reagent loading assembly 7 includes a liftable cover opening gripper 701 arranged above the reagent compartment 1, and the cover opening gripper 701 can pass through the inlet and outlet of the reagent compartment 1 and enter the reagent compartment 1 to clamp and pull out the sealing plug cover of the corresponding quality control container 14 or press the pulled out sealing plug cover into the quality control container 14.

[0082] Specifically, in this embodiment, the sealing cover 141 is mainly used for the case of a sealing plug cover. For the sealing plug cover, the operation of opening and closing is relatively simple. The opening gripper 701 of the reagent loading assembly 7 is arranged above the inlet and outlet of the reagent compartment 1. When the adapter 15 where the quality control container 14 that needs to be opened corresponds to the inlet and outlet, the opening gripper 701 can be lowered to enter the reagent compartment 1 through the inlet and outlet and clamp the sealing plug cover of the quality control container 14, and then the opening gripper 701 rises to pull out the sealing plug cover, and then the opened quality control container 14 can be transferred to other functional positions with the reagent compartment 1. When the cover needs to be closed at last, the opened quality control container 14 returns to the position corresponding to the inlet and outlet. At this time, the opening gripper 701 clamped with the sealing plug cover descends to press the sealing plug cover back into the mouth of the quality control container 14. For the sealing plug cover, the quality control container 14 is in the reagent compartment 1 during the entire process of opening and closing the cover and circulating. The actual measured entire opening time does not exceed 20s, which can ensure the stability of the quality control product bottle opening.

[0083] In one embodiment, the sealing cover 141 is a sealing plug cover that is interference fit on the mouth of the quality control container 14 or a sealing screw cap that is threadedly fit on the mouth of the quality control container 14; the reagent loading assembly 7 includes a supporting seat 702 and a liftable cover-opening gripper 701 both of which are arranged above the reagent compartment 1, the cover-opening gripper 701 can pass through the inlet and outlet of the reagent compartment 1 and enter the reagent compartment 1 to grab the corresponding quality control container 14, and a supporting groove 703 for placing an adapter 15 for supporting the quality control container 14 is provided on the supporting seat 702; wherein, the cover-opening gripper 701 can clamp the sealing plug cover or sealing screw cap of the quality control container 14 after placing the adapter 15 in the supporting groove 703; a second rotating drive member 19 that can drive the quality control container 14 to rotate is provided at the bottom of the supporting groove 703, so that the sealing screw cap and the quality control container 14 rotate relative to each other.

[0084] Specifically, this embodiment mainly targets the case where the sealing cover 141 adopts a sealing screw cap; for the sealing screw cap, since the quality control container 14 itself needs to be driven to rotate externally, its opening and closing operations additionally have a pick-up and placement process. When the adapter 15 where the quality control container 14 that needs to be opened corresponds to the inlet and outlet, the uncapping gripper 701 can be lowered to enter the reagent compartment 1 through the inlet and outlet and clamp the corresponding adapter 15, and the adapter 15 and the quality control container 14 are taken out of the reagent compartment 1 and placed in the bearing groove 703 on the external bearing seat 702. The second rotating drive member 19 in the bearing groove 703 cooperates with the bottom of the quality control container 14. When the second rotating drive member 19 is started, the uncapping gripper 701 clamps the sealing screw cap and moves upward, so that the sealing screw cap can be screwed off. Then the opening gripper 701 places the sealed screw cap on the supporting seat 702, and then takes out the opened quality control container 14 together with the adapter 15 from the supporting slot 703 and puts them into the storage position 101 in the reagent compartment 1. The opened quality control container 14 can be transferred to other functional positions along with the reagent compartment 1.

[0085] When it is finally necessary to close the cover, the opened quality control container 14 returns to the position corresponding to the inlet and outlet, and the cover-opening gripper 701 descends to take out the opened quality control container 14 together with the adapter 15 and put them back in the bearing groove 703 on the bearing seat 702, and then the cover-opening gripper 701 clamps the sealing screw cap and aligns it with the quality control container 14. While the second rotary drive member 19 is reversely started, the cover-opening gripper 701 drives the sealing screw cap to move downward, so that the sealing screw cap can be tightened; finally, the closed quality control container 14 together with the adapter 15 is grabbed by the cover-opening gripper 701 and put back into the reagent chamber 1. For the sealing screw cap, the opening and closing of the quality control container 14 is carried out on the external bearing seat 702, and the circulation process is in the reagent chamber 1. The measured whole opening time is slightly longer than the sealing plug cover, but does not exceed 100s, which can also ensure the stability of opening the quality control product.

[0086] Furthermore, a rotating power unit 708 is provided on the bearing seat 702, as shown in the accompanying drawings. Figure 5 As shown, the bottom of the second rotary drive member 19 in the bearing slot 703 is connected to a driven gear (see FIG. Figure 5 Not shown in the figure, please refer to the attached Figure 2 ), the driving gear in the rotary power unit 708 meshes with the driven gear, thereby driving the second rotary drive member 19 to rotate.

[0087] In addition, as needed, for the sealed plug cover, it can also adopt the above-mentioned sealing screw cover opening process, that is, for the quality control container 14 with a sealed plug cover, the opening gripper 701 can also take the quality control container 14 together with the adapter 15 out of the reagent chamber 1 and put it on the supporting groove 703 of the supporting seat 702 for opening and closing the cover.

[0088] In one embodiment, as shown in the accompanying drawings Figure 5 As shown, a cover storage groove 705 adjacent to the bearing groove 703 is provided on the bearing seat 702 , and the cover storage groove 705 is used for the cover opening gripper 701 to place the sealing cover 141 removed from the quality control container 14 .

[0089] Optionally, as shown in the attached figure Figure 5 As shown, a relatively protruding support portion 706 is constructed on the groove wall of the storage cover groove 705, and a plurality of support portions 706 are distributed at intervals along the circumferential direction and the tops of the plurality of support portions 706 form a support step for supporting the sealing cover 141, and the height of the support step is lower than the groove opening of the storage cover groove 705; wherein, a drainage groove 707 extending along the depth direction of the storage cover groove 705 is formed between two adjacent support portions 706, and the drainage groove 707 is used to guide the residual liquid on the sealing cover 141 to flow to the bottom of the storage cover groove 705.

[0090] Specifically, when the removed sealing cover 141 is placed in the cover storage groove 705, its bottom is supported by the supporting steps formed by the tops of the multiple supporting parts 706, that is, only the bottom edge area of ​​the sealing cover 141 is in contact with the supporting steps, thereby reducing the contact area and avoiding as much as possible the quality control product solution on the sealing cover 141 from remaining in the contact area between the sealing cover 141 and the cover storage groove 705; and a drainage groove 707 is formed between the two supporting parts 706, which can guide the quality control product solution on the sealing cover 141 to the bottom of the cover storage groove 705, thereby preventing the quality control product solution from remaining on the supporting steps and causing the quality control product to cross.

[0091] In one embodiment, the reagent loading assembly 7 further includes a linear translation mechanism 704 , and the support seat 702 is movably disposed on the linear translation mechanism 704 , so as to be driven by the linear translation mechanism 704 to move to correspond to or stagger with the cover opening gripper 701 .

[0092] Specifically, as shown in the attached figure Figure 2 As shown, for the reagent loading component 7, after the cover opening gripper 701 takes out the corresponding adapter 15 from the reagent chamber 1, the adapter 15 needs to be placed on the supporting seat 702, which involves the transfer of the adapter 15 in the horizontal direction. In this embodiment, the cover opening gripper 701 is set as a fixed structure in the horizontal direction, and the supporting seat 702 is set on the linear translation mechanism 704 to form a movable structure, so that the transfer of the adapter 15 can be achieved by utilizing the active translation of the supporting seat 702.

[0093] In one embodiment, the reagent chamber 1 includes a chamber body 102 and a reagent turntable 103 arranged inside the chamber body 102, and a plurality of storage positions 101 for placing an adapter 15 where a quality control container 14 is located are evenly distributed along the circumference of the reagent turntable 103, and each storage position 101 is provided with a first rotating drive member 16 capable of driving the quality control container 14 to rotate; wherein, a fixed gear 105 coaxial with the reagent turntable 103 is provided below the reagent turntable 103, and a transmission gear 161 is connected to the bottom of the first rotating drive member 16 at the storage position 101, and the transmission gears 161 of the plurality of first rotating drive members 16 are all engaged with the fixed gear 105.

[0094] Specifically, as shown in the attached figure Figure 1 and Figure 2 As shown, the reagent compartment 1 is provided with a plurality of storage locations 101 for placing the quality control containers 14 respectively. In this embodiment, in order to facilitate the transfer of the quality control containers 14, the reagent compartment 1 is configured as a circular structure, and the plurality of storage locations 101 are distributed along the circumference. Figures 2 to 4 As shown, the reagent turntable 103 is driven to rotate by a central driving shaft, and one of its functions is to realize the circulation of the quality control container 14 where the quality control product is located and the reagent container where the reagent is located through rotation.

[0095] Further, the first rotating drive member 16 of the storage position 101 is similar to the second rotating drive member 19 mentioned above in terms of overall structure and operating principle, but has different functions. Based on the design of the fixed gear 105 and the transmission gear 161 of the first rotating drive member 16, when the reagent turntable 103 rotates, the fixed gear 105 remains stationary, and the transmission gear 161 moves along the circumference of the fixed gear 105 and rotates by itself, so that the first rotating drive member 16 can be driven, and then the quality control container 14 on the corresponding adapter 15 is driven to rotate through the first rotating drive member 16, thereby achieving the mixing of the corresponding quality control product. Therefore, the first rotating drive member 16 mainly plays the mixing function when the quality control container 14 circulates or is stored in the reagent compartment 1, preventing the quality control product from being stratified and affecting the test results.

[0096] In one embodiment, as shown in the accompanying drawings Figure 2 As shown, a storage slot 104 is provided at the storage position 101, the bottom of the adapter 15 can be accommodated in the storage slot 104, and the first rotation driving member 16 is provided at the bottom of the storage slot 104 and its top can cooperate with the bottom of the quality control container 14, thereby transmitting the rotation driving force. In one embodiment, for the adapter 15 carrying the quality control container 14, the adapter 15 and the storage slot 104 for placing the adapter 15 in the reagent compartment 1 and / or the adapter 15 and the bearing slot 703 for placing the adapter 15 on the reagent loading assembly 7 are relatively fixed by snaps.

[0097] Specifically, no matter whether the sealing cover 141 adopts a sealing screw cover or a sealing plug cover, during the process of opening the cover, the cover opening gripper 701 needs to drive the sealing cover 141 to move in the direction away from the quality control container 14 (i.e. upward), so at this time it is necessary to ensure that the quality control container 14 and the adapter 15 are relatively fixed and the adapter 15 and the placement structure in which it is located are relatively fixed, that is, it is necessary to ensure that the quality control container 14 and the adapter 15 will not be driven to move when the cover opening gripper 701 drives the sealing cover 141. The relative fixation of the quality control container 14 and the adapter 15 can be achieved by the aforementioned limiter 153. The adapter 15 and the placement structure that supports it (i.e., the storage slot 104 of the reagent compartment 1 or the supporting slot 703 of the reagent loading assembly 7) are detachably fixed relative to each other by a buckle. The specific structure of the buckle is not the main improvement point of the utility model, and can refer to the existing design, which will not be repeated here.

[0098] In one embodiment, the quality control container 14 is carried on an adapter 15, and a placement groove 151 is constructed on the adapter 15. The quality control container 14 can be at least partially accommodated in the placement groove 151 and the part where the sealing cover 141 is located is located outside the placement groove 151; wherein, a limiting member 153 is detachably provided at the notch of the placement groove 151 for fixing the quality control container 14 relative to the placement groove 151.

[0099] Specifically, since the standard quality control container 14 is mainly used to hold quality control products, its structure may not be designed for loading and circulation during the detection process. Therefore, the stability of directly using the quality control container 14 for circulation is poor, and it is difficult to meet the needs of interaction with other components. Therefore, an adapter 15 is used to carry the quality control container 14. The adapter 15 can improve the stability of circulation and meet the needs of interaction with other components.

[0100] The structure of the adapter 15 is shown in the accompanying drawings Figure 6 As shown, a placement groove 151 is constructed thereon, and the shape and size of the placement groove 151 match the quality control container 14, but the depth is smaller than the quality control container 14, so that the sealing cover 141 of the quality control container 14 is located outside the placement groove 151, which is convenient for the reagent loading component 7 to open and close the cover. A stopper 153 is provided at the notch of the placement groove 151 for keeping the quality control container 14 and the placement groove 151 relatively fixed, so that the quality control container 14 itself remains stationary and fixed when the reagent loading component 7 opens and closes the cover, which is convenient for the operation of opening and closing the cover.

[0101] In one embodiment, a rotatable drum 152 is embedded in the adapter 15, and the internal space of the drum 152 is configured as a placement slot 151. The bottom of the drum 152 passes through the adapter 15, and the bottom of the drum 152 is closed and provided with a card slot. The card slot can cooperate with a corresponding rotating driving member to drive the drum 152 to rotate, so that the quality control container 14 rotates.

[0102] Specifically, as shown in the attached figure Figure 6 As shown, the adapter 15 is provided with a rotating drum 152, and the internal space of the rotating drum 152 is configured as a placement slot 151. After the quality control container 14 is placed in the placement slot 151, it can be relatively fixed to the rotating drum 152 by a stopper 153. The design of the rotating drum 152 can realize the rotation and mixing of the quality control product by rotation, and realize the opening and closing of the sealing cover 141 (i.e., the sealing rotating cover) of the screw cap type by rotation, and is compatible with the opening and closing cover of the sealing cover 141 (i.e., the sealing plug cover) of the plug cap type, and is also compatible with the opening and closing cover of the sealing cover 141 (i.e., the sealing flip cover) of the flip cap type. The rotation of the drum 152 is achieved by the cooperation between the card slot at the bottom thereof and the corresponding rotating drive member. For example, it can cooperate with the first rotating drive member 16 arranged at the storage position 101 in the reagent chamber 1 for placing the adapter 15. In this way, when the quality control container 14 is placed in the reagent chamber 1 through the adapter 15, the top of the first rotating drive member 16 is inserted into the card slot at the bottom of the drum 152, which can at least achieve real-time rotation and mixing; in addition, the drum 152 can also cooperate with the second rotating drive member 19 arranged at the bearing groove 703 on the bearing seat 702 of the reagent loading assembly 7, that is, the top of the second rotating drive member 19 can be inserted into the card slot at the bottom of the drum 152, so that the quality control container 14 can be driven to rotate by the drum 152, thereby realizing the opening and closing of the sealed screw cover on the reagent loading assembly 7.

[0103] In one embodiment, the limiting member 153 is constructed as an annular structure with a center hole, and the outer peripheral surface of the limiting member 153 is threadedly matched with the inner wall of the placement groove 151; for the quality control container 14 accommodated in the placement groove 151, the part where the sealing cover 141 is located passes through the center hole, and the limiting step 142 constructed at the upper end of the quality control container 14 abuts against the bottom of the limiting member 153.

[0104] Specifically, as shown in the attached figure Figure 6 As shown, the stopper 153 adopts an annular structure with an external thread on the outer circumference, and the placement groove 151 is integrally constructed as a round hole groove matching the cylindrical standard quality control container 14, and the inner wall at the notch of the placement groove 151 is provided with an internal thread, and the stopper 153 can be threadedly matched with the placement groove 151 to achieve a detachable function. When the stopper 153 is assembled in the notch of the placement groove 151, its top is buckled on the notch end face of the placement groove 151, and its bottom is abutted against the stopper step 142 at the upper end of the quality control container 14, thereby achieving the fixation between the quality control container 14 and the placement groove 151.

[0105] In one embodiment, a rectangular incubation tray 501 is disposed next to the reagent chamber 1, and a plurality of incubation holes for placing reaction cups are distributed in an array on the incubation tray 501, and the temperature recovery zone and the incubation zone on the incubation tray 501 are both rectangular areas, and the area of ​​the temperature recovery zone 17 is smaller than that of the incubation zone 18; or, the incubation tray 501 is an annular rotatable structure surrounding the reagent chamber 1, and a plurality of incubation holes for placing reaction cups distributed along the circumferential direction are provided on the annular incubation tray 501, and the incubation tray 501 is divided into a temperature recovery zone 17 and an incubation zone 18 in the circumferential direction.

[0106] Specifically, as shown in the attached figure Figure 1 As shown, the incubation tray 501 can be a ring-shaped rotatable structure surrounding the reagent chamber 1, and the incubation holes are distributed circumferentially on the incubation tray 501. At the same time, the space of the incubation tray 501 is divided into a temperature recovery zone 17 and an incubation zone in the circumferential direction. Preferably, the central angle corresponding to the temperature recovery zone 17 is smaller than the central angle corresponding to the incubation zone 18. As shown in the accompanying drawings Fig. 9 As shown, the incubation tray 501 may also be of a rectangular structure (or other structures), and the incubation holes are distributed in an array on the incubation tray 501 .

[0107] Optionally, as shown in the attached figure Figure 1 As shown, the multiple incubation holes on the annular incubation disk 501 constitute multiple incubation hole groups, each incubation hole group includes multiple incubation holes distributed along the circumferential direction, and the multiple incubation hole groups are distributed along the radial direction of the incubation disk 501. Figure 1 As shown, two incubation well groups are provided, which can be divided into different functional areas to meet corresponding practical needs.

[0108] In one embodiment, the incubation component 5 further includes a first magnetic separation cleaning component 9 and a second magnetic separation cleaning component 10 for cleaning the solution in the reaction cup. The first magnetic separation cleaning component 9, the second magnetic separation cleaning component 10, the reaction cup scheduling component 2 and the detection component 6 are circumferentially distributed around the incubation component 5. A reagent dispensing component 4 for injecting a first reagent is provided between the reaction cup scheduling component 2 and the reagent chamber 1.

[0109] Among them, a first scheduling gripper 11 is arranged between the reaction cup scheduling component 2, the detection component 6 and the incubation component 5, a second scheduling gripper 12 is arranged between the first magnetic separation and cleaning component 9 and the incubation component 5, and a third scheduling gripper 13 is arranged between the second magnetic separation and cleaning component 10 and the incubation component 5.

[0110] Specifically, as shown in the attached figure Figure 1As shown, the sample analyzer is also provided with a separation and cleaning component for cleaning the solution in the reaction cup during the quality control test and the sample test. The cleaning component and other components are arranged around the incubation component 5, wherein the first magnetic separation cleaning component 9 and the second magnetic separation cleaning component 10 are used for the first and second cleaning respectively, for cleaning impurities in the solution. The circulation of the reaction cup between the components is realized by the transfer function of the incubation component 5 itself and in combination with the scheduling gripper.

[0111] In one embodiment, it also includes a second reagent filling component 8 arranged adjacent to the first magnetic separation and cleaning component 9, the second reagent filling component 8 is located within the rotation radius of the second scheduling gripper 12, and a reagent dispensing component 4 is arranged between the second reagent filling component 8 and the reagent chamber 1; wherein, the second reagent filling component 8 is used to place the reaction cup cleaned by the first magnetic separation and cleaning component 9, so that the reagent dispensing component 4 injects the second reagent into the reaction cup.

[0112] Specifically, as shown in the attached figure Figure 1 As shown, according to the test needs, the second reagent filling component 8 is mainly used to cooperate with the reagent dispensing component 4 arranged near it to inject the second reagent into the reaction cup. The reaction cup incubated by the incubation component 5 can be placed in the first magnetic separation cleaning component 9 for the first cleaning by the second scheduling gripper 12, and the reaction cup after the first cleaning can be placed in the second reagent filling component 8, and the second reagent is injected into the reaction cup through the reagent dispensing component 4 on the second reagent filling component 8, and then placed in the incubation component 5 for incubation through the second scheduling gripper 12.

[0113] In one embodiment, the reagent dispensing assembly 4 includes a reagent arm and a dispensing needle disposed on the reagent arm. The reagent arm can drive the dispensing needle to move into the reagent chamber 1 to absorb the reagent or quality control product and can drive the dispensing needle to inject the reagent or quality control product into the reaction cup.

[0114] Specifically, the specific structure of the reagent dispensing component 4 is not shown in the drawings, mainly because it is not the main improvement of the present invention. This embodiment only describes it from the functional perspective, and the specific structural design can refer to the prior art. The reagent dispensing component 4 mainly includes a dispensing needle for absorbing and injecting the corresponding solution and a reagent arm for driving the dispensing needle to perform corresponding actions and transfers.

[0115] In one embodiment, it also includes a sample injection component 3, which includes a sample loading unit and a sample dispensing component. The sample loading unit is used for loading and scheduling samples; the sample dispensing component is arranged between the sample loading unit and the reaction cup scheduling component 2, and is used to absorb the sample and add it to the reaction cup.

[0116] Specifically, the sample loading unit in the sample injection component 3 is used to carry the sample container containing the sample, and the sample dispensing component is used to inject the sample in the sample container into the reaction cup on the reaction cup scheduling component 2. The structure of the sample dispensing component is similar to that of the reagent dispensing component 4. The specific structure can refer to the prior art. The sample injection component 3 is mainly operated when performing sample testing, and the operation of the sample injection component 3 is basically not involved when performing quality control testing.

[0117] In one embodiment, in addition to integrating the rewarming zone 17 into the incubation component 5, the rewarming zone 17 corresponding to the sample analyzer may also be arranged in other ways, including:

[0118] 1. Integrate the temperature recovery zone 17 into the vacant area of ​​other components. Figure 7 As shown in the accompanying drawings Figure 1 The structural design shown can integrate the temperature recovery zone 17 into the reaction cup scheduling component 2. The edge of the scheduling disk of the reaction cup scheduling component 2 is a normal reaction cup scheduling and loading functional area. The temperature recovery zone 17 is designed to be an annular area arranged inside the normal functional area, and a placement hole for placing the reaction cup is further constructed in the temperature recovery zone 17. This method can replace the method of integrating the temperature recovery zone 17 into the incubation component 5, or the two methods can be used at the same time.

[0119] 2. A temperature recovery component is separately provided to form a temperature recovery zone 17. Figure 8 As shown, a temperature recovery component is separately arranged near the reaction cup scheduling component 2 to form a temperature recovery zone 17, and a plurality of temperature recovery placement holes are arranged in the temperature recovery zone 17, so that the reaction cup filled with quality control products on the reaction cup scheduling component 2 can be quickly transferred to the temperature recovery zone 17. At the same time, in order to facilitate the transfer, the temperature recovery zone 17 formed by the temperature recovery component needs to be within the rotation radius of the first scheduling gripper 11 at the reaction cup scheduling component 2. Of course, the temperature recovery component can also be arranged at other available positions as needed, such as within the rotation radius of the second scheduling gripper 12 or the third scheduling gripper 13.

[0120] It should be noted that based on the design of the above components of the sample analyzer, the entire test process of the sample analyzer is roughly as follows, which is divided into a quality control test process and a sample test process:

[0121] 1. Quality control test process:

[0122] (1) The reagent loading component 7 opens the cover of the quality control container 14 in the reagent compartment 1. Depending on the type of the sealing cover 141 of the quality control container 14, the cover can be opened directly in the reagent compartment 1 or the adapter 15 where the quality control container 14 is located can be taken out and opened outside the reagent compartment 1. However, in the end, the opened quality control container 14 needs to be in the reagent compartment 1, and the reagent compartment 1 transfers the opened quality control container 14 to the filling area;

[0123] (2) The reagent dispensing component 4 at the reaction cup scheduling component 2 absorbs the quality control product from the quality control container 14 at the filling area, and then injects it into the reaction cup on the reaction cup scheduling component 2, and then the first scheduling gripper 11 places the reaction cup in the temperature return area 17 for temperature return at a predetermined temperature and a predetermined time; after the quality control product is absorbed, the cover of the quality control container 14 is closed simultaneously;

[0124] (3) After returning to temperature, the reaction cup is transferred back to the reagent dispensing component 4, and the first reagent is sucked from the reagent container in the reagent chamber 1 by the reagent dispensing component 4 at the reaction cup scheduling component 2 and injected into the reaction cup. Then, the reaction cup is placed in the incubation component 5 by the first scheduling gripper 11 for the first incubation at the set temperature and set time.

[0125] (4) After the first incubation is completed, the reaction cup is transferred by the second scheduling gripper 12 to the first magnetic separation cleaning component 9 for cleaning, and then transferred by the second scheduling gripper 12 to the second reagent filling component 8, and the reagent dispensing component 4 at the second reagent filling component 8 draws the second reagent from the reagent container in the reagent chamber 1 and injects it into the reaction cup, and then the second scheduling gripper 12 is used to put the reaction cup into the incubation component 5 for a second incubation at a set temperature and a set time;

[0126] (5) After the second incubation is completed, the reaction cup is transferred by the third scheduling gripper 13 to the second magnetic separation cleaning. After the cleaning is completed, it is transferred by the third scheduling gripper 13 to the incubation component 5. The incubation component 5 transfers the reaction cup to the first scheduling gripper 11. The reaction cup is transferred to the detection component 6 for detection via the first scheduling gripper 11.

[0127] 2. Sample testing process:

[0128] After the injection component 3 injects the sample into the reaction cup on the reaction cup scheduling component 2, the subsequent process can refer to the reagent filling, cleaning and detection process in the aforementioned quality control test process, that is, after the sample is filled, the first reagent filling, the first incubation, the first cleaning, the second reagent filling, the second incubation, the second cleaning and the final detection steps are performed in sequence.

[0129] In addition, although it is said that quality control testing is usually performed before sample testing, this mainly means that the quality control test results need to be performed before the sample test results, because the quality control test results need to be referenced to determine the accuracy of the test, and the quality control test process and the sample test process are two independent processes, so in fact, some processes of the two can be performed at the same time. For example, based on the design of using the incubation tray 501 of the incubation component 5 to warm up the quality control product, the warming temperature of the quality control product can be set to be consistent with the incubation temperature of the sample, so that when the quality control product is warmed up, the sample can also be incubated at the same time.

[0130] Of course, if the temperature of the quality control product has special considerations and cannot be set to be consistent with the incubation temperature of the sample, the temperature of the quality control product can be performed on other components other than the incubation component 5, without affecting the simultaneous performance of some processes of the quality control test and the sample test. In addition, the temperature of the quality control product can also be performed separately in the incubation tray 501, at which time the sample is not incubated, and the temperature of the incubation tray 501 can be adjusted only according to the temperature recovery needs.

[0131] The embodiment of the utility model also provides a sample analysis control method, comprising the following steps:

[0132] S100: The reagent turntable 103 of the reagent chamber 1 is rotated until the target adapter 15 carrying the target quality control container 14 to be opened corresponds to the inlet and outlet of the reagent chamber 1, so that the opening gripper 701 of the reagent loading assembly 7 enters the reagent chamber 1 through the inlet and outlet.

[0133] S200: Use the cover-opening gripper 701 to take out the target adapter 15 and place it on the supporting seat 702 of the reagent loading assembly 7, and open the sealing plug cover or sealing screw cover of the target quality control container 14 on the supporting seat 702, so that the cover-opening gripper 701 places the removed sealing plug cover or sealing screw cover in the cover storage slot 705 of the supporting seat 702, so that the cover-opening gripper 701 grabs the target adapter 15 from the supporting seat 702, and puts the target adapter 15 into the reagent turntable 103 in the reagent compartment 1 through the inlet and outlet;

[0134] Alternatively, the sealing plug cover of the target quality control container 14 is opened by directly clamping the sealing plug cover of the target quality control container 14 in the reagent compartment 1 using the cover opening gripper 701 .

[0135] Specifically, the opening operation of the sealed screw cap can only be performed outside the reagent chamber 1, and the opening operation of the sealed plug cap can be performed outside the reagent chamber 1. Figure 2 As shown, the cover opening gripper 701 places the target adapter 15 in the bearing groove 703 on the bearing seat 702, and performs the cover opening operation of the sealing cover or the sealing plug cover. After the cover opening is completed, the cover opening gripper 701 puts the target adapter 15 back into the reagent turntable 103, and transfers the target adapter 15 to the filling area close to the reagent filling component. The cover opening operation of the sealing plug cover can also be performed directly in the reagent compartment 1, so that the cover opening gripper 701 does not need to be used to take and place the target adapter 15.

[0136] S210: For the sealing plug cover, the cover opening gripper 701 is made to clamp the sealing plug cover and then move in a direction away from the target quality control container 14 to pull out the sealing plug cover.

[0137] S220: For the sealed screw cap, the uncapping gripper 701 is clamped to tighten the sealed screw cap, and the second rotary drive member 19 on the supporting seat 702 is started to drive the rotating drum 152 on the target adapter 15 that accommodates the target quality control container 14 to rotate, and the uncapping gripper 701 is moved in a direction away from the target quality control container 14 to unscrew the sealed screw cap.

[0138] Specifically, as shown in the attached figure Figure 5 As shown, when the opening operation of the sealing plug cover is performed directly in the reagent chamber 1, the opening gripper 701 only needs to reach into the reagent chamber 1 to clamp the sealing plug cover and then pull it out; when the opening operation of the sealing plug cover is performed on the supporting seat 702 outside the reagent chamber 1, the opening gripper 701 needs to reach into the reagent chamber 1 to take out the target adapter 15 and put it into the supporting groove 703 of the supporting seat 702, and then the opening gripper 701 turns to clamp the sealing plug cover and then pull it out, and finally, after the opening gripper 701 places the sealing plug cover in the cover storage groove 705, the opening gripper 701 puts the target adapter 15 back into the reagent turntable 103.

[0139] As shown in the attached picture Figure 5 and Figure 6 As shown, when the opening operation of the sealed screw cap is performed on the supporting seat 702 outside the reagent chamber 1, the opening gripper 701 needs to extend into the reagent chamber 1 to take out the target adapter 15 and put it into the supporting slot 703 of the supporting seat 702, and then the opening gripper 701 turns to clamp the sealed screw cap, while the second rotating drive member 19 in the supporting slot 703 drives the rotating cylinder 152 accommodating the target quality control container 14 to rotate, the opening gripper 701 drives the sealed screw cap to move outward to unscrew the sealed screw cap, and finally, after the opening gripper 701 places the sealed screw cap in the cap storage slot 705, the opening gripper 701 puts the target adapter 15 back into the reagent turntable 103.

[0140] S300 : placing the target adapter 15 on the reagent turntable 103 and rotating the reagent turntable 103 until the target adapter 15 corresponds to the dispensing port of the reagent chamber 1 , that is, corresponds to the reagent dispensing component 4 at the reaction cup scheduling component 2 .

[0141] S400 : The reagent dispensing component 4 is used to absorb the control product in the opened target control container 14 on the target adapter 15 from the dispensing port, and the control product is injected into the cuvette loaded on the cuvette scheduling component 2 .

[0142] S500: using the reaction cup scheduling component 2 and / or the corresponding gripper component to transfer the reaction cup to the temperature recovery zone 17 for temperature recovery at a predetermined temperature and for a predetermined time, and after temperature recovery, the reaction cup enters the subsequent reagent filling and detection process.

[0143] S510: Use the first dispatching gripper 11 to place the reaction cup filled with the quality control product into the temperature recovery zone 17 on the incubation tray 501 of the incubation component 5 for temperature recovery, then use the first dispatching gripper 11 to place the reaction cup after the temperature recovery back into the reaction cup dispatching component 2, so that the reagent dispensing component 4 injects the first reagent into the reaction cup, and then use the first dispatching gripper 11 to dispatch the reaction cup to the incubation component 5 for incubation.

[0144] S520: The incubation tray 501 transfers the incubated reaction cup to the second scheduling gripper 12, and uses the second scheduling gripper 12 to transfer the reaction cup to the first magnetic separation cleaning component 9 for cleaning and to the second reagent filling component 8 so that the reagent dispensing component 4 injects the second reagent into the reaction cup, and then uses the second scheduling gripper 12 to transfer the reaction cup to the incubation component 5 for incubation.

[0145] S530: The incubation tray 501 transfers the incubated cuvette to the third scheduling gripper 13 , and uses the third scheduling gripper 13 to transfer the cuvette to the second magnetic separation and cleaning component 10 for cleaning, and then the third scheduling gripper 13 transfers the cuvette to the incubation tray 501 .

[0146] S540: The incubation tray 501 transfers the reaction cup after the second cleaning to the first scheduling gripper 11, and uses the first scheduling gripper 11 to transfer the reaction cup to the detection component 6 for detection to obtain the detection result of the quality control test.

[0147] Specifically, as shown in the attached figure Figure 1 As shown, the reaction cup is loaded from the reaction cup loading position 204 of the scheduling disk of the reaction cup scheduling component 2, and the scheduling disk schedules the reaction cup to the first reagent filling position 202. The quality control product in the opened target quality control container 14 in the reagent compartment 1 is taken out by the reagent dispensing component 4, and the quality control product is added to the reaction cup at the first reagent filling position 202. Then the reaction cup is rotated to the reaction cup placement position 203 by the scheduling disk, and the reaction cup is grabbed into the first incubation hole 502 of the incubation disk 501 of the incubation component 5 by the first scheduling gripper 11 and rotated to a certain position, and the incubation temperature and incubation time (i.e., the temperature and time) are set according to the ambient temperature, as shown in the accompanying drawings. Fig.10 shown.

[0148] After the set incubation time is reached, the incubation tray 501 cooperates with the first scheduling gripper 11 to schedule the reaction cup to the reaction cup pick-up and placement position 203. The scheduling tray schedules the warmed reaction cup to the first reagent filling position 202, and the reagent dispensing component 4 fills the first reagent into it. The cup is then scheduled to the reaction cup pick-up and placement position 203, taken away by the first scheduling gripper 11 and placed in the first incubation hole 502 of the incubation tray 501.

[0149] After the incubation time is reached, the incubation tray 501 cooperates with the second scheduling gripper 12 to take out the reaction cup from the third incubation hole 504 and place it in the first magnetic separation cleaning component 9 for cleaning. After cleaning, the second scheduling gripper 12 takes it out and places it in the transfer position 801 of the second reagent filling component 8. The second reagent filling component 8 schedules the reaction cup to the second reagent filling position 802, where the reagent dispensing component 4 fills the second reagent into it. Then the second reagent filling component 8 rotates the reaction cup to the transfer position 801, and the second scheduling gripper 12 takes out the reaction cup and places it in the fourth incubation hole 505 of the incubation tray 501 for incubation.

[0150] After the incubation time is reached, the incubation tray 501 cooperates with the third scheduling gripper 13 to take out the reaction cup from the fifth incubation hole 506 and place it in the second magnetic separation cleaning component 10 for a second cleaning. After the cleaning is completed, the third scheduling gripper 13 takes out the reaction cup and places it in a hole near the fifth incubation hole 506, and enables the incubation tray 501 to schedule the reaction cup to the second incubation hole 503, and the first scheduling gripper 11 takes out the reaction cup and places it in the detection component 6 for detection.

[0151] During this process, the quality control products first complete the warming process at a fixed temperature and fixed time, which can ensure the normal progress of the quality control test and obtain the quality control test results normally; the warming temperature and warming time of different quality control products can be set differently. Since the quality control products are placed in a stable constant temperature environment during the warming and incubation process, even if the external environment of the test site is different, the warming temperature and warming quality of the quality control products can be guaranteed to be consistent, ensuring the consistency and accuracy of the quality control test results.

[0152] S600: Compare the quality control results with the preset target value and standard deviation. If the comparison results meet the requirements, the quality control test is completed. If not, the preset number of quality control tests are repeated according to the preset plan. For different types of quality control tests, the test start time, preset target value, standard deviation and number of repeated rounds can be set specifically.

[0153] It should be noted that the above steps are mainly for quality control testing, and the process of sample testing is similar to that of quality control testing, except that the filling and warming of quality control products are not required, and are replaced by the sample filling process, that is, the reaction cup is loaded from the reaction cup loading position 204 of the scheduling disk of the reaction cup scheduling component 2, and then the scheduling disk schedules the reaction cup to the sample filling position 201. The steps and sequence of the reagent filling process, incubation process, cleaning process and detection process subsequent to the sample test are the same as those of the quality control test, and will not be repeated here.

[0154] In addition, since the sample test and quality control test processes are carried out independently, some steps of the process can be carried out at the same time, but the specific operations of the two test processes at the same component need to be carried out crosswise. Fig.11 As shown, since the sample filling, quality control filling and first reagent filling are all performed on the reaction cup scheduling component 2, there may be conflicts at the same time, so the local corresponding step operations may need to be performed back and forth. Fig.11 As shown, at the beginning of the quality control test, the quality control product needs to be added to the reaction cup scheduling component 2, so the sample filling operation that may be performed at this time needs to be suspended (quality control first), and then the quality control product filling is completed and transferred; after the quality control product is heated up (i.e. Fig.11 After the incubation shown in the figure, it is necessary to return to the reaction cup scheduling component 2 to add the first reagent. At this time, the sample filling operation and the first reagent filling operation of the sample need to be suspended (quality control first) and then proceed after the first reagent filling of the quality control product is completed and transferred.

[0155] In one embodiment, after or at the same time as the quality control product is sucked and injected into the cuvette loaded on the cuvette scheduling component 2, the following cover closing step can also be performed synchronously:

[0156] S001: The reagent turntable 103 is rotated in the reverse direction until the target adapter 15 corresponds to the inlet and outlet again.

[0157] S002: Use the cover-opening gripper 701 to take out the target adapter 15 and place it on the supporting seat 702, use the cover-opening gripper 701 to re-cover the removed sealing plug cover or sealing screw cover on the target quality control container 14 on the target adapter 15, and then put the target adapter 15 into the reagent compartment 1 through the inlet and outlet; or

[0158] The cover opening gripper 701 is used to re-close the sealing plug cover it holds on the target quality control container 14 on the target adapter 15 in the reagent compartment 1 .

[0159] In the description of the present invention, it should be understood that the terms "upper", "lower", "bottom", "top", "front", "back", "inside", "outside", "left", "right", etc., indicating directions or positional relationships, are based on the directions or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore should not be understood as a limitation on the present invention.

[0160] Although the present invention is described herein with reference to specific embodiments, it should be understood that these embodiments are merely examples of the principles and applications of the present invention. It should therefore be understood that many modifications may be made to the exemplary embodiments, and other arrangements may be designed without departing from the spirit and scope of the present invention as defined by the appended claims. It should be understood that the features described in the various dependent claims and herein may be combined in a manner different from that described in the original claims. It may also be understood that the features described in conjunction with the individual embodiments may be used in other described embodiments.

Claims

1. A sample analyzer, characterized in that: include: A reagent warehouse, which is used for refrigerated storage and dispatch of reagents and quality control products, wherein the quality control products are contained in quality control containers with sealed lids; A reaction cup scheduling component, which is used for loading and scheduling reaction cups; A reagent dispensing component, which is used to draw the reagent or the quality control product from the quality control container in the reagent compartment and inject it into the reaction cup; An incubation component, wherein a temperature return zone and an incubation zone are formed on an incubation plate of a rectangular fixed structure, wherein the temperature return zone is used to provide a temperature return environment at a set temperature for the quality control product in the reaction cup, and the incubation zone is used to provide an incubation environment at a set temperature for the object in the reaction cup, wherein the object includes a mixed solution formed by mixing reagents with quality control products or samples; A detection component, which is used to analyze and measure the mixed solution after the incubation; as well as The reagent loading component is used to load the reagent from outside the instrument into the reagent chamber, or to dispatch and take out the reagent kit in the reagent chamber; the reagent loading component is also used to move the sealing cover of the quality control container upward or downward relative to the quality control container.

2. The sample analyzer according to claim 1, characterized in that: The temperature return zone is provided with a plurality of temperature return positions, each of which is provided with a placement hole, and the placement hole is used for placing a reaction cup containing a quality control product.

3. The sample analyzer according to claim 1, characterized in that: The temperature regeneration zone is provided with a temperature control unit for providing a set temperature, the temperature control unit includes at least one temperature control unit, and each of the temperature control units corresponds to at least one temperature regeneration position of the temperature regeneration zone; The temperature control unit can provide a set temperature of a corresponding value for the corresponding temperature return position, and the temperatures of different temperature control units are independently controlled.

4. The sample analyzer according to claim 3, characterized in that: A heat preservation unit is arranged in the temperature recovery zone, and the heat preservation unit covers other positions of the temperature control unit except the position corresponding to the temperature recovery position, so as to prevent heat dissipation and keep the temperature control unit warm.

5. The sample analyzer according to claim 1, characterized in that: The reagent loading component can extend into the reagent compartment to directly open or close the sealing cover of the corresponding quality control container; or the reagent loading component can grab the corresponding quality control container from the reagent compartment to open or close the sealing cover, and can put the quality control container with the cover opened or closed back into the reagent compartment.

6. The sample analyzer according to claim 5, characterized in that: The sealing cover is a sealing plug cover that is interference-fitted at the mouth of the quality control container; The reagent loading assembly includes a liftable loading gripper disposed above the reagent chamber, and the loading gripper can pass through the inlet and outlet of the reagent chamber and enter the reagent chamber to clamp and pull out the sealing plug cover of the corresponding quality control container or press the pulled out sealing plug cover into the quality control container.

7. The sample analyzer according to claim 5, characterized in that: The sealing cover is a sealing plug cover that is interference-fitted at the mouth of the quality control container or a sealing screw cover that is threadably fitted at the mouth of the quality control container; The reagent loading assembly includes a bearing seat and a lifting and lowering loading gripper both disposed above the reagent compartment, the loading gripper can pass through the inlet and outlet of the reagent compartment and enter the reagent compartment to grab the corresponding quality control container, and the bearing seat is provided with a bearing slot for placing an adapter for carrying the quality control container; Among them, the loading gripper can clamp the sealing plug cover or the sealing screw cap of the quality control container after placing the adapter in the carrying groove; the bottom of the carrying groove is provided with a second rotating drive component that can drive the quality control container to rotate, so that the sealing screw cap and the quality control container rotate relative to each other.

8. The sample analyzer according to claim 7, characterized in that: The bearing seat is provided with a cover storage groove adjacent to the bearing groove, and the cover storage groove is used for the loading gripper to place the sealing cover removed from the quality control container.

9. The sample analyzer according to claim 8, characterized in that: A relatively protruding support portion is configured on the groove wall of the cover storage groove, a plurality of the support portions are spaced apart along the circumferential direction, and a support step for supporting the sealing cover is formed at the top of the plurality of the support portions, and the height of the support step is lower than the notch of the cover storage groove; Wherein, a drainage groove extending along the depth direction of the cover storage groove is formed between two adjacent support parts, and the drainage groove is used to guide the residual liquid on the sealing cover to flow to the bottom of the cover storage groove.

10. The sample analyzer according to claim 7, characterized in that: The reagent loading assembly also includes a linear translation mechanism, and the supporting seat is movably arranged on the linear translation mechanism to move to correspond to or stagger with the loading gripper under the drive of the linear translation mechanism.

11. The sample analyzer according to claim 7, characterized in that: For the adapter that carries the quality control container, the adapter and the storage slot in the reagent compartment for placing the adapter and / or the adapter and the carrying slot on the reagent loading assembly for placing the adapter are relatively fixed by snaps.

12. The sample analyzer according to any one of claims 1 to 11, characterized in that: The quality control container is carried on an adapter, and a placement groove is configured on the adapter. The quality control container can be at least partially accommodated in the placement groove and the portion where the sealing cover is located is located outside the placement groove; Wherein, a limiting member for fixing the quality control container relative to the placement slot is detachably provided at the slot opening of the placement slot.

13. The sample analyzer according to claim 12, characterized in that: A rotatable drum is embedded in the adapter, and the internal space of the drum is configured as the placement slot. The bottom of the drum passes through the adapter and is closed and provided with a card slot. The card slot can cooperate with a corresponding rotating drive member to drive the drum to rotate, thereby driving the quality control container to rotate.

14. The sample analyzer according to claim 12, characterized in that: The limiting member is constructed as an annular structure with a central hole, and the outer peripheral surface of the limiting member is threadedly matched with the inner wall of the placement groove; For the quality control container accommodated in the placement groove, the portion where the sealing cover is located passes through the central hole, and the limiting step constructed on the upper end of the quality control container abuts against the bottom of the limiting member.

15. The sample analyzer according to claim 1, characterized in that: The reagent dispensing assembly includes a reagent arm and a dispensing needle arranged on the reagent arm. The reagent arm can drive the dispensing needle to move into the reagent chamber to absorb the reagent or the quality control product, and can drive the dispensing needle to inject the reagent or the quality control product into the reaction cup.

Images