Liquid chromatograph temperature control device

Abstract

The utility model relates to the technical field of liquid chromatograms, in particular to a liquid chromatograph temperature control device which comprises a guide rail, a sliding block is slidably connected to the inner side of the guide rail, a fixing frame is fixedly mounted at the outer end of the sliding block, a driving mechanism is fixedly mounted on the inner side of the fixing frame, and the driving mechanism is fixedly connected with the sliding block. A concave base is fixedly installed on the side, away from the guide rail, of the fixing frame. According to the device, the temperature control mechanism is arranged, so that the device can rapidly heat or cool a sample introduction disc for placing a sample vessel with a sample, during heating, an annular electric heating plate is attached to the bottom of the sample vessel for rapid heating, and the temperature change is monitored through a temperature sensor; during cooling, the circulating pump is started, water liquid is driven to flow in the heat conduction coil pipe and exchange heat with the sample vessel, meanwhile, the semiconductor cooler is used for cooling the cooling liquid in the water tank, so that the sample vessel is rapidly cooled, the temperature regulation and control reaction change rate of the device is high, and the overall temperature regulation and control performance is improved.

Description

Technical Field

[0001] The present application relates to the technical field of liquid chromatography, and in particular to a temperature control device for a liquid chromatograph. Background Art

[0002] Liquid chromatograph is a main device used to achieve liquid chromatography separation. Its working principle is based on the difference in the distribution ratio of the mixture between liquid-solid or two immiscible liquids. Specifically, the liquid chromatograph achieves sample separation through two physical and chemical effects: distribution and adsorption. The distribution effect involves the distribution of the sample between the mobile phase and the stationary phase. Different components are separated to different degrees between the two phases due to their different distribution coefficients. The adsorption effect is that the sample molecules are adsorbed on the adsorbent present on the surface of the stationary phase, thereby achieving separation. After these effects occur between the mobile phase and the stationary phase, the sample will be separated into different components and gradually separated in the column. When the sample components reach the detector, the detector can convert the signal into an electrical signal, which is then transmitted to the computer system for data processing and analysis after amplification, filtering and other processing.

[0003] At present, chromatographic detection plays an important role in the field of chemical detection. Its characteristic is that the sampled drugs cannot be contaminated. Therefore, in the process of detecting samples by liquid phase tandem mass spectrometer, the sample plate is often used. The existing sample plate itself does not have a covering device, which cannot well prevent the volatilization of some volatile liquids in the experiment. Especially in the case of continuous injection, the longer the time is spent, the greater the loss of sample liquid will be. At the same time, since the cavity holes on the sample plate are close to each other, when filling the sample solution, if the operation is wrong, the pipette may drip into the adjacent sample hole, or it may overflow and contaminate the adjacent sample hole if it is filled too full. In addition, if oscillation occurs during the movement of the sample plate, the liquid in the sample hole is easy to overflow and cross contamination occurs.

[0004] Through searching, the Chinese patent announcement number CN211856483U discloses a liquid chromatography or liquid chromatography tandem mass spectrometer injection plate, including a rectangular bottom plate, injection holes, a groove on one side of the bottom plate, a cover plate, the cover plate is the same size as the bottom plate, and there are round covers of the same size and number as the injection holes of the bottom plate on the cover plate, and a protrusion is provided on the cover plate. When the cover plate is covered, the groove and the protrusion just fit together, and there is a fold on the cover plate that can be folded, or the cover plate is a strip cover plate, the length of the strip cover plate is the same as the length of the bottom plate, and the width can only cover a row of injection holes on the bottom plate. The injection plate can reduce the splashing of liquid into adjacent sample holes caused by improper operation of the operator, avoid inaccurate test results caused by different liquid volatilization degrees, avoid cross contamination of drugs, and avoid spilling of drugs due to shaking of the instrument.

[0005] With respect to the above-mentioned related technologies, the utility model inventor found the following defects:

[0006] Although the above device can play a certain role in sealing and preventing spillage during use, it lacks a corresponding heating structure during its specific use, and lacks a corresponding temperature control function during its use, and temperature changes will affect the fluidity and separation effect of the sample solvent. The lack of a temperature control structure means that the temperature on the injection plate may not be able to remain stable, resulting in a large amount of viscous heat generated by the friction between the chromatographic column and the mobile phase, affecting the temperature distribution inside the chromatographic column. This may cause the viscosity of the mobile phase to change before entering the chromatographic column, affecting its flow characteristics under high pressure, and thus reducing the separation efficiency. The control structure is crucial for the injection plate of liquid chromatography. It can not only improve the separation efficiency and analytical stability, but also ensure data quality and durability of the instrument. Obviously, the above device is not convenient for flexible temperature control, and the temperature cannot be flexibly increased. At the same time, when cooling is required, the temperature cannot be quickly adjusted to drop. It can be seen that it has certain defects and shortcomings in use and needs to be improved. Utility Model Content

[0007] In order to improve the overall temperature control accuracy and convenience of the device and to improve its inspection convenience, the present application provides a liquid chromatograph temperature control device.

[0008] The present application provides a temperature control device for a liquid chromatograph, which adopts the following technical solution: comprising a guide rail, a slider is slidably connected to the inner side of the guide rail, a fixing frame is fixedly installed on the outer end of the slider, a driving mechanism is fixedly installed on the inner side of the fixing frame, a concave seat is fixedly installed on the side of the fixing frame away from the guide rail, a displacement mechanism is fixedly installed on both sides of the inner side of the concave seat, a sample injection tray is fixedly installed on the inner side of one of the two groups of displacement mechanisms, a temperature control mechanism is fixedly installed on the bottom of the sample injection tray, and a sealing mechanism is fixedly installed on the inner side of the other of the two groups of displacement mechanisms, and the sealing mechanism covers the top of the sample injection mechanism;

[0009] The temperature control mechanism includes a holding component and a water tank. The holding component is fixedly installed on the inner side of the sample feeding tray at equal intervals. The water tank is fixedly installed on the bottom side of the sample feeding tray. A circulation pump is fixedly installed on one side of the water tank. The input end of the circulation pump is connected to the water tank. A transfer coil is fixedly installed on the output end of the circulation pump. The transfer coil is respectively connected to the holding component. The output end of the holding component is connected to the water tank. A semiconductor refrigerator is fixedly installed on the bottom of the water tank.

[0010] Optionally, the holding component includes a placement seat, which is fixedly installed on the inner side of the sample introduction plate at equal intervals, and a heat-conducting coil is fixedly installed on the inner side of the placement seat. The transfer coil and each heat-conducting coil are connected in series, and the main part of the heat-conducting coil is spirally arranged on the inner side of the placement seat, and a sample dish is inserted into the inner side of the placement seat.

[0011] Optionally, a ring-shaped electric heating plate is fixedly installed at the bottom of the placement seat, a temperature sensor is fixedly installed in the middle of the placement seat, the detection end of the temperature sensor is fit-connected to the bottom of the sample dish, and a single-chip control module is provided on the inner side of the semiconductor refrigerator.

[0012] Optionally, the displacement mechanism includes a first motor and a slide groove, the slide groove is opened on both sides of the concave seat, the first motor is fixedly installed at both ends of one side of the concave seat close to the guide rail, the output end of the first motor passes through the concave seat and is located inside the slide groove and a screw is fixedly installed, the screw is rotatably connected to the inside of the slide groove, the outer surface of the screw is threadedly connected to a sliding rod, the sliding rod is slidably connected to the inner side of the guide rail, and the sample tray is fixedly installed on the inner side of a sliding rod.

[0013] Optionally, the sealing mechanism includes a side plate, which is fixedly mounted on the inner side of another group of sliding rods, an electric push rod is fixedly mounted on the inner end of the side plate, a base frame is fixedly mounted on the top of the electric push rod, a second motor is fixedly mounted on the inner side of the base frame, and a sealing disk is fixedly mounted on the top output end of the second motor.

[0014] Optionally, sealing plugs are fixedly installed at equal intervals on the bottom of the sealing disk, and the bottoms of the sealing plugs are all plugged with the inner upper ends of the sample dishes.

[0015] Optionally, a strip groove is provided on one side of the concave seat close to the electric push rod, the inner side of the strip groove is connected to the inside of the slide groove, a bracket is fixedly installed on the outer side of the slide rod with a side plate, and the outer end of the bracket passes through the strip groove and the top of the sealing disk and is rotatably connected to the side close to the electric push rod.

[0016] Optionally, the overall cross-sectional shape of the slider and the slide rod is set to a convex shape, the inner walls of the slide groove and the guide rail are also set to a convex shape, and the inner walls of the slide groove and the inner walls of the guide rail are fixedly connected with wear-resistant gaskets.

[0017] Optionally, the driving mechanism includes a dual-axis motor and a rack, the dual-axis motor is fixedly mounted on the inner side of a fixed frame, driving gears are fixedly mounted at both side output ends of the dual-axis motor, the rack is fixedly mounted on both sides of the guide rail, and the driving gear and the rack are meshingly connected.

[0018] Optionally, a supporting block is slidably connected to the rear side of the guide rail, a supporting rod is fixedly installed on the outer side of the supporting block, and the front end of the supporting rod is rotatably connected to the middle part of the outer side of the driving gear.

[0019] In summary, this application includes the following beneficial technical effects:

[0020] 1. By setting up a temperature control mechanism, the device can quickly heat up or cool down the sample tray where the sample dish with the sample is placed. When heating up, the annular electric heating plate fits the bottom of the sample dish for rapid heating, and the temperature change is monitored by the temperature sensor; when cooling down, the circulation pump is started to drive the water to flow in the heat conduction coil to exchange heat with the sample dish. At the same time, the semiconductor refrigerator is used to cool the coolant in the water tank, thereby achieving rapid cooling of the sample dish. This design makes the temperature control reaction change rate of the device fast and improves the overall temperature control performance.

[0021] 2. By setting up a driving mechanism, this device shows significant advantages in adjusting the position of the sample tray. It realizes flexible adjustment of the height of the sample tray to adapt to different experimental needs and saves experimental preparation time. At the same time, the device has the function of adjusting the front and rear displacement, so that the sample tray can automatically adapt to different injection positions, improving the adaptation performance. This design improves the accuracy and efficiency of experimental analysis, reduces human errors, and enhances experimental reliability. In addition, it also provides convenience for scientific researchers, simplifies the operation process, allows them to focus more on the experiment itself, and improves work efficiency.

[0022] 3. The device significantly improves the sealing of the sample dish during the sampling process by setting up a sealing mechanism, effectively preventing sample spillage and cross contamination, and ensuring the accuracy of the experimental results. At the same time, when adjusting the position of the sample tray, the sealing tray can move synchronously to maintain the sealing state, prevent sample loss, and improve experimental reliability. In addition, the device is easy to operate, can quickly take and place the sample dish, and improve work efficiency. The auxiliary connection function of the bracket enhances the stability of the sealing tray and prevents sealing failure. In short, the device has excellent sealing performance, convenient and stable operation, and provides scientific researchers with efficient and accurate experimental conditions. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the overall structure in the embodiment of the present application;

[0024] Figure 2 is a schematic diagram of the structure of the rear view in the embodiment of the present application;

[0025] Figure 3 is a schematic diagram of the structure viewed from above in an embodiment of the present application;

[0026] Figure 4 It is a structural schematic diagram of the dislocation state of the sealing mechanism and the sample feeding plate in the embodiment of the present application;

[0027] Figure 5 is a schematic diagram of the structure of the sealing mechanism in an embodiment of the present application when viewed from above;

[0028] Figure 6 It is a schematic diagram of the structure of the guide rail, the slider and the driving mechanism in the embodiment of the present application;

[0029] Figure 7 is a bottom-up structural schematic diagram of a containing component in an embodiment of the present application;

[0030] Figure 8 is a schematic diagram of the structure of the top view of the interior of the containing assembly in the embodiment of the present application;

[0031] Fig. 9 It is a schematic diagram of the circuit connection module of the electronic components in the embodiment of the present application.

[0032] 1. Guide rail; 2. Slider; 3. Fixing frame; 4. Concave seat; 5. Driving mechanism; 51. Dual-axis motor; 52. Rack; 53. Driving gear; 54. Support block; 55. Support rod; 6. Sample tray; 7. Temperature control mechanism; 71. Holding assembly; 711. Placement seat; 712. Heat-conducting coil; 713. Temperature sensor; 714. Sample dish; 715. Ring-shaped electric heating plate; 72. Water tank; 73. Circulating pump; 74. Transfer coil; 75. Semiconductor refrigerator; 8. Sealing mechanism; 81. Side plate; 82. Electric push rod; 83. Base frame; 84. Second motor; 85. Sealing disk; 86. Sealing plug; 87. Strip groove; 88. Bracket; 9. Displacement mechanism; 91. First motor; 92. Slide groove; 93. Screw rod; 94. Slide rod. DETAILED DESCRIPTION

[0033] The following is combined with Figure 1-9 This application is described in further detail.

[0034] The present application embodiment discloses a temperature control device for a liquid chromatograph. Figure 1 As shown, it includes a guide rail 1, a slider 2 is slidably connected to the inner side of the guide rail 1, a fixing frame 3 is fixedly installed on the outer end of the slider 2, a driving mechanism 5 is fixedly installed on the inner side of the fixing frame 3, a concave seat 4 is fixedly installed on the side of the fixing frame 3 away from the guide rail 1, and displacement mechanisms 9 are fixedly installed on both sides of the inner side of the concave seat 4, a sample injection tray 6 is fixedly installed on the inner side of one of the two groups of displacement mechanisms 9, a temperature control mechanism 7 is fixedly installed on the bottom of the sample injection tray 6, and a sealing mechanism 8 is fixedly installed on the inner side of the other group of displacement mechanisms 9 of the two groups of displacement mechanisms 9, and the sealing mechanism 8 covers the top of the sample injection mechanism;

[0035] The temperature control mechanism 7 includes a holding component 71 and a water tank 72. The holding component 71 is fixedly installed on the inner side of the sample feeding tray 6 at equal intervals. The water tank 72 is fixedly installed on one side of the bottom of the sample feeding tray 6. A circulation pump 73 is fixedly installed on one side of the water tank 72. The input end of the circulation pump 73 is connected to the water tank 72. A transfer coil 74 is fixedly installed on the output end of the circulation pump 73. The transfer coil 74 is respectively connected to the holding component 71. The output end of the holding component 71 is connected to the inside of the water tank 72. A semiconductor refrigerator 75 is fixedly installed at the bottom of the water tank 72. The device includes a guide rail 1. A slidable slider 2 is provided on the inner side of the guide rail 1. A fixing frame 3 is fixed on the outer end of the slider 2. A driving mechanism 5 is installed on the inner side of the fixing frame 3. A concave seat 4 is fixed on the other side of the fixing frame 3. Displacement mechanisms 9 are respectively installed on both sides of the inner side of the concave seat 4. Among them, a group of displacement mechanisms The sample tray 6 is fixed on the inner side of the mechanism 9, and a temperature control mechanism 7 is installed at the bottom of the sample tray 6; another set of displacement mechanisms 9 fixes a sealing mechanism 8, which can cover the top of the sample tray 6. The temperature control mechanism 7 consists of a holding component 71 and a water tank 72. The holding component 71 is fixedly installed on the inner side of the sample tray 6 at equal intervals for placing samples. The function of the circulation pump 73 is to extract cooling liquid such as coolant from the water tank 72, and then pump the cooling liquid into the transfer coil 74. The transfer coil 74 is connected to the holding component 71. The cooling liquid flows in the holding component 71, and absorbs the heat of the sample by contacting with the sample and takes it away. Subsequently, the cooling liquid flows back to the water tank 72 to complete a cycle. The whole can quickly control the temperature. At the same time, the holding component 71 itself has a heating function, which is convenient for the device to flexibly control the temperature.

[0036] Please refer to Figure 8The holding component 71 includes a placement seat 711, and the placement seat 711 is fixedly installed on the inner side of the sample injection tray 6 at equal intervals. A heat-conducting coil 712 is fixedly installed on the inner side of the placement seat 711. The transfer coil 74 is connected in series with each heat-conducting coil 712. The main body of the heat-conducting coil 712 is spirally arranged on the inner side of the placement seat 711. The inner side of the placement seat 711 is plugged with a sample dish 714. The holding component 71 is mainly composed of the placement seats 711. These placement seats 711 are fixedly installed on the inner side of the sample injection tray 6 at equal intervals. A heat-conducting coil 712 is fixedly installed on the inner side of each placement seat 711. These heat-conducting coils 712 have good thermal conductivity and can quickly transfer heat to the sample in the sample dish 714, or absorb heat from the sample. It is particularly worth mentioning that the transfer coil 74 and each heat-conducting coil 71 2 are connected in series, which means that the cooling liquid can flow through each heat-conducting coil 712 in sequence under the action of the circulation pump 73, ensuring that the sample dish 714 on each placement seat 711 can be evenly cooled. In addition, the main part of the heat-conducting coil 712 is arranged on the inner side of the placement seat 711 in a spiral manner. This design increases the contact area between the heat-conducting coil 712 and the internal space of the placement seat 711, thereby improving the efficiency of heat conduction. When cooling is required, the cooling liquid can quickly absorb the heat in the sample dish 714. Finally, the inner side of the placement seat 711 is designed with a plug-in structure to facilitate the insertion and removal of the sample dish 714. This design not only simplifies the experimental operation, but also ensures the close contact between the sample dish 714 and the heat-conducting coil 712, further improving the effect of heat conduction.

[0037] Please refer to Figure 3The displacement mechanism 9 includes a first motor 91 and a slide 92. The slide 92 is provided on both sides of the concave seat 4. The first motor 91 is fixedly installed at both ends of one side of the concave seat 4 close to the guide rail 1. The output end of the first motor 91 passes through the concave seat 4 and is fixedly installed with a screw rod 93 inside the slide 92. The screw rod 93 is rotatably connected to the inside of the slide 92. The outer surface of the screw rod 93 is threadedly connected with a slide rod 94. The slide rod 94 is slidably connected to the inner side of the guide rail 1. The sample tray 6 is fixedly installed on the inner side of a slide rod 94. The displacement mechanism 9 mainly consists of the first motor 91. The guide rail 1 is provided on both sides of the concave seat 4 to form a stable sliding track. The first motor 91 is fixedly mounted on both ends of the concave seat 4 near the guide rail 1 to provide a power source for the displacement mechanism 9. When the first motor 91 is started, its output end will penetrate the concave seat 4 into the inside of the guide groove 92 and fix the guide rod 93. The guide rod 93 is rotatably connected inside the guide groove 92 to form a rotatable drive shaft. The outer surface of the guide rod 93 is designed with threads, which are screwed with the threads inside the slide rod 94. The threads of the screw rod 93 match each other, so when the screw rod 93 rotates, the slide rod 94 will move linearly along the screw rod 93 under the action of the thread. This linear motion is constrained by the slide groove 92, ensuring the smooth sliding of the slide rod 94 on the inner side of the guide rail 1. It is particularly worth mentioning that the sample tray 6 is fixedly mounted on the inner side of a slide rod 94, which means that when the first motor 91 drives the screw rod 93 to rotate, the slide rod 94 will drive the sample tray 6 to move accurately. This design not only realizes the stable movement of the sample tray 6, but also ensures the position of the sample tray 6 during the movement. The positioning accuracy provides a strong guarantee for the smooth progress of the experiment. In addition, another group of the displacement mechanism 9 is used to drive the sealing mechanism 8. When the position of the sample tray 6 needs to be adjusted, the sealing mechanism 8 can be synchronously displaced to ensure that the sample tray 6 maintains good sealing performance during the entire experiment. This design not only ensures the reliability of the experiment, but also improves the work efficiency. The displacement mechanism 9 of the temperature control device of the liquid chromatograph realizes the precise displacement of the sample tray 6 and the sealing mechanism 8 through the coordinated work of the first motor 91, the slide groove 92, the screw rod 93 and the slide rod 94.

[0038] Please refer to Figure 8 and Fig. 9A ring-shaped electric heating plate 715 is fixedly installed at the bottom of the placement seat 711, a temperature sensor 713 is fixedly installed in the middle of the placement seat 711, the detection end of the temperature sensor 713 is closely connected to the bottom of the sample dish 714, a single-chip control module is arranged on the inner side of the semiconductor refrigerator 75, and a ring-shaped electric heating plate 715 is fixedly installed at the bottom of the placement seat 711, which can quickly and evenly heat the sample in the sample dish 714. At the same time, a temperature sensor 713 is fixedly installed in the middle of the placement seat 711, and its detection end is closely connected to the bottom of the sample dish 714, so as to monitor the temperature change of the sample in real time. This design ensures the accuracy and real-time nature of temperature data and provides a basis for precise temperature control. More importantly, a single-chip control module is provided on the inner side of the semiconductor refrigerator 75. It intelligently adjusts the working state of the semiconductor refrigerator 75 according to the real-time data provided by the temperature sensor 713. When cooling is required, the semiconductor refrigerator 75 starts quickly to absorb and take away heat; when heating is required, the annular electric heating plate 715 comes into play to provide a stable heat source. This intelligent temperature control method enables the device to respond quickly to temperature changes and accurately maintain the set temperature.

[0039] Please refer to Figure 5The sealing mechanism 8 includes a side plate 81, which is fixedly mounted on the inner side of another group of sliding rods 94. An electric push rod 82 is fixedly mounted on the inner end of the side plate 81. A base frame 83 is fixedly mounted on the top of the electric push rod 82. A second motor 84 is fixedly mounted on the inner side of the base frame 83. A sealing disk 85 is fixedly mounted on the top output end of the second motor 84. The sealing mechanism 8 mainly consists of a side plate 81, an electric push rod 82, a base frame 83, a second motor 84 and a sealing disk 85. The side plate 81 is fixedly mounted on the inner side of another group of sliding rods 94, corresponding to the sliding rod 94 where the sample injection tray 6 is located. This design enables the sealing mechanism 8 to move synchronously with the movement of the sample injection tray 6, ensuring that the sample injection tray 6 can be effectively sealed during the entire experiment. An electric push rod 82 is fixedly mounted on the inner end of the side plate 81. As the main power component of the sealing mechanism 8, the electric push rod 82 can be retracted and retracted as needed, thereby driving the sealing disk 85 to approach or move away from the sample injection tray 6. The top of the electric push rod 82 is fixed A base frame 83 is installed to provide a stable installation platform for the second motor 84. A second motor 84 is fixedly installed on the inner side of the base frame 83, and the motor is used to drive the rotation of the sealing disk 85. A sealing disk 85 is fixedly installed on the top output end of the second motor 84, which is the core component of the sealing mechanism 8. The sealing disk 85 is made of high and low temperature resistant and corrosion-resistant materials, which can ensure that it fits tightly with the sample injection disk 6 during the experiment to prevent heat or sample leakage. When the sample injection disk 6 needs to be sealed, the electric push rod 82 extends to push the sealing disk 85 close to the sample injection disk 6 and fit it tightly. At the same time, the second motor 84 is started to drive the sealing disk 85 to rotate, ensuring that the contact between the sealing disk 85 and the sample injection disk 6 is closer, further improving the sealing effect. This design not only ensures the sealing of the sample injection disk 6 during the experiment, but also improves the accuracy and reliability of the experiment. At the same time, the function of synchronous displacement of the sealing mechanism 8 and the sample injection disk 6 also greatly simplifies the experimental operation and improves work efficiency.

[0040] Please refer to Figure 2A strip groove 87 is provided on one side of the concave seat 4 close to the electric push rod 82, and the inner side of the strip groove 87 is connected to the inside of the slide groove 92. A bracket 88 is fixedly installed on the outside of the slide rod 94 with the side plate 81. The outer end of the bracket 88 passes through the strip groove 87 and the top of the sealing disk 85 close to the side of the electric push rod 82 for rotational connection. The strip groove 87 provided on the side of the concave seat 4 close to the electric push rod 82 is an ingenious design. This strip groove 87 not only provides a passage space for the bracket 88, so that the bracket 88 can smoothly connect the sealing disk 85 and the slide rod 94, but also it is connected to the inside of the slide groove 92, ensuring that the movement of the slide rod 94 in the slide groove 92 will not be hindered in any way. The bracket 88 fixedly installed on the outside of the slide rod 94 with the side plate 81 plays a connecting role. The outer end of the bracket 88 can pass through the strip groove 87 and be rotatably connected to the top of the sealing disk 85 near the side of the electric push rod 82. This connection method allows the sealing disk 85 to smoothly approach or move away from the sample tray 6 under the push of the electric push rod 82, while ensuring the stability of the sealing disk 85 during rotation. The advantage of this design is that it makes the linkage between the sealing mechanism 8 and the displacement mechanism 9 tighter and more efficient. When the slide rod 94 moves under the drive of the screw rod 93, the sealing disk 85 connected through the bracket 88 can move synchronously, thereby realizing real-time sealing of the sample tray 6. At the same time, the sealing disk 85 can also be rotated separately when necessary to adapt to sample dishes 714 of different shapes and sizes, thereby improving the flexibility and adaptability of the seal.

[0041] Please refer to Figure 5 The bottom of the sealing disk 85 is fixedly installed with sealing plugs 86 at equal intervals, and the bottom of the sealing plugs 86 is plugged with the inner upper end of the sample dish 714. The design of the sealing plugs 86 enables the sealing disk 85 to be tightly inserted into the inner upper end of the sample dish 714 when it is attached to the sample feeding disk 6, forming a complete sealing structure. This design not only prevents heat leakage, but also effectively prevents the sample from being contaminated or volatilized by the outside during the experiment. At the same time, the equal spacing of the sealing plugs 86 ensures that each sample dish 714 can obtain uniform sealing pressure, avoiding the problem of sealing failure caused by uneven pressure. This uniform distribution The cloth sealing method not only improves the reliability of the seal, but also ensures the accuracy of the experimental results. In addition, the material selection of the sealing plug 86 is also very critical. In order to ensure that it has good sealing performance and durability, the sealing plug 86 is usually made of high temperature resistant and corrosion resistant materials, which can maintain stable performance during the experiment. The sealing mechanism 8 of the temperature control device of the liquid chromatograph further enhances the sealing effect through the design of the sealing plug 86, providing scientific researchers with a more stable and reliable experimental environment. This design not only improves the accuracy of the experiment, but also extends the service life of the equipment and reduces maintenance costs.

[0042] Please refer to Figure 5The driving mechanism 5 includes a dual-axis motor 51 and a rack 52. The dual-axis motor 51 is fixedly installed on the inner side of the fixed frame 3. A driving gear 53 is fixedly installed at the output ends on both sides of the dual-axis motor 51. The rack 52 is fixedly installed on both sides of the guide rail 1. The driving gear 53 and the rack 52 are meshingly connected. The dual-axis motor 51 is fixedly installed on the inner side of the fixed frame 3, ensuring its stable working state. The driving gear 53 is fixedly installed at the output ends on both sides of the dual-axis motor 51. This design enables the motor to drive the gears on both sides to rotate at the same time, thereby improving the working efficiency. The rack 52 is fixedly installed on both sides of the guide rail 1 and meshingly connected with the driving gear 53. When the dual-axis motor 51 is started, the driving gear 53 will rotate accordingly, and through the meshing action with the rack 52, the rotational motion of the motor is converted into the linear motion of the guide rail 1. This meshing connection method has the advantages of high transmission efficiency and high positioning accuracy, thereby ensuring the stability and accuracy of the temperature control device during movement.

[0043] Please refer to Figure 3 The overall cross-sectional shape of the slider 2 and the slide bar 94 is set to a convex shape, the inner walls of the slide groove 92 and the guide rail 1 are also set to a convex shape, and the inner walls of the slide groove 92 and the inner walls of the guide rail 1 are fixedly connected with wear-resistant gaskets. The overall cross-sectional shape of the slider 2 and the slide bar 94 is set to a convex shape. This design enables them to better match the slide groove 92 and the guide rail 1. The convex structure can not only provide a larger contact area and increase stability, but also prevent the slider 2 and the slide bar 94 from deviating or shaking during movement. The inner walls of the slide groove 92 and the guide rail 1 are also set to a convex shape, which matches the shape of the slider 2 and the slide bar 94, ensuring a close fit between them. This design makes the slider 2 and the slide bar 94 in the slide groove 92 and the guide rail 1. It moves more smoothly in the rail 1, reduces friction and resistance, and improves the transmission efficiency of the entire temperature control device. In addition, the inner wall of the slide groove 92 and the inner wall of the guide rail 1 are fixedly connected with wear-resistant gaskets. The wear-resistant gaskets are made of materials with excellent wear resistance and can effectively reduce the wear of the slider 2 and the slide rod 94 on the slide groove 92 and the guide rail 1 during movement, which not only extends the service life of the temperature control device, but also reduces the maintenance cost. The temperature control device of the liquid chromatograph fully considers stability and wear resistance in the structural design of the slider 2, the slide rod 94, the slide groove 92 and the guide rail 1. By adopting measures such as convex cross-sections and wear-resistant gaskets, it ensures that the temperature control device can operate stably for a long time, providing scientific researchers with reliable and efficient experimental conditions.

[0044] Please refer to Figure 2The rear side of the guide rail 1 is slidably connected with a supporting block 54, and a supporting rod 55 is fixedly installed on the outer side of the supporting block 54. The front end of the supporting rod 55 is rotatably connected to the middle part of the outer side of the driving gear 53. A sliding interface is designed on the rear side of the guide rail 1 to form a sliding connection with the supporting block 54. This connection method allows the supporting block 54 to move smoothly on the guide rail 1 while maintaining its fixed position, providing a stable support for the driving gear 53. A supporting rod 55 is fixedly installed on the outer side of the supporting block 54. This supporting rod 55 not only plays a role of connection and support, but also makes the entire structure more stable. The front end of the supporting rod 55 is rotatably connected to the middle part of the outer side of the driving gear 53. This design The design enables the driving gear 53 to remain stable during rotation, reducing transmission errors caused by vibration or offset. The advantage of this connection method is that it combines the advantages of sliding connection and rotating connection, ensuring both the flexibility of the structure and the accuracy of transmission. At the same time, due to the fixed installation of the supporting block 54 and the supporting rod 55, the entire driving mechanism 5 is more stable during operation, reducing failures caused by structural looseness or deformation. The connection method between the guide rail 1 and the supporting block 54, the supporting rod 55 and the driving gear 53 in the temperature control device of the liquid chromatograph is cleverly and reasonably designed, which not only improves the structural stability of the device, but also ensures the accuracy and reliability of the transmission.

[0045] The implementation principle of a temperature control device for a liquid chromatograph according to an embodiment of the present application is as follows: by setting a temperature control mechanism 7, during use of the device, a sample dish 714 with a sample can be placed on the inner side of a placement seat 711. At this time, the sample dish 714 is inserted into the inner side of a heat-conducting coil 712, and the bottom of the sample dish 714 is fitted and connected with the top of an annular electric heating plate 715. When the temperature needs to be regulated, if the temperature needs to be increased, the annular electric heating plate 715 can be directly started to operate. By using the annular electric heating plate 715 to fit the bottom of the sample dish 714, the annular electric heating plate 715 can be quickly heated. At this time, the temperature sensor 713 contacts the bottom of the sample dish 714 to assist in detecting its temperature change. When the temperature meets the index, the annular electric heating plate 715 is stopped. 15 can be operated, and when the temperature needs to be quickly lowered, the circulation pump 73 can be started to operate. At this time, the circulation pump 73 drives the water to flow inside the transfer coil 74 and each heat-conducting coil 712. At this time, the inner side of the heat-conducting coil 712 is connected to the sample dish in a close connection, and the temperature can be quickly introduced into the water tank 72 through the close heat exchange. A semiconductor refrigerator 75 is arranged at the bottom of the water tank 72. By starting the semiconductor refrigerator 75, the coolant in the water tank 72 can be cooled to assist it in circulating and dissipating heat, so that the sample dish 714 inside the placement seat 711 can be cooled, so that the device can quickly heat up the sample tray 6 during use, and can also quickly cool down, and the overall temperature control response changes The rate is fast, and the temperature can be quickly adjusted, which can improve the overall temperature control performance of the device. First, the device can quickly heat up or cool down the sample tray 6, which greatly improves the efficiency of the experimental operation. When it is necessary to quickly reach a specific temperature condition, the annular electric heating plate 715 can quickly fit the bottom of the sample dish 714 for heating, ensuring that the sample reaches the required temperature in a short time. At the same time, the cooling process is also fast. The circulating pump 73 drives the water to flow in the heat conducting coil 712 to achieve rapid heat exchange with the sample dish 714, and the semiconductor refrigerator 75 is used to cool the coolant, so that the sample dish 714 can be quickly cooled. This efficient temperature control method can greatly shorten the experimental preparation time and improve the analysis efficiency. Secondly, The temperature control performance of the device is stable and reliable. The fitting design of the annular electric heating plate 715 and the bottom of the sample dish 714 ensures that heat can be evenly transferred, avoiding experimental errors caused by temperature gradients. At the same time, the temperature sensor 713 can monitor the temperature changes of the sample dish 714 in real time to ensure that the temperature is controlled within a precise range. During the cooling process, the cooperation of the circulating pump 73 and the semiconductor refrigerator 75 can ensure a uniform cooling effect, avoiding the problem of uneven temperature inside the sample dish 714. In addition, the device also has strong flexibility and adaptability. By adjusting the power of the annular electric heating plate 715 and the flow rate of the circulating pump 73, the temperature control rate can be accurately controlled to meet the temperature change requirements of different experiments. At the same time,The device can also be expanded and upgraded according to experimental needs, such as adding more heat conducting coils 712 or optimizing the performance of semiconductor refrigerators 75 to adapt to higher temperature control tasks. By setting the temperature control mechanism 7, the device shows the advantages of high efficiency, stability, flexibility and adaptability in temperature control, providing reliable guarantee for experimental analysis.

[0046] By setting the driving mechanism 5, the device can be operated by starting the double-axis motor 51 during use. The operation of the double-axis motor 51 can drive the driving gears 53 at both ends to rotate. The rotation of the driving gear 53 can cooperate with the transmission of the rack 52. When the driving gear 53 rotates through the meshing transmission of the rack 52, the slider 2 can be caused to slide inside the guide rail 1. The concave seat 4 can be flexibly adjusted to move up and down by the slider 2 moving up and down inside the guide rail 1, which can enable the device as a whole to flexibly adjust the sample tray 6 to different heights. At the same time, during its use, the first motor 91 can be started to operate. The first motor 91 is used to drive the screw rod 93 inside the slide groove 92 to rotate. The screw rod 93 is located inside the slide groove 92 and slides forward and backward. The slide rod 94 moves forward and backward, so that the forward and backward displacement of the sample tray 6 can be flexibly adjusted. The lifting adjustment of the driving mechanism 5 can enable the sample tray 6 to automatically adjust its position for sample injection, further improving the adaptability of the device. First, the device realizes the flexible adjustment of the position of the sample tray 6. By starting the dual-axis motor 51, the driving gear 53 and the rack 52 cooperate to transmit, so that the slider 2 slides up and down in the guide rail 1, thereby easily adjusting the height of the concave seat 4 and the sample tray 6. This design enables the sample tray 6 to easily adapt to the experimental needs of different heights without manual adjustment, which greatly saves the experimental preparation time. Secondly, the device also has the function of adjusting the front and rear displacement. By starting the first motor 91, the screw rod 93 is driven to slide back and forth in the slide groove 92, driving the slide bar 94 and the sample tray 6 to achieve front and rear displacement. This coordinated adjustment method of lifting and displacement enables the sample tray 6 to automatically adapt to the injection needs of different positions, further improving the adaptability of the device. In addition, this design also significantly improves the accuracy and efficiency of experimental analysis. Since the position of the sample tray 6 can be accurately adjusted, it can be To ensure that the sample is in the best position during the injection process, thereby improving the accuracy of the analysis. At the same time, the automatic adjustment also reduces the error of human operation and further improves the reliability of the experiment. Finally, this design also provides great convenience for scientific researchers. Scientific researchers can easily adjust the position of the injection tray 6 according to experimental requirements without the need for tedious manual operations, so that they can focus more on the experiment itself and improve work efficiency. By setting the driving mechanism 5, the device shows many advantages in adjusting the position of the injection tray 6, such as flexibility, accuracy, efficiency and convenience, which provides great help for scientific researchers.

[0047] By setting up the sealing mechanism 8, during use of the device, the electric push rod 82 can be started to operate, and the electric push rod 82 can be used to push the sealing plate 85 to move downward. At this time, the sealing plate 85 can drive the sealing plug 86 to fill the top of the sample dish 714. At this time, the sealing plug 86 at the bottom of the sealing plate 85 can assist the top of the sample dish 714. Since the sealing mechanism 8 and the temperature control mechanism 7 are both installed on the inner side of the displacement, when it is necessary to adjust the displacement of the sample tray 6, the two groups of first motors 91 can be started to operate, and the first motor 91 can drive the screw rod 93 to drive the slider 2 to move synchronously inside the slide groove 92. At this time, the sample tray 6 and the sealing plate 85 can be driven to move synchronously, so that the device as a whole can stably drive the sample tray. 6, and at the same time, during the displacement of the sample tray 6, the top is in a sealed state through the sealing disk 85, which can further improve the overall sealing performance of the device, avoid the sample inside the sample tray 6 from spilling or cross contamination, and maximize the detection accuracy. At the same time, when the sample tray 6 needs to be opened, the sealing disk 85 can be pushed up by starting the electric push rod 82, and the sealing disk 85 and the sealing plug 86 leave the top of the sample dish 714. At this time, the first motor 91 is started to drive the sliding rod 94 to drive the sealing disk 85 to move away, and then the second motor 84 is started to drive the sealing disk 85 to rotate, so that the sealing disk 85 can be completely dislocated from the top of the sample tray 6, so that the sample dish 714 can be quickly taken in and put out, making the overall use and operation of the device more convenient, and the sliding period of the sealing disk 85 The slide bar 94 and the sealing plate 85 can be connected with the bracket 88 that slides inside the strip groove 87 to further improve the overall stability of the sealing plate 85. Firstly, the device can ensure the sealing of the sample dish 714 during the sampling process. By driving the electric push rod 82, the sealing plate 85 and the sealing plug 86 can fit tightly on the top of the sample dish 714, effectively preventing the sample from spilling and cross contamination. This is particularly important for experiments that require high-precision analysis, and can ensure the accuracy and reliability of the experimental results. Secondly, the device can maintain a sealed state when adjusting the position of the sample tray 6. Since the sealing mechanism 8 and the temperature control mechanism 7 are both installed on the inner side of the displacement mechanism 9, when the height or front and rear position of the sample tray 6 needs to be adjusted, the sealing mechanism 8 and the temperature control mechanism 7 are both installed on the inner side of the displacement mechanism 9. The disk 85 can be displaced synchronously and always fits tightly against the top of the sample dish 714, ensuring that the sample tray 6 maintains good sealing performance during the entire experiment. This can not only prevent the loss of samples, but also improve the reliability and repeatability of the experiment. In addition, the device also has the advantage of convenient operation. When it is necessary to open the sample tray 6, it is only necessary to start the electric push rod 82 to move the sealing disk 85 and the sealing plug 86 upward, and then drive the sealing disk 85 to move away through the motor, so that the sample dish 714 can be easily and quickly taken in and put. This design greatly simplifies the operation process and improves work efficiency. Finally, the auxiliary connection function of the bracket 88 further improves the overall stability of the sealing disk 85. During the sliding of the sealing disk 85, the bracket 88 can slide inside the strip groove 87.Ensure that the connection between the slide bar 94 and the sealing disk 85 is stable and reliable, thereby preventing the sealing failure caused by vibration or external force. By setting the sealing mechanism 8, the device not only has excellent sealing performance, but also is easy to operate, stable and reliable, providing scientific researchers with efficient and accurate experimental conditions, which helps to improve the accuracy and reliability of experimental results.

[0048] The above are all preferred embodiments of the present application, and the protection scope of the present application is not limited thereto. Therefore, any equivalent changes made according to the structure, shape, and principle of the present application should be included in the protection scope of the present application.

Claims

1. A temperature control device for a liquid chromatograph, comprising a guide rail (1), characterized in that: The inner side of the guide rail (1) is slidably connected with a slider (2), the outer end of the slider (2) is fixedly mounted with a fixing frame (3), a concave seat (4) is fixedly mounted on the side of the fixing frame (3) away from the guide rail (1), displacement mechanisms (9) are fixedly mounted on both sides of the inner side of the concave seat (4), a sample tray (6) is fixedly mounted on the inner side of one of the two groups of displacement mechanisms (9), and a temperature control mechanism (7) is fixedly mounted on the bottom of the sample tray (6); The temperature control mechanism (7) comprises a containing assembly (71) and a water tank (72), wherein the containing assembly (71) is fixedly installed at equal intervals on the inner side of the sample feeding tray (6), and the water tank (72) is fixedly installed on one side of the bottom of the sample feeding tray (6). A circulation pump (73) is fixedly installed on one side of the water tank (72), and the input end of the circulation pump (73) is connected to the water tank (72). A transfer coil (74) is fixedly installed on the output end of the circulation pump (73), and the transfer coil (74) is respectively connected to the containing assembly (71), and the output end of the containing assembly (71) is connected to the inside of the water tank (72). A semiconductor refrigerator (75) is fixedly installed on the bottom of the water tank (72); The containing assembly (71) comprises a placement seat (711), the placement seat (711) is fixedly installed at equal intervals on the inner side of the sample feeding plate (6), a heat conducting coil (712) is fixedly installed on the inner side of the placement seat (711), the transfer coil (74) and each heat conducting coil (712) are connected in series, the main body of the heat conducting coil (712) is spirally arranged on the inner side of the placement seat (711), and a sample dish (714) is inserted into the inner side of the placement seat (711); An annular electric heating plate (715) is fixedly mounted on the bottom of the placement seat (711), a temperature sensor (713) is fixedly mounted in the middle of the placement seat (711), a detection end of the temperature sensor (713) is fitted and connected to the bottom of the sample dish (714), and a single-chip control module is provided on the inner side of the semiconductor refrigerator (75).

2. A temperature control device for a liquid chromatograph according to claim 1, characterized in that: The displacement mechanism (9) comprises a first motor (91) and a slide groove (92), wherein the slide groove (92) is provided on both sides of the concave seat (4), the first motor (91) is fixedly mounted on both ends of one side of the concave seat (4) close to the guide rail (1), the output end of the first motor (91) passes through the concave seat (4) and is located inside the slide groove (92) and is fixedly mounted with a lead screw (93), the lead screw (93) is rotatably connected to the inside of the slide groove (92), the outer surface of the lead screw (93) is threadedly connected with a slide rod (94), the slide rod (94) is slidably connected to the inner side of the guide rail (1), and the sample tray (6) is fixedly mounted on the inner side of a slide rod (94).

3. A temperature control device for a liquid chromatograph according to claim 2, characterized in that: A sealing mechanism (8) is fixedly mounted on the inner side of another displacement mechanism (9) of the two displacement mechanisms (9), and the sealing mechanism (8) covers the top of the sample injection mechanism. The sealing mechanism (8) comprises a side plate (81), and the side plate (81) is fixedly mounted on the inner side of the other slide rod (94). An electric push rod (82) is fixedly mounted on the inner end of the side plate (81), and a base frame (83) is fixedly mounted on the top of the electric push rod (82). A second motor (84) is fixedly mounted on the inner side of the base frame (83), and a sealing disk (85) is fixedly mounted on the top output end of the second motor (84).

4. A temperature control device for a liquid chromatograph according to claim 3, characterized in that: Sealing plugs (86) are fixedly installed at equal intervals on the bottom of the sealing disk (85), and the bottom of the sealing plugs (86) is plugged with the inner upper end of the sample dish (714).

5. A temperature control device for a liquid chromatograph according to claim 4, characterized in that: A strip groove (87) is provided on one side of the concave seat (4) close to the electric push rod (82), the inner side of the strip groove (87) is connected to the inside of the slide groove (92), a bracket (88) is fixedly installed on the outer side of the slide rod (94) with the side plate (81), and the outer end of the bracket (88) passes through the strip groove (87) and the top of the sealing disk (85) close to the electric push rod (82) and is rotatably connected.

6. A temperature control device for a liquid chromatograph according to claim 5, characterized in that: The overall cross-sectional shape of the slider (2) and the slide rod (94) is set to be a convex shape, the inner wall of the slide groove (92) and the guide rail (1) is also set to be a convex shape, and the inner wall of the slide groove (92) and the inner wall of the guide rail (1) are fixedly connected with wear-resistant gaskets.

7. A temperature control device for a liquid chromatograph according to claim 1, characterized in that: A driving mechanism (5) is fixedly mounted on the inner side of the fixed frame (3), and the driving mechanism (5) comprises a dual-axis motor (51) and a rack (52). The dual-axis motor (51) is fixedly mounted on the inner side of the fixed frame (3), and driving gears (53) are fixedly mounted at both output ends of the dual-axis motor (51). The racks (52) are fixedly mounted on both sides of the guide rail (1), and the driving gears (53) and the racks (52) are meshingly connected.

8. A temperature control device for a liquid chromatograph according to claim 7, characterized in that: A supporting block (54) is slidably connected to the rear side of the guide rail (1), a supporting rod (55) is fixedly installed on the outer side of the supporting block (54), and the front end of the supporting rod (55) is rotatably connected to the outer middle part of the driving gear (53).

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