Medicine injection equipment for hepatic artery perfusion chemotherapy

Abstract

The medicine injection equipment is characterized in that the medicine injection equipment comprises a blocking catheter and a medicine injection catheter, the blocking catheter comprises an inner tube and an outer tube, the two ends of the outer tube are sealed, and the inner tube is connected into the outer tube in a penetrating mode; the medicine injection catheter is slidably connected into the inner tube; an infusion tube and a blocking tube are arranged between the inner tube and the outer tube; a front balloon and a rear balloon are arranged on the periphery of the outer tube at intervals, and the blocking tube is communicated with the two balloons; the outer tube is provided with a first medicine injection port between the two balloons, and the infusion tube is communicated with the first medicine injection port; the outer tube is provided with a blood inlet on the front side of the front balloon, a first blood outlet on the rear side of the rear balloon, and a second blood outlet between the front balloon and the rear balloon; a first valve is arranged at the blood inlet and only allows a medium to flow into the blood inlet unidirectionally; under the condition that the equipment can enter a target blood vessel, the efficiency and accuracy of medicine injection can be improved, normal flowing of blood is not affected in the process that the equipment enters the blood vessel, and blood diversion and blocking can be avoided.

Description

Technical Field

[0001] The utility model belongs to the technical field of medical equipment, and in particular relates to a drug injection device for hepatic artery perfusion chemotherapy. Background Art

[0002] HAIC (Transcatheter Arterial Chemoembolization) is an interventional treatment method suitable for patients with unresectable liver cancer. This treatment method delivers chemotherapy drugs through the tumor supply artery and induces tumor necrosis through the action of selective anticancer drugs. Studies have shown that in patients with liver cancer with high tumor burden or distributed in multiple parts of the liver, HAIC has certain advantages over TACE.

[0003] At present, microcatheter superselective technology is the basis of HAIC, which refers to the superselective insertion of microcatheters into segments, subsegments, and even direct arterial branches of sub-subsegments of tumor blood supply arteries. At present, scholars at home and abroad have tried to install blocking balloons in perfusion catheters and use blocking balloon catheters in interventional treatment of liver cancer. When the balloon is delivered to the lesion and the catheter is quickly filled, an area is created downstream of the tip of the balloon microcatheter. The pressure (BOASP) in this area is low, which leads to blood flow slowing and redistribution of blood flow from the adjacent arterial network to this low-pressure vascular area, and finally enters the tumor tissue with the lowest pressure. The balloon occlusion technology changes the blood flow and blood pressure in the tumor area, making it easier for drugs to enter the tumor blood vessels, thereby achieving better treatment effects. Before implementation, the balloon microcatheter is superselectively inserted into the tumor terminal branch of the tumor blood supply artery and filled with a blocking balloon. After overcoming the resistance of the systemic circulation, the drug is perfused through the perfusion catheter, and retrograde flow (reflux) is prevented from entering non-targeted locations.

[0004] However, balloon occlusion inevitably blocks the blood supply to the hepatic artery, causing liver ischemia, and the time is limited. Long-term perfusion chemotherapy operations require regular loosening of the balloon, which affects the perfusion process and is complicated to operate. In addition, today's balloon occlusion catheters usually need to be inserted directly into the tumor blood vessels. For complex tumor blood vessels (local stenosis, calcification, and twisting), there are technical problems such as difficulty in superselection; sometimes in the case of multiple blood supplies, one intubation cannot achieve the purpose of all lesion areas receiving drugs, and multiple superselections are required. The operation is complicated and affects the treatment effect; in addition, the existing occlusion balloon and perfusion tube are integrated designs. Once inserted, the position of the balloon and the perfusion port is fixed and cannot be adjusted individually.

[0005] Balloon-occluded catheter HAIC (B-HAIC for short) is a new type of interventional treatment. The balloon occlusion catheter is used for hepatic artery perfusion. The guidewire is passed through the inner lumen tube and guided by the guidewire to make the occlusion balloon catheter pass through the diseased blood vessel. Under the action of the developing marker ring, the hepatic artery is double-balloon occluded: the drug injection double-lumen microcatheter is coaxially connected with the balloon occlusion catheter through the inner lumen tube, which can be used for targeted drug injection to the superselected artery; if there are multiple tumor vessels or complex blood vessels that are difficult to superselect, the double-occlusion balloon catheter is delivered to the starting point or bifurcation of the diseased blood vessel through the action of the developing marker ring, and the double-occlusion balloon is filled. At this time, the matrix-type drug injection micropores between the double-occlusion balloons are used to achieve continuous drug infusion. The distance between the drug injection microcatheter and the occlusion balloon is adjusted as needed. The longitudinal span of the double-occlusion balloon is small and it is an integrated design to improve the treatment efficiency.

[0006] The Chinese utility model with the publication number CN216963282U discloses a tandem double-balloon drug delivery system, including a catheter, a connector is provided at the rear end of the catheter, two balloons are provided at the front end of the catheter, a drug delivery hole is provided on the outer wall of the catheter between the two balloons, the inner cavity of the catheter is divided into three independent channels, the three channels are respectively a balloon expansion channel, a drug injection channel and a guidewire channel, the front end of the catheter is provided with a guidewire traction cavity connected to the guidewire channel, and the connector is provided with a first interface, a second interface and a third interface respectively, the first interface connects the two balloons through the balloon expansion channel, the second interface connects the drug delivery hole through the drug injection channel, and the third interface connects the guidewire channel. This patent discloses a tandem double-balloon drug delivery system, which can expand the two balloons to isolate the intravascular lesion into a closed space, and then inject the drug through the drug injection channel and release it to the closed space through the drug delivery hole, so as to achieve local drug delivery to the lesion, and the drug delivery amount can be precisely controlled.

[0007] Although the above-mentioned drug delivery device can isolate the lesion in the blood vessel to form a closed space through the double balloons, and deliver the drug in the closed space to avoid the drug affecting other tissues of the human body, and leave a blood flow channel to avoid blocking the blood circulation after the balloon is expanded, the device uses the guide wire channel as the blood flow channel. After the balloon is expanded, the guide wire needs to be withdrawn from the channel to conduct the blood. There is a certain time interval, and the blood cannot be guaranteed to flow smoothly during this period. It is uncertain whether it will cause damage to the human body. It is also impossible to avoid the backflow of blood. If the blood coagulates in the channel, blood clots cannot be cleared in time, which poses a safety hazard. In addition, the above-mentioned device has only one drug delivery method, that is, the lesion must be isolated into a closed space through two balloons and the drug is administered in the space. However, if the drug delivery device can enter the corresponding tissue blood vessels, the efficiency of this drug delivery method is relatively low. Summary of the invention

[0008] The purpose of the utility model is to solve the problems mentioned in the background technology and to provide a drug injection device for hepatic artery perfusion chemotherapy, which can improve the efficiency and accuracy of drug injection when the device can enter the target blood vessel, and does not affect the normal flow of blood during the process of the device entering the blood vessel, and can avoid blood diversion and blockage.

[0009] In order to achieve the above technical purpose, the technical solution adopted by the utility model is:

[0010] A drug injection device for hepatic artery perfusion chemotherapy comprises a blocking catheter and an injection catheter, wherein the blocking catheter comprises an inner tube and an outer tube, the outer tube is sealed at both ends, and the inner tube is connected to the inside of the outer tube through penetration; the injection catheter is slidably connected to the inside of the inner tube; a perfusion tube and a blocking tube are arranged between the inner tube and the outer tube; a front balloon and a rear balloon are arranged at intervals on the outer periphery of the outer tube, and the blocking tube is connected to the two balloons; a first drug injection port is arranged on the outer tube between the two balloons, and the perfusion tube is connected to the first drug injection port; the outer tube is provided with a blood inlet on the front side of the front balloon, a first blood outlet on the rear side of the rear balloon, and a second blood outlet between the front and rear balloons; a first valve is arranged at the blood inlet to only allow a medium to flow into the blood inlet in one direction.

[0011] Preferably, the first blood outlet and the second blood outlet are both provided with a wedge-shaped protrusion extending into the outer tube, with the slope of the wedge-shaped protrusion facing the rear side.

[0012] Preferably, the end of the inner tube extends out of the end of the outer tube, and the end of the inner tube is provided with a first conical head, and the first conical head is provided with a through hole matching the injection catheter.

[0013] Preferably, the front end of the outer tube is provided with an independent tube seat which is connected with the inner tube, the perfusion tube and the blocking tube respectively.

[0014] Preferably, a guide tube is provided between the inner tube and the outer tube, the guide tube is connected to the blood inlet, the first blood outlet and the second blood outlet, and a second valve is provided inside the guide tube in front of the blood inlet to only allow the medium to flow in one direction from front to back; an independent tube seat matching the guide tube is also provided at the front end of the outer tube.

[0015] Preferably, the guide tube, perfusion tube and blocking tube are equidistantly distributed in a ring and connected between the inner tube and the outer tube; the guide tube, perfusion tube and blocking tube are connected to the inner tube via a spiral fixing block, which runs through the interior of the outer tube, and the strength of the fixing block gradually decreases from front to back.

[0016] Preferably, a third valve is provided at the first drug injection port to only allow the medium to flow out of the first drug injection port from the perfusion tube in one direction; and a fifth valve is provided at both the first blood outlet and the second blood outlet to only allow the medium to flow from the inside of the blocking catheter to the outside.

[0017] Preferably, a first developing metal marker is provided on the front and rear edges of each balloon in the outer tube.

[0018] Preferably, the front end of the drug injection catheter is provided with a tube seat, the end is provided with a second conical head, and the second conical head is provided with a through hole matching the guide wire; the drug injection catheter is provided with a guide wire cavity and a drug injection cavity which are independent of each other, and the second conical head is connected with the guide wire cavity; the drug injection catheter is provided with a guide wire side hole and a second drug injection port which are respectively connected with the guide wire cavity and the drug injection cavity.

[0019] Preferably, the injection catheter is provided with a second developing metal mark at a position corresponding to the second injection port; and a fourth valve is provided at the second injection port to only allow the medium to flow out of the second injection port from the injection cavity in one direction.

[0020] The beneficial effects of the utility model are:

[0021] The device has two drug administration methods. In addition to the method of forming a closed space through double balloons and injecting drugs in the space, when the blocking catheter can enter the final target blood vessel, the drug injection catheter can be directly extended from the inner tube into the target blood vessel to directly administer the drug. In this drug injection method, the double balloons only expand to prevent the drug from flowing back to the normal blood vessels, and the first drug injection port between the double balloons does not work. The drug injection catheter can quickly, massively and accurately inject the drug into the target blood vessel, which greatly improves the efficiency and accuracy of drug injection compared to the prior art method of injecting drugs between double balloons. Moreover, compared with the double balloons injecting drugs into normal blood vessels, the drug damage to normal human tissues is also reduced by directly injecting drugs into the target blood vessel through the drug injection catheter.

[0022] In the preferred embodiment, a first valve is provided at the blood inlet to prevent blood backflow, and wedge-shaped protrusions are provided at the two blood outlets to slow down the blood flow rate to a certain extent, reduce the impact on the liquid outlet, slowly release the blood flow, reduce the risk of liver ischemia damage, and avoid excessive drug dilution, thereby improving drug utilization efficiency; a second valve is provided on the front side of the blood inlet in the diversion tube to only allow the medium to flow from front to back, which can also prevent blood from being diverted to the tube seat. Due to the presence of the diversion tube and the second valve, when blood clots or other objects that block blood flow appear in the diversion tube, heparin can be injected into the diversion tube through the tube seat connected to the diversion tube to avoid blockage of the diversion tube and affect blood circulation. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of the blocking catheter structure;

[0024] Figure 2 for Figure 1 A schematic diagram of the partially enlarged structure at center A;

[0025] Figure 3 This is a schematic diagram of the partial enlarged structure of the blood inlet;

[0026] Figure 4 It is a schematic diagram of a partially enlarged structure of the first blood outlet and the second blood outlet;

[0027] Figure 5 for Figure 1 Sectional view along section line EE;

[0028] Figure 6 This is a schematic diagram of the structure of the drug injection catheter;

[0029] Figure 7 This is a schematic diagram of the connection between the blocking balloon catheter and the drug injection microcatheter of the device;

[0030] Figure 8 This is a schematic diagram of the spiral fixed block structure of this equipment.

[0031] Label names in the figure:

[0032] 1. Occluding catheter, 2. Injection catheter, 3. Drainage tube, 4. Infusion tube, 5. Occluding tube, 6. First valve, 7. Wedge-shaped protrusion;

[0033] 1-1, inner tube, 1-2, outer tube, 1-3, front balloon, 1-4, rear balloon, 1-5, first drug injection port, 1-6, blood inlet, 1-7, first blood outlet, 1-8, first cone head, 1-9, second blood outlet, 1-10, first developing metal marker, 1-11, fixing block;

[0034] 2-1, second conical head, 2-2, guide wire cavity, 2-3, drug injection cavity, 2-4, guide wire side hole, 2-5, second drug injection port, 2-6, second developing metal marker;

[0035] 3-1, second valve, 3-2, fifth valve. DETAILED DESCRIPTION

[0036] The embodiments of the present invention are described in further detail below in conjunction with the accompanying drawings.

[0037] It should be noted that the terms such as "upper", "lower", "left", "right", "front", "back", etc. used in the utility model are only for the convenience of description and are not used to limit the scope of implementation of the present invention. Changes or adjustments to their relative relationships should be regarded as the scope of implementation of the present utility model without substantially changing the technical content.

[0038] The “front end” mentioned herein is the left end shown in the drawings, the “end” is the right end shown in the drawings, the “front side” is the left side in the drawings, and the “rear side” is the right side in the drawings.

[0039] like Figure 1-8As shown (the first blood outlet 1-7 and the second blood outlet 1-9 have the same structure, so only one additional picture is used Figure 4 To show; Figure 8 It is only to show the specific structure of the fixed block 1-11. Figure 8 The invention discloses a drug injection device for hepatic artery perfusion chemotherapy, comprising a blocking catheter 1 and a drug injection catheter 2, wherein the blocking catheter 1 comprises an inner tube 1-1 and an outer tube 1-2, the outer tube 1-2 is sealed at both ends, the inner tube 1-1 is connected to the inside of the outer tube 1-2, that is, the inner tube 1-1 is connected to the inside of the outer tube 1-2 at both ends, and the drug injection catheter 2 is slidably connected to the inside of the inner tube 1-1; the end of the inner tube 1-1 extends out of the end of the outer tube 1-2, and the end of the inner tube 1-1 is provided with a first conical head 1-8, the first conical head 1-8 is provided with a through hole matching the drug injection catheter 2, and the drug injection catheter 2 can extend from the through hole of the first conical head 1-8, and the outer surface of the first conical head 1-8 is covered with a lubricating hydrophilic coating, which can enhance the flexibility and passability of the blocking catheter in the blood vessel.

[0040] A guide tube 3, a perfusion tube 4 and a blocking tube 5 are provided between the inner tube 1-1 and the outer tube 1-2. It should be noted that the guide tube 3 is not necessarily provided. The guide tube 3 is used as a conduit for blood circulation. Without the guide tube 3, the space between the inner tube 1-1 and the outer tube 1-2 can be used as a blood circulation channel. However, it is preferred to provide a separate guide tube 3 as a blood flow channel.

[0041] The guide tube 3, the perfusion tube 4 and the blocking tube 5 are equidistantly distributed in a ring and connected between the inner tube 1-1 and the outer tube 1-2; the outer sides of the guide tube 3, the perfusion tube 4 and the blocking tube 5 are directly connected to the inner wall of the outer tube 1-2, and the outer sides of the three are connected to the outer wall of the inner tube 1-1 through a spiral fixing block 1-11; the fixing block 1-11 runs through the inside of the outer tube 1-2 (that is, the front and rear ends of the fixing block 1-11 directly reach the front and rear ends of the outer tube 1-2), so that the fixing block 1-11 supports the entire blocking catheter 1, can improve the conduction of the catheter during use, and avoid relative deviation and bending of the catheter during pushing, and improve the passability. The strength of the fixing block 1-11 gradually decreases from front to back, so that while retaining the strength, the end of the blocking catheter is relatively soft, and it is not easy to cause damage when entering the blood vessel and moving.

[0042] The fixing block 1-11 is provided because the inner tube 1-1, the outer tube 1-2, the guide tube 3, the perfusion tube 4 and the blocking tube 5 need to have a certain degree of flexibility and elasticity and cannot be made too hard. The guide tube 3, the perfusion tube 4 and the blocking tube 5 are separated inside the outer tube 1-2, and a relatively rigid fixing block 1-11 is provided to provide effective support while retaining the flexibility of the remaining components; and the fixing block 1-11 is spirally shaped, which also makes the blocking catheter 1 as a whole have better bending performance and can better adapt to the blood vessels.

[0043] The gaps between the flow guiding tube 3 , the perfusion tube 4 and the blocking tube 5 (between the inner tube 1 - 1 and the outer tube 1 - 2 ) may be filled with polymer materials, such as amide or polyetheramide.

[0044] The outer tube 1-2 is provided with a front balloon 1-3 and a rear balloon 1-4 at intervals on the periphery, and the blocking tube 5 is connected to the two balloons. When in use, physiological saline is added to the two balloons through the blocking tube 5 to fill and expand them; the outer tube 1-2 is provided with a first drug injection port 1-5 between the two balloons, and the perfusion tube 4 is connected to the first drug injection port 1-5. A third valve is provided at the first drug injection port 1-5 to only allow the medium to flow out of the first drug injection port 1-5 from the perfusion tube 4 in one direction, thereby preventing the drug from flowing back.

[0045] When in use, first move the first injection port 1-5 to the designated position, then inject normal saline through the blocking catheter 5 to expand the two balloons, forming a closed space between the two balloons (the closed space is connected to the final target blood vessel as much as possible), and then inject the drug into the blood vessel through the first injection port 1-5 through the perfusion tube 4 so that the drug enters the final target blood vessel. This injection method is only one of the methods and is only used when the blocking catheter 1 cannot directly enter the final target blood vessel.

[0046] The outer tube 1-2 is provided with a blood inlet 1-6 on the front side of the front balloon 1-3, a first blood outlet 1-7 on the rear side of the rear balloon 1-4, and a second blood outlet 1-9 between the front and rear balloons; a first valve 6 is provided at the blood inlet 1-6 to only allow the medium to flow into the blood inlet 1-6 in one direction; the guide tube 3 is connected to the blood inlet 1-6, the first blood outlet 1-7 and the second blood outlet 1-9.

[0047] When the blocking catheter 1 moves in the blood vessel, the blood in the blood vessel can also enter the guide tube 3 through the blood inlet 1-6, and then flow out through the two blood outlets, so as to minimize the influence of the blocking catheter on the blood flow, especially when the double balloons are inflated to block the blood vessel, the blood can still remain unobstructed through the blood inlet 1-6 and the two blood outlets, and will not cause long-term blood stagnation during the injection process, resulting in tissue necrosis; and the first valve 6 is provided at the blood inlet 1-6 to prevent blood from flowing back, so as to prevent the blood that has been injected with the drug from flowing back into the main blood vessel and affecting normal human tissues.

[0048] Preferably, a fifth valve 3-2 may be provided at both the first blood outlet 1-7 and the second blood outlet 1-9 to only allow the medium to flow from the inside of the guide tube 3 (which is equivalent to blocking the inside of the catheter 1) to the outside, which can further prevent blood from flowing back.

[0049] The first blood outlet 1-7 and the second blood outlet 1-9 are both provided with a wedge-shaped protrusion 7 extending into the outer tube 1-2, with the slope of the wedge-shaped protrusion 7 facing the rear side. The wedge-shaped protrusion 7 slows down the blood flow velocity to a certain extent, reduces the impact on the liquid outlet, releases the blood flow slowly, reduces the risk of liver ischemic damage, and avoids excessive dilution of the drug, thereby improving the efficiency of drug utilization.

[0050] A second valve 3-1 is provided inside the guide tube 3 at the front side of the blood inlet 1-6 to only allow the medium to flow in one direction from front to back. The second valve 3-1 is provided at the front side of the blood inlet 1-6 to prevent the blood entering the guide tube 3 from flowing to the front end; when blood clots, blood coagulation or other substances hinder the blood circulation inside the guide tube 3, heparin can be pushed into the guide tube 3 from the front end for flushing, thereby keeping the guide tube 3 unobstructed, which is safer and more convenient to operate. The prior art cannot effectively and timely handle this situation.

[0051] The front end of the outer tube 1-2 is provided with an independent tube seat which is respectively connected to the inner tube 1-1, the guide tube 3, the perfusion tube 4 and the blocking tube 5. The tube seat can be made of a mixture of polycarbonate materials; substances are pushed into the corresponding pipes through the corresponding tube seats, for example, the inner tube 1-1 is used to push the injection catheter 2, the guide tube 3 is used to push heparin, the perfusion tube 4 is used to push drugs, and the blocking tube 5 is used to push physiological saline.

[0052] The outer tube 1-2 is provided with a first developing metal marker 1-10 at the front and rear edges of each balloon, that is, a total of four first developing metal markers 1-10 are provided in the outer tube 1-2 (for details, please refer to Figure 1), the first developing metal marker 1-10 is made of platinum-iridium alloy (the second developing marker 2-6 described below also uses this material). The first developing metal marker 1-10 can accurately determine the position of the double balloons, which is convenient for subsequent drug injection operations (the working principle section will be described in detail).

[0053] The front end of the drug injection catheter 2 is provided with a tube seat, which is used to push the drug into the drug injection catheter 2; the end of the drug injection catheter 2 is provided with a second conical head 2-1, and the second conical head 2-1 is provided with a through hole matching the guide wire; the drug injection catheter 2 is provided with a guide wire cavity 2-2 and a drug injection cavity 2-3 which are independent of each other, and the second conical head 2-1 is connected with the guide wire cavity 2-2; the drug injection catheter 2 is provided with a guide wire side hole 2-4 and a second drug injection port 2-5 which are respectively connected with the guide wire cavity 2-2 and the drug injection cavity 2-3.

[0054] The drug injection cavity 2-3 may be partially disposed below the guide wire cavity 2-2 on the rear side (the side close to the end) of the drug injection catheter 2, but the volume of this portion is smaller than the volume of the guide wire cavity 2-2 (see Figure 6 ), the second injection port 2-5 is arranged at a position close to the end of this part; this arrangement is to ensure that the injection catheter 2 does not need to extend too long from the end of the inner tube 1-1 to inject medicine.

[0055] If there is no overlap between the drug injection cavity 2-3 and the guide wire cavity 2-2 in the projection of the axial section, then the second drug injection port 2-5 is set at the farthest end of the drug injection cavity 2-3, close to the front end of the guide wire cavity 2-2. In this way, the guide wire cavity 2-2 must be completely extended from the end of the inner tube 1-1 before the second drug injection port 2-5 can be extended for drug injection. The extended length of the drug injection catheter 2 is too long, which increases the difficulty of operation. Because some of the final target blood vessels have shorter main channels and more branches, if the extension is too long, it may only be able to be extended into one of its branch blood vessels, and injecting drugs in the main channel is the most efficient, so it is preferred to adopt the setting method of this embodiment.

[0056] The second developing metal mark 2-6 (see FIG. Figure 6 ), its function is also to more accurately locate the position of the second drug outlet 2-5 to determine whether it has extended out of the blocking catheter 1 and whether drug injection can be performed; a fourth valve is provided at the second drug injection port 2-5 to only allow the medium to flow out of the second drug injection port 2-5 from the drug injection cavity 2-3 in one direction, thereby preventing drug backflow.

[0057] The first drug outlets 1-5 are a plurality of equally spaced matrix perfusion holes, and the spacing between adjacent perfusion holes is 0.05-1.5 mm, preferably 0.1-1.0 mm.

[0058] The second drug outlet 2-5 also has a plurality of equally spaced array perfusion holes for injecting and releasing drugs so that the drugs can evenly penetrate into the tumor blood vessels to prevent drug reflux: the hole spacing between adjacent perfusion holes of the second drug outlet 2-5 is between 0.05-1.5 mm, preferably 0.1-1.0 mm, the diameter of adjacent perfusion holes of the second drug outlet 2-5 is about 0.05-0.1 mm, and the arrangement can be circular, triangular, elliptical, etc.

[0059] The outer layers of the end of the blocking catheter 1 and the end of the injection catheter 2 are made of low-strength Pebax material to improve the flexibility of the end; the front end of the blocking catheter 1 is made of high-strength Pebax material, the inner layer is made of PTFE material, and the middle layer is made of metal braided material; the injection catheter 2 is a rapid exchange microcatheter, which adopts a stainless steel braided structure and has good anti-twist performance.

[0060] All valves described in this embodiment are one-way valve devices commonly used in medical devices, which only allow one-way flow of media.

[0061] The working principle of the drug injection device for hepatic artery perfusion chemotherapy provided in this application is as follows:

[0062] There are two situations for use:

[0063] The blocking catheter 1 cannot enter the final target blood vessel, but can only enter the main blood vessel of the upper level:

[0064] The guide wire is sent to the target position, and then the guide wire passes through the inner tube 1-1 to guide the blocking catheter 1 to the target position; the first developing metal marker 1-10 is used to accurately determine whether the final target blood vessel is located between the two balloons, and the number of remaining branch blood vessels between the two balloons is as small as possible (to avoid damage to normal tissues by drugs).

[0065] When the position of the blocking catheter 1 meets the above requirements, physiological saline is pushed into the blocking tube 5 to expand the front balloon 1-3 and the rear balloon 1-4, forming a closed area between the two balloons.

[0066] At this time, blood flows normally through the blood inlet 1-6, the first blood outlet 1-7 and the second blood outlet 1-9 at the front and rear sides of the two balloons and between the two balloons. Specifically, blood circulation at the front and rear sides of the balloon is maintained through the blood inlet 1-6 and the first blood outlet 1-7, and blood circulation between the front side of the balloon and the balloon is maintained through the blood inlet 1-6 and the second blood outlet 1-9 (that is, blood is ensured to flow normally into the branch blood vessels between the two balloon closed areas, so that the drug can enter the final target blood vessel with the blood).

[0067] The drug is then pushed through the perfusion tube 4, and injected into the closed area between the two balloons from the first injection port 1-5, and the drug is delivered to the final target blood vessel for treatment through blood flow. The injection process can be continued for a long time because the blood circulation of the entire blood vessel is unobstructed; even if the guide tube 3 is blocked by a blood clot or the like, heparin can be pushed into the guide tube 3 to flush it to ensure the unobstructed blood flow inside it.

[0068] When the injection is completed, the physiological saline in the double balloons is extracted through the blocking tube 5 to make them shrink, and then the blocking catheter 1 is withdrawn.

[0069] The occlusion catheter 1 can directly enter the final target vessel:

[0070] As in the first case, the guide wire is sent to the final target blood vessel, and then the blocking catheter 1 is guided into the final target blood vessel (the position is confirmed by the first developing mark 1-10). When the blocking catheter 1 enters the final target blood vessel, the guide wire is withdrawn, and the injection catheter 2 is passed through the inner tube 1-1 and extended from the first conical head 1-8 at its end.

[0071] Before starting to inject the drug, first inject normal saline into the double balloons through the blocking tube 5 to make them expand and block the final target blood vessel and the external blood vessel main channel, so as to prevent the blood in the final target blood vessel from flowing back into the external blood vessel main channel after the drug injection, and the drug from entering other normal tissues and causing damage to them; however, the blood in the external blood vessel main channel can still enter the final target blood vessel through the blood inlet 1-6 and the first blood outlet 1-7. At this time, although part of the blood will also enter the closed area between the two balloons through the second blood outlet 1-9, because there is no outlet in the closed area at this time (there is no branch blood vessel), only a small part of the blood will flow out from the second blood outlet 1-9, and under the action of pressure, it will not continue to flow out from this outlet, and will only flow out from the first blood outlet 1-7.

[0072] When the double balloons are fully inflated, the drug is directly injected into the final target blood vessel through the second injection port 2-5 of the injection catheter 2. After the double balloons are deflated as in the first case, the blocking catheter 1 and the injection catheter 2 are withdrawn.

[0073] The injection method in the second case avoids the blocking catheter 1 from injecting drugs in the upper vascular trunk of the final target blood vessel. The closed area formed by the double balloons in the upper main trunk cannot necessarily ensure that there is only one branch, the final target blood vessel. There may be other branch blood vessels leading to normal tissues, which will cause damage to normal tissues during injection.

[0074] Moreover, although the blood inlet 1-6, the first blood outlet 1-7 and the second blood outlet 1-9 can keep the blood flowing smoothly, the blood flow in the guide tube 3 will be smaller than that in normal conditions, and the human body will be affected to some extent, especially when the injection process is long. The impact is greater; using the second method, only the diseased tissue connected to the final target blood vessel is affected, which itself needs to be removed by drugs. Inflating the double balloons in the final target blood vessel can avoid the impact of the above-mentioned blood flow reduction on the human body as a whole.

[0075] In the second case, because the drug is injected into the final target blood vessel, the amount and speed of injection can be more and faster than in the upper blood vessel trunk. There is no need to worry about damage to the upper blood vessel trunk due to injection of a large amount of drug in a short time, and the injection efficiency is higher.

[0076] The above are only preferred implementations of the utility model. The protection scope of the utility model is not limited to the above embodiments. All technical solutions under the idea of ​​the utility model belong to the protection scope of the utility model. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should be regarded as the protection scope of the utility model.

Claims

1. A drug injection device for hepatic artery perfusion chemotherapy, characterized in that: The invention comprises a blocking catheter (1) and a drug injection catheter (2), wherein the blocking catheter (1) comprises an inner tube (1-1) and an outer tube (1-2), the outer tube (1-2) having two sealed ends, the inner tube (1-1) being connected to the inside of the outer tube (1-2); the drug injection catheter (2) being connected to the inside of the inner tube (1-1) by sliding; an infusion tube (4) and a blocking tube (5) being arranged between the inner tube (1-1) and the outer tube (1-2); a front balloon (1-3) and a rear balloon (1-4) being arranged at intervals on the outer periphery of the outer tube (1-2); the blocking tube (5) ) are connected to the two balloons; the outer tube (1-2) is provided with a first drug injection port (1-5) between the two balloons, and the perfusion tube (4) is connected to the first drug injection port (1-5); the outer tube (1-2) is provided with a blood inlet (1-6) on the front side of the front balloon (1-3), a first blood outlet (1-7) on the rear side of the rear balloon (1-4), and a second blood outlet (1-9) between the front and rear balloons; a first valve (6) is provided at the blood inlet (1-6) to allow only one-way flow of the medium into the blood inlet (1-6).

2. The drug injection device for hepatic artery perfusion chemotherapy according to claim 1, characterized in that: The first blood outlet (1-7) and the second blood outlet (1-9) are both provided with a wedge-shaped protrusion (7) extending into the outer tube (1-2), with the slope of the wedge-shaped protrusion (7) facing the rear side.

3. The drug injection device for hepatic artery perfusion chemotherapy according to claim 1, characterized in that: The end of the inner tube (1-1) extends out of the end of the outer tube (1-2), the end of the inner tube (1-1) is provided with a first conical head (1-8), and the first conical head (1-8) is provided with a through hole matching the drug injection catheter (2).

4. The drug injection device for hepatic artery perfusion chemotherapy according to claim 1, characterized in that: An independent tube seat is provided at the front end of the outer tube (1-2) and is respectively connected to the inner tube (1-1), the perfusion tube (4) and the blocking tube (5).

5. The drug injection device for hepatic artery perfusion chemotherapy according to claim 4, characterized in that: A flow guide tube (3) is also provided between the inner tube (1-1) and the outer tube (1-2); the flow guide tube (3) is in communication with the blood inlet (1-6), the first blood outlet (1-7) and the second blood outlet (1-9); a second valve (3-1) is provided inside the flow guide tube (3) at the front side of the blood inlet (1-6) to only allow the medium to flow in one direction from front to back; and an independent tube seat matching the flow guide tube (3) is also provided at the front end of the outer tube (1-2).

6. The drug injection device for hepatic artery perfusion chemotherapy according to claim 5, characterized in that: The guide tube (3), the perfusion tube (4) and the blocking tube (5) are equidistantly distributed in an annular manner and connected between the inner tube (1-1) and the outer tube (1-2); the guide tube (3), the perfusion tube (4) and the blocking tube (5) are connected to the inner tube (1-1) via a spiral fixing block (1-11); the fixing block (1-11) penetrates the interior of the outer tube (1-2); and the strength of the fixing block (1-11) gradually decreases from front to back.

7. The drug injection device for hepatic artery perfusion chemotherapy according to claim 1, characterized in that: A third valve is provided at the first drug injection port (1-5) to only allow the medium to flow out of the first drug injection port (1-5) from the perfusion tube (4) in one direction; and a fifth valve (3-2) is provided at both the first blood outlet (1-7) and the second blood outlet (1-9) to only allow the medium to flow from the inside of the blocking catheter (1) to the outside.

8. The drug injection device for hepatic artery perfusion chemotherapy according to claim 1, characterized in that: A first developing metal marker (1-10) is provided on the front and rear edges of each balloon in the outer tube (1-2).

9. The drug injection device for hepatic artery infusion chemotherapy according to claim 1, characterized in that: The front end of the drug injection catheter (2) is provided with a tube seat, and the rear end is provided with a second conical head (2-1), and the second conical head (2-1) is provided with a through hole matching the guide wire; the drug injection catheter (2) is provided with a guide wire cavity (2-2) and a drug injection cavity (2-3) which are independent of each other, and the second conical head (2-1) is connected with the guide wire cavity (2-2); the drug injection catheter (2) is provided with a guide wire side hole (2-4) and a second drug injection port (2-5) which are respectively connected with the guide wire cavity (2-2) and the drug injection cavity (2-3).

10. The drug injection device for hepatic artery infusion chemotherapy according to claim 9, characterized in that: The drug injection catheter (2) is provided with a second developing metal mark (2-6) at a position corresponding to the second drug injection port (2-5); and a fourth valve is provided at the second drug injection port (2-5) to only allow the medium to flow out of the second drug injection port (2-5) from the drug injection cavity (2-3) in one direction.

Images