Washing mechanism for chemiluminescence immunity analyzer

Abstract

The utility model discloses a washing mechanism for a chemiluminescence immunoassay analyzer, which comprises a base, a washing tray rotatably installed in the base and a driving assembly used for driving the washing tray to rotate, cup placing holes are distributed on the washing tray in a circular array, the cup placing holes are used for placing reaction cups, each cup placing hole is arranged along the vertical direction, and the cup placing holes are used for placing the reaction cups. Magnetic assemblies are mounted at the positions, close to the bottoms of the cup placing holes, of the washing tray; when the washing tray rotates relative to the base, the magnetic assembly can synchronously rotate along with the washing tray. The reaction cup has the advantages that the magnetic assembly is fixedly arranged at the bottom of the washing tray, it is guaranteed that the bottom of the reaction cup can be continuously located in a stable magnetic field environment in the whole washing process, the magnetic attraction separation effect of magnetic particles in the cup can be enhanced, and the consistency of the magnetic attraction separation effect can be improved.

Description

Technical Field

[0001] The utility model relates to a chemiluminescent immunoassay analyzer, in particular to a washing mechanism used for the chemiluminescent immunoassay analyzer. Background Art

[0002] Chemiluminescent immunoassay is an analytical method that combines magnetic separation technology, chemiluminescent technology and immunoassay technology. Suspended magnetic particles are used as carriers, with their unique 3D surface and high specific surface area, to provide sufficient contact area and high sensitivity for capturing target molecules. Therefore, magnetic particle chemiluminescent immunoassay method has been widely used in the field of biomedical testing due to its unique advantages.

[0003] The physical structure of the chemiluminescent immunoassay analyzer involves many modules such as filling, mixing, incubation, washing and detection. Among them, the washing module is mainly used to separate the substance to be tested from other substances and to fill the substrate. The washing module is usually composed of a base and a support plate rotatably arranged on the base. The support plate is provided with a number of cup positions. After the reaction cups containing samples, reagents and magnetic particles are placed in the cup positions, the support plate can be rotated to gradually perform steps such as material separation and substrate filling. In the prior art, the magnetic block used for magnetic separation is fixed at the bottom of the base, and the reaction cup needs to rotate with the support plate at the corresponding station. Only then will the magnetic particles inside the reaction cup have a magnetic effect with the magnetic block. The reaction cup cannot be in a magnetic field environment throughout the washing process, and the magnetic separation effect needs to be further improved. Utility Model Content

[0004] In view of this, the utility model provides a washing mechanism for a chemiluminescent immunoassay analyzer, which can keep the reaction cup in a magnetic field environment during the entire washing process, thereby effectively improving the magnetic separation effect.

[0005] To achieve the above purpose, the technical solution of the utility model is as follows:

[0006] A washing mechanism for a chemiluminescent immunoassay analyzer comprises a base, a washing tray rotatably mounted in the base, and a driving assembly for driving the washing tray to rotate, the key of which is:

[0007] The washing tray is provided with cup placement holes in a circular array for placing reaction cups. Each of the cup placement holes is arranged in a vertical direction, and a magnetic component is installed on the washing tray near the bottom of each of the cup placement holes. During the rotation of the washing tray relative to the base, the magnetic component can rotate synchronously with the washing tray.

[0008] By adopting the above structure, the magnetic component is fixedly arranged at the bottom of the washing tray. When the driving component drives the washing tray to rotate, the magnetic component can rotate synchronously with the reaction cup on the cup placement hole, ensuring that the bottom of the reaction cup can be continuously in a stable magnetic field environment during the entire washing process, which can not only enhance the magnetic separation effect of the magnetic particles in the cup, but also improve the consistency of the magnetic separation effect.

[0009] As a preference, the number of the cup placement holes and magnetic components are four groups, the four groups of magnetic components are distributed in a square at the bottom of the washing tray, and each magnetic component is installed on the inner side of the lower part of the corresponding cup placement hole. The above structure has the advantages of reasonable layout and compactness.

[0010] Preferably, the magnetic assembly includes a vertical magnetic block and transverse magnetic blocks closely attached to both ends of the vertical magnetic block, wherein the vertical magnetic block is directly opposite to the side of the cup hole, the side of the vertical magnetic block close to the cup hole is flush with the transverse magnetic block, and the other end protrudes from the transverse magnetic block. The above structure can enhance the magnetic flux of the magnetic field.

[0011] As a preferred embodiment, the washing tray has an outwardly extending flange on the upper part, and cup placement notches are evenly distributed on the flange. With the above structure, the opening of the cup placement notches can directly connect to the cup arrangement channel A1 of the cup arrangement mechanism A in the analyzer, so that the reaction cup in the cup arrangement channel A1 can directly slide into the cup placement notches, which significantly improves the detection efficiency of the analyzer.

[0012] Preferably, the number of the cup placement notches is four groups, the four groups of cup placement notches correspond to the four groups of cup placement holes one by one, and each group of cup placement holes and its corresponding cup placement notches are located in the same radial direction.

[0013] Preferably, a liquid supply and extraction system is provided above the base, and the liquid supply and extraction system can add liquid into the reaction cup or extract waste liquid;

[0014] The base is surrounded by a heating belt and a heat preservation layer, and the liquid supply and extraction system includes a washing needle located above the base, and the washing needle is equipped with a liquid pipe. The above structure can ensure that the ambient temperature of the reaction cup is suitable.

[0015] As a preferred embodiment, the middle part of the liquid pipe is coiled around the wall root inside the base. With the above structure, the liquid in the liquid pipe can be heated to the required temperature in advance.

[0016] Preferably, a rotating shaft rotatably matched with the base is provided at the bottom of the washing tray, the driving assembly is a stepper motor installed at the bottom of the base, and the output shaft of the stepper motor is coaxially fixed to the lower end of the rotating shaft.

[0017] Compared with the prior art, the beneficial effects of the utility model are:

[0018] 1. The washing mechanism for the chemiluminescence immunoassay analyzer provided by the utility model is used, and the magnetic component is fixedly arranged at the bottom of the washing tray. When the driving component drives the washing tray to rotate, the magnetic component can rotate synchronously with the reaction cup on the cup placement hole, ensuring that the bottom of the reaction cup can be continuously in a stable magnetic field environment during the entire washing process, which can not only enhance the magnetic separation effect of the magnetic particles in the cup, but also improve the consistency of the magnetic separation effect, thereby improving the detection accuracy of the final analyzer.

[0019] 2. The four groups of magnetic components are arranged in a square shape, which has the technical advantage of reasonable and compact structure layout. Each magnetic component is composed of three magnetic blocks with a special layout, which can enhance the magnetic flux of the magnetic field and improve the magnetic separation effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a structural schematic diagram of the washing mechanism;

[0021] Figure 2 is a cross-sectional view of the washing mechanism;

[0022] Figure 3 A cross-sectional view showing the internal structure of the washing mechanism;

[0023] Figure 4 is a structural schematic diagram of the base 1;

[0024] Figure 5 is a cross-sectional view of the washing tray 3 (to show the layout of the cup placement hole 31, the cup placement notch 3a1, and the cup placement notch 3a1 and the magnetic component 4);

[0025] Figure 6 This is a reference diagram of the washing mechanism in use. DETAILED DESCRIPTION

[0026] The utility model is further described below in conjunction with embodiments and drawings.

[0027] like Figure 1 , 2 As shown in FIG. 5 , a washing mechanism for a chemiluminescent immunoassay analyzer comprises a base 1 having a chamber 1a with an open upper end, Figure 4 It can be seen that the chamber 1a is a circular chamber. A washing tray 3 is rotatably mounted in the chamber 1a. In this embodiment, Figure 3As shown, the washing tray 3 is constructed into a circular structure, and the washing tray 3 is provided with cup placement holes 31 in a circular array, and the cup placement holes 31 are used to place reaction cups a, and each cup placement hole 31 is arranged in the vertical direction. When installed, the reaction cup a is vertically inserted into the cup placement hole 31 downward. The washing tray 3 is provided with a magnetic component 4 at a position close to the bottom of each cup placement hole 31. A driving component 5 is installed at the bottom of the base 1, and the driving component 5 can drive the washing tray 3 to rotate. When the washing tray 3 rotates relative to the base 1, the magnetic component 4 can rotate synchronously with the washing tray 3.

[0028] Based on the above structural design, after the mechanical gripper inside the analyzer vertically places the reaction cup a on the cup placement hole 31, the washing tray 3 is driven to rotate by the driving component 5, and the cup placement hole 31 rotates grid by grid with the washing tray 3, so that operations such as adding cleaning liquid, extracting waste liquid, and adding substrate to different reaction cups can be realized synchronously. During the rotation of the reaction cup a with the washing tray 3, since the reaction cup a and the magnetic component 4 are relatively fixed, that is, the magnetic component 4 can rotate synchronously with the reaction cup a, it is ensured that the bottom of the reaction cup a can be continuously in a stable magnetic field environment during the entire washing process, which can not only enhance the magnetic separation effect of the magnetic particles in the cup, but also improve the consistency of the magnetic separation effect, thereby improving the final detection accuracy of the analyzer.

[0029] Further, such as Figure 5 As shown, there are four groups of cup placement holes 31 and magnetic components 4, and the four groups of magnetic components 4 are distributed in a square at the bottom of the washing tray 3, and each magnetic component 4 is installed on the inner side of the lower part of the corresponding cup placement hole 31. This layout can enhance the magnetic flux of the magnetic field and improve the magnetic analysis effect.

[0030] Re-attend Figure 5 Each magnetic assembly 4 includes three magnetic blocks. In the same set of magnetic assemblies 4, the three magnetic blocks are the vertical magnetic block 4a and the horizontal magnetic blocks 4b closely attached to the two ends of the vertical magnetic block 4a. The vertical magnetic block 4a is directly opposite to the side of the cup hole 31. The side of the vertical magnetic block 4a close to the cup hole 31 is flush with the horizontal magnetic block 4b, and the other end protrudes from the horizontal magnetic block 4b. Such a design has the technical advantages of reasonable and compact structural layout, further enhances the magnetic flux of the magnetic field, and improves the magnetic separation effect.

[0031] Please refer to Figure 3 and Figure 5 The washing tray 3 has a flange 3a extending radially outward on the upper part, and cup placement notches 3a1 are evenly distributed on the flange 3a. Figure 6It can be seen that the opening of the cup placement notch 3a1 can directly connect to the cup arrangement channel A1 of the cup arrangement mechanism A in the analyzer, so that the reaction cup in the cup arrangement channel A1 can slide directly into the cup placement notch 3a1, which significantly improves the detection efficiency of the analyzer and helps the product to achieve a compact design. In addition, the washing mechanism adds a transfer function on the basis of the washing function, avoiding the mechanical gripper from transferring the reaction cup a through other transfer mechanisms, and the washing efficiency is higher.

[0032] For example Figure 5 As shown, in this embodiment, the number of cup placement notches 3a1 is four groups, and the four groups of cup placement notches 3a1 correspond to the four groups of cup placement holes 31 one by one, and each group of cup placement holes 31 and its corresponding cup placement notches 3a1 are located in the same radial direction. This consideration allows the mechanical gripper in the analyzer to accurately grip the reaction cup on the cup placement notches 3a1 and the cup placement holes 31.

[0033] like Figure 1 As shown, a liquid supply and extraction system 6 is provided above the base 1, and the liquid supply and extraction system 6 can add liquid to the reaction cup a or extract waste liquid. The liquid supply and extraction system 6 includes a washing needle 61 located above the base 1, and the washing needle 61 is equipped with a liquid line tube 62. In the process of washing the liquid sample, the temperature of the washing liquid, the substrate liquid and the sample liquid should be appropriate. Therefore, in combination with Figure 2 As shown, the chamber 1a is surrounded by a heating belt 1b and a heat preservation layer 1c. The heating belt 1b heats up the interior of the chamber 1a to ensure the ambient temperature of the reaction cup a, and the heat preservation layer 1c can keep the temperature of the interior of the chamber 1a constant after the temperature is increased. At the same time, when in use, the liquid line tube 62 is arranged inside the chamber 1a, and the liquid in the liquid line tube 62 can be heated to the required temperature in advance to ensure that the temperature of the liquid in the reaction cup a is controlled within a more accurate range, which helps to improve the final detection accuracy of the chemiluminescent immunoassay analyzer.

[0034] Further, such as Figure 1 , 2 As shown in FIG. 4 , a mounting through hole 1d is provided on the side of the base 1, and an annular groove 1e is provided along the inner wall of the bottom of the chamber 1a. The liquid pipe 62 passes through the mounting through hole 1d into the chamber 1a and surrounds along the annular groove 1e, so that the middle of the liquid pipe 62 is coiled at the wall root inside the base 1. In this embodiment, the liquid pipe 62 is wound twice in the chamber 1a.

[0035] Please refer to Figure 2 A rotating shaft 3b is provided at the bottom of the washing tray 3 and is rotatably matched with the base 1. The driving assembly 5 is a stepper motor installed at the bottom of the base 1. The output shaft of the stepper motor is coaxially fixed to the lower end of the rotating shaft 3b. When the stepper motor works, the rotating shaft 3b is driven to rotate, which can drive the washing tray 3 to rotate.

[0036] Finally, it should be noted that the above description is only a preferred embodiment of the present invention. Under the guidance of the present invention, ordinary technicians in this field can make a variety of similar expressions without violating the purpose and claims of the present invention, and such changes fall within the scope of protection of the present invention.

Claims

1. A washing mechanism for a chemiluminescent immunoassay analyzer, comprising a base (1), a washing tray (3) rotatably mounted in the base (1), and a driving assembly (5) for driving the washing tray (3) to rotate, characterized in that: The washing tray (3) is provided with cup placement holes (31) in a circular array, the cup placement holes (31) are used to place reaction cups (a), and each of the cup placement holes (31) is arranged in a vertical direction. The washing tray (3) is provided with a magnetic component (4) at a position close to the bottom of each of the cup placement holes (31); when the washing tray (3) rotates relative to the base (1), the magnetic component (4) can rotate synchronously with the washing tray (3).

2. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The number of the cup placement holes (31) and the number of the magnetic components (4) are both four groups, and the four groups of the magnetic components (4) are distributed in a square shape at the bottom of the washing tray (3), and each of the magnetic components (4) is installed on the inner side of the lower part of the corresponding cup placement hole (31).

3. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 2, characterized in that: The magnetic assembly (4) comprises a vertical magnetic block (4a) and transverse magnetic blocks (4b) closely attached to both ends of the vertical magnetic block (4a), wherein the vertical magnetic block (4a) is directly opposite to the side of the cup hole (31), and the side of the vertical magnetic block (4a) close to the cup hole (31) is flush with the transverse magnetic block (4b), and the other end protrudes from the transverse magnetic block (4b).

4. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The upper part of the washing tray (3) is provided with a flange (3a) extending outwards, and cup placement notches (3a1) are evenly distributed on the flange (3a).

5. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 4, characterized in that: The number of the cup placement notches (3a1) is four groups, the four groups of cup placement notches (3a1) correspond to the four groups of cup placement holes (31) one by one, and each group of cup placement holes (31) and its corresponding cup placement notches (3a1) are located in the same radial direction.

6. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 1, characterized in that: A liquid supply and extraction system (6) is provided above the base (1), and the liquid supply and extraction system (6) can add liquid into the reaction cup (a) or extract waste liquid; The base (1) is surrounded by a heating belt (1b) and a heat-insulating layer (1c). The liquid supply and extraction system (6) comprises a washing needle (61) located above the base (1). The washing needle (61) is equipped with a liquid pipe (62).

7. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 6, characterized in that: The middle portion of the liquid pipe (62) is coiled around the wall root inside the base (1).

8. The washing mechanism for a chemiluminescent immunoassay analyzer according to claim 1, characterized in that: The bottom of the washing tray (3) is provided with a rotating shaft (3b) rotatably matched with the base (1); the driving assembly (5) is a stepping motor installed at the bottom of the base (1); the output shaft of the stepping motor is coaxially fixed to the lower end of the rotating shaft (3b).

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