Magnetic stirring device

Abstract

The utility model provides a magnetic stirring device. The magnetic stirring device comprises a reaction tank; the bearing seat is connected with the reaction tank; the driving motor is arranged at the top of the reaction tank through the bearing seat; the outer magnetic sleeve is connected with the driving motor; the inner magnetic sleeve is connected with the bearing seat and is magnetically coupled with the outer magnetic sleeve; the isolation sleeve is arranged between the outer magnetic sleeve and the inner magnetic sleeve and is used for isolating the inner space and the outer space of the reaction tank; one end of the driving shaft is connected with the inner magnetic sleeve, and the other end is provided with a nozzle distribution disc; first nozzles are formed in the nozzle distribution disc; the stirring shaft is connected with the driving shaft through the nozzle distribution disc; the stirring paddle is connected with the stirring shaft; gaps are formed among the inner magnetic sleeve, the driving shaft, the isolation sleeve and the bearing seat; the cleaning inlet is formed in the isolation sleeve and communicated with the gap; and the gap extends to the first nozzle to form a first cleaning channel.

Description

Technical Field

[0001] The utility model relates to the technical field of designing biological reaction equipment, and particularly to a magnetic stirring device. Background Art

[0002] In terms of cleaning technology, the magnetic stirring device used in biological reactions mainly adopts the online cleaning (CIP) method. CIP is the abbreviation of Clean In Place, which is a cleaning method that does not require the disassembly of the equipment. This cleaning method can ensure the cleanliness of the inside of the reaction container while meeting the requirements of aseptic operation, which is particularly important for the biopharmaceutical industry.

[0003] In the prior art, when performing CIP cleaning on a bioreactor magnetic stirring device, using a cleaning ball (spray ball) is a common method.

[0004] like Figure 1 As shown in the figure, a common container structure with an overhead magnetic stirrer 100, in order to meet the cleanliness requirements of pharmaceutical equipment, generally needs to install cleaning balls 110 or cleaning nozzles in the upper, middle and lower areas of the container. Since the shielding of the magnetic stirrer in the tank will form a cleaning dead angle, it is generally necessary to install multiple cleaning balls 210 in the upper area of ​​the container of the overhead magnetic stirrer 200, such as Figure 2 shown.

[0005] However, there are the following problems when using cleaning balls for CIP cleaning:

[0006] First, there are too many cleaning balls, and the internal structure of the container is complicated, so the structure of the outside of the container is also complicated (more pipes, control valves, temperature measuring points and steam traps, etc. need to be added), resulting in higher production costs and reduced system stability.

[0007] Secondly, the cleaning ball will wear out after a period of use and needs to be replaced regularly, or durable materials and reasonable designs can be selected to extend the service life of the cleaning ball. Moreover, the cleaning ball device and its related equipment (such as spray pumps, pipes, etc.) also require regular maintenance and necessary repairs, all of which further increase the production and use costs.

[0008] Again, this method has the following defects in cleaning effect:

[0009] 1. Incomplete cleaning: The cleaning ball may not cover all areas of the agitator, especially some hard-to-reach corners, which may cause residue accumulation and affect the cleanliness of the equipment. Especially when the cleaning liquid pressure is high, atomization may occur, further reducing the cleaning effect.

[0010] 2. Low cleaning efficiency: Using cleaning balls may take a long time to ensure that the equipment is fully cleaned, which may reduce production efficiency.

[0011] 3. Verification difficulties: Ensuring that the cleaning balls can clean the entire agitator system evenly and effectively may require a complex verification process to prove that there is no residue.

[0012] 4. Wear of cleaning balls: Long-term use of cleaning balls may cause them to wear out and require regular replacement, increasing maintenance costs.

[0013] 5. Material selection of cleaning balls: The material of the cleaning balls needs to meet specific hygiene and corrosion resistance standards to avoid contamination of the liquid in the bioreactor.

[0014] 6. Standardization of cleaning procedures: In order to ensure the cleaning effect, a strict cleaning procedure needs to be formulated, which may involve complex operating steps and time control.

[0015] 7. Installation and removal of cleaning balls: In some designs, the installation and removal of cleaning balls may be difficult, which will increase the complexity and time of the operation.

[0016] 8. Impact of cleaning ball on agitator: In some cases, the cleaning ball may cause damage to the surface of the agitator, especially when rotating at high speed.

[0017] It can be seen from the above that developing a new CIP cleaning solution suitable for magnetic stirring devices is an urgent problem to be solved in the prior art. Utility Model Content

[0018] In view of this, the present application aims to solve the technical problems in the prior art of online cleaning of bioreactor magnetic stirring devices, such as complex structure, many cleaning dead corners, and high cost caused by the use of multiple cleaning balls.

[0019] The embodiment of the present application provides a magnetic stirring device, including: a reaction tank; a bearing seat connected to the reaction tank; a drive motor, which is arranged on the top of the reaction tank through the bearing seat; an outer magnetic sleeve, which is connected to the drive motor; an inner magnetic sleeve, which is connected to the bearing seat and magnetically coupled to the outer magnetic sleeve; an isolation sleeve, which is arranged between the outer magnetic sleeve and the inner magnetic sleeve and is used to isolate the inner and outer spaces of the reaction tank; a drive shaft, one end of which is connected to the inner magnetic sleeve; a first nozzle is arranged on the drive shaft; a gap is formed between the inner magnetic sleeve and the drive shaft and the isolation sleeve and the bearing seat; a cleaning inlet is arranged on the isolation sleeve and is connected to the gap; the gap extends to the first nozzle to form a first cleaning channel.

[0020] Furthermore, the first nozzle is a slit or an opening.

[0021] Furthermore, there are multiple first nozzles.

[0022] Furthermore, a nozzle distribution plate is provided at the other end of the driving shaft, and the first nozzle is provided on the surface of the nozzle distribution plate.

[0023] Furthermore, the driving shaft has a cavity structure inside, which is connected to the gap through an opening in the side wall; the second nozzle is arranged on the driving shaft and connected to the cavity structure; the cleaning inlet, the gap, the cavity structure and the second nozzle are connected to form a second cleaning channel.

[0024] Furthermore, a nozzle distribution plate is provided at the other end of the driving shaft, and the second nozzle is provided on the nozzle distribution plate.

[0025] Furthermore, the second nozzle is a slit or an opening.

[0026] Furthermore, the number of the second nozzles is multiple.

[0027] Furthermore, the magnetic stirring device also includes: a stirring shaft connected to the driving shaft; the stirring shaft is a hollow structure, connected to the cavity, and a third nozzle is arranged on it and connected to the hollow structure; the cleaning inlet, the gap, the cavity structure, the hollow structure and the third nozzle are connected to form a third cleaning channel.

[0028] Furthermore, the third nozzle is a slit or an opening.

[0029] Furthermore, there are multiple third nozzles.

[0030] The magnetic stirring device provided in this application has its own cleaning function, and compared with the prior art, it has the following advantages:

[0031] Beneficial effects:

[0032] 1. Use the cleaning channel of the magnetic stirring device to guide the cleaning liquid from the drive shaft to the drive shaft nozzle distribution plate, and generate a jet through the nozzle designed and opened on the nozzle distribution plate for spray cleaning;

[0033] 2. Since the drive shaft will rotate during cleaning, there will be no dead angle for cleaning even if there is only one nozzle;

[0034] 3. The structure of this nozzle can be excavated according to the cleaning requirements. Generally, it can be a long gap, a short gap or an opening with a certain angle. Different nozzles can also be set according to specific cleaning requirements. It has a strong cleaning impact force and is very simple to implement.

[0035] 4. The original cleaning channel of the agitator is used, so there is no need to add additional pipes, control valves, temperature measuring points, etc.

[0036] 5. Because the number of cleaning balls and corresponding pipes, valves, etc. are reduced, the internal and external space at the top of the container is relatively increased, which is conducive to the installation of other components;

[0037] 6. There are many ways to introduce the cleaning liquid from the cleaning channel of the agitator itself into the nozzle distribution plate of the drive shaft. For example, it can be introduced from the top or middle of the drive shaft. It only needs to make the drive shaft hollow or partially hollow.

[0038] 7. If you need to shorten the cleaning time of the container and improve the cleaning efficiency, you can increase the number of nozzles without adding additional costs;

[0039] 8. Further introduce the cleaning liquid into the stirring shaft, and cut out the required nozzles at appropriate positions of the stirring shaft, so that the cleaning balls originally designed and installed can be completely eliminated. Not only the cost is greatly reduced, but also the parts and pipes in the tank are reduced, making it very simple. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The following is a brief introduction to the drawings used in describing the embodiments of the present application:

[0041] Figure 1 It is a structural schematic diagram of an overhead magnetic stirrer in the prior art;

[0042] Figure 2 It is a structural schematic diagram of an overhead magnetic stirrer in the prior art;

[0043] Figure 3 It is a structural schematic diagram of a magnetic stirring device provided in one embodiment of the present application;

[0044] Figure 4 is a structural schematic diagram of a magnetic stirring device provided in another embodiment of the present application;

[0045] Figure 5 is a structural schematic diagram of a magnetic stirring device provided in another embodiment of the present application;

[0046] Figure 6 It is a structural schematic diagram of a magnetic stirring device provided in another embodiment of the present application. DETAILED DESCRIPTION

[0047] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the specific implementation methods of the present application will be described below with reference to the accompanying drawings. The accompanying drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other accompanying drawings and other implementation methods can be obtained based on these drawings without creative work. Adjustments and improvements made without departing from the concept of the present application are all within the scope of protection of the present application.

[0048] In order to simplify the drawings, the drawings in the embodiments of the present application only schematically show the parts related to the present application, and they do not represent the actual structure of the product. In addition, in order to simplify the drawings and facilitate understanding, in some drawings, only parts with the same structure or function are schematically shown, and there may be more or fewer parts with the same structure or function in reality.

[0049] In this application, unless otherwise clearly specified and limited, ordinal numbers, such as "first", "second", etc., are only used to distinguish and describe related objects, and cannot be understood as indicating or implying the relative importance or order between related objects; in addition, they do not represent the number of related objects. "And / or" is used to describe the relationship between related objects, which includes any relationship between related objects. For example, "a and / or b" includes: "a alone", "b alone", or "a and b". The terms "installation" and "connection" should be understood in a broad sense. For example, "installation" can be direct installation or installation through other components; "connection" can be direct connection or connection through other components. The term "relatively arranged" includes parallel relative or relative at a certain angle. The angle is not limited and is determined according to the number of relatively arranged objects.

[0050] In the embodiments shown in the drawings, directional indications (such as up, down, left, right, front, and back, etc.) are not absolute but relative when describing the structure and movement of each component, and are not used to limit the direction of the product in actual use.

[0051] In view of the following problems when using cleaning balls for CIP cleaning in the prior art:

[0052] First, there are too many cleaning balls, and the internal structure of the container is complicated, so the structure of the outside of the container is also complicated (more pipeline control valves, temperature measuring points and steam traps, etc. need to be added), resulting in higher production costs and reduced system stability.

[0053] Secondly, the cleaning ball will wear out after a period of use and needs to be replaced regularly, or durable materials and reasonable designs can be selected to extend the service life of the cleaning ball. Moreover, the cleaning ball device and its related equipment (such as spray pumps, pipes, etc.) also require regular maintenance and necessary repairs, all of which further increase the production and use costs.

[0054] Thirdly, due to the complex internal structure of the container, there are many dead corners in cleaning, and the position of the cleaning ball is relatively fixed, it is impossible to achieve comprehensive cleaning, so there are defects such as poor cleaning effect.

[0055] An embodiment of the present application provides a magnetic stirring device to solve the above-mentioned problems of the prior art.

[0056] The following is a description with reference to the accompanying drawings:

[0057] Please refer to Figure 3 , which is a schematic diagram of the structure of a magnetic stirring device provided in one embodiment of the present application. Figure 3 As shown,

[0058] The magnetic stirring device 300, in this embodiment, is a top-mounted magnetic stirring device, comprising: a reaction tank 310; a bearing seat 320, connected to the reaction tank 310. In the embodiment of the present application, the bearing seat 320 is connected to the reaction tank 310 through a flange, wherein a portion of the bearing seat 310 is arranged outside the reaction tank 310, and another portion is arranged inside the reaction tank 310. The bearing seat 310 is provided with a bearing. The bearing is used to support the stirring blade to ensure its stable rotation. In the field of biopharmaceuticals, ceramic bearings or bearings made of other corrosion-resistant and wear-resistant materials are generally used. The drive motor 330 is arranged on the top of the reaction tank 310 through the bearing seat 320, and serves as a power source for the magnetic stirring device. The drive motor 330 is responsible for providing rotational power. The outer magnetic sleeve 340 is connected to the drive motor 330, and a permanent magnet is installed inside the outer magnetic sleeve 340 for generating a magnetic field. The inner magnetic sleeve 350 is connected to the bearing seat 320 and is magnetically coupled to the outer magnetic sleeve 340. The isolation sleeve 360 ​​is disposed between the outer magnetic sleeve 340 and the inner magnetic sleeve 350, and is used to isolate the inner and outer spaces of the reaction tank 310 to prevent material leakage while allowing magnetic force transmission. The inner magnetic sleeve 350 and the outer magnetic sleeve 340 are isolated from each other. The inner magnetic sleeve 350 is disposed in the internal space formed by the isolation sleeve 360 ​​and the reaction tank 310, while the outer magnetic sleeve 340 is disposed in the external space opposite to the internal space. The drive shaft 370 is connected to the inner magnetic sleeve 350 at one end; a first nozzle 381 is provided on the drive shaft 370. There is a gap 390 between the inner magnetic sleeve 350 and the drive shaft 370 and the isolation sleeve 360 ​​and the bearing seat 320; a cleaning inlet 361 is disposed on the isolation sleeve 360 ​​and communicates with the gap 390; the gap 300 extends to the first nozzle 381 to form a first cleaning channel.

[0059] In this embodiment, the magnetic stirring device uses its own existing channel space to form a cleaning channel, and introduces the cleaning liquid from the cleaning inlet 361 through the gap 300 between the inner magnetic sleeve 350 and the drive shaft 370 and the isolation sleeve 360 ​​and the bearing seat 320, and drains it along the side wall of the drive shaft 370 to the first nozzle 381 on the drive shaft 370. The pressure of the cleaning liquid injection is used to generate a jet at the first nozzle 381 for spray cleaning, and no atomization will occur under the premise of ensuring a strong cleaning impact force, thereby achieving the purpose of thorough cleaning. In addition, since the drive shaft 370 rotates during cleaning, the cleaning liquid injected at the first nozzle 381 will be ejected under the action of centrifugal force, forming a larger and wider cleaning area, avoiding cleaning dead corners, and further improving the cleaning effect. Moreover, due to the rotation of the drive shaft 370 during cleaning, when setting the number of nozzles, one or more nozzles can be set according to the intensity requirements of cleaning.

[0060] In the embodiment of the present application, the shape and structure of the nozzle can be excavated according to the cleaning requirements, generally it can be a long gap with a certain angle, a short gap, an opening or any other form of nozzle (this application is not limited, and any form that can achieve the purpose of this application is within the scope of protection of this application), with strong cleaning impact force, and it is very simple to implement. Different cleaning nozzles can also be set as nozzles according to cleaning requirements to achieve specific cleaning effects.

[0061] In the embodiment of the present application, one end of the driving shaft 370 is connected to the inner magnetic sleeve 350, and the nozzle distribution disk 380 is set at the other end. The first nozzle 381 is set on the surface of the nozzle distribution disk 380, and the nozzle is formed by drilling / opening according to the cleaning requirements. The jet angle and pressure of the cleaning liquid at the first nozzle 381 can be effectively controlled, thereby further improving the cleaning effect.

[0062] The magnetic stirring device provided in this embodiment utilizes the original space channel of the stirrer, and does not need to add additional control valves, temperature measuring points, etc., which reduces the number of cleaning balls used and the corresponding pipelines, valves, etc. The internal and external spaces at the top of the container are relatively increased, which is convenient for the installation of other components. Therefore, under the premise of ensuring the cleaning effect, the device structure is greatly simplified, the stability of the system is improved, and the production cost is effectively reduced.

[0063] Please refer to Figure 4 , which is a structural schematic diagram of a magnetic stirring device provided in another embodiment of the present application.

[0064] In this embodiment, the driving shaft 470 has a cavity structure 471 inside, and the driving shaft 470 can be made hollow or partially hollow according to the cleaning requirements, and connected to the gap 490 through the opening 472 on the side wall; the second nozzle 410 is arranged on the driving shaft 470 and connected to the cavity structure 471; the cleaning inlet 461, the gap 490, the cavity structure 471 and the second nozzle 410 are connected to form a second cleaning channel.

[0065] The cleaning agent enters the gap 490 between the inner magnetic sleeve 450 and the drive shaft 470 and the isolation sleeve 460 and the bearing seat 420 through the cleaning inlet 461. A portion of the cleaning agent flows along the side wall of the drive shaft 470 to the first nozzle 481, for example, arranged on the surface of the nozzle distribution plate 480, and the pressure of the cleaning liquid injection is used to generate a jet at the first nozzle 481 for spray cleaning. Another portion of the cleaning agent enters the cavity structure 471 through the opening 472 on the side wall of the drive shaft 470 and is then sprayed out through the second nozzle 410 to clean the inside of the reaction tank. The cleaning agent is introduced through two cleaning channels at the same time and sprayed out from the nozzles respectively, and the rotation of the drive shaft further increases the cleaning range and realizes all-round cleaning without dead angles.

[0066] This embodiment is another way to introduce the cleaning liquid into the drive shaft 470. It also utilizes the existing channel space of the magnetic stirring device itself and cooperates to process the drive shaft 470 into a cavity structure 471, so that it becomes a part of the drainage channel, and the cleaning liquid is drained to the cleaning injection position. And the shape, position and number of the nozzle can be set according to the needs of cleaning without adding additional costs. In this embodiment, the second nozzle 410 can also be set on the nozzle distribution plate 480 of the drive shaft 470, and its shape is a gap or an opening or a nozzle, or any other form of nozzle (this application is not limited, and any form that can achieve the purpose of this application is within the scope of protection of this application). For example, the cleaning liquid introduction opening 472 can be set at the top or middle of the drive shaft 470.

[0067] In addition, if you need to shorten the container cleaning time and improve cleaning efficiency, you can increase the number of nozzles without adding additional costs, see Figure 5 The number of the second nozzles 510 arranged on the driving shaft 570 is two, which are connected to the cavity structure 571 of the driving shaft 570 through the opening 572 on the side wall of the driving shaft 570 to form a plurality of second cleaning channels to achieve a better cleaning effect. The present application is not limited to this, and any design that can achieve the purpose of the present application is included in the scope of the present application.

[0068] See also Figure 6 , which is a structural schematic diagram of a magnetic stirring device provided in another embodiment of the present application.

[0069] In this embodiment, the stirring shaft 690 is connected to the driving shaft 670; the stirring paddle 680 is connected to the stirring shaft 690, directly in contact with the material, and is used to stir the material in the reaction tank to achieve functions such as mixing, mass transfer, and heat transfer. The stirring shaft 690 is a hollow structure 691, which is connected to the cavity structure 671, and a third nozzle 692 is provided on its side wall to communicate with the hollow structure 691; the cleaning inlet 661, the gap 600, the cavity structure 671, the hollow structure 691 and the third nozzle 692 are connected to form a third cleaning channel.

[0070] The cleaning agent enters the gap 600 between the inner magnetic sleeve 650 and the drive shaft 670 and the isolation sleeve 660 and the bearing seat 620 through the cleaning inlet 661. A portion of the cleaning agent flows along the side wall of the drive shaft 670 to the first nozzle 681 on the drive shaft 670, and the pressure of the cleaning liquid injection is used to generate a jet at the first nozzle 681 for spray cleaning. The second portion of the cleaning agent enters the cavity structure 671 through the opening 672 on the side wall of the drive shaft 670 and is then sprayed through the second nozzle 610. The third portion of the cleaning agent enters the hollow structure 691 of the stirring shaft 690 and is sprayed through the third nozzle 610 to perform all-round cleaning in the reaction tank. The cleaning agent is introduced through three cleaning channels at the same time and sprayed out from the nozzles respectively, accompanied by the rotation of the drive shaft and the stirring shaft, which further increases the cleaning range and achieves all-round cleaning without dead angles.

[0071] The magnetic stirring device provided in the embodiment of the present application utilizes its own channel space to form a cleaning channel, drains the cleaning liquid from the drive shaft to the drive shaft, and generates a jet for spray cleaning through the nozzle set on the drive shaft. Moreover, different cleaning channels can be configured according to the specific needs of cleaning, and nozzles of different positions, shapes and numbers can be set to achieve a comprehensive and thorough cleaning effect without adding additional control valves, temperature measuring points, etc., reducing the number of cleaning balls used and the corresponding pipelines, valves, etc., and the internal and external spaces at the top of the container are relatively increased, which is convenient for the installation of other components.

[0072] Therefore, under the premise of ensuring the cleaning effect, the device structure is greatly simplified, the stability of the system is improved and the production cost is effectively reduced.

[0073] In the above embodiments, the description of each embodiment has its own emphasis. For parts that are not described or recorded in detail in a certain embodiment, reference can be made to the relevant descriptions of other embodiments.

[0074] It should be noted that the above embodiments can be freely combined as needed. The above are only some implementation methods of the present application. For ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present application, and these improvements and modifications should also be regarded as the protection scope of the present application.

Claims

1. A magnetic stirring device, characterized in that: include: Reaction tank; A bearing seat connected to the reaction tank; A driving motor is arranged on the top of the reaction tank through the bearing seat; An outer magnetic sleeve connected to the driving motor; An inner magnetic sleeve, connected to the bearing seat and magnetically coupled to the outer magnetic sleeve; An isolation sleeve, disposed between the outer magnetic sleeve and the inner magnetic sleeve, for isolating the inner and outer spaces of the reaction tank; A driving shaft, one end of which is connected to the inner magnetic sleeve; A first nozzle is arranged on the driving shaft; There is a gap between the inner magnetic sleeve and the driving shaft and the isolation sleeve and the bearing seat; A cleaning inlet is provided on the isolation sleeve and communicated with the gap; The gap extends to the first nozzle to form a first cleaning channel.

2. The magnetic stirring device according to claim 1, characterized in that: The first nozzle is a slit or an opening.

3. The magnetic stirring device according to claim 1, characterized in that: The number of the first nozzles is plural.

4. The magnetic stirring device according to claim 1, characterized in that: A nozzle distribution disk is disposed at the other end of the driving shaft, and the first nozzle is disposed on the surface of the nozzle distribution disk.

5. The magnetic stirring device according to claim 1, characterized in that: The driving shaft has a hollow structure inside and is connected to the gap through an opening in the side wall; A second nozzle is disposed on the driving shaft and communicated with the cavity structure; The cleaning inlet, the gap, the cavity structure and the second nozzle are connected to form a second cleaning channel.

6. The magnetic stirring device according to claim 5, characterized in that: A nozzle distribution plate is disposed at the other end of the driving shaft, and the second nozzle is disposed on the nozzle distribution plate.

7. The magnetic stirring device according to claim 5, characterized in that: The second nozzle is a slit or an opening.

8. The magnetic stirring device according to claim 5, characterized in that: The number of the second nozzles is plural.

9. The magnetic stirring device according to claim 5, characterized in that: include: A stirring shaft connected to the driving shaft; The stirring shaft is a hollow structure, connected to the cavity, and a third nozzle is arranged on the stirring shaft and connected to the hollow structure; The cleaning inlet, the gap, the cavity structure, the hollow structure and the third nozzle are connected to form a third cleaning channel.

10. The magnetic stirring device according to claim 9, characterized in that: The third nozzle is a slit or an opening.

11. The magnetic stirring device according to claim 9, characterized in that: The number of the third nozzles is plural.

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