Simple magnetic bead extraction device

Abstract

The utility model provides a simple magnetic bead extraction device which comprises a carrier support, a magnetic steel bar, a handle and a buckle. The number of the carrier supports is two, and any one of the carrier supports is provided with a plurality of magnetic steel rods. The handle is arranged between the two carrier supports and used for connecting the two carrier supports, buckles are arranged at the two ends of the handle respectively, any buckle is detachably connected with the corresponding carrier support, and a handheld part is arranged in the middle of the handle. By using one row or two rows of magnetic steel rods, magnetic beads can be adsorbed and transferred manually in the pretreatment process of a magnetic bead method sample without depending on a full-automatic extraction instrument, and the magnetic bead adsorption device is suitable for the condition that the sample size is relatively small, and is beneficial to saving the cost and reducing the waste of resources; the two rows of magnetic steel bars are connected through the buckles and the handles, and when one row or two rows of magnetic steel bars are selected to be used, the magnetic steel bars are easy to disassemble and assemble.

Description

Technical Field

[0001] The utility model relates to the technical field of magnetic bead extraction experimental equipment, in particular to a simple magnetic bead extraction device. Background Art

[0002] The magnetic bead method is a commonly used operation method for the extraction of nucleic acids, proteins, and small molecule compounds. The working principle of the magnetic bead method is to use magnetic beads as carriers, utilize magnetic beads to adsorb nucleic acids, proteins, and small molecule compounds under high salt and low pH or low salt and high pH, ​​and separate them from nucleic acids, proteins, and small molecule compounds under low salt and high pH or high salt and low pH, and then use magnetic rods to adsorb magnetic beads and transfer liquid to achieve the entire extraction and purification process of nucleic acids, proteins, and small molecule compounds.

[0003] The existing Chinese patent with publication number CN215627881U discloses a magnetic rod frame component based on a nucleic acid extractor, including a connecting assembly, the connecting assembly includes a concave frame, a symmetrical first cylinder is installed inside the concave frame, a first moving rod is slidably clamped inside the first cylinder, a first spring is sleeved on the upper end of the first moving rod, a symmetrical clamping ring is clamped at the lower end of the first moving rod, a second cylinder is installed on one side of the first cylinder, a second moving rod is slidably clamped inside the second cylinder, a limiting column is installed at one end of the second moving rod, and a first connecting rod is installed at the other end of the symmetrical second moving rod, a magnetic rod assembly is clamped inside the concave frame, and the magnetic rod assembly includes a deep well plate, and 96 magnetic rod bodies are installed on the deep well plate.

[0004] The prior art has the following defects:

[0005] (1) When the sample size is relatively small, if more than two rows of magnetic rod assemblies are still used, there is a waste of resources;

[0006] (2) The connection method between multiple rows of magnetic rods is relatively complicated and difficult to disassemble. Utility Model Content

[0007] In view of the defects in the prior art, the purpose of the utility model is to provide a simple magnetic bead extraction device.

[0008] According to the utility model, a simple magnetic bead extraction device is provided, comprising: a carrier support, a magnetic steel rod, a handle and a buckle;

[0009] The carrier supports include two, and any of the carrier supports is provided with a plurality of magnetic steel rods;

[0010] The handle is arranged between two carrier brackets for connecting the two carrier brackets. Buckles are respectively arranged at both ends of the handle. Any buckle is detachably connected to the corresponding carrier bracket. A hand-holding part is arranged in the middle of the handle.

[0011] Preferably, eight magnetic steel rods are provided on any of the carrier supports.

[0012] Preferably, the plurality of magnetic steel rods are arranged at equal intervals along the axial direction of the carrier support.

[0013] Preferably, the magnetic steel rod comprises a cylindrical shape, the carrier support comprises a cylindrical shape, and the axis of the magnetic steel rod is perpendicular to the axis of the carrier support.

[0014] Preferably, the buckle and the handle comprise an integral structure.

[0015] Preferably, the inner diameter of the buckle allows the carrier bracket to pass through, and the inner diameter of the buckle does not allow the magnetic steel rod to pass through.

[0016] Preferably, the handle comprises a curved handle.

[0017] Preferably, the buckle comprises a U-shaped elastic buckle or a locking buckle.

[0018] Preferably, the handle is made of a flexible material.

[0019] Preferably, the flexible material includes rubber or an elastic rope with iron wire.

[0020] Compared with the prior art, the utility model has the following beneficial effects:

[0021] 1. The utility model uses one or two rows of magnetic steel bars, and can manually complete the adsorption and transfer of magnetic beads in the sample pre-treatment process of the magnetic bead method without relying on a fully automatic extractor. It is suitable for situations where the sample volume is relatively small, which is beneficial to saving costs and reducing waste of resources;

[0022] 2. The utility model connects two rows of magnetic steel bars by using buckles and handles, and is easy to disassemble and assemble when one or two rows of magnetic steel bars are used.

[0023] 3. The utility model facilitates the lifting and transfer of the magnetic steel rod during operation through the handle design. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Other features, objects and advantages of the present invention will become more apparent by reading the detailed description of non-limiting embodiments with reference to the following drawings:

[0025] Figure 1 This is a schematic diagram of the structure of a simple magnetic bead extraction device mainly embodied in the utility model;

[0026] In the figure:

[0027] Buckle 1 Carrier bracket 3

[0028] Handle 2 with magnetic steel rod 4 DETAILED DESCRIPTION

[0029] The utility model is described in detail below in conjunction with specific embodiments. The following embodiments will help those skilled in the art to further understand the utility model, but do not limit the utility model in any form. It should be pointed out that for those of ordinary skill in the art, several changes and improvements can be made without departing from the concept of the utility model. These all belong to the protection scope of the utility model.

[0030] like Figure 1 As shown, a simple magnetic bead extraction device provided by the utility model includes a carrier support 3, a magnetic steel rod 4, a handle 2 and a buckle 1. The carrier support 3 includes two, both used to fix the magnetic steel rod 4, and any carrier support 3 is provided with multiple magnetic steel rods 4, and the multiple magnetic steel rods 4 are fixed on the carrier support 3, and the magnetic steel rods 4 are used for adsorption and transfer of magnetic beads. The handle 2 is arranged between the two carrier supports 3, and is used to connect the two carrier supports 3, and can be used for the movement of the magnetic steel rod 4 during use. Buckles 1 are respectively arranged at both ends of the handle 2, and any buckle 1 is detachably connected to the corresponding carrier support 3. A hand-held part is arranged in the middle of the handle 2 for convenient hand-held operation.

[0031] The simple magnetic bead extraction device of the utility model is suitable for the case where the sample quantity is relatively small. The magnetic steel rod 4 under one carrier support 3 or two carrier supports 3 can be used. The magnetic steel rod 4 can be manually adsorbed and transferred in the sample pre-treatment process of the magnetic bead method without relying on a fully automatic extraction instrument, which saves costs and reduces the waste of resources. In addition, the utility model uses a buckle 1 and a handle 2 to connect two rows of magnetic steel rods 4. When one or two rows of magnetic steel rods 4 are selected, it is easy to disassemble and assemble.

[0032] Specifically, a plurality of magnetic steel bars 4 are arranged at equal intervals along the axial direction of the carrier support 3, and the distance between any two adjacent magnetic steel bars 4 is equal. Eight magnetic steel bars 4 are arranged on any carrier support 3, so that such a carrier support 3 has eight channels, and two carrier supports 3 have sixteen channels after being combined. The magnetic steel bars 4 include a cylindrical shape, and the carrier support 3 includes a cylindrical shape, and the axis of the magnetic steel bars 4 is perpendicular to the axis of the carrier support 3.

[0033] Specifically, the buckle 1 and the handle 2 include an integrated structure. When assembling or disassembling, only the connecting part between the buckle and the carrier bracket needs to be operated, which makes it more convenient for the handle and the buckle to connect the two carrier brackets together, and also easy to separate the two carrier brackets.

[0034] The handle 2 includes an arc-shaped handle, and a hand-held portion is arranged in the middle of the handle. The hand-held portion is arranged at the highest point of the arc, which is convenient for holding the magnetic rod assembly. The material of the handle 2 includes a flexible material. The material of the handle 2 can be selected from a flexible material such as rubber or an elastic rope with iron wire. The handle 2 is selected from a flexible material. The flexible material has good elasticity and can appropriately adjust the distance between the two carrier brackets 3 to adapt to the position between the samples, which is convenient for the magnetic steel rod 4 to better and faster absorb and transfer the magnetic beads.

[0035] The inner diameter of the buckle 1 allows the carrier support 3 to pass through, but does not allow the magnetic steel bar 4 to pass through. The buckle 1 includes a U-shaped elastic buckle or a lock buckle. The U-shaped elastic buckle is semicircular or arc-shaped. The opening of the U-shaped elastic buckle is aligned with the carrier support 3 and the carrier support 3 is inserted into the U-shaped elastic buckle. The inner diameter of the U-shaped elastic buckle allows the carrier support 3 to pass through, but does not allow the magnetic steel bar 4 to pass through. The U-shaped elastic buckle can move on the carrier support 3, but the movement of the U-shaped elastic buckle is limited between two adjacent magnetic steel bars 4. Similarly, a button for opening or closing the lock buckle opening is provided on the lock buckle. The lock buckle opening is opened to align with the carrier support 3 and the carrier support 3 is inserted into the lock buckle. The lock buckle opening is closed. The inner diameter of the lock buckle allows the carrier support 3 to pass through, but does not allow the magnetic steel bar 4 to pass through. The lock buckle can move on the carrier support 3, but the movement of the lock buckle is limited between two adjacent magnetic steel bars 4.

[0036] During use, one or two carrier holders 3 with magnetic steel rods 4 can be selected according to the number of samples to use eight channels or sixteen channels. When eight channels are selected, the handle 2 can be pulled to separate the buckle 1 from the carrier holder 3, and one of the carrier holders 3 can be directly held by hand, and the magnetic steel rod of one carrier holder can be used to absorb and transfer magnetic beads; when sixteen channels are selected, the handle 2 can be pressed to buckle the buckle 1 on the carrier holder 3, and the handheld part of the handle 3 can be held by hand, and the magnetic steel rods 4 of two carrier holders 3 can be used to absorb magnetic beads. When the magnetic beads are completely absorbed, the magnetic beads can be transferred to other reagents by pulling and moving the handle 2. In this way, the magnetic rod assembly of the utility model is easy to assemble and disassemble, and can be used for the absorption and transfer of magnetic beads of a small number of samples, avoiding the use of an automatic extractor for a large number of samples when a small number of samples are needed, which is conducive to avoiding waste of resources and saving costs.

[0037] In the description of the present application, it should be understood that the terms "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the referred device or element must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0038] The above describes the specific embodiments of the present invention. It should be understood that the present invention is not limited to the above specific embodiments, and those skilled in the art can make various changes or modifications within the scope of the claims, which does not affect the essence of the present invention. In the absence of conflict, the embodiments of the present application and the features in the embodiments can be combined with each other at will.

Claims

1. A simple magnetic bead extraction device, characterized in that: include: A carrier bracket (3), a magnetic steel rod (4), a handle (2) and a buckle (1); The carrier supports (3) include two, and a plurality of magnetic steel rods (4) are arranged on each of the carrier supports (3); The handle (2) is arranged between two carrier supports (3) and is used to connect the two carrier supports (3). Buckles (1) are respectively arranged at both ends of the handle (2). Any of the buckles (1) is detachably connected to the corresponding carrier support. A hand-held portion is arranged in the middle of the handle (2).

2. The simple magnetic bead extraction device according to claim 1, characterized in that: Eight magnetic steel rods (4) are arranged on any of the carrier supports (3).

3. The simple magnetic bead extraction device according to claim 1, characterized in that: The plurality of magnetic steel rods (4) are arranged at equal intervals along the axial direction of the carrier support (3).

4. The simple magnetic bead extraction device according to claim 1, characterized in that: The magnetic steel rod (4) comprises a cylindrical shape, the carrier support (3) comprises a cylindrical shape, and the axis of the magnetic steel rod (4) is perpendicular to the axis of the carrier support (3).

5. The simple magnetic bead extraction device according to claim 1, characterized in that: The buckle (1) and the handle (2) comprise an integrated structure.

6. The simple magnetic bead extraction device according to claim 1, characterized in that: The inner diameter of the buckle (1) allows the carrier bracket (3) to pass through, but the inner diameter of the buckle (1) does not allow the magnetic steel rod (4) to pass through.

7. The simple magnetic bead extraction device according to claim 1, characterized in that: The handle (2) comprises an arc-shaped handle.

8. The simple magnetic bead extraction device according to claim 1, characterized in that: The buckle (1) comprises a U-shaped elastic buckle or a locking buckle.

9. The simple magnetic bead extraction device according to claim 1, characterized in that: The material of the handle (2) includes a flexible material.

10. The simple magnetic bead extraction device according to claim 9, characterized in that: The flexible material includes rubber or an elastic rope with iron wire.

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