Drug delivery device

Abstract

The utility model relates to the technical field of medical instruments, and discloses a drug delivery device which comprises an outer tube and an inner tube inserted in the outer tube, the inner tube penetrates through the outer tube, one end of the inner tube is sleeved with a blocking balloon, the outer tube is sleeved with a restraining balloon, a blocking space is formed between the blocking balloon and the restraining balloon, and a tumor is located in the blocking space; the outer tube is internally provided with a balloon flow channel used for feeding liquid into the restraint balloon so as to inflate the restraint balloon; a liquid inlet flow channel for feeding liquid into the blocking balloon to expand the blocking balloon is formed in the hollow inner tube; a dosing opening is formed in the outer tube, the dosing opening is communicated with the plugging space, and a dosing flow channel communicated with the dosing opening is formed in the outer tube. The infusion efficiency is improved, and the treatment effect is optimized.

Description

Technical Field

[0001] The present application relates to the technical field of medical devices, and in particular to a drug delivery device. Background Art

[0002] A tumor is a genetic disease. It refers to a cell whose genes change under the influence of carcinogenic factors, causing the cell to lose normal regulation of its growth, leading to abnormal proliferation of local tissue cells and the formation of a new growth. This new growth often forms a local mass, hence the name.

[0003] In the process of treating tumors, it is necessary to administer medicine to the tumor site. In order to effectively improve the efficiency of administering medicine to the affected area, a drug delivery device is mostly used.

[0004] Existing drug delivery devices are not convenient for blocking the sprayed drug solution when administering drugs to the patient's affected area, especially when using vascular targeted therapy. In the absence of inhibition of the tumor's adjacent blood vessels, blood flow is easily reversed, causing the drug solution to be driven to flow to other normal parts, which not only causes drug leakage and makes it difficult to achieve the expected treatment effect, but also easily causes a certain degree of damage to the normal parts. Utility Model Content

[0005] The purpose of this application is to overcome the problem of drug diversion in the prior art and to provide a drug delivery device. The blocking balloon and the restraining balloon confine the tumor within the blocking space, and deliver the drug to the lesion site through the drug delivery port to achieve the purpose of eliminating the tumor. The blocking balloon and the restraining balloon reduce the possibility of drug diversion to the outside, improve the infusion efficiency, and optimize the treatment effect.

[0006] In order to achieve the above-mentioned purpose, the present application provides a drug delivery device, comprising an outer tube and an inner tube inserted in the outer tube, the inner tube passes through the outer tube, a blocking balloon is sleeved on one end of the inner tube, a restraining balloon is sleeved on the outer tube, a blocking space is formed between the blocking balloon and the restraining balloon, and the tumor is located in the blocking space;

[0007] A balloon flow channel is provided in the outer tube for feeding liquid into the constraint balloon to inflate the constraint balloon;

[0008] The inner tube is hollow and has a liquid inlet channel for injecting liquid into the blocking balloon to inflate the blocking balloon;

[0009] The outer tube is provided with a drug delivery port, the drug delivery port is communicated with the blocking space, and the outer tube is provided with a drug delivery channel communicated with the drug delivery port.

[0010] In some embodiments, a base is provided at one end of the outer tube away from the drug delivery port, and a filling port is formed on the base of the balloon flow channel, and the filling port is used to connect to an external infusion device.

[0011] In some embodiments, the length of the filling port decreases along the direction toward the balloon channel.

[0012] In some embodiments, the outer tube is provided with a drug administration port for connecting to an external infusion device, and the drug administration port is communicated with the drug administration channel.

[0013] In some embodiments, the external infusion device is a filling pump or a syringe.

[0014] In some embodiments, a penetrating instrument hole is opened in the outer tube, the axial direction of the instrument hole is consistent with the axial direction of the outer tube, and the inner tube passes through the instrument hole.

[0015] In some embodiments, the drug delivery channel is a special-shaped channel.

[0016] In some embodiments, the outer tube includes a polymer outer layer and a metal reinforcement layer which are arranged in sequence from the outside to the inside along the radial direction, and a polymer inner layer is arranged on the inner side walls of the balloon flow channel and the drug delivery flow channel.

[0017] In some embodiments, both ends of the constraining balloon are provided with developing rings, and the developing rings are coaxially sleeved on the outer circumferential surface of the outer tube.

[0018] In some embodiments, both the occluding balloon and the constraining balloon are compliant balloons.

[0019] Through the above technical solution, the outer tube and the inner tube of the drug delivery device are close to the target blood vessel, and the blocking balloon and the restraining balloon are filled to confine the tumor within the blocking space. Then, the drug solution is delivered to the lesion site through the drug delivery port to achieve the purpose of eliminating the tumor. The blocking balloon and the restraining balloon reduce the possibility of the drug solution being shunted outward, improve the infusion efficiency, and optimize the treatment effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 is a cross-sectional view of the drug delivery device disclosed in the present application;

[0021] Figure 2 is a cross-sectional view of the drug delivery device disclosed in the present application;

[0022] Figure 3 It is a schematic diagram of the drug delivery device disclosed in the present application in a use state.

[0023] Description of Reference Numerals

[0024] 1. Outer tube; 11. Balloon flow channel; 111. Filling port; 12. Drug delivery channel; 121. Drug delivery port; 122. Drug delivery port; 13. Instrument hole; 14. Polymer outer layer; 15. Metal reinforcement layer; 2. Inner tube; 21. Liquid inlet channel; 3. Blocking balloon; 4. Constraint balloon; 5. Blocking space; 6. Base; 7. Polymer inner layer; 8. Development ring. DETAILED DESCRIPTION

[0025] The following is a further detailed description of the embodiments of the present disclosure in conjunction with the accompanying drawings and examples. The detailed description of the following embodiments and the accompanying drawings are used to exemplarily illustrate the principles of the present disclosure, but cannot be used to limit the scope of the present disclosure. The present disclosure can be implemented in many different forms and is not limited to the specific embodiments disclosed herein, but includes all technical solutions that fall within the scope of the claims.

[0026] The present disclosure provides these embodiments to make the present disclosure thorough and complete, and to fully express the scope of the present disclosure to those skilled in the art. It should be noted that unless otherwise specifically stated, the relative arrangement of the parts and steps, the composition of the materials, the numerical expressions and the numerical values ​​set forth in these embodiments should be interpreted as being merely exemplary, and not as limiting.

[0027] It should be noted that, in the description of the present disclosure, unless otherwise specified, the meaning of "multiple" is greater than or equal to two; the terms "upper", "lower", "left", "right", "inner", "outer", etc., indicating the orientation or positional relationship, are only for the convenience of describing the present disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation of the present disclosure. When the absolute position of the object being described changes, the relative positional relationship may also change accordingly.

[0028] In addition, the words "first", "second" and similar words used in the present disclosure do not indicate any order, quantity or importance, but are only used to distinguish different parts. "Vertical" does not mean vertical in the strict sense, but is within the tolerance range. "Parallel" does not mean parallel in the strict sense, but is within the tolerance range. "Include" or "comprising" and similar words mean that the elements before the word include the elements listed after the word, and do not exclude the possibility of including other elements.

[0029] Reference Figure 1 and Figure 3 The present application discloses a drug delivery device, comprising an outer tube 1 and an inner tube 2 inserted in the outer tube 1, the inner tube 2 penetrates the outer tube 1, a blocking balloon 3 is sleeved on one end of the inner tube 2, a restraining balloon 4 is sleeved on the outer tube 1, a blocking space 5 is formed between the blocking balloon 3 and the restraining balloon 4, and the tumor is located in the blocking space 5;

[0030] The outer tube 1 is provided with a balloon flow channel 11 for feeding liquid into the constraining balloon 4 to inflate the constraining balloon 4;

[0031] The inner tube 2 is hollow and has a liquid inlet channel 21 for inflating the blocking balloon 3.

[0032] The outer tube 1 is provided with a drug delivery port 122 , which is communicated with the blocking space 5 , and the outer tube 1 is provided with a drug delivery channel 12 which is communicated with the drug delivery port 122 .

[0033] The drug delivery device disclosed in the present application includes an outer tube 1, which is a long straight tube. A constraining balloon 4 is sleeved on the outer tube 1. In a non-expanded state, the constraining balloon 4 is attached to the outer wall of the outer tube 1. In an expanded state, the constraining balloon 4 is spherical. A balloon flow channel 11 is opened in the outer tube 1. The length direction of the balloon flow channel 11 is consistent with the length direction of the outer tube 1. The balloon flow channel 11 is connected to the inner cavity of the constraining balloon 4. Through the balloon flow channel 11, the user can inject liquid into the constraining balloon 4 to inflate the constraining balloon 4.

[0034] An inner tube 2 is inserted into the outer tube 1. The inner tube 2 is coaxial with the outer tube 1. The inner tube 2 is longer than the outer tube 1. The inner tube 2 penetrates the outer tube 1, that is, the two ends of the inner tube 2 extend from the two ends of the outer tube 1. The end of the inner tube 2 close to the constraining balloon 4 is sleeved with a blocking balloon 3. The inner tube 2 passes through the blocking balloon 3. In the non-expanded state, the blocking balloon 3 is attached to the outer wall of the inner tube 2. In the expanded state, the blocking balloon 3 is spherical, and a blocking space 5 is formed between the blocking balloon 3 in the expanded state and the constraining balloon 4, so that the tumor is confined in the blocking space 5. The end of the inner tube 2 away from the blocking balloon 3 is open. The inner tube 2 is hollow inside to form a liquid inlet channel 21. The liquid inlet channel 21 is connected to the inner cavity of the blocking balloon 3. Through the liquid inlet channel 21, the user can inject liquid into the blocking balloon 3 to inflate the blocking balloon 3.

[0035] A drug delivery channel 12 is also provided in the outer tube 1. The length direction of the drug delivery channel 12 is consistent with the length direction of the outer tube 1. One end of the drug delivery channel 12 passes through the end of the outer tube 1 and communicates with the outside world, and the other end passes through the side wall of the outer tube 1 to form a drug delivery port 122. The drug delivery port 122 is connected to the blocking space 5. The user can inject liquid medicine into the end of the drug delivery channel 12 that communicates with the outside world. The liquid medicine flows into the blocking space 5 through the drug delivery channel 12 and contacts the tumor in the blocking space 5.

[0036] During use, the outer tube 1 of the drug delivery device approaches the target blood vessel, and the restraining balloon 4 is filled by injecting liquid into the balloon channel 11 to block the blood flow. Then, the inner tube 2 is inserted into the outer tube 1 until the end of the inner tube 2 with the blocking balloon 3 passes over the tumor, and liquid is injected into the liquid inlet channel 21 to make the blocking balloon 3 swell, forming a blocking space 5 between the blocking balloon 3 and the restraining balloon 4, thereby confining the tumor in the blocking space 5, and finally, the drug solution is delivered to the lesion site through the drug delivery channel 12 with the drug delivery port 122 to achieve the purpose of eliminating the tumor. The blocking balloon 3 and the restraining balloon 4 reduce the possibility of the drug solution being shunted outward, thereby improving the infusion efficiency and optimizing the treatment effect.

[0037] Reference Figure 1 and Figure 3 In some embodiments, a base 6 is provided at one end of the outer tube 1 away from the drug delivery port 122, and a filling port 111 is formed on the base 6 of the balloon flow channel 11, and the filling port 111 is used to connect to an external infusion device.

[0038] In some embodiments, a base 6 is provided at one end of the outer tube 1 away from the drug delivery port 122. The base 6 is in a truncated cone shape. The diameter of the base 6 away from the end of the outer tube 1 is greater than the diameter of the end close to the outer tube 1. The base 6 is used to connect the device to improve stability. A through filling port 111 is formed on the base 6. The filling port 111 is connected to the balloon flow channel 11. During the use of the drug delivery device, the filling port 111 is connected to an external infusion device, and the external infusion device injects liquid into the balloon flow channel 11 through the filling port 111.

[0039] Reference Figure 1 In some embodiments, the length of the filling port 111 decreases along the direction toward the balloon channel 11 .

[0040] In some embodiments, the length direction of the filling port 111 is consistent with the length direction of the balloon channel 11, and the diameter of the filling port 111 decreases from the outside to the inside, that is, the diameter of the filling port 111 decreases in the direction toward the balloon channel 11, thereby improving stability during liquid inlet.

[0041] Reference Figure 1 In some embodiments, the outer tube 1 is provided with a drug administration port 121 for connecting to an external infusion device, and the drug administration port 121 is communicated with the drug administration channel 12 .

[0042] In some embodiments, a drug administration port 121 is provided on the outer tube 1, and the drug administration port 121 is connected to one end of the drug administration channel 12 away from the drug administration port 122. During the use of the drug administration device, the drug administration port 121 is connected to an external infusion device, and the external infusion device injects liquid into the drug administration channel 12 through the drug administration port 121. The drug administration port 121 is located on the base 6 and is arranged through the base 6.

[0043] In some embodiments, the drug administration port 121 extends outward from the side wall of the outer tube 1 .

[0044] Reference Figure 1 In some embodiments, the external infusion device is a filling pump or a syringe.

[0045] In some embodiments, the external infusion device is a filling pump or a syringe, and liquid is injected into the drug delivery channel 12, the balloon channel 11, and the liquid inlet channel 21 through the filling pump or the syringe.

[0046] Reference Figure 1 and Figure 2In some embodiments, a penetrating instrument hole 13 is opened in the outer tube 1 , the axial direction of the instrument hole 13 is consistent with the axial direction of the outer tube 1 , and the inner tube 2 passes through the instrument hole 13 .

[0047] In some embodiments, an instrument hole 13 is opened in the outer tube 1, and the instrument hole 13 is coaxial with the outer tube 1. The diameter of the instrument hole 13 is greater than the diameter of the inner tube 2. The inner tube 2 passes through the instrument hole 13. When the blocking balloon 3 on the inner tube 2 is in a contracted state, the inner tube 2 can slide freely in the instrument hole 13.

[0048] Reference Figure 1 and Figure 2 In some embodiments, the drug delivery channel 12 is a special-shaped channel.

[0049] In some embodiments, the cross-section of the drug delivery channel 12 is semicircular, which is different from the shape of a conventional circular channel.

[0050] In other embodiments, the drug delivery channel 12 may be in other shapes.

[0051] Reference Figure 1 and Figure 2 In some embodiments, the outer tube 1 includes a polymer outer layer 14 and a metal reinforcement layer 15 which are arranged in sequence from the outside to the inside along the radial direction, and a polymer inner layer 7 is arranged on the inner side walls of the balloon flow channel 11 and the drug delivery flow channel 12.

[0052] In some embodiments, the outer tube 1 includes a polymer outer layer 14 and a metal reinforcement layer 15 which are arranged radially from the outside to the inside in sequence. The polymer outer layer 14 can be made of a polymer material, and the metal reinforcement layer 15 can be in the form of a woven mesh or a hypotube or various combinations. A polymer inner layer 7 is arranged on the inner side wall of the balloon flow channel 11 and the drug delivery channel 12. The polymer inner layer 7 can be made of PTFE. The drug delivery channel 12 is a drug delivery channel. The use of PTFE material can reduce the friction coefficient of the inner wall of the tube and increase the smoothness of the drug delivery channel 12 when the drug delivery device is in use.

[0053] Reference Figure 1 In some embodiments, developing rings 8 are provided at both ends of the constraining balloon 4 , and the developing rings 8 are coaxially sleeved on the outer circumferential surface of the outer tube 1 .

[0054] In some embodiments, two developing rings 8 are sleeved on the outer wall of the outer tube 1 , and the two developing rings 8 are respectively located on both sides of the constraining balloon 4 , serving as developing marks.

[0055] Reference Figure 1 In some embodiments, both the occluding balloon 3 and the constraining balloon 4 are compliant balloons.

[0056] In some embodiments, the blocking balloon 3 and the constraining balloon 4 are both compliant balloons made of rubber material. After being filled with fluid, they have a marked maximum expansion volume, have a fixed shape and size under an internal pressure above a certain intensity (ignoring the slight shape and size changes exceeding the maximum expansion volume), have no obvious elastic shape and have a certain hardness, and the balloon has good wall adhesion.

[0057] In a preferred embodiment of the drug delivery device disclosed in the present invention, it includes an outer tube 1, which is a long straight tube, and a constraining balloon 4 is sleeved on the outer tube 1. In a non-expanded state, the constraining balloon 4 is attached to the outer wall of the outer tube 1, and in an expanded state, the constraining balloon 4 is spherical. A balloon flow channel 11 is opened in the outer tube 1, and the length direction of the balloon flow channel 11 is consistent with the length direction of the outer tube 1. The balloon flow channel 11 is connected to the inner cavity of the constraining balloon 4. Through the balloon flow channel 11, the user can inject liquid into the constraining balloon 4 to inflate the constraining balloon 4.

[0058] Two developing rings 8 are sleeved on the outer wall of the outer tube 1 . The two developing rings 8 are respectively located on both sides of the restraining balloon 4 , and serve as developing marks.

[0059] An inner tube 2 is inserted into the outer tube 1. The inner tube 2 is coaxial with the outer tube 1. The inner tube 2 is longer than the outer tube 1. The inner tube 2 penetrates the outer tube 1, that is, the two ends of the inner tube 2 extend from the two ends of the outer tube 1. A through instrument hole 13 is opened in the outer tube 1. The instrument hole 13 is coaxial with the outer tube 1. The diameter of the instrument hole 13 is longer than the diameter of the inner tube 2. The inner tube 2 penetrates the instrument hole 13. A blocking balloon 3 is sleeved on one end of the inner tube 2 close to the constraining balloon 4. The inner tube 2 passes through the blocking balloon 3. In the non-expanded state, the blocking balloon 3 is attached to the outer wall of the inner tube 2. In the expanded state, the blocking balloon 3 is spherical, and a blocking space 5 is formed between the blocking balloon 3 in the expanded state and the constraining balloon 4, so that the tumor is confined in the blocking space 5. One end of the inner tube 2 away from the blocking balloon 3 is open, and the inner tube 2 is hollow inside to form a liquid inlet channel 21, which is communicated with the inner cavity of the blocking balloon 3. Through the liquid inlet channel 21, the user can inject liquid into the blocking balloon 3 to inflate the blocking balloon 3.

[0060] Both the blocking balloon 3 and the restraining balloon 4 are compliant balloons made of rubber. After being filled with fluid, they have a marked maximum expansion volume, have a fixed shape and size under an internal pressure above a certain intensity (ignoring the slight shape and size changes exceeding the maximum expansion volume), have no obvious elastic shape and have a certain hardness, and the balloon has good wall adhesion.

[0061] A drug delivery channel 12 is also provided in the outer tube 1. The cross-section of the drug delivery channel 12 is semicircular, which is different from the shape of a conventional circular channel. The length direction of the drug delivery channel 12 is consistent with the length direction of the outer tube 1. One end of the drug delivery channel 12 passes through the end of the outer tube 1 and communicates with the outside world, and the other end passes through the side wall of the outer tube 1 to form a drug delivery port 122. The drug delivery port 122 is connected to the blocking space 5. The user can inject liquid medicine into the end of the drug delivery channel 12 that is connected to the outside world. The liquid medicine flows into the blocking space 5 through the drug delivery channel 12 and contacts the tumor in the blocking space 5.

[0062] The end of the outer tube 1 away from the drug delivery port 122 is provided with a base 6, the base 6 is truncated, the diameter of the end of the base 6 away from the outer tube 1 is greater than the diameter of the end close to the outer tube 1, and the base 6 is used to connect the instrument to improve stability. A through filling port 111 is formed on the base 6, the filling port 111 is connected to the balloon flow channel 11, the length direction of the filling port 111 is consistent with the length direction of the balloon flow channel 11, and the diameter of the filling port 111 decreases from the outside to the inside, that is, the diameter of the filling port 111 decreases along the direction toward the balloon flow channel 11. The base 6 is also provided with a drug delivery port 121, the drug delivery port 121 is connected to the end of the drug delivery channel 12 away from the drug delivery port 122, and the drug delivery port 121 is arranged through the base 6.

[0063] The filling port 111 and the drug delivery port 121 are connected to an external infusion device, which is a filling pump or a syringe, through which liquid is delivered into the drug delivery channel 12 , the balloon channel 11 , and the liquid inlet channel 21 .

[0064] The outer tube 1 includes a polymer outer layer 14 and a metal reinforcement layer 15 which are arranged in sequence from the outside to the inside in the radial direction. The polymer outer layer 14 can be made of a polymer material, and the metal reinforcement layer 15 can be in the form of a woven mesh or a hypotube or various combinations. A polymer inner layer 7 is arranged on the inner side wall of the balloon flow channel 11 and the drug delivery flow channel 12. The polymer inner layer 7 can be made of PTFE. The drug delivery flow channel 12 is a drug delivery channel. The use of PTFE material can reduce the friction coefficient of the inner wall of the tube and increase the smoothness of the drug delivery flow channel 12 when the drug delivery device is in use.

[0065] So far, various embodiments of the present disclosure have been described in detail. In order to avoid obscuring the concept of the present disclosure, some details known in the art are not described. Based on the above description, those skilled in the art can fully understand how to implement the technical solution disclosed here.

[0066] Although some specific embodiments of the present disclosure have been described in detail by way of examples, it should be understood by those skilled in the art that the above examples are for illustration only and are not intended to limit the scope of the present disclosure. It should be understood by those skilled in the art that the above embodiments may be modified or some technical features may be replaced by equivalents without departing from the scope and spirit of the present disclosure. In particular, the various technical features mentioned in the various embodiments may be combined in any manner as long as there is no structural conflict.

Claims

1. A drug delivery device, characterized in that: The invention comprises an outer tube (1) and an inner tube (2) inserted in the outer tube (1), wherein the inner tube (2) penetrates the outer tube (1), a blocking balloon (3) is sleeved on one end of the inner tube (2), a restraining balloon (4) is sleeved on the outer tube (1), a blocking space (5) is formed between the blocking balloon (3) and the restraining balloon (4), and the tumor is located in the blocking space (5); The outer tube (1) is provided with a balloon flow channel (11) for feeding liquid into the constraining balloon (4) to inflate the constraining balloon (4); The inner tube (2) is hollow and has a liquid inlet channel (21) for letting liquid into the blocking balloon (3) to inflate the blocking balloon (3); The outer tube (1) is provided with a drug delivery port (122), the drug delivery port (122) is in communication with the blocked space (5), and the outer tube (1) is provided with a drug delivery channel (12) in communication with the drug delivery port (122).

2. The drug delivery device according to claim 1, characterized in that: A base (6) is provided at one end of the outer tube (1) away from the drug delivery port (122), and a filling port (111) is formed on the base (6) of the balloon flow channel (11), and the filling port (111) is used to connect to an external infusion device.

3. The drug delivery device according to claim 2, characterized in that: The diameter of the filling port (111) decreases gradually in the direction toward the balloon flow channel (11).

4. The drug delivery device according to claim 1, characterized in that: The outer tube (1) is provided with a drug delivery port (121) for connecting to an external infusion device, and the drug delivery port (121) is in communication with the drug delivery channel (12).

5. The drug delivery device according to claim 2, characterized in that: The external infusion device is a filling pump or a syringe.

6. The drug delivery device according to claim 1, characterized in that: The outer tube (1) is provided with a penetrating instrument hole (13), the axial direction of the instrument hole (13) is consistent with the axial direction of the outer tube (1), and the inner tube (2) passes through the instrument hole (13).

7. The drug delivery device according to claim 1, characterized in that: The drug delivery channel (12) is a special-shaped channel.

8. The drug delivery device according to claim 1, characterized in that: The outer tube (1) comprises a polymer outer layer (14) and a metal reinforcement layer (15) which are arranged in sequence from the outside to the inside along the radial direction, and a polymer inner layer (7) is arranged on the inner side walls of the balloon flow channel (11) and the drug delivery flow channel (12).

9. The drug delivery device according to claim 1, characterized in that: Both ends of the restraining balloon (4) are provided with developing rings (8), and the developing rings (8) are coaxially sleeved on the outer peripheral surface of the outer tube (1).

10. The drug delivery device according to claim 1, characterized in that: The blocking balloon (3) and the constraining balloon (4) are both compliant balloons.

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