Immunohistochemical liquid drainage device

Abstract

The utility model belongs to the technical field of medical tools, and particularly relates to an immunohistochemical liquid guiding device which comprises two liquid guiding arms, the middle portions of the two liquid guiding arms are connected into a whole capable of relatively rotating through a rotating shaft, one end of each liquid guiding arm is provided with a handheld portion, the other end of each liquid guiding arm is provided with an arm rod, a liquid guiding portion is arranged between the two arm rods, and the handheld portions are connected with the arm rods. The liquid guiding part comprises a liquid guiding line, one end of the liquid guiding line is arranged on one arm rod, the other end of the liquid guiding line is arranged in the other arm rod through a line inlet, and a positioning adjusting assembly is arranged in the mounting groove. The staining cost is reduced while the immunohistochemical staining quality is ensured, the device is simple, controllable and quick to operate, and the preparation efficiency is improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical tools, in particular to an immunohistochemical liquid guide. Background Art

[0002] Although some hospitals have begun to use fully automatic immunohistochemical staining equipment to automate the staining of immunohistochemical sections in order to achieve stable staining effects, manual immunohistochemical staining has the following advantages compared to machines: 1. More convenient; 2. The appropriate amount of solution can be added according to the size of the tissue to save expensive reagents and reduce costs; 3. When rare antibodies are needed, manual work is still the first choice. At the same time, due to the financial constraints of the hospital, many hospital pathology technicians still use manual methods for immunohistochemical staining; in addition, in scientific research activities, due to the relatively small amount of slices required, researchers also perform immunohistochemical staining manually. Therefore, manual immunohistochemical staining still has a wide range of application scenarios.

[0003] Adding blocking solution, primary antibody solution, and secondary antibody solution are all important steps in preparing immunohistochemical sections. Although the order and purpose of the operation are different, the operation contents are similar: add an appropriate amount of solution around the target tissue to cover the tissue (some laboratories use the method of adding an appropriate amount of solution in the hydrophobic circle drawn by the histochemical pen). Technicians often need to add a relatively excessive amount of solution (ineffective loss of solution) and shake the slide to make the solution flow and spread, but this operation is not efficient and cannot ensure that each tissue slice can be fully and evenly soaked. Sometimes the solution leaks out of the slice and causes secondary loading or staining failure; some experienced technicians will choose to use some sharp-pointed instruments to guide the flow of liquid, but this often damages the tissue slice. Utility Model Content

[0004] In view of this, the purpose of the utility model is to provide an immunohistochemical liquid guide device to solve the problem that the existing liquid guide equipment cannot ensure that the tissue slice can be fully and evenly immersed each time.

[0005] Based on the above purpose, the utility model provides an immunohistochemical liquid discharge device, comprising two liquid discharge arms, the middle parts of the two liquid discharge arms are connected by a rotating shaft to form a relatively rotatable whole, one end of each liquid discharge arm is provided with a hand-held part, and the other end is provided with an arm rod, and a liquid discharge part is provided between the two arm rods, and the liquid discharge part includes:

[0006] A liquid lead wire, one end of which is detachably connected to one of the arm rods, and the other end of which is arranged inside the other arm rod through a wire inlet, and the wire inlet is arranged on one side of the other arm rod;

[0007] A waist-shaped through hole is arranged on the other arm rod, a sliding shaft is provided inside the waist-shaped through hole for sliding connection, and the sliding shaft is fixedly connected to one end of the liquid guide line;

[0008] A mounting groove is arranged on a side of the other arm away from the wire inlet, and a positioning adjustment component for locking the sliding shaft is arranged inside the mounting groove;

[0009] The positioning and adjusting component is started to drive the sliding shaft to move in the waist-shaped through hole, and the positioning and adjusting component is closed to lock the sliding shaft in the waist-shaped through hole.

[0010] Preferably, the tip of each arm is an obtuse angle.

[0011] Preferably, another of the arm rods is internally rotatably connected with a traction wheel, the traction wheel is arranged close to the line inlet, and the liquid guide line is sleeved on the traction wheel.

[0012] Preferably, a mounting sleeve is fixedly provided at one end of the liquid guide line, and the mounting sleeve is plugged onto one of the arm rods, and a disassembly opening for removing the sliding shaft is provided at one end of the waist-shaped through hole close to the rotating shaft.

[0013] Preferably, the positioning adjustment assembly includes two gears, which are respectively arranged on one side of the sliding shaft, one end of each of the gears is rotatably connected to a mounting plate, each of the mounting plates is slidably connected to an inner wall of the mounting groove, each of the gears is meshed with racks on both sides, each of the racks is slidably connected to the mounting plate, an extending drive block is provided in the mounting groove, one end of two of the racks is fixedly connected to one side of the drive block, and the other two racks are respectively attached to the sliding shaft, at least two springs are provided between the other two racks and the drive block, the two ends of each spring are respectively fixedly connected to the drive block and the other two racks, and a plurality of evenly distributed limit shafts are provided at a place of the mounting groove away from the drive block.

[0014] Preferably, the hand-held portion is a ring.

[0015] Preferably, an adjustment mechanism may also be provided at the upper ends of the two liquid-introducing arms.

[0016] The beneficial effects of the utility model are as follows: the sliding shaft is driven to move in the waist-shaped through hole by the positioning adjustment component to adjust the distance between the two arm rods and the length of the liquid guide line, so as to operate according to the size of the tissue, and the amount of solution suitable for the size of the tissue can be dripped while ensuring that the tissue is fully and evenly soaked, thereby reducing the production cost. The device is simple, controllable and quick to operate, and the preparation efficiency is improved. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the technical solutions in the present invention or the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings in the following description are only for the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0018] Figure 1 It is a schematic diagram of the overall structure of the embodiment of the utility model;

[0019] Figure 2 For the utility model embodiment Figure 1 A schematic diagram of the cross-sectional structure at point A;

[0020] Figure 3 This is a schematic diagram of the structure of the positioning and adjusting assembly of an embodiment of the utility model;

[0021] Figure 4 It is a structural schematic diagram of the adjustment structure of an embodiment of the utility model.

[0022] The markings in the figure are:

[0023] 1. Liquid-introduction arm; 2. Rotating shaft; 3. Arm; 4. Liquid-introduction line; 5. Line inlet; 6. Waist-shaped through hole; 7. Sliding shaft; 8. Mounting groove; 9. Traction wheel; 10. Mounting sleeve; 11. Disassembly opening; 12. Gear; 13. Mounting plate; 14. Rack; 15. Driving block; 16. Spring; 17. Limiting shaft; 18. Ring; 19. Adjustment mechanism. DETAILED DESCRIPTION

[0024] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with specific embodiments.

[0025] It should be noted that, unless otherwise defined, the technical terms or scientific terms used in the present invention should be understood by people with ordinary skills in the field to which the present invention belongs. The words "first", "second" and similar words used in the present invention do not indicate any order, quantity or importance, but are only used to distinguish different components. "Include" or "comprise" and similar words mean that the elements or objects appearing before the word include the elements or objects listed after the word and their equivalents, without excluding other elements or objects. "Connect" or "connected" and similar words are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "down", "left", "right" and the like are only used to indicate relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0026] like Figures 1 to 4 As shown, an immunohistochemical liquid discharge device comprises two liquid discharge arms 1, the middle parts of the two liquid discharge arms 1 are connected by a rotating shaft 2 to form a relatively rotatable whole, one end of each liquid discharge arm 1 is provided with a hand-held part, and the other end is provided with an arm 3, and a liquid discharge part is provided between the two arm 3, and the liquid discharge part comprises:

[0027] A liquid lead wire 4, one end of which is detachably connected to one of the arm rods 3, and the other end of which is disposed inside the other arm rod 3 through a wire inlet 5, and the wire inlet 5 is disposed on one side of the other arm rod 3;

[0028] A waist-shaped through hole 6 is provided on the other arm 3, and a sliding shaft 7 is provided inside the waist-shaped through hole 6 for sliding connection, and the sliding shaft 7 is fixedly connected to one end of the liquid guide line 4;

[0029] A mounting groove 8 is provided on a side of the other arm 3 away from the wire inlet 5, and a positioning adjustment component for locking the sliding shaft 7 is provided inside the mounting groove 8;

[0030] The positioning and adjusting component is started to drive the sliding shaft 7 to move in the waist-shaped through hole 6, and the positioning and adjusting component is closed to lock the sliding shaft 7 in the waist-shaped through hole 6.

[0031] For example, the sliding shaft 7 is driven to move in the waist-shaped through hole 6 through the positioning and adjustment component to adjust the distance between the two arm rods 3 and the length of the liquid guide line 4, so that the operation can be performed according to the size of the tissue. While dripping the amount of solution suitable for the size of the tissue, the tissue can be ensured to be fully and evenly soaked, thereby reducing the production cost. The device is simple, controllable and quick to operate, and the preparation efficiency is improved.

[0032] As an optional embodiment, the tip of each arm 3 is an obtuse angle.

[0033] By setting the tip of the arm 3 to an obtuse angle, the drainage line 4 can be ensured to contact the surface of the dripping solution, and the solution can be evenly spread on the surface of the tissue slice by moving the drainage arm 1, while avoiding scratching the tissue slice and causing fragmentation or displacement.

[0034] As an optional embodiment, another of the arm rods 3 is internally rotatably connected with a traction wheel 9 , the traction wheel 9 is disposed close to the line inlet 5 , and the liquid diversion line 4 is sleeved on the traction wheel 9 .

[0035] For example, the traction wheel 9 is provided to reduce the friction between the liquid lead line 4 and the line inlet 5 .

[0036] As an optional embodiment, a mounting sleeve 10 is fixedly provided at one end of the liquid guide line 4, and the mounting sleeve 10 is plugged into one of the arm rods 3. The end of the waist-shaped through hole 6 close to the rotating shaft 2 is provided with a disassembly opening 11 for removing the sliding shaft 7.

[0037] For example, a mounting hole is provided on the arm 3, and the mounting sleeve 10 is fixed by a tight fit with the mounting hole. The mounting sleeve 10 is removed from the arm 3 to loosen the liquid guide line 4. At the same time, one end of the liquid guide line 4 is untied, and the sliding shaft 7 can be taken out by moving to the disassembly port 11, and the other end of the liquid guide line 4 is untied, thereby realizing the disassembly and installation of the liquid guide line 4.

[0038] As an optional embodiment, the positioning adjustment assembly includes two gears 12, which are respectively arranged on one side of the sliding shaft 7, one end of each of the gears 12 is rotatably connected to a mounting plate 13, each of the mounting plates 13 is slidably connected to an inner wall of the mounting groove 8, both sides of each of the gears 12 are meshed with racks 14, each of the racks 14 is slidably connected to the mounting plate 13, an extended driving block 15 is provided in the mounting groove 8, one end of two of the racks 14 is fixedly connected to one side of the driving block 15, and the other two racks 14 are respectively attached to the sliding shaft 7, at least two springs 16 are provided between the other two racks 14 and the driving block 15, the two ends of each spring 16 are respectively fixedly connected to the driving block 15 and the other two racks 14, and a plurality of evenly distributed limit shafts 17 are provided at a place of the mounting groove 8 away from the driving block 15.

[0039] For example, according to the size of the tissue, by pressing down the driving block 15, the driving block 15 drives a rack 14 to move, and the rack 14 drives another rack 14 to move through the gear 12, so that the other rack 14 is separated from the limiting shaft 17, and then by moving the driving block 15, the driving block 15 drives the mounting plate 13 to move through the two racks 14. After the other rack 14 is separated from the limit shaft 17, it can drive the sliding shaft 7 to move in the waist-shaped through hole 6 to adjust the length of the drainage line 4. When the length of the drainage line 4 is adjusted, the two racks 14 are reset by the spring 16, so that the other rack 14 cooperates with the limiting shaft 17 to lock the position of the sliding shaft 7.

[0040] As an optional embodiment, the hand-held portion is a circular ring 18, and the edges can be rounded to facilitate hand-holding.

[0041] For example, the ring 18 is used for a user's finger to pass through.

[0042] For example, according to the size of the tissue, by pressing down the driving block 15, the driving block 15 drives a rack 14 to move, and the rack 14 drives another rack 14 to move through the gear 12, so that the other rack 14 is separated from the limiting shaft 17, and then by moving the driving block 15, the driving block 15 drives the mounting plate 13 to move through the two racks 14. After the other rack 14 is separated from the limit shaft 17, it can drive the sliding shaft 7 to move in the waist-shaped through hole 6 to adjust the length of the drainage line 4. When the length of the drainage line 4 is adjusted, the two racks 14 are reset by the spring 16, so that the other rack 14 cooperates with the limiting shaft 17 to lock the position of the sliding shaft 7.

[0043] As an optional embodiment, an adjustment mechanism 19 may be further provided at the upper ends of the two liquid-drawing arms 1 to ensure the distance between the liquid-drawing line 4 and the slice.

[0044] For example, the use of adhesive can make the adjustment mechanism bonded to the side of the drainage arm. The screw can be turned as needed. During the drainage process, when the nut abuts against the slice, an appropriate distance is maintained between the nut and the drainage line 4 to prevent the drainage line 4 from directly contacting the slice surface and damaging the tissue.

[0045] Those skilled in the art should understand that the discussion of any of the above embodiments is only exemplary and is not intended to imply that the scope of the present invention is limited to these examples; under the concept of the present invention, the technical features in the above embodiments or different embodiments can also be combined, the steps can be implemented in any order, and there are many other changes in different aspects of the present invention as described above, which are not provided in detail for the sake of simplicity. Any omissions, modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. An immunohistochemical liquid discharge device, comprising two liquid discharge arms (1), the two liquid discharge arms (1) are connected by a rotating shaft (2) to form a relatively rotatable whole, one end of each liquid discharge arm (1) is provided with a hand-held portion, the other end is provided with an arm (3), and a liquid discharge portion is provided between the two arm rods (3), characterized in that: The liquid introduction part comprises: A liquid lead wire (4), one end of which is detachably connected to one of the arm rods (3), and the other end of which is arranged inside the other arm rod (3) through a wire inlet (5), and the wire inlet (5) is arranged on one side of the other arm rod (3); A waist-shaped through hole (6) is provided on the other arm (3), a sliding shaft (7) is provided inside the waist-shaped through hole (6) for sliding connection, and the sliding shaft (7) is fixedly connected to one end of the liquid guide wire (4); A mounting groove (8) is arranged on a side of the other arm (3) away from the wire inlet (5), and a positioning adjustment component for locking the sliding shaft (7) is arranged inside the mounting groove (8); The positioning and adjusting component is started to drive the sliding shaft (7) to move in the waist-shaped through hole (6), and the positioning and adjusting component is closed to lock the sliding shaft (7) in the waist-shaped through hole (6).

2. The immunohistochemistry fluid guide according to claim 1, characterized in that: The tip of each arm (3) is an obtuse angle.

3. The immunohistochemical fluid guide according to claim 1, characterized in that: A traction wheel (9) is rotatably connected inside the other arm (3), and the traction wheel (9) is arranged close to the line inlet (5), and the liquid lead line (4) is sleeved on the traction wheel (9).

4. The immunohistochemical fluid guide according to claim 1, characterized in that: A mounting sleeve (10) is fixedly provided at one end of the liquid guide line (4), and the mounting sleeve (10) is plugged and arranged on one of the arm rods (3). A disassembly opening (11) for removing the sliding shaft (7) is provided at one end of the waist-shaped through hole (6) close to the rotating shaft (2).

5. The immunohistochemical fluid guide according to claim 1, characterized in that: The positioning adjustment assembly comprises two gears (12), which are respectively arranged on one side of the sliding shaft (7); one end of each gear (12) is rotatably connected to a mounting plate (13); each mounting plate (13) is slidably connected to an inner wall of the mounting groove (8); both sides of each gear (12) are meshed with racks (14); each rack (14) is slidably connected to the mounting plate (13); a driving block (15) extending out is provided in the mounting groove (8); One end of two of the racks (14) is fixedly connected to one side of the driving block (15), and the other two racks (14) are respectively attached to the sliding shaft (7). At least two springs (16) are provided between the other two racks (14) and the driving block (15), and the two ends of each spring (16) are respectively fixedly connected to the driving block (15) and the other two racks (14), and a plurality of evenly distributed limit shafts (17) are provided at a location of the mounting groove (8) away from the driving block (15).

6. The immunohistochemical fluid guide according to claim 1, characterized in that: The hand-held part is a circular ring (18).

7. The immunohistochemical fluid guide according to claim 1, characterized in that: An adjustment mechanism (19) may also be provided at the upper ends of the two liquid-introducing arms (1).

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