System for loading nitric oxide on blood in vitro

Abstract

The utility model belongs to the field of medical instruments, and discloses a system for loading nitric oxide in vitro on blood, which enables an artificial membrane lung to be connected with a rolling pump and a blood collecting bag, and realizes that mixed gas of NO and O2 is introduced into the artificial membrane lung through the synergistic effect of the artificial membrane lung, the rolling pump and the blood collecting bag, so that the blood oxygenation function is effectively realized. By arranging the blood storage bag and the blood collection bag, an in-vitro NO closed-loop load system of blood is formed, the closed-loop load system only needs to operate the blood once, the probability of blood pollution is reduced, all the components are connected through the connectors, certain flexibility is achieved, and the blood collection bag is convenient to use. Therefore, the device can be suitable for different medical scenes and patient requirements.

Description

Technical Field

[0001] The utility model belongs to the field of medical equipment, and in particular relates to a blood extracorporeal nitric oxide loading system. Background Art

[0002] Transfusion of red blood cell products is an important clinical treatment method. Red blood cells carry and deliver oxygen to tissues. Studies have shown that the destruction of red blood cell products increases with the extension of storage time, among which free hemoglobin (fHb) increases. fHb in the blood is related to transfusion-related adverse reactions, especially acute kidney injury (AKI) after transfusion. Current studies suggest that fHb-induced transfusion-related adverse reactions are related to its removal of endothelial-derived nitric oxide (NO). After fHb combines with NO, it generates methemoglobin (Met Hb), and its reaction rate is 6000 times that of intracellular Hb and NO, thereby rapidly depleting endothelial-derived NO, inducing endothelial dysfunction, inflammatory response, platelet activation and oxidative stress, thereby leading to the occurrence of transfusion-related adverse reactions. How to reduce fHb-induced adverse reactions is a key research direction for preventing transfusion-related adverse reactions. For example, exogenous haptoglobin and hemopexin are used to bind to excess free hemoglobin and iron-containing heme released by hemoglobin degradation, and transport them to specific cells for degradation and metabolism; or drugs that can produce NO in the body are used to supplement the consumed endogenous NO. However, since the above methods require the infusion of additional protein products or drugs, their dosage and clinical safety and effectiveness are difficult to determine. Therefore, they are not suitable for adjuvant treatment during clinical transfusion therapy.

[0003] Animal experiments and clinical studies have confirmed that the use of exogenous NO gas can convert fHb in the blood into MetHb, making it lose the ability to remove endogenous NO, thereby reducing fHb-related adverse reactions. For example, the incidence of postoperative AKI in patients undergoing extracorporeal circulation-assisted cardiac surgery can be reduced by inhaling exogenous NO and connecting exogenous NO to the extracorporeal circulation oxygen supply system. However, since the efficiency of NO inhalation is low in patients without endotracheal intubation, and special equipment is required for NO inhalation, it is not available in all medical units and is not easy to promote. Moreover, NO and O2 can react quickly to generate toxic nitrogen dioxide (NO2), and patients may suffer respiratory damage when inhaling high concentrations of NO2; and long-term and large-scale inhalation of NO can lead to an increase in the proportion of MetHb in the body, affecting oxygen delivery.

[0004] Therefore, in the early exploration, an attempt was made to load fHb-rich blood in vitro by establishing an in vitro loading device, in order to reduce its ability to consume NO before fHb enters the body. This method is theoretically more advantageous than the systemic use of NO donors or inhaled NO therapy. However, the early loading device was implemented on the basis of existing medical equipment, using blood transfusion devices, infusion pumps, artificial membrane lungs, etc., and was not a closed-loop system. Therefore, the operation was complicated during implementation, and there might be problems such as blood contamination and low loading efficiency. Summary of the invention

[0005] The utility model aims to overcome the shortcomings of the above implementation, such as complex operation, possible blood contamination and low loading efficiency, and provide a blood extracorporeal nitric oxide loading system.

[0006] In order to achieve the above purpose, the utility model adopts the following technical solutions:

[0007] A blood extracorporeal nitric oxide loading system comprises an artificial membrane lung, wherein the blood inlet of the artificial membrane lung is connected to a blood storage bag, the bleeding port of the artificial membrane lung is connected to the inlet of a roller pump, the outlet of the roller pump is connected to a blood collection bag, the blood collection bag is connected to the blood inlet of the artificial membrane lung, and a mixed gas of NO and O2 is introduced into the air inlet of the artificial membrane lung.

[0008] A further improvement of the utility model is that the air outlet of the artificial membrane lung is connected to the waste gas collecting device.

[0009] A further improvement of the utility model is that the roller pump adopts a continuous roller pump.

[0010] A further improvement of the utility model is that the roller pump is connected to a control device, and the control device is used to adjust the rotation speed of the roller pump.

[0011] A further improvement of the utility model is that a timer is arranged on the roller pump.

[0012] A further improvement of the utility model is that a first control valve is arranged on the blood inlet of the artificial membrane lung.

[0013] A further improvement of the utility model is that the bleeding port of the artificial membrane lung is connected to the roller pump via a blood input pipeline.

[0014] A further improvement of the utility model is that a second control valve is provided on the blood input pipeline.

[0015] A further improvement of the utility model is that the roller pump is connected to the blood collection bag via a blood output pipeline.

[0016] Compared with the prior art, the utility model has the following beneficial effects:

[0017] The utility model connects the artificial membrane lung to the roller pump and the blood collection bag. Through the synergistic effect of the artificial membrane lung, the roller pump and the blood collection bag, the NO and O2 mixed gas is passed into the artificial membrane lung, thereby effectively realizing the blood oxygenation function. The utility model forms an extracorporeal NO closed-loop load system for blood by setting a blood storage bag and a blood collection bag. The closed-loop load system only needs to operate the blood once, reducing the probability of blood contamination. The various components of the utility model are connected through a connection port, which has a certain flexibility, so that the device can be applied to different medical scenarios and patient needs.

[0018] Furthermore, the utility model is provided with a control device, which can be automatically operated after one installation, and the load time can be set according to the amount of blood to achieve different load effects, freeing up manpower and saving time. And the load process can be stopped at any time by adjusting the load time, which increases the controllability on the basis of ensuring the load effect to cope with the urgent demand for blood.

[0019] Furthermore, the utility model is provided with an exhaust gas collection device, which can reduce air pollution. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 It is a system diagram of the utility model;

[0021] Figure 2 It is a schematic diagram of the artificial membrane lung in the utility model;

[0022] Among them, 1. blood storage bag; 2. artificial membrane lung; 3. roller pump; 4. blood collection bag; 5. waste gas absorption device; 6. first control valve, 7. second control valve. DETAILED DESCRIPTION

[0023] In order to further understand the content of the utility model, the utility model is described in detail below in conjunction with the accompanying drawings and specific embodiments. It should be understood that the embodiments are only for explaining the utility model and are not intended to limit it.

[0024] See also Figure 1 and Figure 2A blood extracorporeal nitric oxide loading system includes an artificial membrane lung 2, the blood inlet of the artificial membrane lung 2 is connected to a blood storage bag 1, a first control valve 6 is provided on the blood inlet of the artificial membrane lung 2, the bleeding port of the artificial membrane lung 2 is connected to the inlet of a roller pump 3, the outlet of the roller pump 3 is connected to a blood collection bag 4, the blood collection bag 4 is connected to the blood inlet of the artificial membrane lung 2, and a mixture of NO and O2 is introduced into the air inlet of the artificial membrane lung 2. The air outlet of the artificial membrane lung 2 is connected to an exhaust gas collection device 5. The roller pump 3 is connected to a control device, and the control device is used to adjust the rotation speed of the roller pump 3. A timer is provided on the roller pump 3. The bleeding port of the artificial membrane lung 2 is connected to the roller pump 3 through a blood input pipeline, and the roller pump 3 is connected to the blood collection bag 4 through a blood output pipeline, and a second control valve 7 is provided on the blood input pipeline.

[0025] Preferably, the roller pump 3 is a continuous roller pump.

[0026] When in use, the artificial membrane lung 2, the blood storage bag 1, the roller pump 3, the blood collection bag 4 and the waste gas collection device 5 are assembled to ensure the sealing and safety of the connecting pipelines. A gas mixed with NO and O2 is introduced through the air inlet of the artificial membrane lung 2 for extracorporeal oxygenation of the blood entering the artificial membrane lung 2. The blood storage bag 1 is connected to the blood inlet of the artificial membrane lung 2 to ensure that blood can enter the artificial membrane lung. The bleeding port of the artificial membrane lung 2 is connected to the inlet of the roller pump 3 to ensure that blood can be pushed into the system. The roller pump 3 is connected to a control device, which is responsible for adjusting the speed of the roller pump and using a timer to monitor the operating time of the system. The air outlet of the artificial membrane lung 2 is connected to the waste gas collection device 5 to safely collect and treat the waste gas generated in the system. A first control valve 6 is provided on the blood inlet of the artificial membrane lung 2, and a second control valve 7 is provided on the blood input pipeline for adjusting the blood input amount to ensure that the blood circulation in the system is effectively controlled. The roller pump 3 is connected to the blood collection bag 4 through the blood output pipeline to collect the oxygenated blood.

[0027] During use, blood oxygen levels, gas mixture ratios and other relevant parameters can be regularly monitored to ensure that the system operates stably and is adjusted according to the patient's needs.

[0028] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the utility model rather than to limit it. Although the utility model is described in detail with reference to the above embodiments, ordinary technicians in the relevant field should understand that the specific implementation methods of the utility model can still be modified or replaced by equivalents, and any modification or equivalent replacement that does not depart from the spirit and scope of the utility model should be included in the scope of protection of the claims of the utility model.

Claims

1. A blood extracorporeal nitric oxide loading system, characterized in that: The invention comprises an artificial membrane lung (2), wherein the blood inlet of the artificial membrane lung (2) is connected to a blood storage bag (1), the bleeding outlet of the artificial membrane lung (2) is connected to the inlet of a roller pump (3), the outlet of the roller pump (3) is connected to a blood collection bag (4), the blood collection bag (4) is connected to the blood inlet of the artificial membrane lung (2), and a mixed gas of NO and O2 is introduced into the air inlet of the artificial membrane lung (2).

2. The blood extracorporeal nitric oxide loading system according to claim 1, characterized in that: The air outlet of the artificial membrane lung (2) is connected to a waste gas collecting device (5).

3. The blood extracorporeal nitric oxide loading system according to claim 1, characterized in that: The roller pump (3) adopts a continuous roller pump.

4. A blood extracorporeal nitric oxide loading system according to claim 1 or 3, characterized in that: The roller pump (3) is connected to a control device, and the control device is used to adjust the rotation speed of the roller pump (3).

5. A blood extracorporeal nitric oxide loading system according to claim 1 or 3, characterized in that: The roller pump (3) is provided with a timer.

6. The blood extracorporeal nitric oxide loading system according to claim 1, characterized in that: A first control valve (6) is provided on the blood inlet of the artificial membrane lung (2).

7. The blood extracorporeal nitric oxide loading system according to claim 1, characterized in that: The bleeding port of the artificial membrane lung (2) is connected to a roller pump (3) via a blood input pipeline.

8. The blood extracorporeal nitric oxide loading system according to claim 7, characterized in that: A second control valve (7) is provided on the blood input pipeline.

9. The blood extracorporeal nitric oxide loading system according to claim 1, characterized in that: The roller pump (3) is connected to the blood collection bag (4) via a blood output pipeline.

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