Reagent bottle batch freeze-drying disc with auxiliary half pressing plugs

By designing a batch freeze-dried tray with auxiliary semi-pressure plugs, the reagent bottle plugs are stably clamped by slots on the tray and the clamps and magnets in the fixing frame, the problems of low efficiency and poor accuracy of manual semi-pressure plugs are solved, and efficient and stable freeze-drying operation and product qualification improvement are achieved.

CN222799579UActive Publication Date: 2025-04-25ZHENGZHOU BIAOYUAN BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202421745369.0
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Filing Date
2024-07-23
Publication Date
2025-04-25
Estimated Expiration
2034-07-23

AI Technical Summary

Technical Problem

In the prior art, manual semi-pressure plugging operation is not only inefficient but also easily leads to incorrect placement of the bottle plug, resulting in the inability to sublimate the moisture during lyophilization or the bottle plug falls off, affecting the product pass rate.

Method used

A batch freeze-dried reagent bottle with auxiliary semi-pressure plug was designed to insert the reagent bottle through multiple slots on the tray, and the reagent bottle plug was stably clamped with the splint in the fixing frame and the suction magnet to ensure that it was always in the semi-pressure plug state.

Benefits of technology

The stable clamping of the reagent bottle plug is achieved, ensuring that the reagent bottle plug is always in a semi-pressure plug during lyophilization operation, improving the production efficiency and product qualification rate of lyophilization product preparation, and simplifying the full-pressure plug operation.

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Abstract

The utility model discloses a reagent bottle batch freeze-drying disc with auxiliary half pressing plugs, which comprises a tray and a containing cavity with an upper opening, and a plurality of rows of slots are uniformly distributed at the bottom of the containing cavity at intervals; the fixing frame is adaptively buckled on the opening edge of the tray, horizontal sliding grooves are symmetrically formed in the front frame edge and the rear frame edge of the fixing frame, a plurality of pairs of clamping plates in one-to-one correspondence with the insertion grooves in each row are arranged in the horizontal sliding grooves in a sliding mode, and a plurality of semicircular openings vertically corresponding to the insertion grooves in the whole row are evenly distributed in the clamping faces of the clamping plates; the semicircular openings in each pair of clamping plates are buckled in a matched mode to form a bottle plug clamping hole right opposite to the upper portion of the inserting groove. The device has the advantages that batch freeze-drying of materials in reagent bottles is achieved, it is ensured that reagent bottle plugs are always in a half-plug-pressing state during freeze-drying operation, in addition, the device can be matched with the plug-pressing function of a freeze dryer, full-plug-pressing operation of all the reagent bottle plugs can be completed at a time, the working efficiency of full-plug-pressing operation is improved, the production efficiency of freeze-drying product preparation is improved, and the production cost is reduced. And the product qualification rate is ensured.
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Description

Technical Field

[0001] The utility model relates to the technical field of vacuum freeze drying, in particular to a reagent bottle batch freeze drying tray with an auxiliary semi-press plug. Background Art

[0002] Vacuum freeze drying technology freezes water-containing materials into solids. It is a new drying method that uses the sublimation properties of water to dehydrate materials at low temperature and achieve drying under low temperature and low pressure conditions. Since vacuum freeze drying technology is carried out in a low temperature and low oxygen environment, most biological reactions will stagnate, and there is no liquid water in the treatment process. The water will directly sublimate in a solid state, so that the original structure and shape of the material are protected to the greatest extent, and finally a high-quality dried product with both appearance and internal quality is obtained.

[0003] At present, in order to ensure that the freeze-dried products can be well protected, the reagent bottles must be fully corked before the products are opened and used to ensure the vacuum degree in the bottles; and when the products are placed in the freeze dryer for freeze drying, the reagent bottles need to be semi-corked to ensure that the internal moisture of the products can be sublimated and discharged during the freeze drying process. Semi-corked means that after the liquid is divided into bottles, the bottle stopper with a venting notch is placed on the bottle mouth of each reagent bottle, and the venting notch should be kept above the bottle mouth to ensure that the inside and outside of the reagent bottle are connected, ensuring that the moisture can be sublimated during freeze drying. At the same time, the bottle stopper treated with semi-corked must ensure that the freeze dryer's corking function can be used directly for full corked treatment after the freeze drying is completed.

[0004] Existing large-scale production workshops often use equipment with a plugging function such as a plugging machine for semi-plugging treatment, but such equipment is expensive, costly, and bulky. It is extremely inconvenient to perform semi-plugging treatment for freeze-drying operations of small batches of products. Therefore, many freeze-dried products are often manually semi-plugged during the production process (i.e., manually placing the bottle stopper on the bottle mouth of the reagent bottle). The manual semi-plugging operation has strict requirements on the position of the bottle stopper in the bottle mouth. The bottle stopper must be placed vertically, and the exhaust notch on the bottle stopper needs to be kept above the bottle mouth, and it cannot be inserted too deep; therefore, the manual semi-plugging operation will not only prolong the time that the product is exposed to the environment after packaging, increasing the risk of product performance being affected, but also greatly increase the error rate of the bottle stopper placement position. Placing the bottle stopper too deep can easily cause the water to fail to sublimate, and placing the bottle stopper too shallowly or tilted can easily cause the bottle stopper to fall off during plugging, and even cause the reagent bottle to tip over, reducing the product qualification rate. Summary of the invention

[0005] The utility model aims to provide a batch freeze-drying tray for reagent bottles with auxiliary semi-pressing plugs in view of the defects of the prior art.

[0006] In order to achieve the above purpose, the utility model can adopt the following technical solutions:

[0007] The reagent bottle batch freeze-drying tray with auxiliary semi-press plugs of the utility model comprises:

[0008] The tray has an upper opening containing cavity, and the bottom of the containing cavity is evenly spaced and arranged with multiple rows of slots for inserting reagent bottles;

[0009] A fixed frame is adapted to be snapped onto the edge of the tray, and horizontal slide grooves are symmetrically provided on the front and rear frame edges of the fixed frame. Multiple pairs of clamps corresponding to each column of the slots are slidably arranged in the horizontal slide grooves, and multiple semicircular openings corresponding to the upper and lower columns of the slots are evenly distributed on the clamping surfaces of the clamps, and the semicircular openings on each pair of clamps are adapted to be snapped together to form bottle plug clamping holes for clamping reagent bottle plugs directly above the slots.

[0010] Specifically, an L-shaped slot with the same direction is provided on one set of opposite side edges of the tray, and a card block adapted to be mounted in the L-shaped slot is provided on the fixing frame, so that the fixing frame can be easily and accurately snapped onto the edge of the tray.

[0011] Furthermore, in order to ensure that the semicircular opening clamps the reagent bottle plug more firmly, mutually attracting magnets can be arranged on the clamping surfaces of each pair of the clamping plates.

[0012] The utility model has the advantages of placing reagent bottles in batches by means of multiple rows of slots on a tray, thereby realizing batch freeze drying of materials in the reagent bottles; by adapting a fixed frame that is snap-fitted to the tray and cooperating with multiple pairs of clamps that slide horizontally in the fixed frame, the reagent bottle plugs can be firmly clamped so that they are half-plugged on the reagent bottles one by one, ensuring that the reagent bottle plugs are always in a half-plugged state during the freeze drying operation, ensuring that the materials in the bottles can be effectively freeze dried, and also easily releasing the reagent bottle plugs after the freeze drying is completed, so that the fixed frame can be removed and the plugging function of the freeze dryer can be directly matched, and the full plugging operation of all reagent bottle plugs can be completed at one time, thereby improving the work efficiency of the full plugging operation, thereby improving the production efficiency of freeze-dried product preparation, and ensuring the product qualification rate. BRIEF DESCRIPTION OF THE DRAWINGS

[0013] Figure 1 It is a structural schematic diagram of the utility model. DETAILED DESCRIPTION

[0014] The following will be combined with the drawings in the embodiments of the utility model to clearly and completely describe the technical solutions in the embodiments of the utility model. Obviously, the described embodiments are only part of the embodiments of the utility model, not all of the embodiments. Based on the embodiments of the utility model, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the utility model.

[0015] like Figure 1 As shown, the reagent bottle batch freeze-drying tray with auxiliary semi-press plugs of the utility model includes a tray 1 and a fixing frame 2.

[0016] Among them, the tray 1 is a rectangular metal plate, which has an upper open loading cavity 3; a plurality of rows of slots 4 are evenly spaced at the bottom of the loading cavity 3, and each row contains a plurality of slots 4 arranged in parallel, so that all the slots 4 are arranged in a rectangular array on the bottom of the loading cavity 3; and the slot diameter of each slot 4 should match the outer diameter of the reagent bottle containing the material to be freeze-dried, so that the reagent bottle can be firmly inserted.

[0017] The fixing frame 2 is a rectangular frame that is adapted to be snapped onto the edge of the tray 1; specifically, at least one pair of L-shaped snap slots 5 with the same direction can be opened on one of the opposite side edges of the tray 1, and a card block 6 that can be adapted to be snapped into the L-shaped snap slot 5 is provided on the bottom surface of the fixing frame 2, so that the card block 6 can be inserted vertically downward into the L-shaped snap slot 5, and then the card block 6 and the L-shaped snap slot 5 can be easily adapted and snapped into by pushing horizontally, so that the fixing frame 2 can be easily and accurately snapped onto the edge of the tray 1.

[0018] In addition, horizontal slide grooves 7 are symmetrically provided on the front and rear frame edges of the fixed frame 2, and multiple pairs of clamps 8 corresponding to each column of slots 4 are slidably arranged in the horizontal slide grooves 7, and multiple semicircular openings 9 corresponding to the hole positions of the entire column of slots 4 are evenly distributed on the clamping surfaces of the clamps 8. When the semicircular openings 9 on each pair of clamps 8 are fitted and snapped together, bottle plug clamping holes for clamping reagent bottle plugs are formed, and the position of the bottle plug clamping holes can be easily fine-tuned to make them just above the entire column of slots 4, so that when the bottle plug clamping holes clamp the reagent bottle plugs, it can ensure that the reagent bottle plugs are just on the slots 4, and the semi-plugging operation of the reagent bottle plug and the reagent bottle can be easily and accurately completed.

[0019] Furthermore, in order to ensure that the semicircular opening 9 clamps the reagent bottle stopper more firmly, mutually attractive retaining magnets 10 can be provided on the clamping surface of each pair of clamps 8. Specifically, the retaining magnets 10 are embedded on the clamping surfaces of the clamps 8 between adjacent semicircular openings 9. When the paired clamps 8 are buckled together, the retaining magnets 10 can be utilized to firmly attract them together, thereby ensuring that the semicircular openings 9 are buckled more firmly.

[0020] When in use, first insert the reagent bottles containing the materials to be freeze-dried into the slots 4 one by one, then snap the fixing frame 2 onto the tray 1, and then operate the paired clamps 8 to clamp the reagent bottle plugs, and ensure that each reagent bottle plug is aligned one-to-one with the reagent bottle, thereby forming a semi-pressed plug between the reagent bottle plug and the reagent bottle, so that the reagent bottle can be placed in the freeze dryer for freeze-drying operation, realizing batch freeze-drying, ensuring that all reagent bottle plugs are always in a semi-pressed plug state during the freeze-drying operation, and ensuring that the materials in the bottles can be effectively freeze-dried.

[0021] After the freeze-drying is completed, each pair of splints 8 is manually opened to release the reagent bottle plugs, so that the reagent bottle plugs fall vertically from top to bottom into the mouth of the reagent bottle. At this time, the fixed frame 2 is removed, and the plugging function of the freeze dryer can be directly matched to complete the full plugging operation of all reagent bottle plugs at one time, thereby improving the work efficiency of the full plugging operation, thereby improving the production efficiency of the freeze-dried product preparation and ensuring the product qualification rate.

[0022] It should be noted that all directional indications in the embodiments of the present invention (such as up, down, left, right, front, back...) are only used to explain the relative position relationship, movement status, etc. between the components under a certain specific posture (as shown in the accompanying drawings). If the specific posture changes, the directional indication will also change accordingly.

Claims

1. A batch freeze-drying tray for reagent bottles with auxiliary semi-stoppers, characterized in that: include The tray has an upper opening containing cavity, and the bottom of the containing cavity is evenly spaced and arranged with multiple rows of slots for inserting reagent bottles; A fixed frame is adapted to be snapped onto the edge of the tray, and horizontal slide grooves are symmetrically provided on the front and rear frame edges of the fixed frame. Multiple pairs of clamps corresponding to each column of the slots are slidably arranged in the horizontal slide grooves, and multiple semicircular openings corresponding to the upper and lower columns of the slots are evenly distributed on the clamping surfaces of the clamps, and the semicircular openings on each pair of clamps are adapted to be snapped together to form bottle plug clamping holes for clamping reagent bottle plugs directly above the slots.

2. The reagent bottle batch freeze-drying tray with auxiliary half-stopper according to claim 1, characterized in that: The clamping surfaces of each pair of clamping plates are provided with mutually attracting magnets.

3. The reagent bottle batch freeze-drying tray with auxiliary half-stopper according to claim 1, characterized in that: An L-shaped bayonet with the same direction is provided on one group of opposite side edges of the tray, and a card block adapted to be mounted in the L-shaped bayonet is provided on the fixing frame.