Experimental animal nose instillation administration gaseous anesthesia auxiliary device
By designing a gas anesthesia auxiliary device for nasal infusion delivery of experimental animals including an anesthesia gas supply mechanism, anesthesia box and a drip infusion mechanism, the problem of insufficient anesthesia time and excessive anesthesia during the drip infusion process was solved, and the continuous anesthesia and rapid awakening of experimental animals during the drip infusion process was achieved, and the success rate of experiments was improved.
Patent Information
- Application Number
- CN202420908746.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-04-28
- Publication Date
- 2025-03-25
- Estimated Expiration
- 2034-04-28
AI Technical Summary
The existing gas anesthesia method can easily lead to insufficient anesthesia time or ineffective anesthesia during the nasal infusion of experimental animals, and excessive anesthesia will cause irreversible damage to experimental animals and affect the success rate of the experiment.
Design an anesthesia assistive device for nasal infusion delivery gas in experimental animals, including an anesthetic gas supply mechanism, anesthesia box and a drip mechanism. An anesthetic gas is continuously introduced into the anesthetic cover through the anesthetic gas supply mechanism to ensure that the experimental animals maintain a continuous anesthetic state during the drip process.
Through continuous low doses of anesthetic gas supply, ensure that the experimental animals are in anesthesia state throughout the instillation process, avoid anesthesia failure, and use a lower anesthetic dose to reduce the harm to the experimental animals and improve the success rate of the experiment.
Smart Images
Figure CN222657259U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of experimental tools, in particular to a gas anesthesia auxiliary device for nasal drip medication of experimental animals. Background Art
[0002] Rats, mice, rabbits, monkeys, etc. are often used as experimental animals in medical research in experiments in medicine, physiology, pharmacology, pathology, pathophysiology and other disciplines. For example, when establishing an asthma model, it is necessary to perform nasal instillation on experimental animals to achieve multiple nasal drug administration. During the multiple drug instillation process, gas anesthesia is generally used (intraperitoneal injection of liquid anesthesia has a long anesthesia time and great harm to experimental animals; and it is easy to cause excessive anesthesia dosage to cause anesthesia death of experimental animals; and each anesthesia uses intraperitoneal injection with a wound, and multiple anesthesia increases the risk of infection and the risk of death due to improper injection) to ensure that the experimental animals are in a controllable (anesthesia time is controllable, and experimental animals wake up quickly after leaving gas anesthesia inhalation. Compared with liquid anesthesia, there is no wound, no risk, little harm to experimental animals, and multiple anesthesia causes minimal harm to experimental animals) sedation state. The existing drug administration operation usually performs an instillation operation on experimental animals after gas anesthesia. However, with this anesthesia method, the anesthesia time is often insufficient, and the anesthesia of the experimental animals fails during the instillation process. Excessive anesthesia before instillation will cause irreversible damage to the experimental animals, thereby affecting the success rate of the experiment. Summary of the invention
[0003] The utility model aims to solve at least one of the technical problems mentioned above and provides a gas anesthesia auxiliary device for nasal instillation of drug administration for experimental animals, which can continuously anesthetize the experimental animals at a low dose during the nasal instillation of the experimental animals to ensure that the experimental animals are in an anesthetized state during the entire instillation process and will not cause harm to the experimental animals.
[0004] In order to achieve the above-mentioned purpose, the technical solution adopted by the utility model is: a gas anesthesia auxiliary device for nasal drip administration of experimental animals, including an anesthetic gas supply mechanism, an anesthesia box and a drip mechanism, the anesthesia box has an air inlet and an air outlet, the air inlet and the air outlet are respectively connected to the anesthetic gas supply mechanism through an air inlet pipeline and an air outlet pipeline, the drip mechanism includes a mounting seat and an anesthesia mask, the anesthesia mask is arranged on the mounting seat and is connected to the anesthetic gas supply mechanism through an air supply pipeline, a hanging line for hanging the experimental animal is arranged in the anesthesia mask, and a drip hole is also opened on the anesthesia mask.
[0005] Preferably, the mounting seat includes a base and a mounting frame vertically arranged on the base, and the anesthesia mask is arranged on the mounting frame.
[0006] Preferably, the anesthesia mask is connected to a slider, which is slidably matched with the mounting frame and can be adjusted up and down relative to the mounting frame.
[0007] Preferably, a fixing block is provided on the mounting frame, and a slot for connecting with the air supply pipeline is provided on the fixing block.
[0008] Preferably, the anesthesia mask is funnel-shaped with a small upper portion and a large lower portion.
[0009] Preferably, the suspension wire is a metal wire.
[0010] Preferably, the anesthesia mask is provided with a mounting hole for mounting a hanging wire.
[0011] The beneficial effect is as follows: compared with the prior art, the utility model provides an experimental animal nasal drip drug administration gas anesthesia auxiliary device by setting an anesthesia box and a drip mechanism connected to an anesthetic gas supply mechanism, and can provide anesthetic gas to the anesthesia box and the drip mechanism through the anesthetic gas supply mechanism. Before dripping, the experimental animal is preliminarily anesthetized in the anesthesia box, and then the incisors of the experimental animal are matched with the hanging wire to hang the head of the experimental animal in the anesthesia mask, and finally the drip operation is performed on the experimental animal in the anesthesia mask through the drip hole. During the entire drip process, anesthetic gas is continuously introduced into the anesthesia mask through the anesthetic gas supply mechanism, so that the experimental animal can maintain a state of continuous anesthesia during the drip process to prevent the occurrence of anesthesia failure, and because the experimental animal is continuously anesthetized by using anesthetic gas during the drip process, a lower anesthetic dose can be used, so that the experimental animal can quickly wake up after the drip is completed, thereby effectively avoiding damage to the body of the experimental animal to ensure the success rate of the experiment. BRIEF DESCRIPTION OF THE DRAWINGS
[0012] The specific implementation of the utility model is further described in detail below with reference to the accompanying drawings, wherein:
[0013] Figure 1 This is a schematic diagram of the structure of a gas anesthesia auxiliary device for nasal instillation of drug administration for experimental animals according to the utility model;
[0014] Figure 2 This is a schematic diagram of the structure of the anesthesia mask. DETAILED DESCRIPTION
[0015] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.
[0016] It should be noted that when a component is referred to as being "fixed to" another component, it may be directly on the other component or there may be a central component. When a component is considered to be "connected to" another component, it may be directly connected to the other component or there may be a central component at the same time. When a component is considered to be "set on" another component, it may be directly set on the other component or there may be a central component at the same time. When a component is referred to as being "set in the middle", it does not only mean being set in the middle, as long as it is not set at both ends within the range defined by the middle. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only.
[0017] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.
[0018] like Figure 1 and Figure 2 As shown, the present application discloses a gas anesthesia auxiliary device for nasal drip administration of experimental animals, including an anesthetic gas supply mechanism 1, an anesthesia box 2 and a drip mechanism 3. It should be noted that the anesthetic gas supply mechanism 1 commonly used in the present application is an existing structure, for example, the existing VMR small animal anesthesia machine on the market can be used, the anesthesia box 2 has an air inlet and an air outlet, the air inlet and the air outlet are respectively connected to the anesthetic gas supply mechanism 1 through an air inlet pipeline 4 and an air outlet pipeline 5, and a cover that can be opened and closed is provided on the top of the anesthesia box 2 to facilitate placing the experimental animal in the anesthesia box 2 or taking the experimental animal out of the anesthesia box 2. The drip mechanism 3 includes a mounting seat 6 and an anesthesia cover 7, the anesthesia cover 7 is arranged on the mounting seat 6, and is connected to the anesthetic gas supply mechanism 1 through an air supply pipeline 8, a hanging line 9 for hanging the experimental animal is provided in the anesthesia cover 7, and a drip hole 10 is also provided on the anesthesia cover 7.
[0019] The utility model is a gas anesthesia auxiliary device for nasal drip administration of experimental animals. By setting an anesthesia box 2 and a drip mechanism 3 connected to an anesthetic gas supply mechanism 1, anesthetic gas can be provided to the anesthesia box 2 and the drip mechanism 3 through the anesthetic gas supply mechanism 1. Before dripping, the experimental animal is preliminarily anesthetized in the anesthesia box 2, and then the incisors of the experimental animal are matched with the hanging wire 9 to hang the head of the experimental animal in the anesthesia cover 7. Finally, the drip operation is performed on the experimental animal in the anesthesia cover 7 through the drip hole 10. During the entire drip process, anesthetic gas is continuously introduced into the anesthesia cover 7 through the anesthetic gas supply mechanism 1, so that the experimental animal can maintain a state of continuous anesthesia during the drip process to prevent the occurrence of anesthesia failure. In addition, since the experimental animal is continuously anesthetized by using anesthetic gas during the drip process, a lower anesthetic dose can be used, so that the experimental animal can quickly wake up after the drip is completed, thereby effectively avoiding damage to the body of the experimental animal to ensure the success rate of the experiment.
[0020] In one specific embodiment of the present application, the mounting seat 6 may include a base 11 and a mounting frame 12 vertically arranged on the base 11, and the anesthesia mask 7 is arranged on the mounting frame 12. The base 11 can be flat and the mounting frame 12 can be tubular, and the bottom end is vertically fixed to the base 11.
[0021] Furthermore, the outer wall of the anesthesia mask 7 can be connected to a slider 13, which is slidably matched with the mounting frame 12 and can be adjusted up and down relative to the mounting frame 12, so that the installation height of the anesthesia mask 7 can be adjusted as needed, and anesthesia masks 7 of different sizes can be replaced, thereby being suitable for experimental animals of different sizes. Specifically, the slider 13 is provided with a sliding hole that is slidably matched with the mounting frame 12, and the slider 13 is also provided with an adjusting bolt, and the end of the adjusting bolt can extend into the sliding hole. After the installation height of the sliding hole is adjusted, the end of the adjusting bolt is abutted against the mounting frame 12 by tightening the adjusting bolt, thereby locking the sliding hole on the mounting frame 12.
[0022] In another specific embodiment of the present application, a fixing block 14 may be provided on the mounting frame 12, and a card slot for engaging with the air supply pipeline 8 may be provided on the fixing block 14. When the height of the anesthesia mask 7 is adjusted and fixed, the air supply pipeline 8 may be engaged and fixed to the fixing block 14 through the card slot, thereby improving the stability of the installation of the air supply pipeline 8.
[0023] In one preferred embodiment of the present application, the anesthesia mask 7 is funnel-shaped with a small upper portion and a large lower portion, and the upper portion of the anesthesia mask 7 is connected to the air supply pipeline 8. By adopting the funnel-shaped anesthesia mask 7, it is convenient to insert the head of the experimental animal into the anesthesia mask 7 from the bottom of the anesthesia mask 7 and hang the experimental animal on the hanging line 9.
[0024] Furthermore, in order to reduce the wear of the suspension wire 9 by the teeth of the experimental animals, the suspension wire 9 can be made of metal wire, such as steel wire, copper wire, etc.
[0025] Furthermore, the anesthesia mask 7 may be provided with mounting holes 15 for mounting the suspension wires 9 , and two mounting holes 15 are symmetrically arranged on both sides of the anesthesia mask 7 to facilitate the installation of the suspension wires 9 .
[0026] The above embodiments are only used to illustrate the technical solution of the utility model but not to limit it. Any modification or equivalent substitution that does not deviate from the spirit and scope of the utility model shall be included in the scope of the technical solution of the utility model.
Claims
1. A gas anesthesia assisting device for nasal instillation of drug delivery to experimental animals, characterized in that: The invention comprises an anesthetic gas supply mechanism (1), an anesthetic box (2) and a drip mechanism (3). The anesthetic box (2) has an air inlet and an air outlet, the air inlet and the air outlet are connected to the anesthetic gas supply mechanism (1) via an air inlet pipeline (4) and an air outlet pipeline (5) respectively. The drip mechanism (3) comprises a mounting seat (6) and an anesthetic mask (7). The anesthetic mask (7) is arranged on the mounting seat (6) and is connected to the anesthetic gas supply mechanism (1) via an air supply pipeline (8). A hanging line (9) for hanging an experimental animal is arranged inside the anesthetic mask (7), and a drip hole (10) is also provided on the anesthetic mask (7).
2. The gas anesthesia auxiliary device for nasal instillation of drug delivery to experimental animals according to claim 1, characterized in that: The mounting seat (6) comprises a base (11) and a mounting frame (12) vertically arranged on the base (11), and the anesthesia mask (7) is arranged on the mounting frame (12).
3. The gas anesthesia auxiliary device for nasal instillation of drug delivery to experimental animals according to claim 2, characterized in that: The anesthesia mask (7) is connected to a slider (13), which is slidably matched with the mounting frame (12) and can be adjusted up and down relative to the mounting frame (12).
4. The gas anesthesia auxiliary device for nasal instillation of drug delivery to experimental animals according to claim 2, characterized in that: The mounting frame (12) is provided with a fixing block (14), and the fixing block (14) is provided with a slot for being connected with the air supply pipeline (8).
5. The gas anesthesia auxiliary device for nasal instillation of drug delivery to experimental animals according to claim 1, characterized in that: The anesthesia mask (7) is in the shape of a funnel with a small upper portion and a large lower portion.
6. The gas anesthesia auxiliary device for nasal instillation of drug delivery to experimental animals according to claim 1, characterized in that: The suspension wire (9) is a metal wire.
7. The gas anesthesia auxiliary device for nasal instillation of drug delivery to experimental animals according to claim 1, characterized in that: The anesthesia mask (7) is provided with a mounting hole (15) for mounting a suspension wire (9).