Transvascular biopsy puncture sampling device

Abstract

The utility model relates to a transvascular biopsy puncture sampling device which comprises a biopsy needle, the biopsy needle comprises a control handle and a puncture guide wire, one end of the puncture guide wire is fixedly connected with the control handle, the other end of the puncture guide wire is provided with a bent part, the bent part is made of memory metal, and the initial state of the bent part is a bent state; a puncture part is arranged at the end of the bent part, a sampling part is arranged at the position, close to the puncture part, of the bent part, and a plurality of developing marks which are evenly arranged at intervals are arranged at the end, away from the control handle, of the puncture guide wire. According to the utility model, the intracranial lesion site can be sampled through small intracranial microvessels, effective hemostasis can be carried out on large intracranial vessels, the high trauma risk caused by biopsy in the traditional opening process is solved, the minimally invasive defect caused by a minimally invasive mode to the skull is also avoided, and the non-invasive advantage of vascular intervention is achieved; the method has the beneficial effects of small trauma, low risk and good postoperative prognosis.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a transvascular biopsy puncture sampling device. Background Art

[0002] The diagnosis of intracranial space-occupying lesions has always been a difficult problem for neurosurgery. At present, some space-occupying lesions can be preliminarily diagnosed through imaging examinations, but for most space-occupying lesions, craniotomy is still required to obtain lesion tissue for pathological diagnosis. Craniotomy is not only traumatic and risky, but also brings a huge psychological burden to patients and their families.

[0003] With the development of minimally invasive surgical techniques, minimally invasive sampling devices through the skull are also widely used. For example, Chinese patent CN116999116A discloses a minimally invasive transcranial bone marrow injection and sampling device, which includes an injection sampling mechanism and an actuator, wherein the injection sampling mechanism includes a drill bit and a liquid reservoir, the drill bit is below the liquid reservoir, and a through flow channel is provided inside the drill bit; a push rod is provided in the liquid reservoir, one end of the push rod in the liquid reservoir is sealed with the inner wall of the liquid reservoir, and a transfer sleeve is provided at the lower end of the liquid reservoir; the actuator The mechanism is on one side of the injection sampling mechanism, and the actuator includes a guide rail, a power device and a feeding device; a clamping element is provided outside the drill bit, and the clamping element includes a transmission device and a locking device, and a sensor is provided inside the clamping element; the transmission device extends to the actuator side and is vertically connected to the guide rail, the liquid storage tank is connected to the guide rail, and the drill bit and the liquid storage cylinder are parallel to the guide rail; a limiting structure is also provided below the actuator, and the limiting structure is composed of a limiting ring and a sliding rod, and a sliding groove parallel to the guide rail is provided at the lower end of the actuator, and the sliding rod slides in the sliding groove. The device in the above-mentioned prior art needs to perform sampling after a minimally invasive channel is formed by opening a hole in the skull.

[0004] Another example is a stereotactic percutaneous minimally invasive puncture system for treating intracranial lesions disclosed in Chinese patent CN104958094B, which includes a puncture part, a guide part, a limiter part, and a drainage part. For deep lesions, such as hematomas, abscesses, and cysts, the best puncture point, target, and path are determined based on preoperative CT or MR, and a puncture treatment system of corresponding specifications is selected. The puncture part, the guide part, the limiter part, and the drainage tube are assembled and fixed, and the puncture and puncture depth are determined before skull puncture. When the percutaneous puncture penetrates the skull, the puncture is suspended, the puncture part is connected to electrocoagulation, and electrocoagulation hemostasis is achieved on the dura mater and pia mater, and then subsequent puncture treatment is performed. The aforementioned prior art also requires opening a hole in the skull for puncture treatment.

[0005] The devices in the above-mentioned prior art, whether for injection or sampling, require the skull to be drilled to produce an injection or sampling channel. Although this method is less traumatic than craniotomy, it may still cause damage to surrounding blood vessels and nerves, cause complications such as intracranial hematoma, and cause skull defects. Before the end of most minimally invasive surgeries, soft materials are needed to seal the skull defects, including the use of gelatin sponges, hemostatic gauze, fat, muscle, fascia, mucosal flaps, artificial meninges, biological or chemical glues, etc. The above tissues may be absorbed by the human body over time; and may be washed open when the intracranial pressure suddenly increases, causing cerebrospinal fluid leakage or concurrent infection. Before the end of a few surgeries, hard materials are used to seal skull defects, including bony nasal septum, titanium mesh, bone cement, iliac bone trimming pieces and other materials. Bone nasal septum defects are prone to collapse of the nose or nasal septum perforation after surgery. Titanium mesh is difficult to trim and easily punctures surrounding tissues. Bone cement has poor shaping and occupies volume. Removing iliac bones is traumatic.

[0006] With the development of interventional technology, intravascular interventional technology has become a feasible solution. For example, Chinese patent CN220213038U discloses a transvascular renal biopsy intracavitary puncture kit, which includes a soft guide cannula and a sampling needle core inserted into the inside thereof. A tensioning tube is inserted into the end of the soft guide cannula. The sampling needle core includes a steel wire needle, an insertion rod connected to the left end of the steel wire needle, and a rotating needle groove connected to the right end of the steel wire needle. The rotating needle groove is used to rotate forward to cut kidney tissue; an external threaded column is connected between the steel wire needle and the insertion rod, and the rotation of the insertion rod drives the rotating needle groove forward or backward; a receiving cavity for accommodating the rotating needle groove is provided inside the end of the tensioning tube. Although the aforementioned puncture kit can realize transvascular sampling, it is designed for peripheral blood vessels with a larger diameter, which cannot meet the requirements of intracranial small microvessel biopsy and intracranial sampling. In addition, the aforementioned sampling puncture kit cannot meet the requirements of intracranial hemostasis.

[0007] In view of this, the utility model provides a transvascular biopsy puncture sampling device, which can realize the sampling of intracranial lesions through small intracranial capillaries and can effectively stop bleeding of larger intracranial blood vessels, thereby solving the high trauma risk brought by traditional open biopsy and avoiding minimally invasive defects to the skull caused by minimally invasive methods. At the same time, it has the non-invasive advantages of transvascular intervention, has the beneficial effects of less trauma, low risk and good postoperative prognosis, can reduce the psychological pressure of patients and their families, and has a positive effect on subsequent treatment. Utility Model Content

[0008] The utility model is intended to provide a transvascular biopsy puncture sampling device to solve the deficiencies in the prior art. The technical problem to be solved by the utility model is achieved through the following technical solutions.

[0009] A transvascular biopsy puncture sampling device comprises a biopsy needle, wherein the biopsy needle comprises a control handle and a puncture guide wire, wherein one end of the puncture guide wire is fixedly connected to the control handle, and the other end of the puncture guide wire is provided with a bending portion, wherein the bending portion is made of memory metal and its initial state is a bending state; a puncture portion is provided at the end of the bending portion, and a sampling portion is provided at a position on the bending portion close to the puncture portion, wherein the puncture portion is used to puncture a target sampling position, and the sampling portion is used to sample the target sampling position and accommodate the sample taken; a plurality of evenly spaced developing marks are provided at one end of the puncture guide wire away from the control handle, and the total length of the developing marks at least covers the bending portion.

[0010] Preferably, the interior of the curved portion is hollow, the puncture portion includes a tip located at the end of the curved portion, the sampling portion includes an open groove located on the curved portion close to the tip, the side wall end of the open groove is thin, and the depth of the open groove is greater than the radius of the puncture guide wire.

[0011] Preferably, a thread-like convex pattern is provided in the curved portion at least at a location located at the opening groove.

[0012] Preferably, the length of the open groove is 1 to 5 cm.

[0013] Preferably, the puncture portion comprises a puncture cap located at the end of the curved portion, the outer end of the puncture cap is in a pointed cone shape, and the sampling portion comprises a conical groove arranged on the inner side of the puncture cap.

[0014] Preferably, a plurality of barbs are provided in the conical groove.

[0015] Preferably, it further comprises a balloon device, wherein the balloon device comprises a balloon catheter and a balloon part.

[0016] Preferably, a cavity is provided inside the balloon catheter, and the cavity is used to accommodate and allow the puncture guide wire to pass through.

[0017] Preferably, the length of the curved portion is 1 to 15 cm.

[0018] In the utility model, the diameter of the smaller blood vessels in the skull is 1 to 2 mm. The physical properties of the puncture guide wire need to satisfy the requirement of being able to enter the small blood vessels in the skull and also need to have a certain rigidity to ensure that the end can accurately enter the lesion site. In order to satisfy the requirement of entering the small blood vessels in the skull, the puncture guide wire needs to be thin enough. However, contradictory to this, the thinner the puncture guide wire is, the weaker its rigidity is, and the more difficult it is for it to enter the lesion site. In this embodiment, in order to solve this problem, a curved portion made of memory metal is provided at the distal end of the puncture guidewire. The intracranial lesion location is located outside the blood vessel and close to the outer wall of the blood vessel. When puncturing and sampling the intracranial lesion location, the guidewire catheter is first passed through the target blood vessel according to the operating procedure to reach the corresponding lesion location of the blood vessel. The puncture guidewire is inserted into the guidewire catheter and follows the guidewire catheter to the target location. The distal end of the puncture guidewire is provided with a curved portion, which is made of memory metal. The initial state is a curved state. The curved portion is in a straight state in the guidewire catheter due to the limitation of the guidewire catheter. When the distal end of the puncture guidewire reaches the exit of the guidewire catheter, that is, the position in the blood vessel corresponding to the lesion location, the puncture The guidewire continues to move forward, and after it is freed from the restriction of the guidewire catheter, the curved part rebounds, so that the puncture part at the end of the curved part breaks the blood vessel wall under the action of the rebound force and pierces the lesion. A developing mark is set on the curved part, and the operator can observe its position through the imaging system. After the puncture guidewire pierces the lesion, the operator rotates the puncture guidewire through the control handle to make it further drill into the lesion, so that the sampling is more sufficient. After sampling the lesion through the sampling part, the puncture guidewire is withdrawn from the lesion, and the sample of the lesion will be stored in the sampling part. The puncture guidewire is withdrawn into the guidewire catheter and removed, so as to obtain the sample of the lesion for subsequent pathological diagnosis. After the sampling is completed, the Onyx glue embolization catheter is used to perform liquid embolism on the blood vessel through the guidewire catheter to reduce the possibility of bleeding.

[0019] The utility model provides a transvascular biopsy puncture sampling device, which can realize the sampling of intracranial lesions through small intracranial capillaries and can effectively stop bleeding of larger intracranial blood vessels, thereby solving the high trauma risk brought by traditional open biopsy and avoiding minimally invasive defects to the skull caused by minimally invasive methods. At the same time, it has the non-invasive advantages of transvascular intervention, has the beneficial effects of small trauma, low risk and good postoperative prognosis, can reduce the psychological pressure of patients and their families, and has a positive effect on subsequent treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of an embodiment of the utility model;

[0021] Figure 2 It is a structural schematic diagram of an embodiment of the bending portion in the utility model;

[0022] Figure 3It is a structural schematic diagram of another embodiment of the bending portion in the utility model;

[0023] Figure 4 It is a structural schematic diagram of another embodiment of the utility model;

[0024] The reference numerals in the accompanying drawings are: 1. control handle, 2. puncture guidewire, 21. bending portion, 22. developing mark, 211. tip, 212. opening groove, 213. thread-like convex pattern, 214. puncture cap, 215. conical groove, 216. barb, 3. guidewire catheter, 4. balloon device. DETAILED DESCRIPTION

[0025] It should be noted that, in the absence of conflict, the embodiments and features in the embodiments of the present application can be combined with each other. The present utility model will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0026] Embodiment 1:

[0027] Reference Figure 1 As shown, a transvascular biopsy puncture sampling device, the improvement of which is that: it includes a biopsy needle, the biopsy needle includes a control handle 1 and a puncture guide wire 2, one end of the puncture guide wire 2 is fixedly connected to the control handle 1, and the other end of the puncture guide wire 2 is provided with a bending portion 21, the bending portion 21 is made of memory metal, and its initial state is a bending state; the end of the bending portion 21 is provided with a puncture portion, and a sampling portion is provided at a position close to the puncture portion on the bending portion 21, the puncture portion is used to pierce the target sampling position, the sampling portion is used to sample the target sampling position and accommodate the sample taken, and the end of the puncture guide wire 2 away from the control handle 1 is provided with a plurality of evenly spaced development marks 22, and the total length of the development mark 22 at least covers the bending portion 21.

[0028] In this embodiment, the diameter of the smaller blood vessels in the skull is 1 to 2 mm. The physical properties of the puncture guide wire 2 need to satisfy the requirement of being able to enter the small blood vessels in the skull, and also need to have a certain rigidity to ensure that the end can accurately enter the lesion site. In order to satisfy the requirement of entering the small blood vessels in the skull, the puncture guide wire 2 needs to be thin enough. Paradoxically, the thinner the puncture guide wire 2 is, the weaker its rigidity is, and the more difficult it is for it to enter the lesion site. In this embodiment, in order to solve this problem, a curved portion 21 made of memory metal is provided at the distal end of the puncture guidewire 2. The intracranial lesion position is located outside the blood vessel and close to the outer wall of the blood vessel. When puncturing and sampling the intracranial lesion position, similar to minimally invasive interventional surgery through blood vessels, the guidewire catheter 3 is first passed through the target blood vessel according to the operating procedure to reach the corresponding lesion position of the blood vessel, and the puncture guidewire 2 is inserted into the guidewire catheter 3 and reaches the target position along the guidewire catheter 3. A curved portion 21 is provided at the distal end of the puncture guidewire 2. The curved portion 21 is made of memory metal and is in a curved state in the initial state. The curved portion 21 is in a straight state in the guidewire catheter 3 due to the restriction of the guidewire catheter 3. When the distal end of the puncture guidewire 2 reaches the outlet of the guidewire catheter 3, that is, the blood vessel corresponding to the lesion position, When the puncture guide wire 2 is in the inner position, the puncture guide wire 2 continues to move forward. After breaking away from the restriction of the guide wire catheter 3, the curved portion 21 rebounds, so that the puncture portion at the end of the curved portion 21 breaks the blood vessel wall under the action of the rebound force and penetrates the lesion site. The curved portion 21 is provided with a developing mark 22, and the operator can observe its position through the imaging system. After the puncture guide wire 2 penetrates the lesion site, the operator rotates the puncture guide wire 2 by controlling the handle 1 to make it further drill into the lesion site, so that the sampling is more sufficient. After sampling the lesion site through the sampling part, the puncture guide wire 2 is withdrawn from the lesion site, and the sample of the lesion site will be stored in the sampling part. The puncture guide wire is withdrawn into the guide wire catheter 3 and removed, so as to obtain the sample of the lesion site for subsequent pathological diagnosis. After the sampling is completed, the Onyx glue embolization catheter is used to perform liquid embolism on the blood vessel through the guide wire catheter 3 to reduce the possibility of bleeding.

[0029] The present embodiment provides a transvascular biopsy puncture sampling device, which can achieve sampling of intracranial lesions through small intracranial capillaries and can effectively stop bleeding of larger intracranial blood vessels, thereby solving the high trauma risk brought by traditional open biopsy and avoiding minimally invasive defects to the skull caused by minimally invasive methods. At the same time, it has the non-invasive advantages of transvascular intervention, has the beneficial effects of less trauma, lower risk, and good postoperative prognosis, and can reduce the psychological pressure of patients and their families, producing a positive effect on subsequent treatment.

[0030] Furthermore, the length of the curved portion 21 is 1 to 15 cm.

[0031] Embodiment 2:

[0032] Based on Example 1, Figure 2 As shown, the interior of the curved portion 21 is hollow, the puncture portion includes a tip 211 located at the end of the curved portion 21, and the sampling portion includes an open groove 212 located on the curved portion 21 close to the tip 211, the side wall end of the open groove 212 is thin, and the depth of the open groove 212 is greater than the radius of the puncture guide wire 2.

[0033] In this embodiment, when the curved portion 21 breaks away from the restriction of the guide wire catheter 3 and rebounds, the tip 211 punctures the blood vessel under the action of the rebound force and penetrates into the diseased part that is in contact with the blood vessel wall. By controlling the handle 1 to twist the puncture guide wire 2, the tip 211 further drills into the diseased part. At the same time, part of the tissue at the diseased part enters the hollow cavity of the curved portion 21 from the tip 211, and part of it is cut into the opening groove 212 by the side wall end of the thin opening groove 212 and stored in the opening groove 212. When the puncture guide wire 2 is withdrawn, the tissue at the diseased part is stored in the opening groove 212 and is taken out, thereby completing the sampling.

[0034] Furthermore, a thread-shaped convex pattern 213 is provided in the curved portion 21 at least at the location of the opening groove 212 .

[0035] In this embodiment, the provision of the thread-shaped convex pattern 213 increases the friction force of the inner wall of the opening groove 212, thereby preventing the diseased tissue from slipping and better accommodating the obtained diseased tissue sample.

[0036] Furthermore, the length of the opening slot 212 is 1 to 5 cm.

[0037] Embodiment 3:

[0038] Based on Example 1, Figure 3 As shown, the puncture portion includes a puncture cap 214 located at the end of the curved portion 21 , the outer end of the puncture cap 214 is in a pointed cone shape, and the sampling portion includes a conical groove 215 arranged on the inner side of the puncture cap 214 .

[0039] In this embodiment, when the curved portion 21 breaks away from the restriction of the guide wire catheter 3 and rebounds, the puncture cap 214 punctures the blood vessel under the action of the rebound force and penetrates into the diseased part that is in contact with the blood vessel wall. By controlling the handle 1 to twist the puncture guide wire 2, the puncture cap 214 further drills into the diseased part. At the same time, a part of the tissue at the diseased part is cut and filled into the conical groove 215 at the end of the conical groove 215. When the puncture guide wire 2 is withdrawn, the tissue at the diseased part stored in the conical groove 215 is taken out, thereby completing the sampling.

[0040] Furthermore, a plurality of barbs 216 are disposed in the conical groove 215 .

[0041] In this embodiment, the provision of the barbs 216 helps to hang the diseased tissue sample to prevent it from falling off, thereby achieving a better sampling effect.

[0042] Embodiment 4:

[0043] Based on any of the above embodiments, Figure 4 As shown, it also includes a balloon device 4, which includes a balloon catheter and a balloon part.

[0044] Furthermore, a cavity is provided inside the balloon catheter, and the cavity is used to accommodate and allow the puncture guide wire 2 to pass through.

[0045] In this embodiment, when the blood vessel to be sampled is relatively large, after the guidewire catheter 3 passes through the target blood vessel, the puncture guidewire 2 can be passed into the cavity of the balloon catheter, and the guidewire catheter 3 can be passed together to reach the target position, so that the balloon is inflated to block most of the blood in the blood vessel. The puncture guidewire 2 passes through the cavity of the balloon catheter to complete the sampling work. After the sampling is completed, the puncture guidewire 2 is withdrawn, and then the Onyx glue embolization catheter is passed through the cavity of the balloon catheter to perform liquid embolism on the blood vessel to avoid postoperative bleeding.

[0046] It should be noted that the above detailed descriptions are exemplary and are intended to provide further explanation of the present application. Unless otherwise specified, all technical and scientific terms used herein have the same meaning as commonly understood by those of ordinary skill in the art to which the present application belongs.

[0047] It should be noted that the terms used herein are only for describing specific embodiments and are not intended to limit the exemplary embodiments described in the present application. As used herein, unless the context clearly indicates otherwise, the singular form is also intended to include the plural form. In addition, it should also be understood that when the terms "comprise" and / or "include" are used in this specification, it indicates the presence of features, steps, operations, devices, components and / or combinations thereof.

[0048] It should be noted that the terms "first", "second", etc. in the specification and claims of the present application and the above-mentioned drawings are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that the terms used in this way can be interchangeable where appropriate, so that the embodiments of the present application described herein can be implemented in an order other than those illustrated or described herein.

[0049] In addition, the terms "include" and "have" and any variations thereof are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or apparatus that includes a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units that are not explicitly listed or inherent to these processes, methods, products, or apparatuses.

[0050] For ease of description, spatially relative terms, such as "above", "above", "on the upper surface of", "above", etc., may be used herein to describe the spatial positional relationship between a device or feature and other devices or features as shown in the figure. It should be understood that spatially relative terms are intended to include different orientations of the device in use or operation in addition to the orientation described in the figure. For example, if the device in the accompanying drawings is inverted, the device described as "above other devices or structures" or "above other devices or structures" will be positioned as "below other devices or structures" or "below other devices or structures". Thus, the exemplary term "above" may include both "above" and "below". The device may also be positioned in other different ways, such as rotated 90 degrees or in other orientations, and the spatially relative descriptions used herein are interpreted accordingly.

[0051] In the above detailed description, reference is made to the accompanying drawings, which form a part of this document. In the accompanying drawings, similar symbols typically identify similar components unless the context indicates otherwise. The illustrated embodiments described in the detailed description, drawings, and claims are not meant to be limiting. Other embodiments may be used, and other changes may be made, without departing from the spirit or scope of the subject matter presented herein.

[0052] The above description is only the preferred embodiment of the utility model, and is not intended to limit the utility model. For those skilled in the art, the utility model can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the utility model shall be included in the protection scope of the utility model.

Claims

1. A transvascular biopsy puncture sampling device, characterized in that: The biopsy needle comprises a control handle (1) and a puncture guide wire (2), one end of the puncture guide wire (2) is fixedly connected to the control handle (1), and the other end of the puncture guide wire (2) is provided with a curved portion (21), the curved portion (21) is made of memory metal, and its initial state is a curved state; a puncture portion is provided at the end of the curved portion (21), a sampling portion is provided at a position close to the puncture portion on the curved portion (21), the puncture portion is used to puncture a target sampling position, and the sampling portion is used to sample the target sampling position and accommodate the sample taken; a plurality of evenly spaced imaging marks (22) are provided at one end of the puncture guide wire (2) away from the control handle (1), and the total length of the imaging marks (22) at least covers the curved portion (21).

2. A transvascular biopsy puncture sampling device according to claim 1, characterized in that: The curved portion (21) is hollow inside, the puncture portion includes a tip (211) located at the end of the curved portion (21), and the sampling portion includes an open groove (212) located on the curved portion (21) close to the tip (211), the side wall end of the open groove (212) is thin, and the depth of the open groove (212) is greater than the radius of the puncture guide wire (2).

3. A transvascular biopsy puncture sampling device according to claim 2, characterized in that: A thread-like convex pattern (213) is provided in the curved portion (21) at least at a location located at the opening groove (212).

4. A transvascular biopsy puncture sampling device according to claim 2, characterized in that: The length of the opening groove (212) is 1 to 5 cm.

5. A transvascular biopsy puncture sampling device according to claim 1, characterized in that: The puncture portion comprises a puncture cap (214) located at the end of the curved portion (21), the outer end of the puncture cap (214) is in a pointed cone shape, and the sampling portion comprises a conical groove (215) arranged on the inner side of the puncture cap (214).

6. A transvascular biopsy puncture sampling device according to claim 5, characterized in that: A plurality of barbs (216) are arranged in the conical groove (215).

7. A transvascular biopsy puncture sampling device according to claim 1, characterized in that: It also includes a balloon device (4), wherein the balloon device (4) includes a balloon catheter and a balloon part.

8. A transvascular biopsy puncture sampling device according to claim 7, characterized in that: A cavity is provided inside the balloon catheter, and the cavity is used to accommodate and allow the puncture guide wire (2) to pass through.

9. A transvascular biopsy puncture sampling device according to claim 1, characterized in that: The length of the curved portion (21) is 1 to 15 cm.

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