Kit for rapidly detecting hypertension individualized medication gene polymorphism

Abstract

The utility model relates to the technical field of kits, in particular to a kit for rapidly detecting hypertension individualized medication gene polymorphism, which comprises a kit body, a placing seat, a buffer device and an automatic opening and closing device, the top wall of the kit body is provided with a kit cover through the automatic opening and closing device, and the automatic opening and closing device comprises a threaded rod, a sliding block and a driving motor. A first fixing block and a second fixing block are fixedly installed on the front side and the rear side of the top wall of the kit body respectively, a threaded rod drives a sliding block to linearly move in a first groove body in the rotating process, the sliding block drives a kit cover to move till the kit cover completely covers the kit body, automatic closing of the kit body is achieved, the sealing performance of the kit can be better guaranteed, and the kit is convenient to use. The kit is simple in structure and convenient to use, pollution of the external environment to samples in the kit is avoided, the detection accuracy and reliability are improved, in addition, sample leakage or pollution caused by manual misoperation can be avoided through the automatically-closed kit cover, and the safety of experimenters is guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field of kits, in particular to a kit for rapidly detecting gene polymorphism of hypertension individualized medication. Background Art

[0002] As we all know, the number of patients with hypertension in my country is as high as hundreds of millions, and the incidence rate is still on the rise. The complications caused by hypertension have become the second leading cause of death in my country. At present, controlling blood pressure through drug therapy to reduce complications of hypertension has become the main treatment for hypertension. However, it is very common for individual responses to drugs for the treatment of hypertension to vary clinically, and 20-50% of patients receiving drug treatment do not have good blood pressure control. Research progress in pharmacogenetics and pharmacogenomics has shown that genetic variations in drug-metabolizing enzymes, transporters, and receptors (drug targets) are the main reasons for individual differences in drug response. Identifying susceptibility genes or pathogenic genes associated with hypertension or high blood pressure through genetic testing, screening for susceptibility genes that increase the risk of disease in the population to determine susceptible individuals will help predict the risk of hypertension, develop new drugs, diagnose, and treat individualized diseases. In order to facilitate the detection and assessment of hypertension risk, a human hypertension risk gene polymorphism detection kit was used for detection. The human hypertension risk gene polymorphism detection kit includes a kit consisting of a PCR premixed reaction solution for amplifying CYP2C9, CYP2D6, ADRB1, AGTR1 and ACE5 gene polymorphisms related to human hypertension risk, a positive control and a negative control. Among them, the kit is a common box used to hold chemical reagents for detecting chemical components, drug residues, virus types, etc.

[0003] When the existing rapid detection kit for personalized hypertension genetic polymorphism is in use, the lid of the box cannot be opened and closed automatically after the reagent is placed. The failure of the lid to be opened and closed automatically may affect the sealing of the kit, and pollutants or microorganisms in the external environment may enter the kit and contaminate the sample, thereby affecting the accuracy of the test results. In addition, the general kit has poor shock resistance. When the kit is hit or accidentally dropped during use, the reagents inside the kit are easily damaged by severe vibration. Utility Model Content

[0004] 1. Technical issues to be resolved

[0005] In view of the deficiencies of the prior art, the utility model provides a kit for rapidly detecting gene polymorphisms for individualized medication of hypertension.

[0006] (II) Technical solution

[0007] To achieve the above-mentioned purpose, the utility model provides the following technical solutions: a kit for rapid detection of gene polymorphism for personalized medication of hypertension, comprising a box body, a placement seat, a buffer device and an automatic opening and closing device, the top wall of the box body is installed with a box cover through the automatic opening and closing device, the automatic opening and closing device comprises a threaded rod, a slider and a driving motor, the front and rear sides of the top wall of the box body are respectively fixedly installed with a first fixed block and a second fixed block, the first fixed block and the second fixed block are respectively provided with a first groove body and a second groove body on the corresponding sides, the threaded rod is rotatably installed in the first groove body, the slider is threadedly connected to the threaded rod, the side of the slider away from the first groove body is fixedly connected to one end side wall of the box cover, the driving motor is installed at one end of the threaded rod, the placement seat is installed with the inner cavity of the box body through the buffer device, and the top wall of the placement seat is provided with a plurality of evenly arranged placement grooves.

[0008] In order to prevent the placement seat from being damaged by collision due to severe vibration, the utility model is improved in that the buffer device includes a fixed rod, a moving block, a first spring, a damper and a connecting rod, and rectangular grooves are opened at the bottom of the left and right side walls of the box body, and the fixed rod is installed in the rectangular groove. The moving block is slidably installed on the fixed rod, and two groups of first springs located on the left and right sides of the moving block are sleeved on the fixed rod, and a damper is installed on the side of the moving block away from the rectangular groove, and the end of the damper away from the moving block is hingedly connected to a connecting rod, and the other end of the connecting rod is hingedly connected to the bottom wall of the placement seat.

[0009] Preferably, the utility model is improved in that the bottom wall of the placement seat is connected to the bottom wall of the box body via a second spring.

[0010] Preferably, the utility model is improved in that the side wall of the placement seat is connected to the side wall of the box body via a third spring.

[0011] In order to position one end of the box body, the utility model is improved in that a third fixing block is installed on the top wall of one end of the box body, and a positioning groove is opened on the third fixing block, and the positioning groove is adapted to the left end of the box cover.

[0012] In order to limit the position of the box cover, the utility model has an improvement in that a baffle is installed at one end of the box cover away from the third fixing block, and the baffle is higher than the box cover and has a semi-cylindrical design.

[0013] In order to ensure the sealing of the other end of the box cover, the utility model is improved in that a sealing strip is installed on the side wall of the baffle close to the box body, and a sealing groove is opened on the side wall of the box body close to the baffle, and the sealing strip is adapted to the sealing groove.

[0014] In order to guide the movement of the box cover, the utility model has an improvement in that a guide rod is fixedly installed in the second groove body, a sleeve is slidably installed on the guide rod, and the side of the sleeve away from the second fixed block is fixedly connected to the side wall of the box cover.

[0015] (III) Beneficial effects

[0016] Compared with the prior art, the utility model provides a rapid detection kit for hypertension individualized medication gene polymorphism, which has the following beneficial effects:

[0017] The rapid detection kit for genetic polymorphism of personalized hypertension medication can automatically open and close the box cover by means of an automatic opening and closing device, and can also avoid sample leakage or contamination caused by human operating errors, thereby ensuring the safety of experimenters. The box cover does not need to be opened or closed manually by the user, which simplifies the operation steps, making it more convenient and quick for users to use the kit. It can also ensure that the kit always remains in a well-sealed state during transportation, storage and use, avoiding contamination of the sample in the kit by the external environment, ensuring the quality of the sample and the accuracy of the test results, and improving the safety of the experiment.

[0018] The rapid detection kit for personalized hypertension gene polymorphism can minimize the impact of external forces such as bumps and vibrations during transportation or storage by means of a buffer device, so that the box body has a buffering and shock-absorbing function. The kit can better protect the internal samples and reagents, prevent damage or leakage caused by external forces, ensure the integrity and stability of samples and reagents, and reduce the impact of external factors on samples and reagents to a certain extent, thereby improving the accuracy and reliability of the test results and reducing the possibility of reagent damage.

[0019] The kit for rapid detection of gene polymorphism for personalized medication of hypertension has a positioning groove, a baffle, a sealing groove and a sealing strip, so that when the box cover moves to close automatically, one end of the box cover enters the positioning groove, and the baffle at the other end of the box cover drives the sealing strip to enter the sealing groove, so as to seal the other end of the box cover, thereby preventing the external environment from affecting the placement environment inside the box body and sealing the box body. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the three-dimensional structure of the utility model from a first angle;

[0021] Figure 2 This is a schematic diagram of the three-dimensional structure of the utility model from a second angle;

[0022] Figure 3 For the utility model Figure 2 A schematic diagram of the structure at the local A of the enlarged part;

[0023] Figure 4 This is a schematic diagram of a half-cut three-dimensional structure of the box body of the utility model;

[0024] Figure 5 For the utility model Figure 4 An enlarged structural diagram of part B.

[0025] In the figure: 1, box body; 2, placement seat; 3, box cover; 4, threaded rod; 5, slider; 6, driving motor; 7, first fixed block; 8, second fixed block; 9, first slot body; 10, second slot body; 11, placement slot; 12, fixed rod; 13, moving block; 14, first spring; 15, damper; 16, connecting rod; 17, rectangular slot; 18, second spring; 19, third spring; 20, third fixed block; 21, positioning slot; 22, baffle; 23, sealing strip; 24, sealing slot; 25, guide rod; 26, sleeve. DETAILED DESCRIPTION

[0026] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0027] See also Figure 1-5A rapid detection kit for gene polymorphism of personalized hypertension medication comprises a box body 1, a placement seat 2, a buffer device and an automatic opening and closing device, the top wall of the box body 1 is installed with a box cover 3 through the automatic opening and closing device, the automatic opening and closing device comprises a threaded rod 4, a slider 5 and a drive motor 6, the front and rear sides of the top wall of the box body 1 are respectively fixedly installed with a first fixed block 7 and a second fixed block 8, the first fixed block 7 and the second fixed block 8 are respectively provided with a first slot 9 and a second slot 10 on the corresponding side, the threaded rod 4 is rotatably installed in the first slot 9, the slider 5 is threadedly connected to the threaded rod 4, the side of the slider 5 away from the first slot 9 is fixedly connected to one end side wall of the box cover 3, the drive motor 6 is installed at one end of the threaded rod 4, the The inner cavity of the box body 1 is equipped with the placement seat 2 through the buffer device, and the top wall of the placement seat 2 is provided with a plurality of evenly arranged placement grooves 11. In this embodiment, the reagents are placed in the placement grooves 11 provided on the placement seat 2 in sequence, and then the drive motor 6 is started. The output end of the drive motor 6 drives the threaded rod 4 to rotate, and the threaded rod 4 drives the slider 5 to move linearly in the first groove body 9 during the rotation process. The slider 5 drives the box cover 3 to move until the box cover 3 completely covers the box body 1, thereby realizing automatic closing of the box body 1, which can better ensure the sealing of the test kit and avoid contamination of the sample in the test kit by the external environment, thereby improving the accuracy and reliability of the detection. In addition, the automatically closed box cover 3 can also avoid sample leakage or contamination caused by human operating errors, thereby ensuring the safety of the experimenter.

[0028] In actual use, in order to further prevent the placement seat 2 from being damaged by collision due to severe vibration, in this embodiment, the buffer device includes a fixed rod 12, a moving block 13, a first spring 14, a damper 15 and a connecting rod 16. A rectangular groove 17 is provided at the bottom of the left and right side walls of the box body 1. The fixed rod 12 is installed in the rectangular groove 17. The moving block 13 is slidably installed on the fixed rod 12. Two groups of first springs 14 located on the left and right sides of the moving block 13 are sleeved on the fixed rod 12. The damper 15 is installed on the side of the moving block 13 away from the rectangular groove 17. The end of the damper 15 away from the moving block 13 is hingedly connected to the connecting rod 16. The other end of the connecting rod 16 is hingedly connected to the bottom wall of the placement seat 2. When the box body 1 is hit, the placement seat 2 inside the box body 1 drives the connecting rod 16, and the connecting rod 16 drives the damper 15 and the moving block 13 to move horizontally in the rectangular groove 17 under the action of inertia. The slider 5 moves on the fixed rod 12, and the elastic force of the two groups of first springs 14 arranged on the left and right of the slider 5 reduces a part of the vibration of the placement seat 2. In this way, the vibration of the box body can be greatly reduced to prevent the reagent tube in the device from being damaged by collision due to severe vibration. The connecting rod 16 and the damper 15 will reduce the impact force caused by inertia, which reduces the possibility of reagent damage.

[0029] Preferably, in this embodiment, the bottom wall of the placement seat 2 is connected to the bottom wall of the box body 1 via a second spring 18 , and the second spring 18 plays an auxiliary buffering role in connecting the bottom wall of the box body 1 with the bottom wall of the placement seat 2 .

[0030] Preferably, in this embodiment, the side wall of the placement seat 2 is connected to the side wall of the box body 1 via a third spring 19. The third spring 19 connects the box body 1 and the side wall of the placement seat 2, and the third spring 19 can play an auxiliary buffering role.

[0031] During actual use, one end of the box body 1 is further positioned. In this embodiment, a third fixing block 20 is installed on the top wall of one end of the box body 1. A positioning groove 21 is provided on the third fixing block 20. The positioning groove 21 is adapted to the left end of the box cover 3. During the automatic closing process of the box cover 3, the box cover 3 moves to the end of the box body 1 and enters the positioning groove 21 to position one end of the box cover 3, so that the box body 1 can be accurately positioned and closed.

[0032] During actual use, the box cover 3 is further limited. In this embodiment, a baffle 22 is installed at one end of the box cover 3 away from the third fixed block 20. The baffle 22 is higher than the box cover 3 and has a semi-cylindrical design. The baffle 22 can limit the side wall of the box body 1, and the semi-cylindrical design of the baffle 22 can make the end lines of the box body 1 smoother.

[0033] In actual use, the sealing of the other end of the box cover 3 is further ensured. In this embodiment, a sealing strip 23 is installed on the side wall of the baffle 22 close to the box body 1, and a sealing groove 24 is opened on the side wall of the box body 1 close to the baffle 22. The sealing strip 23 is adapted to the sealing groove 24. During the automatic closing process of the box cover 3, the baffle 22 drives the sealing strip 23 to enter the sealing groove 24 to seal the other end of the box cover 3 to prevent the external environment from affecting the placement environment inside the box body 1.

[0034] During actual use, the movement of the box cover 3 is further guided. In this embodiment, a guide rod 25 is fixedly installed in the second groove body 10, and a sleeve 26 is slidably installed on the guide rod 25. The side of the sleeve 26 away from the second fixed block 8 is fixedly connected to the side wall of the box cover 3. During the movement of the box cover 3, the sleeve 26 drives the sleeve 26 to slide on the guide rod 25, which guides the movement of the box cover 3 and prevents the box cover 3 from deviating from the moving trajectory during the movement.

[0035] In order to explain in detail the possible application scenarios, technical principles, specific schemes that can be implemented, and the purposes and effects that can be achieved, the following is a detailed description of the specific embodiments listed in conjunction with the accompanying drawings. The embodiments described herein are only used to more clearly illustrate the technical solutions of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0036] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A kit for rapid detection of gene polymorphism for personalized hypertension medication, comprising a box body (1), a placement seat (2), a buffer device and an automatic opening and closing device, characterized in that: The top wall of the box body (1) is provided with a box cover (3) via an automatic opening and closing device, the automatic opening and closing device comprising a threaded rod (4), a slider (5) and a driving motor (6), a first fixing block (7) and a second fixing block (8) are respectively fixedly installed on the front and rear sides of the top wall of the box body (1), a first groove body (9) and a second groove body (10) are respectively provided on the corresponding sides of the first fixing block (7) and the second fixing block (8), the threaded rod (4) is rotatably installed in the first groove body (9), the slider (5) is threadedly connected to the threaded rod (4), the side of the slider (5) away from the first groove body (9) is fixedly connected to a side wall of one end of the box cover (3), the driving motor (6) is installed on one end of the threaded rod (4), the inner cavity of the box body (1) is provided with the placement seat (2) via the buffer device, and the top wall of the placement seat (2) is provided with a plurality of evenly arranged placement grooves (11).

2. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 1, characterized in that: The buffer device comprises a fixed rod (12), a moving block (13), a first spring (14), a damper (15) and a connecting rod (16). A rectangular groove (17) is provided at the bottom of the left and right side walls of the box body (1). The fixed rod (12) is installed in the rectangular groove (17). The moving block (13) is slidably installed on the fixed rod (12). Two groups of first springs (14) located on the left and right sides of the moving block (13) are sleeved on the fixed rod (12). A damper (15) is installed on the side of the moving block (13) away from the rectangular groove (17). One end of the damper (15) away from the moving block (13) is hingedly connected to the connecting rod (16). The other end of the connecting rod (16) is hingedly connected to the bottom wall of the placement seat (2).

3. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 2, characterized in that: The bottom wall of the placement seat (2) is connected to the bottom wall of the box body (1) via a second spring (18).

4. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 3, characterized in that: The side wall of the placement seat (2) is connected to the side wall of the box body (1) via a third spring (19).

5. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 4, characterized in that: A third fixing block (20) is installed on the top wall of one end of the box body (1), and a positioning groove (21) is provided on the third fixing block (20), and the positioning groove (21) is adapted to the left end of the box cover (3).

6. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 5, characterized in that: A baffle (22) is installed at one end of the box cover (3) away from the third fixing block (20); the baffle (22) is taller than the box cover (3) and is of semi-cylindrical design.

7. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 6, characterized in that: A sealing strip (23) is installed on a side wall of the baffle (22) close to the box body (1), and a sealing groove (24) is provided on a side wall of the box body (1) close to the baffle (22), and the sealing strip (23) is adapted to fit the sealing groove (24).

8. A kit for rapid detection of gene polymorphism for personalized hypertension medication according to claim 7, characterized in that: A guide rod (25) is fixedly installed in the second groove body (10), a sleeve (26) is slidably installed on the guide rod (25), and the sleeve (26) is fixedly connected to the side wall of the box cover (3) at a side away from the second fixing block (8).

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