A skin expander for nude mouse experiments

By designing a skin dilator for nude mice experiments, the combination of water capsules and piston components was used to solve the problem of deformation and cartilage puncture when buried subcutaneously by nude mice, and the effect of enhancing skin elasticity was achieved.

CN222708448UActive Publication Date: 2025-04-04SHANGHAI EAST HOSPITAL EAST HOSPITAL TONGJI UNIV SCHOOL OF MEDICINE
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Patent Information

Application Number
CN202421010530.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-05-11
Publication Date
2025-04-04
Estimated Expiration
2034-05-11

AI Technical Summary

Technical Problem

When buried under the skin of nude mice, GelMA hydrogel is prone to deform and collapse due to skin tension pulling, and the cartilage hardness after growth is high and it is easy to pierce the skin.

Method used

A skin dilator for nude mice experiments was designed, including a syringe tube, a piston assembly, ancillary assembly, an expansion assembly and a water capsule. By burying the water capsule inside the skin, the adjustment auxiliary component squeezes the piston assembly, and injecting water into the water capsule, the water capsule expands, thereby enhancing the subcutaneous space and skin elasticity.

Benefits of technology

It prevents hydrogel from deforming in the early stage and prevents cartilage from punctured by the skin in the later stage, which significantly improves the elasticity and stability of the skin.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model provides a skin expander for nude mouse experiments, comprising: an injection tube, a piston assembly is arranged inside the injection tube, an auxiliary assembly is arranged on the outer surface of the injection tube, an expansion assembly is arranged on the outer surface of the injection tube, a connecting tube is fixedly connected to the bottom of the injection tube, a water bag is fixedly connected to the other end of the connecting tube, a rubber piston is movably installed inside the injection tube, a piston rod is fixedly connected to the top of the rubber piston, a threaded rod is movably installed on the outer surface of the injection tube, a threaded block is threadedly connected to the outer surface of the threaded rod, and a connecting rod is fixedly connected to the top of the threaded block. The skin expander for nude mouse experiments provided by the utility model embeds the water bag inside the skin, adjusts the auxiliary assembly to squeeze the piston assembly to inject into the inside of the water bag, and the water bag becomes larger, thereby increasing the subcutaneous space and improving the elasticity of the skin, preventing the embedded hydrogel from deforming in the early stage, and preventing the regenerated cartilage from piercing the skin in the later stage.
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Description

Technical Field

[0001] The utility model relates to the field of medical supplies, in particular to a skin expander used for nude mouse experiments. Background Art

[0002] Microtia is one of the most common congenital malformations. In order to treat this disease, in the research field, researchers mainly wrap chondrocytes with GelMA hydrogel to construct an ear-shaped scaffold, bury the ear-shaped scaffold under the skin of nude mice, and let it grow into an ear-shaped cartilage under the skin of nude mice. This is currently a research hotspot in this field.

[0003] However, on the one hand, the hardness of GelMA hydrogel is relatively low, and when directly buried under the skin of nude mice, it is easy for the hydrogel to deform and collapse due to the tension of the skin; on the other hand, when the subcutaneous cartilage grows, the hardness of the cartilage is high and it is easy to pierce the skin.

[0004] Therefore, it is necessary to provide a skin expander for nude mouse experiments to solve the above technical problems. Utility Model Content

[0005] The utility model provides a skin expander for nude mouse experiments, which solves the problem of deformation and puncture of the skin caused by hydrogel being embedded in the skin.

[0006] In order to solve the above technical problems, the utility model provides a skin expander for nude mouse experiments, comprising: an injection tube, a piston assembly is arranged inside the injection tube, and an auxiliary assembly is arranged on the outer surface of the injection tube;

[0007] An expansion assembly, the expansion assembly is arranged on the outer surface of the injection tube, the expansion assembly includes a connecting tube, and the connecting tube is fixedly connected to the bottom of the injection tube;

[0008] A water bag is fixedly connected to the other end of the connecting tube.

[0009] Preferably, the piston assembly comprises a rubber piston, the rubber piston is movably mounted inside the injection tube, and the top of the rubber piston is fixedly connected to a piston rod.

[0010] Preferably, the auxiliary component includes a threaded rod, which is movably mounted on the outer surface of the injection tube, the outer surface of the threaded rod is threadedly connected with a threaded block, the top of the threaded block is fixedly connected with a connecting rod, and one end of the top of the connecting rod is fixedly connected to the surface of the top of the piston rod.

[0011] Preferably, a water inlet and outlet assembly is provided at the bottom of the injection tube, and the water inlet and outlet assembly includes an injection port, and the injection port is opened on the surface of the bottom of the injection tube, and a liquid changing head is fixedly connected to the surface of the bottom of the injection tube.

[0012] Preferably, a sealing conversion assembly is provided inside the bottom of the injection tube, and the sealing conversion assembly includes a rotating disk, which is movably installed inside the bottom of the injection tube, and a liquid passage port is opened on the surface of the rotating disk.

[0013] Preferably, a rotation fixing assembly is provided at the bottom of the rotating disk, and the rotation fixing assembly includes a transmission belt, and the transmission belt is fixedly connected to the bottom of the rotating disk, and a rotating block is fixedly connected to the bottom of the transmission belt, and a fixing pin is movably installed inside the rotating block.

[0014] Compared with the related art, the skin expander for nude mouse experiments provided by the utility model has the following beneficial effects:

[0015] The utility model provides a skin expander for nude mouse experiments, which embeds a water bag into the skin, adjusts the auxiliary component to squeeze the piston component to inject into the water bag, and the water bag becomes larger, thereby increasing the subcutaneous space and improving skin elasticity, preventing the embedded hydrogel from deforming in the early stage and preventing the regenerated cartilage from piercing the skin in the later stage. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 A schematic structural diagram of a first embodiment of a skin expander for nude mouse experiments provided by the utility model;

[0017] Figure 2 for Figure 1 The front cross-sectional structural schematic diagram shown;

[0018] Figure 3 A schematic structural diagram of a second embodiment of a skin expander for nude mouse experiments provided by the utility model;

[0019] Figure 4 for Figure 3 An enlarged schematic diagram of part A is shown.

[0020] Numbers in the figure: 1. Injection tube,

[0021] 2. Piston assembly, 21. Rubber piston, 22. Piston rod,

[0022] 3. Auxiliary components, 31. Threaded rod, 32. Threaded block, 33. Connecting rod,

[0023] 4. expansion assembly, 41. connecting tube, 42. water bag,

[0024] 5. Water inlet and outlet assembly, 51. Injection port, 52. Liquid exchange head,

[0025] 6. Seal conversion assembly, 61. Rotating disk, 62. Liquid port,

[0026] 7. Rotating and fixing assembly, 71. Transmission belt, 72. Rotating block, 73. Fixing pin. DETAILED DESCRIPTION

[0027] The utility model is further described below in conjunction with the accompanying drawings and implementation modes.

[0028] First embodiment

[0029] Please refer to Figure 1 and Figure 2 ,in, Figure 1 A schematic structural diagram of a first embodiment of a skin expander for nude mouse experiments provided by the utility model; Figure 2 for Figure 1 A front cross-sectional structural schematic diagram is shown. A skin expander for nude mouse experiments comprises: an injection tube 1, a piston assembly 2 is arranged inside the injection tube 1, and an auxiliary assembly 3 is arranged on the outer surface of the injection tube 1;

[0030] An expansion component 4, the expansion component 4 is arranged on the outer surface of the injection tube 1, the expansion component 4 includes a connecting tube 41, and the connecting tube 41 is fixedly connected to the bottom of the injection tube 1;

[0031] The water bag 42 is fixedly connected to the other end of the connecting tube 41 .

[0032] The function of the piston assembly 2 is to inject the water inside the injection tube 1 into the water bag 42 by moving up and down. The function of the auxiliary assembly 3 is to facilitate the up and down movement of the piston assembly 2 while being fixed at any position to prevent the piston assembly 2 from rebounding. An opening is opened at the bottom of the injection tube 1, and one end of the connecting tube 41 is fixedly inserted inside the opening.

[0033] The piston assembly 2 includes a rubber piston 21 , which is movably installed inside the injection tube 1 , and a piston rod 22 is fixedly connected to the top of the rubber piston 21 .

[0034] The size of the rubber piston 21 is just right to fit the inner wall of the injection tube 1, and it is made of elastic rubber material with good sealing properties. A hole is opened at the top of the injection tube 1, and the bottom of the piston rod 22 is embedded in the interior of the injection tube 1 through the hole and fixedly connected to the top of the rubber piston 21.

[0035] The auxiliary component 3 includes a threaded rod 31, which is movably mounted on the outer surface of the injection tube 1. The outer surface of the threaded rod 31 is threadedly connected with a threaded block 32, and the top of the threaded block 32 is fixedly connected with a connecting rod 33. One end of the top of the connecting rod 33 is fixedly connected to the surface of the top of the piston rod 22.

[0036] A rod is fixedly connected to the outer surface of the right end of the injection tube 1, and the threaded rod 31 is rotatably connected to the outer surface of the left end of the injection tube 1. There are two threaded blocks 32, and the two threaded blocks 32 are movably sleeved on the outer surface of the connecting rod at the right end of the injection tube 1 and threadedly sleeved on the outer surface of the threaded rod 31. The connecting rod 33 is a rod with a plate fixedly connected to the top of the two connecting rods. There are two plates, and the bottoms of the two connecting rods are respectively fixedly connected to the tops of the two threaded blocks 32, and the two connecting plates are respectively fixedly connected to the tops of the two connecting rods, and the other ends are fixedly connected to the surface of the top of the piston rod 22.

[0037] The working principle of the skin expander for nude mouse experiments provided by the utility model is as follows:

[0038] First, bury the water bag 42 into the skin of the nude mouse, and then rotate the threaded rod 31. The threaded block 32 pulls the piston rod 22 downward through the connecting rod 33, and the rubber piston 21 squeezes the water inside the injection tube 1 downward. The water enters the water bag 42 through the connecting tube 41, and the water bag 42 expands, thereby expanding the skin, increasing the subcutaneous space and skin elasticity.

[0039] Compared with the related art, the skin expander for nude mouse experiments provided by the utility model has the following beneficial effects:

[0040] The utility model provides a skin expander for nude mouse experiments, which embeds a water bag 42 into the skin, adjusts the auxiliary component 3 to squeeze the piston component 2 to inject into the water bag 42, and the water bag 42 becomes larger, thereby increasing the subcutaneous space and improving the elasticity of the skin, preventing the embedded hydrogel from deforming in the early stage, and preventing the regenerated cartilage from piercing the skin in the later stage.

[0041] Second embodiment

[0042] Please refer to Figure 3 and Figure 4 Based on the skin dilator for nude mouse experiments provided in the first embodiment of the present application, the second embodiment of the present application proposes another skin dilator for nude mouse experiments. The second embodiment is only a preferred embodiment of the first embodiment, and the implementation of the second embodiment will not affect the independent implementation of the first embodiment.

[0043] Specifically, the second embodiment of the present application provides a skin dilator for nude mouse experiments. The difference is that, in a skin dilator for nude mouse experiments, a water inlet and outlet component 5 is provided at the bottom of the injection tube 1, and the water inlet and outlet component 5 includes an injection port 51, and the injection port 51 is opened on the surface of the bottom of the injection tube 1, and a liquid changing head 52 is fixedly connected to the surface of the bottom of the injection tube 1.

[0044] The injection port 51 is opened at the center of the bottom of the injection tube 1, and one end of the connecting tube 41 can be inserted into the injection port 51, so that the water inside the injection tube 1 can flow into the expansion component 4 through the injection port 51. The liquid changing head 52 is conical in shape and is fixedly connected to the bottom of the injection tube 1 at the left end of the injection port 51. When the water needs to be replaced, the water can be discharged and sucked in through the liquid changing head 52.

[0045] A sealing conversion assembly 6 is disposed inside the bottom of the injection tube 1 . The sealing conversion assembly 6 includes a rotating disk 61 movably mounted inside the bottom of the injection tube 1 . A liquid passage 62 is provided on the surface of the rotating disk 61 .

[0046] The rotating disk 61 is rotatably installed inside the bottom of the injection tube 1 and is in the shape of a disk. The size of the liquid through port 62 is just the size of the injection port 51 and the top of the liquid changing head 52. Therefore, when the liquid through port 62 is inside the injection port 51, the rotating disk 61 seals the liquid changing head 52, so that water can be injected into the interior of the expansion component 4. When the liquid through port 62 is inside the liquid changing head 52, the rotating disk 61 seals the injection port 51, so that water can be replaced.

[0047] A rotating fixing assembly 7 is provided at the bottom of the rotating disk 61, and the rotating fixing assembly 7 includes a transmission belt 71, and the transmission belt 71 is fixedly connected to the bottom of the rotating disk 61, and a rotating block 72 is fixedly connected to the bottom of the transmission belt 71, and a fixing pin 73 is movably installed inside the rotating block 72.

[0048] The transmission belt 71 is composed of two pulleys and a belt meshing connection, one of which is fixedly connected to the center of the bottom of the rotating disk 61, and the other pulley is rotatably connected to the inside of the bottom of the injection tube 1 near the rear end. The rotating block 72 is fixedly connected to the gear through the surface of the bottom of the injection tube 1 and is movably installed on the outer surface of the bottom of the injection tube 1. The fixed pin 73 is composed of a spring sleeved on the outer surface of a rod, and a hole is opened at the bottom of the injection tube 1. Under the elastic force of the spring, the top of the fixed pin 73 can be embedded in the inside of the hole, thereby realizing the fixation of the rotating block 72 and the rotating disk 61.

[0049] The working principle of the skin expander for nude mouse experiments provided by the utility model is as follows:

[0050] When it is necessary to replace the water inside the injection tube 1, pull the fixed pin 73 downward, use the top of the fixed pin 73 to disengage from the inside of the hole opened at the bottom of the injection tube 1, and then rotate the rotating block 72, and drive the rotating disk 61 to rotate through the transmission belt 71. When the rotating disk 61 rotates 180 degrees, the liquid port 62 is at the top of the liquid replacement head 52, and the rotating disk 61 seals the injection port 51. Then, the rubber piston 21 is used to squeeze the water inside the injection tube 1, and the water is discharged through the liquid replacement head 52. Then, the liquid replacement head 52 is inserted into the new water, and the rubber piston 21 moves upward. The water is sucked into the interior of the injection tube 1 through the liquid replacement head 52. After completion, rotate the rotating block 72 again, and the rotating disk 61 rotates another 180 degrees. The liquid port 62 is at the top of the injection port 51, the rotating disk 61 seals the top of the liquid replacement head 52, and the top of the fixed pin 73 is stuck in the hole opened at the bottom of the injection tube 1 to fix the rotating block 72.

[0051] Compared with the related art, the skin expander for nude mouse experiments provided by the utility model has the following beneficial effects:

[0052] The utility model provides a skin dilator for nude mouse experiments. The sealing conversion component 6 can be driven to rotate by rotating the fixing component 7, so that the injection port 51 and the liquid replacement head 52 can be sealed and opened. The operation is simple, and the liquid inside the injection tube 1 can be replaced without disassembling the connecting tube 41.

[0053] The above description is only an embodiment of the present invention, and does not limit the patent scope of the present invention. Any equivalent structure or equivalent process transformation made by using the contents of the specification and drawings of the present invention, or directly or indirectly applied in other related technical fields, are also included in the patent protection scope of the present invention.

Claims

1. A skin expander for nude mouse experiments, characterized in that: include: An injection tube, wherein a piston assembly is disposed inside the injection tube, and an auxiliary assembly is disposed on the outer surface of the injection tube; An expansion assembly, the expansion assembly is arranged on the outer surface of the injection tube, the expansion assembly includes a connecting tube, and the connecting tube is fixedly connected to the bottom of the injection tube; A water bag is fixedly connected to the other end of the connecting tube.

2. The skin expander for nude mouse experiments according to claim 1, characterized in that: The piston assembly comprises a rubber piston, which is movably mounted inside the injection tube, and a piston rod is fixedly connected to the top of the rubber piston.

3. The skin expander for nude mouse experiments according to claim 2, characterized in that: The auxiliary component includes a threaded rod, which is movably mounted on the outer surface of the injection tube, the outer surface of the threaded rod is threadedly connected with a threaded block, the top of the threaded block is fixedly connected with a connecting rod, and one end of the top of the connecting rod is fixedly connected to the surface of the top of the piston rod.

4. The skin expander for nude mouse experiments according to claim 1, characterized in that: A water inlet and outlet assembly is disposed at the bottom of the injection tube, and the water inlet and outlet assembly includes an injection port. The injection port is opened on the surface of the bottom of the injection tube, and a liquid changing head is fixedly connected to the surface of the bottom of the injection tube.

5. The skin expander for nude mouse experiments according to claim 4, characterized in that: A sealing conversion assembly is arranged inside the bottom of the injection tube. The sealing conversion assembly comprises a rotating disk. The rotating disk is movably mounted inside the bottom of the injection tube. A liquid passage is provided on the surface of the rotating disk.

6. The skin expander for nude mouse experiments according to claim 5, characterized in that: A rotation fixing assembly is arranged at the bottom of the rotating disk, and the rotation fixing assembly comprises a transmission belt, and the transmission belt is fixedly connected to the bottom of the rotating disk, and a rotating block is fixedly connected to the bottom of the transmission belt, and a fixing pin is movably installed inside the rotating block.