Drug delivery experimental device for ultrasonic drug permeation instrument

Abstract

The utility model discloses a drug delivery experiment device for an ultrasonic drug permeation instrument, which comprises an experiment environment building unit, a drug delivery experiment unit and a drug delivery experiment unit, the ultrasonic unit is arranged in the liquid environment in the experimental environment building unit, the ultrasonic unit comprises a first ultrasonic transducer and a second ultrasonic transducer which are oppositely arranged, and an ultrasonic standing wave field is formed between the first ultrasonic transducer and the second ultrasonic transducer; the medicine conveying unit is used for conveying medicine particles into the ultrasonic standing wave field; the recording unit is used for recording the number of the drug particles captured by the ultrasonic standing wave field. The liquid environment is arranged, and the ultrasonic unit and the medicine conveying unit are arranged in the liquid environment, so that the capturing conditions of different medicine particles by different ultrasonic powers can be effectively experimented, the influence of different ultrasonic powers on the movement of different medicine particles can be verified, and power data support is provided for the ultrasonic medicine penetration instrument; and the leading-in effect of the ultrasonic medicine penetration instrument is greatly enhanced, so that the treatment effect is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of drug delivery, and in particular relates to a drug delivery experimental device used for an ultrasonic drug penetration instrument. Background Art

[0002] The ultrasonic drug penetration instrument uses the electric field generated by asymmetric medium-frequency current to produce a directional driving force on drug molecules, allowing the active ingredients in the drug to penetrate the skin more deeply and effectively into the human body, achieving the effect of needle-free transdermal drug delivery. This technology does not require metabolism and has no systemic toxic side effects. It is a green, safe and effective method of drug delivery.

[0003] The working principle of ultrasonic drug penetration instrument is to use the vibration and cavitation effect of ultrasound to change the permeability of the skin stratum corneum, making it easier for drug molecules to pass through the skin barrier and enter the deep tissue. At the same time, the energy of ultrasound can promote the molecular movement of drugs, accelerate the diffusion of drugs in tissues, increase the concentration of drugs in the lesion site, and thus enhance the treatment effect.

[0004] Ultrasonic drug permeation instrument has many advantages. First, it improves the transdermal absorption rate of drugs, allowing drugs to reach the lesion site more quickly and shorten the treatment time. Secondly, because the drug acts directly on the lesion site, it reduces the distribution of drugs throughout the body and reduces the side effects of drugs. In addition, ultrasonic drug permeation instrument can also select appropriate drugs and treatment plans according to the patient's condition and needs to achieve individualized treatment. In clinical applications, ultrasonic drug permeation instrument is widely used in the treatment of diseases in various departments. For example, in the gastroenterology department, it can be used to treat digestive system diseases such as acute and chronic gastritis and colitis; in the urology department, it can be used to treat urinary system diseases such as chronic cystitis and bladder tuberculosis.

[0005] However, different powers of ultrasonic drug permeation devices have different effects on the introduction of different drugs, and it is impossible to intuitively judge the effectiveness of the introduction during treatment, so the treatment effect cannot be guaranteed. Utility Model Content

[0006] In view of the problems in the background technology, the purpose of the utility model is to provide a drug delivery experimental device for an ultrasonic drug permeation instrument, which is used to test the effect of different ultrasonic powers on the introduction of drugs, including:

[0007] The experimental environment building unit is equipped with a liquid environment for experiments;

[0008] An ultrasonic unit is arranged in the liquid environment in the experimental environment building unit, the ultrasonic unit comprises a first ultrasonic transducer and a second ultrasonic transducer arranged opposite to each other, and an ultrasonic standing wave field is formed between the first ultrasonic transducer and the second ultrasonic transducer;

[0009] a drug delivery unit, used for delivering drug particles into the ultrasonic standing wave field;

[0010] A recording unit is used to record the number of the drug particles captured by the ultrasonic standing wave field.

[0011] Preferably, the ultrasonic unit includes a mounting frame, and the first ultrasonic transducer and the second ultrasonic transducer are mounted on the mounting frame in sequence up and down, and the first ultrasonic transducer is located above the second ultrasonic transducer.

[0012] Preferably, the mounting frame comprises a mounting seat, a first mounting rod, a second mounting rod, a first cross bar and a second cross bar, the first mounting rod and the second mounting rod are arranged on the mounting seat at intervals, the first cross bar and the second cross bar are successively installed up and down between the first mounting rod and the second mounting rod, the first ultrasonic transducer is arranged on the lower end surface of the first cross bar, and the second ultrasonic transducer is arranged on the upper end surface of the second cross bar;

[0013] The second mounting rod comprises a fixed rod and an adjusting screw, wherein the fixed rod is fixedly mounted on the mounting seat, a rotating hole is arranged at the upper end of the fixed rod, a rotating shaft is arranged at the lower end of the adjusting screw, and the adjusting screw passes through the rotating shaft and is rotatably connected to the rotating hole;

[0014] One end of the first cross bar is sleeved and slidably connected to the first mounting rod, and the other end is sleeved and threadedly connected to the adjusting screw. The two ends of the second cross bar are respectively fixedly connected to the first mounting rod and the fixed rod. The distance between the first ultrasonic transducer and the second ultrasonic transducer is adjusted by rotating the adjusting screw.

[0015] Preferably, a handle is provided at the upper end of the adjusting screw, and the adjusting screw is driven to rotate by the handle.

[0016] Preferably, a limiting flange is provided at the upper end of the fixing rod for limiting the lowest position of the first cross bar.

[0017] Preferably, the first mounting rod is provided with a scale for displaying the distance between the first ultrasonic transducer and the second ultrasonic transducer.

[0018] Preferably, the experimental environment building unit includes a water tank, in which distilled water is stored.

[0019] Preferably, the drug delivery unit includes a delivery tube and an injection assembly, one end of the delivery tube is connected to the injection assembly, and the other end extends into the liquid environment and is arranged toward the ultrasonic standing wave field, and the injection assembly injects a suspension containing the drug particles into the ultrasonic standing wave field through the delivery tube.

[0020] Preferably, the drug delivery unit comprises a column, the delivery tube is a hose, the injection assembly is a syringe, a plurality of tube clamps are provided on the column, and the delivery tube is fixed on the tube clamps.

[0021] Preferably, the recording unit comprises a camera for taking pictures of the ultrasonic standing wave field.

[0022] Due to the adoption of the above technical solution, the utility model has the following advantages and positive effects compared with the prior art:

[0023] 1. The utility model sets up a liquid environment, and sets up an ultrasonic unit and a drug delivery unit in the liquid environment, so as to effectively experiment with the capture of different drug particles by different ultrasonic powers, verify the influence of different ultrasonic powers on the movement of different drug particles, provide power data support for the ultrasonic drug penetration instrument, greatly enhance the introduction effect of the ultrasonic drug penetration instrument, and improve the treatment effect.

[0024] 2. The utility model can adjust the distance between the first ultrasonic transducer and the second ultrasonic transducer by rotating the adjusting screw, so that the distance between the two can be easily adjusted to the required distance to verify the influence of different distances on the movement of drug particles.

[0025] 3. The injection assembly of the utility model injects a suspension containing drug particles into the ultrasonic standing wave field through a delivery tube. Injecting the suspension containing drug particles into a liquid environment through a delivery tube can prevent bubbles from being generated in the liquid environment, that is, it can reduce the disturbance to the liquid environment, because a disturbed liquid environment will affect the experimental results. If the first ultrasonic transducer and the second ultrasonic transducer are turned on after waiting for the liquid environment to calm down, the drug particles will run out of the ultrasonic standing wave field. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The specific implementation of the utility model is further described in detail below with reference to the accompanying drawings, wherein:

[0027] Figure 1 This is a front view of the utility model;

[0028] Figure 2 This is a schematic diagram of the ultrasonic unit of the utility model;

[0029] Figure 3 It is a side view of the utility model;

[0030] Figure 4 It is a top view of the utility model.

[0031] Description of reference numerals:

[0032] 1. Base; 2. Water tank; 3. First ultrasonic transducer; 4. Second ultrasonic transducer; 5. Scale; 6. Mounting seat; 7. First mounting rod; 8. Fixed rod; 9. Adjusting screw; 10. Limiting flange; 11. First cross bar; 12. Second cross bar; 13. Handle; 14. Post; 15. Delivery tube; 16. Syringe; 17. Extension plate; 18. Tube clamp; 19. Camera; 20. Camera stand; 21. Slide. DETAILED DESCRIPTION

[0033] The utility model is further described in detail below in conjunction with the accompanying drawings and specific embodiments. According to the following description, the advantages and features of the utility model will become clearer. It should be noted that the accompanying drawings are all in a very simplified form and use non-precise ratios, which are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the utility model.

[0034] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

[0035] See also Figures 1 to 4 The core of the utility model is to provide a drug delivery experimental device for an ultrasonic drug permeation instrument, which is used to test the effect of different ultrasonic powers on the introduction of drugs, including a base 1, an experimental environment building unit, an ultrasonic unit, a drug delivery unit and a recording unit.

[0036] The experimental environment building unit is arranged on the base 1. The experimental environment building unit is used to build the environment required for the experiment. The experimental environment building unit is provided with a liquid environment for the experiment. The liquid environment can provide buoyancy for the drug particles for subsequent experiments. In this embodiment, the experimental environment building unit includes a water tank 2. The water tank 2 stores distilled water. The distilled water can reduce the impact on the drug particles and facilitate observation. Of course, in other embodiments, the liquid environment can also be other media, which is not limited in this embodiment.

[0037] The ultrasonic unit is arranged in the distilled water in the water tank 2, and the ultrasonic unit includes a first ultrasonic transducer 3 and a second ultrasonic transducer 4 which are arranged opposite to each other, and an ultrasonic standing wave field is formed between the first ultrasonic transducer 3 and the second ultrasonic transducer 4. The ultrasonic unit also includes a mounting frame, and the first ultrasonic transducer 3 and the second ultrasonic transducer 4 are successively mounted on the mounting frame up and down, and the first ultrasonic transducer 3 is located above the second ultrasonic transducer 4.

[0038] Specifically, the mounting frame includes a mounting seat 6, a first mounting rod 7, a second mounting rod, a first cross bar 11 and a second cross bar 12. The first mounting rod 7 and the second mounting rod are arranged on the mounting seat 6 at intervals. The first cross bar 11 and the second cross bar 12 are installed between the first mounting rod 7 and the second mounting rod in sequence from top to bottom. The first ultrasonic transducer 3 is arranged on the lower end surface of the first cross bar 11, and the second ultrasonic transducer 4 is arranged on the upper end surface of the second cross bar 12.

[0039] The second mounting rod includes a fixed rod 8 and an adjusting screw 9. The fixed rod 8 is fixedly mounted on the mounting seat 6. A rotating hole is provided at the upper end of the fixed rod 8. A rotating shaft is provided at the lower end of the adjusting screw 9. The adjusting screw 9 is passed through the rotating shaft and is rotatably connected to the rotating hole. One end of the first cross bar 11 is sleeved and slidably connected to the first mounting rod 7, and the other end is sleeved and threadedly connected to the adjusting screw 9. The two ends of the second cross bar 12 are respectively fixedly connected to the first mounting rod 7 and the fixed rod 8. The spacing between the first ultrasonic transducer 3 and the second ultrasonic transducer 4 is adjusted by rotating the adjusting screw 9.

[0040] By rotating the adjusting screw 9 to adjust the distance between the first ultrasonic transducer 3 and the second ultrasonic transducer 4, the distance between the two can be conveniently adjusted to a desired distance to verify the influence of different distances on the movement of drug particles.

[0041] Preferably, a handle 13 is provided at the upper end of the adjusting screw 9, and the adjusting screw 9 is driven to rotate by the handle 13. A limiting flange 10 is provided at the upper end of the fixing rod 8, which is used to limit the lowest position of the first cross bar 11 to prevent the first cross bar 11 from moving down excessively. A scale 5 is provided on the first mounting rod 7, which is used to display the spacing between the first ultrasonic transducer 3 and the second ultrasonic transducer 4, so that the first ultrasonic transducer 3 and the second ultrasonic transducer 4 can be easily adjusted to the desired spacing.

[0042] The drug delivery unit is used to deliver drug particles into the ultrasonic standing wave field. Specifically, the drug delivery unit includes a delivery tube 15 and an injection assembly. In this embodiment, the delivery tube 15 is a hose, and the injection assembly is a syringe 16. One end of the delivery tube 15 is connected to the syringe 16, and the other end extends into the distilled water and is arranged toward the ultrasonic standing wave field. The syringe 16 injects a suspension containing drug particles into the ultrasonic standing wave field through the delivery tube 15. The drug delivery unit also includes a column 14, on which a plurality of tube clamps 18 are provided. The delivery tube 15 is fixed to the tube clamp 18, and an extension plate 17 is also provided near the ultrasonic standing wave field on the column 14. The extension plate 17 extends toward the ultrasonic standing wave field, and a tube clamp 18 is provided on the extension plate 17. The lower end of the delivery tube 15 is fixed to the tube clamp 18 on the extension plate 17, and the lower end of the delivery tube 15 is adjusted to face the ultrasonic standing wave field through the tube clamp 18 on the extension plate 17.

[0043] The injection component injects a suspension containing drug particles into the ultrasonic standing wave field through the delivery tube 15. Injecting the suspension containing drug particles into distilled water through the delivery tube 15 can prevent the generation of bubbles in the liquid environment, that is, it can reduce the disturbance of the distilled water, because the disturbance of the distilled water will affect the experimental results. If the first ultrasonic transducer 3 and the second ultrasonic transducer 4 are turned on after waiting for the distilled water to calm down, the drug particles will run out of the ultrasonic standing wave field.

[0044] The recording unit is used to record the number of drug particles captured by the ultrasonic standing wave field. In this embodiment, the recording unit includes a camera 19 for taking pictures at the ultrasonic standing wave field, and the water tank 2 is made of a transparent material. The camera 19 is mounted on the base 1 through a camera frame 20, and the base 1 is provided with two parallel slide grooves 21 extending toward the water tank 2. The two sides of the camera frame 20 are respectively slidably connected to the two slide grooves 21. The distance between the camera 19 and the ultrasonic standing wave field can be adjusted through the slide grooves 21 to adjust the focal length of the camera 19, so that the captured picture is clearer. The camera 19 can specifically be a micro-focus digital camera, and a black backing plate can be pasted on the side of the water tank 2 away from the camera 19 to enhance the recognition of the drug particles.

[0045] The working process of the utility model is further described below:

[0046] Before the experiment, a suspension containing drug particles is prepared, the suspension is extracted by the syringe 16, and the delivery tube 15 is connected. The syringe 16 injects the suspension into the delivery tube 15 to remove the air in the delivery tube 15, and then the delivery tube 15 is installed on the column 14.

[0047] Then, distilled water is added into the water tank 2 to immerse the ultrasonic unit, and the first ultrasonic transducer 3 and the second ultrasonic transducer 4 are connected to the signal generator. The signal generator is set to transmit a continuous sine wave signal with a frequency of 2 MHz. After passing through the power amplifier, the real-time voltage is read using an oscilloscope.

[0048] Finally, the first ultrasonic transducer 3 and the second ultrasonic transducer 4 are turned on, and the suspension is slowly injected into the ultrasonic standing wave field. After the binding state of the drug particles is stabilized, the camera 19 takes a photo. After the image is obtained, simple image processing is performed on it to reduce the brightness and improve the contrast and clarity.

[0049] In this embodiment, real drug particles are used in the experiment. In other embodiments, white polystyrene particles with the same diameter as the drug particles can also be used.

[0050] The utility model sets up a liquid environment and sets an ultrasonic unit and a drug delivery unit in the liquid environment, which can effectively experiment with the capture of different drug particles by different ultrasonic powers, so as to verify the influence of different ultrasonic powers on the movement of different drug particles, provide power data support for the ultrasonic drug penetration instrument, greatly enhance the introduction effect of the ultrasonic drug penetration instrument, and improve the treatment effect.

[0051] The above is a detailed description of the embodiments of the present invention in conjunction with the accompanying drawings, but the present invention is not limited to the above embodiments. Even if various changes are made to the present invention, if these changes fall within the scope of the claims of the present invention and their equivalents, they still fall within the protection scope of the present invention.

Claims

1. A drug delivery experimental device for an ultrasonic drug permeation instrument, used to test the effect of different ultrasonic powers on drug introduction, characterized in that: include: The experimental environment building unit is equipped with a liquid environment for experiments; An ultrasonic unit is arranged in the liquid environment in the experimental environment building unit, the ultrasonic unit comprises a first ultrasonic transducer and a second ultrasonic transducer arranged opposite to each other, and an ultrasonic standing wave field is formed between the first ultrasonic transducer and the second ultrasonic transducer; a drug delivery unit, used for delivering drug particles into the ultrasonic standing wave field; A recording unit is used to record the number of the drug particles captured by the ultrasonic standing wave field.

2. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 1, characterized in that: The ultrasonic unit comprises a mounting frame, and the first ultrasonic transducer and the second ultrasonic transducer are mounted on the mounting frame in sequence up and down, and the first ultrasonic transducer is located above the second ultrasonic transducer.

3. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 2, characterized in that: The mounting frame includes a mounting seat, a first mounting rod, a second mounting rod, a first cross bar and a second cross bar, the first mounting rod and the second mounting rod are arranged on the mounting seat at intervals, the first cross bar and the second cross bar are successively installed up and down between the first mounting rod and the second mounting rod, the first ultrasonic transducer is arranged on the lower end surface of the first cross bar, and the second ultrasonic transducer is arranged on the upper end surface of the second cross bar; The second mounting rod comprises a fixed rod and an adjusting screw, wherein the fixed rod is fixedly mounted on the mounting seat, a rotating hole is arranged at the upper end of the fixed rod, a rotating shaft is arranged at the lower end of the adjusting screw, and the adjusting screw passes through the rotating shaft and is rotatably connected to the rotating hole; One end of the first cross bar is sleeved and slidably connected to the first mounting rod, and the other end is sleeved and threadedly connected to the adjusting screw. The two ends of the second cross bar are respectively fixedly connected to the first mounting rod and the fixed rod. The distance between the first ultrasonic transducer and the second ultrasonic transducer is adjusted by rotating the adjusting screw.

4. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 3, characterized in that: A handle is provided at the upper end of the adjusting screw, and the adjusting screw is driven to rotate by the handle.

5. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 3, characterized in that: A limiting flange is provided at the upper end of the fixing rod for limiting the lowest position of the first cross bar.

6. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 3, characterized in that: The first mounting rod is provided with a scale for displaying the distance between the first ultrasonic transducer and the second ultrasonic transducer.

7. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 1, characterized in that: The experimental environment building unit comprises a water tank in which distilled water is stored.

8. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 1, characterized in that: The drug delivery unit includes a delivery tube and an injection assembly, one end of the delivery tube is connected to the injection assembly, and the other end extends into the liquid environment and is arranged toward the ultrasonic standing wave field. The injection assembly injects a suspension containing the drug particles into the ultrasonic standing wave field through the delivery tube.

9. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 8, characterized in that: The drug delivery unit comprises a column, the delivery tube is a hose, the injection assembly is a syringe, a plurality of tube clamps are arranged on the column, and the delivery tube is fixed on the tube clamps.

10. The drug delivery experimental device for ultrasonic drug permeation instrument according to claim 1, characterized in that: The recording unit comprises a camera for taking pictures of the ultrasonic standing wave field.

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