A magnetic separation lifting structure, a mixing and swinging lifting device and equipment

Abstract

The utility model relates to the field of magnetic sorting technology, and specifically to a magnetic sorting lifting structure, a mixing and swinging lifting device and equipment. The magnetic sorting lifting structure includes a consumable mounting plate, a supporting component, a moving component and a guiding component. The supporting component is arranged at the bottom of the consumable mounting plate, and the guiding component is connected to the moving component. A cam bearing follower is arranged on the supporting component, and at least one oblique guide hole is arranged on the guiding component. The cam bearing follower is installed in the oblique guide hole. When the moving component drives the guiding component to move horizontally, the oblique guide hole can adjust the longitudinal position of the cam bearing follower to adjust the longitudinal position of the consumable mounting plate. By converting the lateral movement of the moving component into the longitudinal movement of the consumable mounting plate, the change in the size of the magnetic field where the magnetic cell fluid is located during magnetic sorting is realized.

Description

Technical Field

[0001] The utility model relates to the technical field of magnetic separation, and in particular to a magnetic separation lifting structure, a mixing and swinging lifting device and equipment. Background Art

[0002] At present, in order to purify antigen cells in cell therapy, it is often necessary to separate immunomagnetic bead cells by magnetic sorting. Some cell surface antigens have specific antibodies connected to magnetic beads. Such cells can be connected to magnetic beads through antigens to form immunomagnetic bead cells. Magnetic sorting technology is that in an external magnetic field, immunomagnetic bead cells that have been bound to magnetic beads are adsorbed and retained in the magnetic field, and other cells that are not bound to magnetic beads are not magnetic and cannot stay in the magnetic field, thereby achieving the purpose of separating immunomagnetic bead cells. The existing common magnetic sorting method is to manually apply a magnetic field to a test tube containing magnetic cell fluid and remove the magnetic field to achieve the sorting of magnetic cell fluid. However, for large-throughput or large-capacity magnetic cell fluid, the use of this magnetic sorting method needs to be carried out in batches, which greatly affects work efficiency. Utility Model Content

[0003] In order to solve the problem of low efficiency of the magnetic separation method in the prior art when applied to large-flux or large-capacity magnetic cell fluid, the utility model provides a magnetic separation lifting structure, a mixing and swinging lifting device and equipment.

[0004] In a first aspect, an embodiment of the utility model provides a magnetic separation lifting structure, comprising a consumables mounting plate for placing magnetic separation consumables, at least one supporting component arranged at the bottom of the consumables mounting plate, a moving component arranged below the consumables mounting plate, and a guide component connected to the moving component;

[0005] A cam bearing follower is provided on the supporting component, and at least one oblique guide hole is provided on the guiding component. The cam bearing follower is installed in the oblique guide hole. When the moving component drives the guiding component to move laterally, the oblique guide hole can adjust the longitudinal position of the cam bearing follower to adjust the longitudinal position of the consumable mounting plate.

[0006] In some embodiments, the moving assembly includes a lead screw motor, a lead screw, a linear guide rail, a guide block, a lead screw nut, and a first bracket;

[0007] One end of the screw rod is connected to the screw rod motor, and the other end of the screw rod is movably connected to the first bracket; the screw rod nut is sleeved on the screw rod; the guide block is sleeved on the screw rod and connected to the screw rod nut, the bottom of the guide block is connected to the guide component, and the top of the guide block is provided with a groove, and the groove is engaged with the linear guide rail; the linear guide rail is provided on the first bracket.

[0008] In some embodiments, a guide groove is provided on at least one side of the linear guide rail, a protrusion matching the guide groove is provided in the groove, and the guide groove and the protrusion cooperate with each other to limit the guide block from sliding out of the linear guide rail.

[0009] In some embodiments, at least one group of positioning components is further included, wherein the positioning components include an optical coupling device and a baffle.

[0010] The optical coupling device is arranged on one side of the first bracket; the baffle is arranged on one side of the guide block and is located on the same side as the optical coupling device.

[0011] In some embodiments, a magnet and a magnet mounting seat are also included, wherein the magnet is disposed in the magnet mounting seat, and the magnet mounting seat is disposed between the consumable mounting plate and the moving component and is movably connected to the consumable mounting plate.

[0012] In some embodiments, at least one through hole is provided on the magnet mounting seat, and the through hole is used to accommodate the support component to pass through.

[0013] In some embodiments, at least one guide shaft is disposed at the bottom of the consumable mounting plate, and a linear bearing cooperating with the guide shaft is correspondingly disposed on the magnet mounting seat, and the guide shaft is placed in the linear bearing.

[0014] In some embodiments, at least one angle sensor is disposed on the magnet mounting seat, and the angle sensor is used to read the swing parameters of the magnetic separation lifting structure.

[0015] In a second aspect, the embodiment of the utility model further provides a magnetic separation mixing and swinging lifting device, the magnetic separation mixing and swinging lifting device comprises the magnetic separation lifting structure as described in any of the above embodiments, and also comprises a magnetic separation mixing and swinging structure;

[0016] A first cantilever pin is provided on the first side of the magnet mounting seat, and a synchronous wheel is installed on the first cantilever pin;

[0017] The magnetic separation mixing and swinging structure includes a mixing and swinging motor, a driving wheel and a synchronous belt. The driving wheel is connected to the output shaft of the mixing and swinging motor. The synchronous belt is sleeved on the driving wheel and the synchronous wheel. The driving wheel is used to drive the synchronous wheel to rotate through the synchronous belt under the drive of the mixing and swinging motor, thereby swinging the magnet mounting seat.

[0018] In some embodiments, the magnetic separation mixing and swinging structure further includes a reducer, one end of the reducer is connected to the mixing and swinging motor, and the other end of the reducer is connected to the driving wheel.

[0019] In some embodiments, the magnetic separation and mixing structure also includes a second bracket, the second bracket includes a mixing base plate and a first support plate and a second support plate arranged in parallel, the first support plate, the second support plate and the mixing motor are all installed on the mixing base plate, and the driving wheel is installed on the first support plate.

[0020] In some embodiments, a first mounting hole is provided on the first support plate, a first bearing is provided in the first mounting hole, and the first cantilever pin is connected to the synchronous wheel through the first bearing.

[0021] In some embodiments, a second cantilever pin is disposed on the second side of the magnet mounting seat, the second side of the magnet mounting seat is disposed parallel to the first side of the magnet mounting seat, and a first limit block is installed on the second cantilever pin;

[0022] A second mounting hole is provided on the second support plate, a second bearing is provided in the second mounting hole, and the second cantilever pin is connected to the first limit block through the second bearing;

[0023] At least one second limiting block is arranged beside the second mounting hole, and the second limiting block is used to cooperate with the first limiting block to limit the swing range of the magnet mounting seat.

[0024] In a third aspect, an embodiment of the utility model further provides a magnetic separation device, which includes a magnetic separation lifting structure as described in any of the above embodiments.

[0025] One or more technical solutions provided in the embodiments of the present utility model have at least the following technical effects or advantages:

[0026] Firstly, a magnetic separation lifting structure proposed in an embodiment of the utility model converts the lateral movement of the guide component into the longitudinal movement of the consumable mounting plate by setting a cam bearing follower under the consumable mounting plate and cooperating with the oblique guide hole set on the guide component, so as to realize the change of the size of the magnetic field where the magnetic cell fluid is located during magnetic separation.

[0027] Secondly, a magnetic separation lifting structure proposed in an embodiment of the utility model is provided with a positioning component. When the moving component moves to a specified position, the positioning component sends a signal to facilitate confirmation by the staff.

[0028] Again, a magnetic separation lifting structure proposed in an embodiment of the utility model is provided with a magnet, and magnetic separation of large-flux or large-capacity magnetic cell fluid can be achieved without the need for an external magnet.

[0029] The embodiment of the utility model also proposes a magnetic separation mixing and swinging lifting structure, which includes a magnetic separation lifting structure and a magnetic separation mixing and swinging structure. The magnetic separation lifting structure is used to change the size of the magnetic field during magnetic separation, and the magnetic cell fluid is shaken evenly through the magnetic separation mixing and swinging structure, thereby avoiding the accumulation of immune magnetic bead cells in the magnetic cell fluid and causing the loss of some immune magnetic bead cells, thereby realizing the magnetic separation of large-throughput or large-capacity magnetic cell fluid. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] The utility model is further described below in conjunction with the accompanying drawings and embodiments.

[0031] Figure 1 This is an exploded view of a magnetic separation lifting structure in one embodiment of the utility model;

[0032] Figure 2 It is a schematic diagram of an inverted structure of a guide component in a magnetic separation lifting structure in one embodiment of the utility model;

[0033] Figure 3 It is a schematic diagram of an inverted structure of a moving component in a magnetic separation lifting structure in one embodiment of the utility model;

[0034] Figure 4 It is a schematic diagram of an inverted structure in which a guide component in a magnetic separation lifting structure is installed on a moving component in one embodiment of the utility model;

[0035] Figure 5 This is a schematic cross-sectional structure diagram of a magnetic separation lifting structure in one embodiment of the utility model;

[0036] Figure 6 This is a schematic diagram of the first angle structure of a magnetic separation mixing and swing lifting device in an embodiment of the utility model;

[0037] Figure 7 It is an exploded view of a magnetic separation mixing and swing lifting device in an embodiment of the utility model;

[0038] Figure 8 This is a structural schematic diagram of a magnetic separation mixed swing structure in an embodiment of the utility model;

[0039] Fig. 9 This is a second angle structural schematic diagram of a magnetic separation mixing and swing lifting device in an embodiment of the utility model;

[0040] Fig.10 It is a schematic diagram of the right swing structure of a magnetic separation mixing swing lifting device in an embodiment of the utility model;

[0041] Fig.11 It is a schematic diagram of the left swing structure of a magnetic separation mixed swing lifting device in an embodiment of the utility model;

[0042] 100. Magnetic separation lifting structure; 1. Consumables mounting plate; 2. Support component; 3. Moving assembly; 31. Screw motor; 32. Screw; 33. Linear guide; 331. Guide groove; 34. Guide block; 341. Groove; 3411. Protrusion; 35. Screw nut; 36. First bracket; 361. Moving bottom plate; 362. First side plate; 363. Second side plate; 364. Screw bearing; 4. Guide component; 41. Oblique strip Guide hole; 411, first waist-shaped hole; 412, second waist-shaped hole; 413, strip hole; 42, connecting plate; 43, guide plate; 5, cam bearing follower; 6, positioning assembly; 61, optical coupling device; 62, baffle; 7, magnet; 8, magnet mounting seat; 81, through hole; 9, guide shaft; 10, linear bearing; 11, angle sensor; 12, first cantilever pin; 13, synchronous wheel; 14, second cantilever pin; 15, first limit block;

[0043] 200, magnetic separation mixing and swinging structure; 16, mixing and swinging motor; 17, driving wheel; 18, synchronous belt; 19, reducer; 20, second bracket; 201, mixing and swinging bottom plate; 202, first support plate; 2021, first mounting hole; 203, second support plate; 2031, second mounting hole; 21, first bearing; 22, second bearing; 23, second limit block. DETAILED DESCRIPTION

[0044] The following will clearly and completely describe the concept, specific structure and technical effects of the utility model in combination with the embodiments and drawings, so as to fully understand the purpose, characteristics and effects of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of them. Based on the embodiments of the utility model, other embodiments obtained by technicians in this field without creative work are all within the scope of protection of the utility model. In addition, all the connection / connection relationships involved in the patent do not refer to the direct connection of components, but refer to the formation of a better connection structure by adding or reducing connection accessories according to the specific implementation situation. The various technical features in the creation of the utility model can be combined interchangeably without conflicting with each other.

[0045] Magnetic sorting technology is a cell sorting technology that separates a specific cell subpopulation from a mixed cell sample based on the characteristics of the cells. Some cell surface antigens have specific antibodies connected to magnetic beads. Such cells can be connected to magnetic beads through antigens to form immunomagnetic bead cells. Magnetic sorting technology is in an external magnetic field, where the immunomagnetic bead cells that have been bound to magnetic beads are adsorbed and retained in the magnetic field, while other cells that are not bound to magnetic beads are not magnetic and cannot stay in the magnetic field, thereby achieving the purpose of separating immunomagnetic bead cells. The existing common magnetic sorting method is to manually apply a magnetic field to a test tube containing magnetic cell fluid and remove the magnetic field to achieve the sorting of magnetic cell fluid. However, for large-throughput or large-capacity magnetic cell fluids, the use of this magnetic sorting method needs to be carried out in batches, which greatly affects work efficiency.

[0046] In order to solve the problem of low efficiency of the magnetic separation method in the above-mentioned prior art when applied to large-flux or large-capacity magnetic cell fluid, the embodiment of the utility model proposes a magnetic separation lifting structure, a mixing and swinging lifting device and equipment.

[0047] See also Figure 1 , Figure 1 It is an exploded view of a magnetic separation lifting structure in one embodiment of the utility model.

[0048] like Figure 1 As shown, a magnetic separation lifting structure 100 proposed in an embodiment of the utility model includes a consumable mounting plate 1, a supporting component 2, a moving component 3 and a guiding component 4.

[0049] The consumables mounting plate 1 is used to place magnetic separation consumables. In the embodiment of the utility model, the magnetic separation consumables are magnetic separation plates. The consumables mounting plate 1 is provided with at least one spring clamp for fixing the magnetic separation consumables and at least one pipe clamp slot for fixing the pipes led out of the magnetic separation plate. The magnetic cell fluid is magnetically separated in the magnetic separation consumables.

[0050] The support component 2 is arranged at the bottom of the consumable mounting plate 1, and the number of the support component 2 is at least one. A cam bearing follower 5 is arranged on the support component 2. In the embodiment of the utility model, two support components 2 are symmetrically arranged at the bottom of the consumable mounting plate 1, and the shape of the support component 2 is U-shaped, the top of which is fixedly connected to the bottom of the consumable mounting plate 1, and the bottom of which is parallel to the consumable mounting plate 1. The cam bearing followers 5 are respectively arranged on the opposite sides of the bottom of the two support components 2.

[0051] The moving component 3 is arranged below the consumable material installation plate 1 and is not directly connected to the consumable material installation plate 1 .

[0052] The guide component 4 is connected to the moving component 3, and the moving component 3 can drive the guide component 4 to move in the lateral direction. At least one oblique strip-shaped guide hole 41 is provided on the guide component 4, and the cam bearing follower 5 is installed in the oblique strip-shaped guide hole 41. When the moving component 3 drives the guide component 4 to move in the lateral direction, the oblique strip-shaped guide hole 41 moves in the lateral direction following the guide component 4. The oblique strip-shaped guide hole 41 is a strip-shaped guide hole that forms a certain angle with the horizontal plane. When the oblique strip-shaped guide hole 41 moves in the lateral direction, the cam bearing follower 5 moves upward or downward in the longitudinal direction under the action of the oblique strip-shaped guide hole 41, and the consumable mounting plate 1 moves in the longitudinal direction following the cam bearing follower 5 driven by the support component 2.

[0053] When magnetic cell fluid is placed on the consumable mounting plate 1 and a magnet is fixedly placed under the consumable mounting plate 1, the lateral movement of the guide component 4 is converted into the longitudinal movement of the consumable mounting plate 1 through the oblique guide hole 41 and the cam bearing follower 5, so that the magnetic cell fluid loaded on the consumable mounting plate 1 is close to or away from the magnet, thereby changing the size of the magnetic field where the magnetic cell fluid is located.

[0054] See also Figure 2 , Figure 2 The utility model is a schematic diagram of an inverted structure of a guide component in a magnetic separation lifting structure in one embodiment.

[0055] like Figure 2 As shown, in an embodiment of the utility model, the guide component 4 includes a connecting plate 42 and two guide plates 43, and the two guide plates 43 are respectively arranged at the two ends of the connecting plate 42 and vertically connected to the connecting plate 42. When the guide component 4 is connected to the moving component 3 through the connecting plate 42, the two guide plates 43 are respectively placed on both sides of the moving component 3. The two guide plates 43 are respectively provided with oblique strip-shaped guide holes 41, and the oblique strip-shaped guide holes 41 on the two guide plates 43 are symmetrically arranged. The two ends of the oblique strip-shaped guide hole 41 are respectively a first waist-shaped hole 411 and a second waist-shaped hole 412 parallel to the horizontal plane, and the first waist-shaped hole 411 and the second waist-shaped hole 412 are not on the same horizontal plane. The obliquely arranged strip-shaped hole 413 connects the first waist-shaped hole 411 and the second waist-shaped hole 412 to form the oblique strip-shaped guide hole 41.

[0056] See also Figure 3 , Figure 3 It is a schematic diagram of the inverted structure of a moving component in a magnetic separation lifting structure in one embodiment of the utility model.

[0057] For clarity, Figure 3 Using the inverted structural schematic diagram of the moving component 3, the following describes the positional relationship when the moving component 3 is inverted.

[0058] like Figure 3As shown, the moving assembly 3 includes a screw motor 31 , a screw 32 , a linear guide rail 33 , a guide block 34 , a screw nut 35 and a first bracket 36 .

[0059] The first bracket 36 includes a movable bottom plate 361, a first side plate 362, a second side plate 363 and a screw bearing 364. The first side plate 362 and the second side plate 363 are respectively disposed on both sides of the movable bottom plate 361 and vertically connected to the movable bottom plate 361, and the screw bearing 364 is disposed on the second side plate 363.

[0060] The linear guide rail 33 is disposed on the first bracket 36 . Specifically, the linear guide rail 33 is disposed on a side of the movable base plate 361 of the first bracket 36 facing the screw rod.

[0061] The screw motor 31 is disposed on the first side plate 362 of the first bracket 36 , and the output shaft of the screw motor 31 is connected to the screw 32 .

[0062] One end of the screw rod 32 is connected to the output shaft of the screw motor 31, and the other end is movably connected to the first bracket 36, so that the screw rod 32 can rotate under the drive of the screw motor 31. Specifically, the other end of the screw rod 32 is connected to the screw bearing 364, and when the screw rod 32 rotates under the drive of the screw motor 31, the screw bearing 364 can reduce the friction of the screw rod 32, so that the screw rod 32 rotates more smoothly.

[0063] The lead screw nut 35 is sleeved on the lead screw 32, and the guide block 34 is sleeved on the lead screw 32 and connected to the lead screw nut 35. The lead screw 32 is provided with a spiral pattern, and the lead screw nut 35 is sleeved on one side of the lead screw 32 and has a thread matching the spiral pattern of the lead screw 32. When the lead screw 32 rotates under the drive of the lead screw motor 31, the lead screw nut 35 moves laterally along the spiral pattern on the lead screw 32, and since the guide block 34 is connected to the lead screw nut 35, the lead screw nut 35 drives the guide block 34 to move laterally.

[0064] The bottom of the guide block 34 (i.e., the top of the guide block 34 when the moving assembly 3 is upright) is provided with a groove 341, and the groove 341 is engaged with the linear guide rail 33. Specifically, at least one side of the linear guide rail 33 is provided with a guide groove 331, and a protrusion 3411 matching the guide groove 331 is provided in the groove 341, and the guide groove 331 and the protrusion 3411 cooperate with each other to limit the guide block 34 from sliding out of the linear guide rail 33. In the embodiment of the utility model, the guide grooves 331 are provided on both sides of the linear guide rail 33, and correspondingly, the protrusions 3411 matching the guide grooves 331 are provided on both sides of the groove 341.

[0065] See also Figure 4 , Figure 4It is a schematic diagram of an inverted structure in which a guide component in a magnetic separation lifting structure is installed on a moving component in one embodiment of the utility model.

[0066] like Figure 4 As shown, the top of the guide block 34 (ie, the bottom of the guide block 34 when the moving assembly 3 is upright) is connected to the guide component 4. Specifically, the top of the guide block 34 is connected to the connecting plate 42 of the guide component 4.

[0067] See also Figure 3 The magnetic separation lifting structure proposed in the embodiment of the utility model further includes at least one set of positioning components 6, the positioning components 6 include an optical coupler 61 and a baffle 62, the optical coupler 61 is arranged on one side of the first bracket 36, and the baffle 62 is arranged on one side of the guide block 34 and is located on the same side as the optical coupler 61. The optical coupler 61 has an output end and an input end. When there is no object placed between the output end and the input end of the optical coupler 61, the optical coupler 61 is in a conducting state; see Figure 4 When the guide block 34 drives the baffle 62 to move to the side of the first bracket 36 where the optical coupler 61 is provided, the baffle 62 is placed between the output end and the input end of the optical coupler 61, and the optical coupler 61 is not conducting, which means that the guide block 34 has driven the guide component 4 to reach the specified position, and the consumable mounting plate 1 rises or falls to the specified position. In the embodiment of the utility model, positioning components 6 are respectively provided on both sides of the moving component 3, and the optical coupler 61 can be used to know whether the consumable mounting plate 1 rises or falls to the specified position.

[0068] See also Figure 5 , Figure 5 It is a schematic cross-sectional structure diagram of a magnetic separation lifting structure in one embodiment of the utility model.

[0069] like Figure 5 As shown, when the guide component 4 is laterally moved to one end of the first bracket 36 through the moving assembly 3, the cam bearing follower 5 rises along the oblique strip guide hole 41 to the top of the oblique strip guide hole 41, and drives the consumable mounting plate 1 to rise to the specified highest point through the support component 2, and the baffle 62 is placed between the output end and the input end of the optical coupling device 61, and the optical coupling device 61 is not conducting. It can be known that the consumable mounting plate 1 has reached the specified highest point through the non-conduction phenomenon of the optical coupling device 61. Similarly, when the guide component 4 is laterally moved to the other end of the first bracket 36 through the moving assembly 3, the cam bearing follower 5 descends along the oblique strip guide hole 41 to the bottom of the oblique strip guide hole 41, and drives the consumable mounting plate 1 to descend to the specified lowest point through the support component 2, and the baffle 62 on the other side is placed between the output end and the input end of the optical coupling device 61 on the other side, and the optical coupling device 61 on the other side is not conducting. It can be known that the consumable mounting plate 1 has reached the specified lowest point through the non-conduction phenomenon of the optical coupling device 61 on the other side.

[0070] See also Figure 1 A magnetic sorting lifting structure proposed in an embodiment of the utility model also includes a magnet 7 and a magnet mounting seat 8. The magnet 7 is arranged in the magnet mounting seat 8. The magnet mounting seat 8 is arranged between the consumable mounting plate 1 and the moving component 3, and is movably connected to the consumable mounting plate 1.

[0071] A magnet mounting seat 8 is arranged between the consumable mounting plate 1 and the moving component 3, and the consumable mounting plate 1 is movably connected to the magnet mounting seat 8. The consumable mounting plate 1 can be moved longitudinally relative to the magnet 7 located on the magnet mounting seat 8 through the moving component 3, so as to change the size of the magnetic field where the magnetic cell fluid on the consumable mounting plate 1 is located without placing additional magnets.

[0072] At least one through hole 81 is provided on the magnet mounting seat 8, and the through hole 81 is used to accommodate the support component 2 to pass through. By providing the through hole 81 on the magnet mounting seat 8 to accommodate the support component 2 to pass through, it can stabilize the support component 2 and the consumable mounting plate 1 and limit the movement of the support component 2 in the horizontal direction. In the embodiment of the utility model, since two support components 2 are provided, and the shape of the support component 2 is U-shaped, correspondingly, four through holes 81 are provided on the magnet mounting seat 8 to accommodate the support component 2 to pass through.

[0073] At least one guide shaft 9 is provided at the bottom of the consumable mounting plate 1, and a linear bearing 10 that cooperates with the guide shaft 9 is correspondingly provided on the magnet mounting seat 8, and the guide shaft 9 is placed in the linear bearing 10. By providing the guide shaft 9 at the bottom of the consumable mounting plate 1 and correspondingly providing the linear bearing 10 on the magnet mounting seat 8, the consumable mounting plate 1 is moved in the direction in which the linear bearing 10 extends through the guide shaft 9 and the linear bearing 10. In the embodiment of the utility model, the consumable mounting plate 1 and the magnet mounting seat 8 are both rectangular, and the guide shafts 9 are respectively provided at the four vertex corners of the bottom of the consumable mounting plate 1, and correspondingly, the linear bearings 10 are respectively provided at the vertex corners of the magnet mounting seat 8.

[0074] At least one angle sensor 11 is disposed on the magnet mounting seat 8 , and the angle sensor 11 is used to read the swing parameters of the magnetic separation lifting structure 100 .

[0075] In summary, the working principle of the magnetic sorting lifting structure is as follows: the magnetic cell fluid to be magnetically sorted flows into the magnetic sorting consumables on the consumables mounting plate 1, the screw motor 31 is started to drive the screw 32 to rotate, the guide block 34 drives the guide component 4 to move laterally through the screw nut 35, and the consumables mounting plate 1 is lowered by the cooperation of the cam bearing follower 5 and the guide component 4, and the consumables mounting plate 1 is close to the magnet 7 below it, and the magnetic field where the magnetic cell fluid to be magnetically sorted is located increases. Under the action of the magnet 7, the immune magnetic cells in the magnetic cell fluid are adsorbed at the bottom of the magnetic sorting consumables, and the non-immune magnetic cells are flushed into the waste liquid bag, and the magnetic cell fluid to be magnetically sorted is continuously introduced into the magnetic sorting consumables for magnetic sorting, so as to realize the magnetic sorting of large flux or large capacity magnetic cell fluid. After the magnetic sorting is completed, the consumables mounting plate 1 is controlled to rise to be away from the magnet 7 below it, and the adsorbed immune magnetic cells are moved out of the magnetic field and collected.

[0076] The utility model also proposes a magnetic separation mixing and swing lifting device, see Figure 6 , Figure 6 This is a schematic diagram of the first angle structure of a magnetic separation and mixing swing lifting device in an embodiment of the utility model.

[0077] like Figure 6 As shown, the magnetic separation and mixing-swing lifting device includes a magnetic separation and lifting structure 100 and a magnetic separation and mixing-swing structure 200 as described in any of the above embodiments. The magnetic separation and lifting structure 100 is used to change the size of the magnetic field in which the magnetic cell fluid is located to achieve magnetic separation of the magnetic cell fluid. The magnetic separation and mixing-swing structure 200 is used to swing the magnetic separation and lifting structure 100 to achieve shaking of the magnetic cell fluid placed on the magnetic separation and lifting structure 100, thereby avoiding the accumulation of immune magnetic bead cells in the magnetic cell fluid, which causes some immune magnetic bead cells to be unable to be fully adsorbed and lost, thereby achieving magnetic separation of large-flux or large-capacity magnetic cell fluid.

[0078] See also Figure 7 , Figure 7 It is an exploded view of a magnetic separation mixing and swing lifting device in an embodiment of the utility model.

[0079] like Figure 1 and Figure 7As shown, a first cantilever pin 12 is provided on the first side of the magnet mounting seat 8, and a synchronous wheel 13 is installed on the first cantilever pin 12. A second cantilever pin 14 is provided on the second side of the magnet mounting seat 8, and the second side of the magnet mounting seat 8 is arranged parallel to the first side of the magnet mounting seat 8, and a first limit block 15 is installed on the second cantilever pin 14. A keyway is provided in the first cantilever pin 12 and the second cantilever pin 13, and a flat key is pressed in the keyway. An inner hole keyway is provided on the synchronous wheel 13 and the first limit block 15, and the first limit block 15 is installed with the second cantilever pin 14 by pressing the flat key in the inner hole keyway; the synchronous wheel 13 is installed with the first cantilever pin 12 by pressing the flat key in the inner hole keyway. When the synchronous wheel 13 rotates, the synchronous wheel 13 drives the magnet mounting seat 8 to swing through the first cantilever pin 12.

[0080] See also Figure 8 , Figure 8 It is a structural schematic diagram of a magnetic separation mixing swing structure in an embodiment of the utility model.

[0081] like Figure 8 As shown, the magnetic separation mixing and swinging structure 200 includes a mixing and swinging motor 16 , a driving wheel 17 and a synchronous belt 18 . The driving wheel 17 is connected to the output shaft of the mixing and swinging motor 16 , and the synchronous belt 18 is sleeved on the driving wheel 17 .

[0082] In addition, the magnetic separation mixing and swinging structure 200 also includes a reducer 19, one end of the reducer 19 is connected to the mixing and swinging motor 16, and the other end of the reducer 19 is connected to the driving wheel 17. The reducer 19 is connected to the output shaft of the mixing and swinging motor 16 to increase the output torque while reducing the rotation speed of the mixing and swinging motor 16.

[0083] The magnetic separation mixing and swinging structure 200 also includes a second bracket 20, which includes a mixing and swinging bottom plate 201 and a first support plate 202 and a second support plate 203 arranged in parallel. The first support plate 202, the second support plate 203 and the mixing and swinging motor 19 are all installed on the mixing and swinging bottom plate 201, and the driving wheel 17 is installed on the first support plate 202. A first mounting hole 2021 is provided on the first support plate 202, and a first bearing 21 is provided in the first mounting hole 2021. A second mounting hole 2031 is provided on the second support plate 203, and a second bearing 22 is provided in the second mounting hole 2031. At least one second stop block 23 is provided beside the second mounting hole 2031.

[0084] See also Fig. 9 , Fig. 9 This is a second angle structural schematic diagram of a magnetic separation and mixing swing lifting device in an embodiment of the utility model.

[0085] like Fig. 9As shown, the synchronous belt 18 is sleeved on the driving wheel 17 and the synchronous wheel 13. The driving wheel 17 drives the synchronous wheel 13 to rotate through the synchronous belt 18 under the drive of the mixing motor 16, thereby realizing the swing of the magnet mounting seat 8. Since the consumable mounting plate 1 is connected to the magnet mounting seat 8, the consumable mounting seat 1 swings with the magnet mounting seat 8 to achieve the shaking of the magnetic cell solution.

[0086] The first cantilever pin 12 is connected to the synchronous wheel 13 through the first bearing 21 to fix one end of the magnet mounting seat 8 on the second bracket 20. In addition, the first bearing 21 can reduce the friction between the first cantilever pin 12 and the first support plate 202 when the first cantilever pin 12 is driven by the synchronous wheel 13, so that the first cantilever pin 12 swings more smoothly.

[0087] The second cantilever pin 14 is connected to the first limit block 15 through the second bearing 22 to fix the other end of the magnet mounting seat 8 on the second bracket 20. In addition, the second bearing 22 can make the second cantilever pin 14 swing more smoothly due to the friction between the second cantilever pin 14 and the second support plate 203 when the magnet mounting seat 8 swings.

[0088] At least one second limit block 23 is disposed beside the second mounting hole 2031, and the second limit block 23 limits the swing amplitude of the first limit block 15 and thus limits the swing range of the magnet mounting seat 8. In the embodiment of the utility model, second limit blocks 23 are respectively disposed on both sides of the second mounting hole 2031 to limit the swing range of the magnet mounting seat 8.

[0089] See also Fig.10 , Fig.10 It is a schematic diagram of the right swing structure of a magnetic separation mixing swing lifting device in an embodiment of the utility model.

[0090] like Fig.10 As shown, when the magnetic separation mixing swing structure 200 drives the magnetic separation lifting structure 100 to swing right and the first limit block 15 abuts against the second limit block 23 on the left, the second limit block 23 on the left limits the first limit block 15 to continue to move to the left, thereby limiting the magnetic separation lifting structure 100 from continuing to swing to the right, so as to achieve the effect of limiting the right side swing range of the magnetic separation lifting structure 100.

[0091] See also Fig.11 , Fig.11 It is a schematic diagram of the left-swing structure of a magnetic separation mixed-swing lifting device in an embodiment of the utility model.

[0092] like Fig.11As shown, similarly, when the magnetic separation mixing swing structure 200 drives the magnetic separation lifting structure 100 to swing left and the first limit block 15 abuts against the second limit block 23 on the right, the second limit block 23 on the right limits the first limit block 15 to continue to move to the right, thereby limiting the magnetic separation lifting structure 100 from continuing to swing to the left, so as to achieve the effect of limiting the left side swing range of the magnetic separation lifting structure 100.

[0093] In summary, the working principle of the magnetic sorting mixing and swinging lifting device is as follows: the magnetic cell fluid to be magnetically sorted flows into the magnetic sorting consumables on the consumables mounting plate 1, the consumables mounting plate 1 is driven to descend to approach the magnet 7, and the magnetic sorting mixing and swinging structure 200 is started to swing the magnetic sorting lifting structure 100 back and forth at a certain angle to shake the magnetic cell fluid on the magnetic sorting consumables. Under the action of the magnet 7, the immunomagnetic cells in the magnetic cell fluid are adsorbed at the bottom of the magnetic sorting consumables, and the non-immunomagnetic cells are flushed into the waste liquid bag. The magnetic cell fluid to be magnetically sorted is continuously introduced into the magnetic sorting consumables for magnetic sorting, and the magnetic sorting mixing and swinging structure 200 is continuously used to shake the magnetic cell fluid to avoid the accumulation of immunomagnetic cells, so as to achieve magnetic sorting of large-flux or large-capacity magnetic cell fluids.

[0094] The embodiment of the utility model further proposes a magnetic separation device, which includes the magnetic separation lifting structure as described in any of the above embodiments.

[0095] In summary, a magnetic separation lifting structure proposed in an embodiment of the utility model converts the lateral movement of the guide component into the longitudinal movement of the consumable mounting plate by setting a cam bearing follower under the consumable mounting plate and cooperating with the oblique guide hole set on the guide component, so as to realize the change of the size of the magnetic field where the magnetic cell fluid is located during magnetic separation.

[0096] Secondly, a magnetic separation lifting structure proposed in an embodiment of the utility model is provided with a positioning component. When the moving component moves to a specified position, the positioning component sends a signal to facilitate confirmation by the staff.

[0097] Again, a magnetic separation lifting structure proposed in an embodiment of the utility model is provided with a magnet, and magnetic separation of large-flux or large-capacity magnetic cell fluid can be achieved without the need for an external magnet.

[0098] The embodiment of the utility model also proposes a magnetic separation mixing and swinging lifting structure, which includes a magnetic separation lifting structure and a magnetic separation mixing and swinging structure. The magnetic separation lifting structure is used to change the size of the magnetic field during magnetic separation, and the magnetic cell fluid is shaken evenly through the magnetic separation mixing and swinging structure, thereby avoiding the accumulation of immune magnetic bead cells in the magnetic cell fluid and causing the loss of some immune magnetic bead cells, thereby realizing the magnetic separation of large-throughput or large-capacity magnetic cell fluid.

[0099] The above is a specific description of the preferred implementation of the utility model, but the invention of the utility model is not limited to the described embodiments. Technical personnel familiar with the field can also make various equivalent deformations or substitutions without violating the spirit of the utility model. These equivalent deformations or substitutions are all included in the scope defined by the claims of this application.

Claims

1. A magnetic separation lifting structure, characterized in that: It comprises a consumables mounting plate for placing magnetic separation consumables, at least one supporting component arranged at the bottom of the consumables mounting plate, a moving component arranged below the consumables mounting plate, and a guiding component connected to the moving component; A cam bearing follower is provided on the supporting component, and at least one oblique guide hole is provided on the guiding component. The cam bearing follower is installed in the oblique guide hole. When the moving component drives the guiding component to move laterally, the oblique guide hole can adjust the longitudinal position of the cam bearing follower to adjust the longitudinal position of the consumable mounting plate.

2. The magnetic separation lifting structure according to claim 1, characterized in that: The moving assembly includes a lead screw motor, a lead screw, a linear guide rail, a guide block, a lead screw nut and a first bracket; One end of the screw rod is connected to the screw rod motor, and the other end of the screw rod is movably connected to the first bracket; the screw rod nut is sleeved on the screw rod; the guide block is sleeved on the screw rod and connected to the screw rod nut, the bottom of the guide block is connected to the guide component, and the top of the guide block is provided with a groove, and the groove is engaged with the linear guide rail; the linear guide rail is provided on the first bracket.

3. The magnetic separation lifting structure according to claim 2, characterized in that: A guide groove is provided on at least one side of the linear guide rail, a protrusion matching the guide groove is provided in the groove, and the guide groove and the protrusion cooperate with each other to limit the guide block from sliding out of the linear guide rail.

4. The magnetic separation lifting structure according to claim 2, characterized in that: It also includes at least one set of positioning components, wherein the positioning components include an optical coupling device and a baffle, The optical coupling device is arranged on one side of the first bracket; the baffle is arranged on one side of the guide block and is located on the same side as the optical coupling device.

5. The magnetic separation lifting structure according to claim 1, characterized in that: It also includes a magnet and a magnet mounting seat, wherein the magnet is arranged in the magnet mounting seat, and the magnet mounting seat is arranged between the consumable material mounting plate and the moving component and is movably connected to the consumable material mounting plate.

6. The magnetic separation lifting structure according to claim 5, characterized in that: The magnet mounting seat is provided with at least one through hole, and the through hole is used to accommodate the support component to pass through.

7. The magnetic separation lifting structure according to claim 5, characterized in that: At least one guide shaft is arranged at the bottom of the consumables mounting plate, and a linear bearing cooperating with the guide shaft is correspondingly arranged on the magnet mounting seat, and the guide shaft is placed in the linear bearing.

8. The magnetic separation lifting structure according to claim 5, characterized in that: At least one angle sensor is arranged on the magnet mounting seat, and the angle sensor is used to read the swing parameters of the magnetic separation lifting structure.

9. A magnetic separation mixing and swinging lifting device, characterized in that: The magnetic separation mixing and swinging lifting device comprises the magnetic separation lifting structure according to any one of claims 5 to 8, and also comprises a magnetic separation mixing and swinging structure; A first cantilever pin is provided on the first side of the magnet mounting seat, and a synchronous wheel is installed on the first cantilever pin; The magnetic separation mixing and swinging structure includes a mixing and swinging motor, a driving wheel and a synchronous belt. The driving wheel is connected to the output shaft of the mixing and swinging motor. The synchronous belt is sleeved on the driving wheel and the synchronous wheel. The driving wheel is used to drive the synchronous wheel to rotate through the synchronous belt under the drive of the mixing and swinging motor, thereby swinging the magnet mounting seat.

10. The magnetic separation mixing swing lifting device according to claim 9, characterized in that: The magnetic separation mixing and swinging structure also includes a reducer, one end of which is connected to the mixing and swinging motor, and the other end of which is connected to the driving wheel.

11. The magnetic separation mixing swing lifting device according to claim 9, characterized in that: The magnetic separation mixing and swinging structure also includes a second bracket, which includes a mixing and swinging bottom plate and a first support plate and a second support plate arranged in parallel. The first support plate, the second support plate and the mixing and swinging motor are all installed on the mixing and swinging bottom plate, and the driving wheel is installed on the first support plate.

12. The magnetic separation mixing swing lifting device according to claim 11, characterized in that: A first mounting hole is provided on the first support plate, a first bearing is provided in the first mounting hole, and the first cantilever pin is connected to the synchronous wheel through the first bearing.

13. The magnetic separation mixing swing lifting device according to claim 11, characterized in that: A second cantilever pin is arranged on the second side of the magnet mounting seat, the second side of the magnet mounting seat is arranged parallel to the first side of the magnet mounting seat, and a first limiting block is installed on the second cantilever pin; A second mounting hole is provided on the second support plate, a second bearing is provided in the second mounting hole, and the second cantilever pin is connected to the first limit block through the second bearing; At least one second limiting block is arranged beside the second mounting hole, and the second limiting block is used to cooperate with the first limiting block to limit the swing range of the magnet mounting seat.

14. A magnetic separation device, characterized in that: The magnetic separation equipment comprises the magnetic separation lifting structure according to any one of claims 1 to 8.

Images