Microfluidic chip

Abstract

The utility model belongs to the technical field of microfluidics, and discloses a micro-fluidic chip. The micro-fluidic chip comprises a chip cover plate and a chip bottom plate which are in bonding connection, and through liquid outlet flow channels are formed in the chip cover plate and the chip bottom plate; one side of the chip cover plate is attached to the chip bottom plate, the other side of the chip cover plate is provided with a cavity communicated with the liquid outlet channel, and the liquid outlet channel forms an opening in the bottom surface of the cavity; an impact part is arranged in the cavity in a protruding mode and arranged on the periphery of the opening. The chip cover sheet and the chip bottom sheet are bonded to form the micro-fluidic chip, and a sheet spraying structure of injection molding processing is replaced, so that the processing of the micro-fluidic chip is more flexible and is not limited by a mold, and a relatively fine structure can be processed; the cavity and the impact part are arranged on the chip cover plate, the liquid is dispersed by the impact force generated by the impact part, and the dispersed liquid can be sprayed out along the liquid outlet flow channel from the opening, so that smaller atomized particles are obtained, and the atomization effect of the liquid is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of microfluidics, in particular to a microfluidics chip. Background Art

[0002] Microfluidic chip analysis technology integrates the basic operation units such as sample preparation, reaction, dissociation, and detection in the biological, chemical, and medical analysis processes into a micro-nanoscale chip to automatically complete the entire detection and analysis process; the liquid enters the microfluidic chip, and the liquid forms atomized particles after passing through the microfluidic chip.

[0003] In the prior art, the spray plate structure at the nozzle of a traditional spray bottle is processed by injection molding. The structure processed by injection molding is limited by the mold, making it difficult to process a fine structure; the spray plate structure cannot break up the liquid, resulting in poor atomization effect of the liquid and larger atomized particles.

[0004] That is, the existing spray plate structure has the disadvantages that it is difficult to process fine structures due to mold limitations when using injection molding, and it is also unable to break up the liquid, resulting in poor atomization effect of the liquid. Utility Model Content

[0005] The utility model aims to provide a microfluidic chip to solve the problems that the existing spray chip structure is difficult to process fine structures due to mold limitations when using injection molding, and the liquid cannot be dispersed, resulting in poor atomization effect of the liquid.

[0006] To achieve this purpose, the utility model adopts the following technical solutions:

[0007] The utility model provides a microfluidic chip, which comprises a chip cover sheet and a chip bottom sheet which are bonded and connected, wherein the chip cover sheet and the chip bottom sheet are provided with a through liquid outlet channel;

[0008] One side of the chip cover sheet is attached to the chip bottom sheet, and the other side is provided with a cavity connected to the liquid outlet channel, and the liquid outlet channel forms an opening at the bottom surface of the cavity;

[0009] An impact portion is convexly provided in the cavity, and the impact portion is arranged on the outer periphery of the opening.

[0010] As an optional technical solution for a microfluidic chip, the impact part includes at least two impact blocks, a gap extending to the opening is left between two adjacent impact blocks, and the impact blocks are centrally symmetrically arranged about a center point of the opening.

[0011] As an optional technical solution for a microfluidic chip, the impact block extends spirally outward from the opening.

[0012] As an optional technical solution for a microfluidic chip, the thickness of the impact block gradually decreases in a direction away from the opening.

[0013] As an optional technical solution for a microfluidic chip, the top surface of the impact block is a curved surface that is low in the middle and high at the edges.

[0014] As an optional technical solution for a microfluidic chip, the liquid outlet channel includes a first liquid outlet hole penetrating the chip cover, and the first liquid outlet hole is a circular hole.

[0015] As an optional technical solution for a microfluidic chip, the liquid outlet channel also includes a second liquid outlet hole penetrating the chip bottom sheet, the second liquid outlet hole is connected to the first liquid outlet hole, and the second liquid outlet hole is a tapered hole.

[0016] As an optional technical solution for a microfluidic chip, the inner diameter of the large end of the tapered hole is larger than the inner diameter of the first liquid outlet hole.

[0017] As an optional technical solution for a microfluidic chip, the axial directions of the first liquid outlet hole and the second liquid outlet hole coincide with each other.

[0018] As an optional technical solution for a microfluidic chip, the chip cover is made of silicon material, and / or the chip bottom plate is made of glass material.

[0019] Beneficial effects:

[0020] The utility model provides a microfluidic chip, which includes a chip cover and a chip bottom sheet bonded together, wherein a liquid outlet channel is provided in the chip cover and the chip bottom sheet; one side of the chip cover is attached to the chip bottom sheet, and the other side is provided with a cavity connected to the liquid outlet channel, and the liquid outlet channel forms an opening at the bottom surface of the cavity; an impact portion is convexly provided in the cavity, and the impact portion is arranged at the outer periphery of the opening. By arranging the chip cover and the chip bottom sheet to bond to form a microfluidic chip, the spray piece structure of the injection molding process is replaced, so that the processing of the microfluidic chip is more flexible and not restricted by the mold, so that a more delicate structure can be processed; by arranging the cavity and the impact portion on the chip cover, the liquid is dispersed by the impact force generated by the impact portion, and the dispersed liquid can be sprayed out from the opening along the liquid outlet channel, thereby obtaining smaller atomized particles, and improving the atomization effect of the liquid. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The structure of the microfluidic chip provided by the embodiment of the utility model is shown in FIG. Figure 1 ;

[0022] Figure 2 It is a partial cross-sectional view of the microfluidic chip provided by an embodiment of the utility model;

[0023] Figure 3 The structure of the microfluidic chip provided by the embodiment of the utility model is shown in FIG. Figure 2 ;

[0024] Figure 4 The structure of the microfluidic chip provided by the embodiment of the utility model is shown in FIG. Figure 3 ;

[0025] Figure 5 The structure of the microfluidic chip provided by the embodiment of the utility model is shown in FIG. Figure 4 .

[0026] In the figure:

[0027] 10. chip cover; 11. opening; 12. impact part; 121. impact block; 13. first liquid outlet;

[0028] 20. Chip bottom film; 21. Second liquid outlet. DETAILED DESCRIPTION

[0029] The present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It is to be understood that the specific embodiments described herein are only used to explain the present invention, rather than to limit the present invention. It should also be noted that, for ease of description, only the parts related to the present invention, rather than all structures, are shown in the accompanying drawings.

[0030] In the description of the present invention, unless otherwise clearly specified and limited, the terms "connected", "connected", and "fixed" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0031] In the present utility model, unless otherwise clearly specified and limited, a first feature being "above" or "below" a second feature may include that the first and second features are in direct contact, or may include that the first and second features are not in direct contact but are in contact through another feature between them. Moreover, a first feature being "above", "above" and "above" a second feature includes that the first feature is directly above and obliquely above the second feature, or simply indicates that the first feature is higher in level than the second feature. A first feature being "below", "below" and "below" a second feature includes that the first feature is directly below and obliquely below the second feature, or simply indicates that the first feature is lower in level than the second feature.

[0032] In the description of this embodiment, the terms "upper", "lower", "right", etc., are based on the directions or positions shown in the drawings, and are only for the convenience of description and simplified operation, rather than indicating or implying that the device or element referred to must have a specific direction, be constructed and operated in a specific direction, and therefore cannot be understood as a limitation of the present invention. In addition, the terms "first" and "second" are only used to distinguish in the description and have no special meaning.

[0033] like Figure 1 and Figure 2 As shown, this embodiment provides a microfluidic chip, which includes a chip cover 10 and a chip bottom film 20 bonded to each other, wherein the chip cover 10 and the chip bottom film 20 are provided with a through liquid outlet channel; one side of the chip cover 10 is attached to the chip bottom film 20, and the other side is provided with a cavity connected to the liquid outlet channel, and the liquid outlet channel forms an opening 11 on the bottom surface of the cavity; an impact portion 12 is convexly provided in the cavity, and the impact portion 12 is arranged on the periphery of the opening 11.

[0034] Bonding refers to the technology of directly combining two homogeneous materials or heterogeneous materials with clean surfaces, which have been cleaned and activated, under certain conditions to form an integrated structure. The specific implementation can refer to existing technologies, such as hot compression bonding technology.

[0035] A microfluidic chip is formed by bonding a chip cover 10 and a chip bottom film 20, replacing the spray film structure of the injection molding process, so that the processing of the microfluidic chip is more flexible and not restricted by the mold, so that more delicate structures can be processed; by arranging a cavity and an impact part 12 on the chip cover 10, the impact force generated by the impact part 12 disperses the liquid, and the dispersed liquid can be sprayed out from the opening 11 along the liquid outlet channel, so as to obtain smaller atomized particles and improve the atomization effect of the liquid.

[0036] In the present embodiment, the chip cover 10 and the chip bottom film 20 are both in the shape of square plates; a square cavity is provided on the top of the chip cover 10, and transitional rounded corners are provided at the corners of the cavity; the opening 11 and the impact portion 12 are provided at the center of the cavity; the chip cover 10 is made of silicon, and the chip bottom film 20 is made of glass. In other embodiments, the microfluidic chip can be bonded by any two or more materials of silicon, glass, silicon oxide, metal, and metal compounds. It is understandable that the number of bonded layers can be two or more layers. In other embodiments, the chip cover 10 and the chip bottom film 20 can also be circular, and a circular cavity is provided in the chip cover 10.

[0037] Specifically, the liquid outlet channel includes a first liquid outlet hole 13 penetrating the chip cover sheet 10, and the first liquid outlet hole 13 is a circular hole; the liquid outlet channel also includes a second liquid outlet hole 21 penetrating the chip bottom sheet 20, and the second liquid outlet hole 21 is connected to the first liquid outlet hole 13, and the second liquid outlet hole 21 is a tapered hole. By setting the first liquid outlet hole 13 on the chip cover sheet 10, and setting the first liquid outlet hole 13 as a circular hole, the first liquid outlet hole 13 penetrates the chip cover sheet 10 and forms an opening 11 on the bottom surface of the cavity, so that the liquid can flow into the first liquid outlet hole 13 after being impacted and dispersed by the impact block 121; by setting the second liquid outlet hole 21 as a tapered hole, the liquid sprays out from the tapered hole, which is conducive to further impact and dispersion of the liquid in the second liquid outlet hole 21.

[0038] In this embodiment, the inner diameter of the large end of the tapered hole is larger than the inner diameter of the first liquid outlet hole 13; the axial directions of the first liquid outlet hole 13 and the second liquid outlet hole 21 coincide with each other, and both extend in the vertical direction. By setting the large end of the tapered hole larger than the inner diameter of the first liquid outlet hole 13, the liquid enters the second liquid outlet hole 21 from the first liquid outlet hole 13 and hits the side wall of the tapered hole, which helps to disperse the liquid; by setting the axial directions of the first liquid outlet hole 13 and the second liquid outlet hole 21 to coincide with each other, it is ensured that the liquid can flow smoothly in the liquid outlet channel.

[0039] In this embodiment, the inner diameter of the small end of the tapered hole is larger than the inner diameter of the first liquid outlet hole 13; the second liquid outlet hole 21 is conical; the length of the first liquid outlet hole 13 is smaller than the length of the second liquid outlet hole 21. By setting the second liquid outlet hole 21 to be conical, it is helpful for the liquid to flow smoothly on the inner wall of the second liquid outlet hole 21. In other embodiments, the length of the first liquid outlet hole 13 may be equal to or larger than the length of the second liquid outlet hole 21; the first liquid outlet hole 13 may also be set to be a tapered hole.

[0040] Furthermore, the impact part 12 includes at least two impact blocks 121, and a gap extending to the opening 11 is left between two adjacent impact blocks 121, and the impact blocks 121 are centrally symmetrically arranged about the center point of the opening 11. By setting the centrally symmetrical impact blocks 121, the impact blocks 121 can play a role in uniformly breaking up the liquid at the periphery of the opening 11; the broken up liquid can flow along the gap between the two adjacent impact blocks 121 to the opening 11 and enter the liquid outlet channel. In other embodiments, the impact part 12 can also be arranged as an integrated annular structure, the impact part 12 is arranged at the periphery of the opening 11, and a through hole for liquid flow is opened at the periphery of the impact part 12.

[0041] Optionally, the impact block 121 extends outward in a spiral from the opening 11; the thickness of the impact block 121 gradually decreases in the direction away from the opening 11; the top surface of the impact block 121 is an arc surface with a low center and high edges. By setting the impact block 121 to extend in a spiral, the collision between the liquid and the impact block 121 is intensified, which helps the liquid to collide and diverge; by setting the thickness of the impact block 121 to gradually decrease, the liquid on the surface of the impact block 121 can flow down smoothly along the top of the impact block 121; by setting the top surface of the impact block 121 to be an arc surface with a low center and high sides, the arc surface can guide the flow of the liquid.

[0042] By changing the number, shape, size of the impact blocks 121 and adjusting the angle, depth, and width of the liquid outlet channel, specialized and diversified particle sizes can be obtained, thereby improving the applicability of the microfluidic chip; the liquid outlet channel can be a straight channel or a curved channel; depending on the type of liquid, the structure of the liquid outlet channel can be appropriately surface modified to meet the use of different liquids.

[0043] See also Figure 3 The microfluidic chip has two impact blocks 121, and the two impact blocks 121 are centrally symmetrically arranged about the center point of the opening 11. Figure 4 The microfluidic chip has three impact blocks 121, and the three impact blocks 121 are centrally symmetrically arranged about the center point of the opening 11. Figure 5 The microfluidic chip has four impact blocks 121 , and the four impact blocks 121 are centrally symmetrically arranged about the center point of the opening 11 .

[0044] The following is the preparation and specific use process of the microfluidic chip:

[0045] The silicon wafer with the impact block 121 is bonded to the glass with the tapered hole, and the two are stacked to form a liquid outlet channel. Then, the excess silicon wafer part on the non-bonding side is polished to obtain a microfluidic chip.

[0046] The impact force generated by the impact block 121 disperses the liquid, and part of the liquid directly flows from the opening 11 into the liquid outlet channel along the gap between the two adjacent impact blocks 121; part of the liquid flows in a spiral line along the top surface of the impact block 121, and after the liquid flows to the bottom surface of the cavity, it flows from the opening 11 into the liquid outlet channel along the gap between the two adjacent impact blocks 121; the liquid is ejected from the tapered hole.

[0047] By changing the size and number of the impact blocks 121, the depth and angle of the liquid outlet channel, the size and shape of the tapered hole and other conditions, the effect of adjusting the particle size and angle of the sprayed liquid can be achieved.

[0048] Obviously, the above embodiments of the present invention are merely examples for the purpose of clearly illustrating the present invention, and are not intended to limit the implementation methods of the present invention. For those skilled in the art, various obvious changes, readjustments and substitutions can be made without departing from the scope of protection of the present invention. It is not necessary and impossible to list all implementation methods here. Any modifications, equivalent substitutions and improvements made within the spirit and principles of the present invention shall be included in the scope of protection of the claims of the present invention.

Claims

1. A microfluidic chip, characterized in that: It comprises a chip cover sheet (10) and a chip bottom sheet (20) which are bonded to each other, wherein the chip cover sheet (10) and the chip bottom sheet (20) are provided with a through liquid outlet channel; One side of the chip cover sheet (10) is attached to the chip bottom sheet (20), and the other side is provided with a cavity connected to the liquid outlet channel, and the liquid outlet channel forms an opening (11) on the bottom surface of the cavity; An impact portion (12) is convexly provided in the cavity, and the impact portion (12) is arranged on the outer periphery of the opening (11).

2. The microfluidic chip according to claim 1, characterized in that: The impact portion (12) comprises at least two impact blocks (121), a gap extending to the opening (11) is left between two adjacent impact blocks (121), and the impact blocks (121) are arranged in a central symmetric manner about a center point of the opening (11).

3. The microfluidic chip according to claim 2, characterized in that: The impact block (121) extends spirally outward from the opening (11).

4. The microfluidic chip according to claim 3, characterized in that: The thickness of the impact block (121) gradually decreases in a direction away from the opening (11).

5. The microfluidic chip according to claim 3, characterized in that: The top surface of the impact block (121) is a curved surface with a lower middle and higher edges.

6. The microfluidic chip according to claim 1, characterized in that: The liquid outlet channel comprises a first liquid outlet hole (13) penetrating the chip cover sheet (10), and the first liquid outlet hole (13) is a circular hole.

7. The microfluidic chip according to claim 6, characterized in that: The liquid outlet channel further comprises a second liquid outlet hole (21) penetrating the chip bottom sheet (20); the second liquid outlet hole (21) is connected to the first liquid outlet hole (13); the second liquid outlet hole (21) is a tapered hole.

8. The microfluidic chip according to claim 7, characterized in that: The inner diameter of the large end of the tapered hole is larger than the inner diameter of the first liquid outlet hole (13).

9. The microfluidic chip according to claim 7, characterized in that: The axial directions of the first liquid outlet hole (13) and the second liquid outlet hole (21) coincide with each other.

10. The microfluidic chip according to any one of claims 1 to 9, characterized in that: The chip cover sheet (10) is made of silicon material, and / or the chip bottom sheet (20) is made of glass material.

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