Drug intermediate separation and purification device

Abstract

The utility model provides a drug intermediate separation and purification device which comprises a box body, a stirring barrel is fixedly mounted at the top of the interior of the box body, a stirring mechanism is arranged in the stirring barrel, a feeding opening is fixedly formed in the top of the stirring barrel, and a first drainage pipe is fixedly mounted at the bottom of the stirring barrel. Through the use of the filtering mechanism, after a medicine intermediate solution is separated and purified, medicine residues generated after separation can be filtered through a filter screen in a fixed frame, a second motor is started to work, a reciprocating lead screw is driven to rotate, a moving part is driven to reciprocate up and down in a mounting frame, and when the moving part moves, medicine residues generated after separation can be filtered through the filter screen. And the sliding grooves are formed in an inverted V shape, so that when the sliding blocks move, the connecting rods and the wiping cylinders can be driven to move up and down along the sliding grooves, the surfaces of the filter screens are cleaned through the wiping cylinders, and residues obtained after cleaning can be collected through the collecting box.

Description

Technical Field

[0001] The utility model relates to the field of separation and purification of drug intermediates, and in particular to a device for separation and purification of drug intermediates. Background Art

[0002] Drug intermediates are important raw materials in the drug synthesis process, and their purity and quality directly affect the efficacy and safety of the final drug. In the production process of drug intermediates, multiple chemical reactions and separation and purification operations are usually required, which requires the use of separation and purification equipment. However, the existing drug intermediate separation and purification equipment still has some problems when used.

[0003] During the separation and purification process of drug intermediates, a filtering device is needed to separate and filter the residues of drug separation; however, during the use of existing filtering devices, the filter screen is prone to clogging, and the operator needs to manually clear it. The operation process is time-consuming and labor-intensive, and affects the efficiency of filtration. Therefore, we have made improvements and proposed a drug intermediate separation and purification device. Utility Model Content

[0004] In view of the deficiencies in the prior art, the utility model provides a drug intermediate separation and purification device, which solves the problems mentioned in the background technology.

[0005] In order to achieve the above-mentioned utility model purpose, the utility model provides the following technical solutions:

[0006] A drug intermediate separation and purification device is provided to solve the above problems.

[0007] The specific application is as follows:

[0008] The invention comprises a box body, a stirring barrel is fixedly installed on the top of the box body, a stirring mechanism is arranged inside the stirring barrel, a feeding port is fixedly installed on the top of the stirring barrel, a first drain pipe is fixedly installed on the bottom of the stirring barrel, a first valve is fixedly installed on the outside of the first drain pipe, a filtering mechanism is arranged on the lower side of the stirring barrel inside the box body, a second drain pipe is fixedly installed on one side surface of the box body, and a second valve is fixedly installed on the outer surface of the second drain pipe;

[0009] The stirring mechanism comprises a first motor, and the first motor is fixedly mounted on the top of the stirring barrel, a rotating shaft is fixedly mounted on the output end of the first motor, and a stirring rod is fixedly mounted on the outer surface of the rotating shaft.

[0010] As a preferred technical solution of the present application, the filtering mechanism includes a fixed frame, and there are two fixed frames, both of which are L-shaped and fixedly installed inside the box, a fixed frame is provided between the two fixed frames, and the fixed frame is arranged in an inverted V shape, and a filter is fixedly installed inside the fixed frame.

[0011] As a preferred technical solution of the present application, a slide groove is provided on the inner wall of the rear end of the box body, and the slide groove is arranged in an inverted V shape, and the two sides of the slide groove are arranged parallel to the two sides of the fixed frame. The interior of both ends of the slide groove is slidably connected with a connecting rod, and a wiping cylinder is fixedly installed on the outer surface of the connecting rod, and the wiping cylinder is in contact with the filter screen.

[0012] As a preferred technical solution of the present application, a mounting frame is fixedly installed on the back of the box, and a moving part is slidably connected inside the mounting frame. Slide blocks are slidably connected on both sides of the moving part, and the connection between the slide block and the connecting rod is a fixed connection.

[0013] As a preferred technical solution of the present application, a second motor is fixedly mounted on the upper surface of the mounting frame, and a reciprocating screw is fixedly connected to the output end of the second motor. The reciprocating screw is rotatably connected inside the mounting frame, and the connection between the reciprocating screw and the moving part is a threaded connection.

[0014] As a preferred technical solution of the present application, fixing plates are fixedly installed on both inner walls of the box body, and a collection box is slidably connected to the upper surface of the fixing plate, and a handle is fixedly installed on one side surface of the collection box.

[0015] Compared with the prior art, the utility model has the following beneficial effects:

[0016] In the scheme of this application:

[0017] By setting up the use of the filtering mechanism, after the drug intermediate solution is separated and purified, the drug residues produced after the separation can be filtered through the filter screen inside the fixed frame, and the second motor is started to drive the reciprocating screw to rotate, and drive the moving part to reciprocate up and down in the installation frame. When the moving part moves, it drives the two sliders inside to slide. Since the slide groove is opened in an inverted V shape, when the slider moves, it can drive the connecting rod and the wiping cylinder to move up and down along the slide groove, and the surface of the filter screen can be cleaned by the wiping cylinder. The cleaned residue can be collected by the collection box. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 A three-dimensional structural schematic diagram of the drug intermediate separation and purification device provided in this application;

[0019] Figure 2A schematic diagram of the three-dimensional structure of the internal structure of the drug intermediate separation and purification device provided in this application;

[0020] Figure 3 This is a schematic diagram of the cross-sectional structure of the pharmaceutical intermediate separation and purification device provided in the present application;

[0021] Figure 4 The drug intermediate separation and purification device provided in this application Figure 2 A schematic diagram of the enlarged structure of the middle part A;

[0022] Figure 5 A schematic diagram of the three-dimensional structure of the rear side of the drug intermediate separation and purification device provided in this application;

[0023] Figure 6 This is a schematic diagram of the three-dimensional structure inside the installation frame of the drug intermediate separation and purification device provided in this application.

[0024] Indicated in the figure:

[0025] 1. Box body; 2. Mixing barrel; 3. Mixing mechanism; 301. First motor; 302. Rotating shaft; 303. Mixing rod; 4. Feed inlet; 5. First drain pipe; 6. First valve; 7. Filter mechanism; 701. Fixed frame; 702. Fixed frame; 703. Filter net; 704. Slide; 705. Connecting rod; 706. Wiping cylinder; 707. Mounting frame; 708. Moving part; 709. Sliding block; 710. Second motor; 711. Reciprocating screw; 712. Fixed plate; 713. Collecting box; 714. Handle; 8. Second drain pipe; 9. Second valve. DETAILED DESCRIPTION

[0026] To make the purpose, technical solution and advantages of the embodiment of the utility model clearer, the technical solution in the embodiment of the utility model will be described clearly and completely in conjunction with the accompanying drawings. Obviously, the described examples are part of the embodiments of the utility model, not all of the embodiments.

[0027] Therefore, the following detailed description of the embodiments of the present invention is not intended to limit the scope of the present invention to be protected, but merely represents some embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0028] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features and technical solutions in the embodiments may be combined with each other.

[0029] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, further definition and explanation thereof is not required in subsequent drawings.

[0030] In the description of the present utility model, it should be noted that the orientation or position relationship indicated by the terms "upper" and "lower" is based on the orientation or position relationship shown in the drawings, or the orientation or position relationship in which the utility model product is usually placed when in use, or the orientation or position relationship commonly understood by those skilled in the art. Such terms are only for the convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present utility model. In addition, the terms "first" and "second" are only used to distinguish the description, and cannot be understood as indicating or implying relative importance.

[0031] In order to solve the technical problems in the background technology, the following drug intermediate separation and purification device is provided:

[0032] Combination Figure 1 - Figure 6 As shown, a drug intermediate separation and purification device provided by the utility model comprises a casing 1, a stirring barrel 2 is fixedly mounted on the top of the casing 1, a stirring mechanism 3 is arranged inside the stirring barrel 2, a feed port 4 is fixedly mounted on the top of the stirring barrel 2, a first drain pipe 5 is fixedly mounted on the bottom of the stirring barrel 2, and a first valve 6 is fixedly mounted on the outside of the first drain pipe 5, a filtering mechanism 7 is arranged on the lower side of the stirring barrel 2 inside the casing 1, a second drain pipe 8 is fixedly mounted on the surface of one side of the casing 1, and a second valve 9 is fixedly mounted on the outer surface of the second drain pipe 8, the stirring mechanism 3 comprises a first motor 301, and the first motor 301 is fixedly mounted on the top of the stirring barrel 2, a rotating shaft 302 is fixedly mounted on the output end of the first motor 301, and a stirring rod 303 is fixedly mounted on the outer surface of the rotating shaft 302.

[0033] In this embodiment: the drug intermediate solution is poured into the stirring barrel 2 from the feed port 4, and the purified reaction drug is added, and the first motor 301 is started at the same time. The first motor 301 drives the rotating shaft 302 at the output end to rotate, and the rotating shaft 302 also drives the stirring rod 303 to rotate, so that the drug intermediate solution inside the stirring barrel 2 is stirred evenly to improve the separation and purification effect. Subsequently, the separated and purified drug intermediate solution can be discharged into the box 1 by opening the first valve 6, and the solution can be discharged from the box 1 by opening the second valve 9.

[0034] refer to Figure 1 - Figure 4On the basis of the above embodiment, the separated and purified drug intermediate solution can be filtered. This embodiment provides the following design:

[0035] As a preferred embodiment, the filtering mechanism 7 includes a fixing frame 701, and two fixing frames 701 are provided. Both fixing frames 701 are L-shaped and fixedly installed inside the box body 1. A fixing frame 702 is provided between the two fixing frames 701, and the fixing frame 702 is in an inverted V shape. A filter net 703 is fixedly installed inside the fixing frame 702.

[0036] In this embodiment, the solution is discharged from the first drain pipe 5 and passes through the fixed frame 702 and the internal filter screen 703. The separated and purified solution can be filtered through the filter screen 703. The L-shaped fixed frames 701 on both sides can facilitate the placement of the fixed frame 702.

[0037] refer to Figure 2 - Figure 3 On the basis of the above embodiment, when the filter 703 is blocked, the surface of the filter 703 can be cleaned. The present embodiment provides the following design:

[0038] As a preferred embodiment, a slide groove 704 is provided on the inner wall at the rear end of the box body 1, and the slide groove 704 is arranged in an inverted V shape, and the two sides of the slide groove 704 are arranged parallel to the two sides of the fixed frame 702, and the interiors of both ends of the slide groove 704 are slidably connected with connecting rods 705, and the outer surface of the connecting rod 705 is fixedly installed with a wiping cylinder 706, and the wiping cylinder 706 is in contact with the filter screen 703.

[0039] In this embodiment: when the connecting rods 705 on both sides slide inside the slide groove 704, the wiping cylinder 706 on the surface will be driven to move. Since the two sides of the slide groove 704 are arranged in parallel with the two sides of the fixed frame 702, the wiping cylinder 706 is in contact with the filter screen 703. When the wiping cylinder 706 moves, the surface of the filter screen 703 can be wiped to avoid blockage.

[0040] refer to Figure 6 On the basis of the above embodiment, the wiping cylinders 706 on both sides can be driven to rotate synchronously. The present embodiment provides the following design:

[0041] As a preferred embodiment, a mounting frame 707 is fixedly installed on the back of the box body 1, and a moving part 708 is slidably connected inside the mounting frame 707, and sliders 709 are slidably connected on both sides inside the moving part 708, and the connection between the slider 709 and the connecting rod 705 is a fixed connection.

[0042] In this embodiment: the slider 709 slides in the movable member 708, and the connecting rod 705 on one side surface of the slider 709 slides in the slide groove 704. When the movable member 708 moves up and down inside the installation frame 707, the slide groove 704 can limit the two sliders 709 to move relative to each other, and drive the connecting rod 705 and the wiping cylinder 706 to move relative to each other synchronously, so as to clean the surface of the filter screen 703.

[0043] refer to Figure 5 and Figure 6 On the basis of the above embodiment, the moving member 708 can be driven to reciprocate up and down. The present embodiment provides the following design:

[0044] As a preferred embodiment, a second motor 710 is fixedly mounted on the upper surface of the mounting frame 707, and a reciprocating screw 711 is fixedly connected to the output end of the second motor 710. The reciprocating screw 711 is rotatably connected inside the mounting frame 707, and the reciprocating screw 711 is connected to the moving part 708 by a threaded connection.

[0045] In this embodiment: by starting the second motor 710 and driving the reciprocating screw 711 at the output end to rotate, since the reciprocating screw 711 is threadedly connected to the moving part 708, the moving part 708 can be driven to reciprocate up and down in the installation frame 707, thereby achieving the effect of driving the slider 709, the connecting rod 705 and the wiping cylinder 706 to move, thereby facilitating the cleaning of the surface of the filter screen 703.

[0046] refer to Figure 1 - Figure 4 On the basis of the above embodiment, it is convenient to collect the residue after cleaning. This embodiment provides the following design:

[0047] As a preferred embodiment, a fixing plate 712 is fixedly installed on both inner walls of the box body 1 , and a collection box 713 is slidably connected to the upper surface of the fixing plate 712 , and a handle 714 is fixedly installed on one side surface of the collection box 713 .

[0048] In this embodiment: the collection box 713 is slidably connected to the upper surface of the fixed plate 712, and the collection box 713 is set on one side of the fixed frame 701. The wiping cylinder 706 cleans the residue on the surface of the filter screen 703, which will fall into the collection box 713, and it is convenient to take out the collection box 713 for cleaning.

[0049] Specifically, the working principle of this solution is:

[0050] When in use, the drug intermediate solution is poured into the stirring barrel 2 from the feed port 4, and the purification reaction drug is added, and the first motor 301 is started at the same time. The first motor 301 drives the rotating shaft 302 at the output end to rotate, and the rotating shaft 302 also drives the stirring rod 303 to rotate, so that the drug intermediate solution inside the stirring barrel 2 is stirred evenly to improve the separation and purification effect. Then, the separated and purified drug intermediate solution can be discharged by opening the first valve 6.

[0051] The discharged solution and residue will fall onto the surface of the filter 703 and be filtered by the filter 703. At the same time, the second motor 710 is driven to work and the reciprocating screw 711 at the output end is driven to rotate. Since the reciprocating screw 711 is threadedly connected to the moving part 708, the moving part 708 can be driven to reciprocate up and down in the installation frame 707, and then the slider 709, the connecting rod 705 and the wiping cylinder 706 can be driven to reciprocate following the slide groove 704, so as to clean the surface of the filter 703. The residue after cleaning will fall into the collection box 713 for easy cleaning. The above is the working process of the entire device, and the contents not described in detail in this manual belong to the prior art known to professional and technical personnel in this field.

[0052] The above embodiments are only used to illustrate the present invention and are not intended to limit the technical solutions described in the present invention. Although the present invention has been described in detail with reference to the above embodiments, the present invention is not limited to the above specific implementation methods. Therefore, any modification or equivalent replacement of the present invention; and all technical solutions and improvements thereof that do not depart from the spirit and scope of the present invention are included in the scope of the claims of the present invention.

Claims

1. A pharmaceutical intermediate separation and purification device, comprising a housing (1), characterized in that: A stirring barrel (2) is fixedly mounted on the top of the interior of the box (1), and a stirring mechanism (3) is arranged inside the stirring barrel (2); a feed port (4) is fixedly mounted on the top of the stirring barrel (2), and a first drain pipe (5) is fixedly mounted on the bottom of the stirring barrel (2), and a first valve (6) is fixedly mounted on the outside of the first drain pipe (5); a filtering mechanism (7) is arranged on the lower side of the stirring barrel (2) inside the box (1), and a second drain pipe (8) is fixedly mounted on a side surface of the box (1), and a second valve (9) is fixedly mounted on the outer surface of the second drain pipe (8); The stirring mechanism (3) comprises a first motor (301), and the first motor (301) is fixedly mounted on the top of the stirring barrel (2), a rotating shaft (302) is fixedly mounted on the output end of the first motor (301), and a stirring rod (303) is fixedly mounted on the outer surface of the rotating shaft (302).

2. A pharmaceutical intermediate separation and purification device according to claim 1, characterized in that: The filtering mechanism (7) comprises a fixing frame (701), and two fixing frames (701) are provided, the two fixing frames (701) are both arranged in an L shape, and the two fixing frames (701) are fixedly installed inside the box body (1), a fixing frame (702) is arranged between the two fixing frames (701), and the fixing frame (702) is arranged in an inverted V shape, and a filter screen (703) is fixedly installed inside the fixing frame (702).

3. A pharmaceutical intermediate separation and purification device according to claim 2, characterized in that: A slide groove (704) is provided on the inner wall at the rear end of the box body (1), and the slide groove (704) is arranged in an inverted V shape, and two sides of the slide groove (704) are arranged parallel to two sides of the fixed frame (702), and connecting rods (705) are slidably connected to the inside of both ends of the slide groove (704), and a wiping cylinder (706) is fixedly installed on the outer surface of the connecting rod (705), and the wiping cylinder (706) is in contact with the filter screen (703).

4. A pharmaceutical intermediate separation and purification device according to claim 3, characterized in that: A mounting frame (707) is fixedly mounted on the back of the box body (1), and a moving member (708) is slidably connected inside the mounting frame (707), and sliding blocks (709) are slidably connected to both sides of the moving member (708), and the connection between the sliding block (709) and the connecting rod (705) is a fixed connection.

5. A pharmaceutical intermediate separation and purification device according to claim 4, characterized in that: A second motor (710) is fixedly mounted on the upper surface of the mounting frame (707), and a reciprocating screw (711) is fixedly connected to the output end of the second motor (710); the reciprocating screw (711) is rotatably connected inside the mounting frame (707), and the reciprocating screw (711) and the moving member (708) are connected in a threaded manner.

6. A pharmaceutical intermediate separation and purification device according to claim 1, characterized in that: A fixing plate (712) is fixedly mounted on both inner walls of the box body (1), and a collection box (713) is slidably connected to the upper surface of the fixing plate (712), and a handle (714) is fixedly mounted on one side surface of the collection box (713).

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