Bilirubin extraction pretreatment device based on membrane separation

Abstract

The utility model discloses a bilirubin extraction pretreatment device based on membrane separation, which comprises a filter tank used for filtering impurities in pig bile; the multiple feeding ports are formed in the top of the filter box and used for adding pig bile and medicaments into the filter box; the stirring box is communicated with the filtering box and is used for carrying out stirring pretreatment on the filtered pig bile; when the brush moves back and forth on the filter plate, impurities in pig bile are swept to waste plates at the two ends of the filter plate, waste is collected by placing a collecting barrel at the bottoms of the waste plates, the situation that the surface of the filter plate is blocked and accumulated is avoided, the effect of removing the impurities on the surface of the filter plate without shutdown is achieved, the continuity of the bilirubin preparation process is improved, and the production efficiency is improved. The preparation efficiency is improved, the product quality of the bilirubin in the subsequent enzyme catalysis synthesis-membrane separation coupling purification process is improved, the equipment does not need to be shaken in the operation process, and the stability is good.

Description

Technical Field

[0001] The utility model belongs to the technical field of bilirubin extraction, and specifically relates to a bilirubin extraction pretreatment device based on membrane separation. Background Art

[0002] Bilirubin is an important lipid drug and the main ingredient of more than 100 Chinese patent medicines in the 2020 edition of the Pharmacopoeia, such as paracetamol tablets and Yinqiao Jiedu pills, with huge market demand. Bilirubin is also one of the main ingredients of the rare and precious Chinese medicinal material bezoar, which has extremely high medicinal value.

[0003] At present, bilirubin is mainly extracted from animal bile (such as pig bile), but more than 90% of bilirubin in pig bile is combined with glucuronic acid to form bound bilirubin. This process uses glucuronidase to hydrolyze bound bilirubin in pig bile to generate free bilirubin, and through the glucuronidase enzyme-catalyzed synthesis of free bilirubin-membrane separation coupling purification process, high-purity bilirubin can be extracted and prepared from pig bile.

[0004] A Chinese patent with publication number CN216092552U discloses a pretreatment device for bilirubin filtration and extraction. Through the cooperation of a first filter screen and a second filter screen, the first filter screen is set as a coarse mesh filter screen, and the second filter screen is set as a fine mesh filter screen, so that pig bile is fully filtered, the purity of pig bile is improved, and the pretreatment effect is improved; through the cooperation of side plates, rotating gears, movable rods, moving plates, push rods, rubber pads, reset plates and reset springs, the box is driven to shake to prevent impurities from accumulating on the surfaces of the first filter screen and the second filter screen to cause blockage.

[0005] In the technical solution of the above-mentioned patent, impurities in pig bile are filtered and screened through a filtering component, so that the pig bile is cleaner during subsequent reaction extraction, the membrane separation effect is better, and the quality of bilirubin preparation is better. However, when the device is in use, the box is shaken to avoid accumulation on the surface of the filtering component, which may cause blockage. First, the shaking causes the device to have low stability. Second, after long-term use, the filtered impurities of the filtering component cannot be removed to the outside of the box. After accumulation occurs, the device needs to be shut down for cleaning, which brings inconvenience to the preparation of bilirubin. Utility Model Content

[0006] In order to solve the technical problem in the prior art that impurities filtered during bilirubin extraction pretreatment cannot be removed to the outside of the box, accumulation occurs and the machine needs to be stopped for cleaning, which brings inconvenience to the preparation of bilirubin, the utility model provides a bilirubin extraction pretreatment device based on membrane separation.

[0007] The purpose of the utility model can be achieved through the following technical solutions:

[0008] A bilirubin extraction pretreatment device based on membrane separation, comprising a filter box arranged on four legs, a plurality of feed ports opened on the top of the filter box, a stirring box connected to the bottom of the filter box, and a discharge pipe connected to the bottom of the filter box; a plurality of groups of slide rails arranged up and down are fixedly connected to the inner side wall of the filter box; filter plates are slidably arranged on the slide rails, the length of the filter plates is less than the length of the filter box, and filter holes are opened on the filter plates;

[0009] A chute is provided on one of the side walls of the filter box at a position corresponding to the top of the filter plate, and a brush is slidably connected in the chute, and the brush is fitted with the corresponding filter plate;

[0010] The filter box is fixedly connected with waste plates at positions corresponding to the two ends of the filter plate, and the waste plates are vertically penetrated to the outer wall of the filter box.

[0011] Furthermore, the brush is fixedly connected with a connecting rod at a position corresponding to the outside of the filter box, and a reciprocating screw is arranged in the middle of the connecting rod; a second motor is fixedly arranged outside the filter box, and the output end of the second motor is connected to the reciprocating screw.

[0012] Furthermore, a first motor is fixedly arranged at the bottom of the mixing box, and a rotating shaft penetrating into the mixing box is fixedly connected to the output end of the first motor. An auger blade is fixedly connected to the rotating shaft, and the auger blade is provided with evenly arranged circular holes.

[0013] Furthermore, the distance between the corresponding chute and filter plate is 5-15CM.

[0014] Furthermore, a slot is provided on the side wall of the filter box away from the connecting rod, and a latch plate is fixedly connected to the filter plate at a position corresponding to the slot.

[0015] Furthermore, inclined blocks are fixedly connected to both ends of the filter plate to increase the height of the two ends of the filter plate.

[0016] Furthermore, the filter holes on each set of filter plates have different apertures, and the apertures of the filter holes on the lower filter plate are smaller than the apertures of the filter holes on the upper filter plate.

[0017] Beneficial effects of the utility model:

[0018] The utility model cooperates with the filter plate, the brush and the waste plate. When the brush moves back and forth on the filter plate, it sweeps impurities in the pig bile to the waste plates at both ends of the filter plate. By placing a collecting bucket at the bottom of the waste plate to collect the waste, the clogging and accumulation on the filter plate surface is avoided, and the impurities on the filter plate surface can be removed without stopping the machine, thereby improving the continuity of the bilirubin preparation process, improving the preparation efficiency, and improving the product quality of the bilirubin in the subsequent enzyme catalytic synthesis-membrane separation coupling purification process. In addition, the equipment does not need to be shaken during operation, and has good stability.

[0019] The utility model cooperates with the reciprocating screw rod and the connecting rod, and the motor can drive the brush to move back and forth on the surface of the filter plate, so as to achieve the purpose of cleaning the impurities on the filter plate to both ends of the filter plate, without manual cleaning, and is convenient for the continuous preparation of bilirubin. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the utility model, the drawings required for describing the embodiments are briefly introduced below. Obviously, the drawings described below are only some embodiments of the utility model. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0021] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0022] Figure 2 It is the first cross-sectional view of the utility model;

[0023] Figure 3 It is a second cross-sectional view of the utility model;

[0024] Figure 4 This is a schematic diagram of the structure of the auger blade in the utility model;

[0025] Figure 5 This is a schematic diagram of the structure of the filter plate in the utility model;

[0026] Figure 6 It is a rear view of the utility model;

[0027] In the accompanying drawings, the components represented by the reference numerals are listed as follows:

[0028] 1. Filter box; 2. Mixing box; 3. Slide rail; 4. Filter plate; 41. Inclined block; 42. Pick plate; 43. Slot; 5. Filter hole; 6. Brush; 61. Slide; 62. Connecting rod; 63. Reciprocating screw rod; 64. Second motor; 7. Waste plate; 8. Feed port; 9. First motor; 91. Rotating shaft; 92. Auger blade; 93. Round hole; 10. Discharge pipe. DETAILED DESCRIPTION

[0029] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0030] See also Figure 1 and Figure 6 As shown, a bilirubin extraction pretreatment device based on membrane separation includes a filter box 1 arranged on four legs, a plurality of feed ports 8 opened on the top of the filter box 1, a stirring box 2 connected to the bottom of the filter box 1, and a discharge pipe 10 connected to the bottom of the filter box 1;

[0031] like Figure 2 , Figure 3 as well as Figure 5 As shown, a plurality of groups of slide rails 3 are fixedly connected to the inner side wall of the filter box 1, and the slide rails 3 are arranged in an upper and lower distributed manner inside the filter box 1; a filter plate 4 is slidably arranged on each group of slide rails 3; filter holes 5 are provided on the filter plates 4, and the apertures of the filter holes 5 provided on each group of filter plates 4 are inconsistent, the apertures of the filter holes 5 located on the lower filter plate 4 are smaller than the apertures of the filter holes 5 located on the upper filter plate 4, and the length of the filter plate 4 is smaller than the length of the filter box 1;

[0032] By providing filter holes 5 with different pore sizes on each filter plate 4, impurities of different sizes in the pig bile can be filtered in multiple stages to improve the filtering quality of the pig bile.

[0033] like Figure 3 As shown, a chute 61 is provided on one side wall of the filter box 1 at a position corresponding to the top of the filter plate 4, and a brush 6 is slidably connected in the chute 61. The brush 6 is fitted with the corresponding filter plate 4 to clean impurities on the surface of the filter plate 4; waste plates 7 are fixedly connected to the positions of the filter box 1 at the two ends of the filter plate 4, and the waste plates 7 are vertically penetrated to the outer wall of the filter box 1;

[0034] When the brush 6 moves back and forth on the filter plate 4, it cleans the impurities in the pig bile to the waste plates 7 at both ends of the filter plate 4. By placing a collection bucket at the bottom of the waste plate 7 to collect the waste, clogging and accumulation on the surface of the filter plate 4 can be avoided, so that the impurities on the surface of the filter plate 4 can be removed without stopping the machine, thereby improving the continuity of the bilirubin preparation process and the preparation efficiency.

[0035] like Figure 5 As shown, the brush 6 is fixedly connected with a connecting rod 62 at a position corresponding to the outside of the filter box 1, and a reciprocating screw rod 63 is provided in the middle of the connecting rod 62; a second motor 64 is fixedly provided outside the filter box 1, and the output end of the second motor 64 is connected to the reciprocating screw rod 63;

[0036] Through the cooperation of the reciprocating screw 63 and the connecting rod 62, the motor can drive the brush 6 to move back and forth on the surface of the filter plate 4, so as to achieve the purpose of cleaning the impurities on the filter plate 4 to both ends of the filter plate 4 without manual cleaning, thereby facilitating the continuous preparation of bilirubin.

[0037] like Figure 5As shown, the two ends of the filter plate 4 are fixedly connected with inclined blocks 41, which are used to increase the height of the two ends of the filter plate 4;

[0038] By increasing the height of both ends of the filter plate 4, it can be prevented that pig bile flows out from the waste plates 7 at both ends of the filter plate 4 after being put into the filter box 1 from the feed port 8, resulting in part of the pig bile being unable to be filtered and causing waste.

[0039] like Figure 5-Figure 6 As shown, a slot 43 is provided on the side wall of the filter box 1 away from the connecting rod 62, and a latch plate 42 is fixedly connected to the filter plate 4 at a position corresponding to the slot 43;

[0040] Through the cooperation of the slot 43, the pick plate 42 and the slide rail 3, the operator can remove the filter plate 4 from the slot 43 through the pick plate 42, and install the filter plate 4 on the slide rail 3 inside the filter box 1 from the slot 43, so as to facilitate the removal of the filter plate 4 for cleaning or maintenance after shutdown.

[0041] like Figure 3 As shown, the distance between the corresponding chute 61 and the filter plate 4 is 10CM, which is used to prevent the pig bile on the filter plate 4 from flowing out of the chute 61 to the outside of the filter box 1.

[0042] like Figure 3-Figure 4 As shown, a first motor 9 is fixedly arranged at the bottom of the mixing box 2, and a rotating shaft 91 penetrating into the mixing box 2 is fixedly connected to the output end of the first motor 9, and an auger blade 92 is fixedly connected to the rotating shaft 91, and the auger blade 92 is provided with evenly arranged circular holes 93;

[0043] The first motor 9 drives the auger blade 92 to rotate through the rotating shaft 91. The auger blade 92 mixes the pig bile and the bactericide and other agents entering the mixing box 2. The auger blade 92 is used to perform multi-level stirring between the pig bile and the agent, and the upper layer and the lower layer flow back and forth. The setting of the circular hole 93 makes the fluidity between the pig bile and the agent stronger under the action of the auger blade 92, the stirring effect is better, and the bilirubin preparation efficiency is faster.

[0044] Working principle:

[0045] First, pig bile and medicine are put into the filter plate 4 inside the filter box 1 from the feed port 8. The filter plate 4 separates the pig bile and impurities in the pig bile in multiple stages. The separated pig bile enters the stirring box 2 below to continue mixing and complete the bilirubin extraction pretreatment process; the separated impurities are discharged from the waste plate 7 to the outside of the filter box 1 for centralized collection and treatment.

[0046] During this process, the second motor 64 drives the brush 6 to move back and forth on the filter plate 4, which not only prevents the filter plate 4 from being blocked, but also cleans the impurities on the filter plate 4 to the two ends of the filter plate 4 and discharges them from the waste plate 7, further preventing the filter plate 4 from being blocked due to accumulation of impurities, and solves the problem that the filter plate 4 is easily blocked and it is inconvenient to clean the filter plate 4.

[0047] In the description of the specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the utility model. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0048] The above contents are merely examples and explanations of the structure of the utility model. The technicians in the technical field may make various modifications or additions to the specific embodiments described or replace them in a similar manner. As long as they do not deviate from the structure of the utility model or exceed the scope defined in the claims, they should all fall within the protection scope of the utility model.

Claims

1. A bilirubin extraction pretreatment device based on membrane separation, comprising: A filter box (1) is used to filter impurities in pig bile; A plurality of feed ports (8) are provided, which are opened at the top of the filter box (1) and are used to add pig bile and medicine into the filter box (1); A stirring box (2) is connected to the filtering box (1) and is used for stirring and pre-treating the filtered pig bile; A discharge pipe (10) is arranged in communication with the bottom of the stirring box (2) and is used to discharge the pretreated pig bile from the stirring box (2); Features: The filter box (1) has a plurality of groups of slide rails (3) arranged vertically fixedly connected to the inner side wall; filter plates (4) are slidably arranged on the slide rails (3); the length of the filter plates (4) is less than the length of the filter box (1); and filter holes (5) are provided on the filter plates (4); A slide groove (61) is provided at a position corresponding to the top of the filter plate (4) on one of the side walls of the filter box (1), and a brush (6) is slidably connected in the slide groove (61), and the brush (6) is in contact with the corresponding filter plate (4); The filter box (1) is fixedly connected with a waste plate (7) at positions corresponding to the two ends of the filter plate (4), and the waste plate (7) is vertically extended through the outer wall of the filter box (1).

2. A bilirubin extraction pretreatment device based on membrane separation according to claim 1, characterized in that: The brush (6) is fixedly connected to a connecting rod (62) at a position corresponding to the outside of the filter box (1), and a reciprocating screw rod (63) is provided in the middle of the connecting rod (62); a second motor (64) is fixedly provided on the outside of the filter box (1), and an output end of the second motor (64) is connected to the reciprocating screw rod (63).

3. A bilirubin extraction pretreatment device based on membrane separation according to claim 1, characterized in that: A first motor (9) is fixedly arranged at the bottom of the mixing box (2); a rotating shaft (91) penetrating into the mixing box (2) is fixedly connected to the output end of the first motor (9); an auger blade (92) is fixedly connected to the rotating shaft (91); and the auger blade (92) is provided with evenly arranged circular holes (93).

4. A bilirubin extraction pretreatment device based on membrane separation according to claim 1, characterized in that: The distance between the corresponding chute (61) and the filter plate (4) is 5-15 cm.

5. A bilirubin extraction pretreatment device based on membrane separation according to claim 1, characterized in that: A slot (43) is provided on the side wall of the filter box (1) away from the connecting rod (62), and a latch plate (42) is fixedly connected to the filter plate (4) at a position corresponding to the slot (43).

6. A bilirubin extraction pretreatment device based on membrane separation according to claim 1, characterized in that: The two ends of the filter plate (4) are fixedly connected with inclined blocks (41) for increasing the height of the two ends of the filter plate (4).

7. A bilirubin extraction pretreatment device based on membrane separation according to claim 1, characterized in that: The filter holes (5) formed on each group of filter plates (4) have different apertures, and the apertures of the filter holes (5) located on the lower filter plate (4) are smaller than the apertures of the filter holes (5) located on the upper filter plate (4).

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