Ingredient mixing pre-reaction device for preparing ibuprofen axetil

Abstract

The utility model belongs to the technical field of chemical equipment, and particularly relates to an ingredient mixing pre-reaction device for preparing ibuprofen axetil, which comprises a rearrangement reactor, one end of the rearrangement reactor is connected with a material mixer, and a preheating coil pipe and a stirrer are arranged in the material mixer in a matched mode. The end, away from the rearrangement reactor, of the material mixer is connected with a ketal conveying assembly and an ibuprofen conveying assembly, control units are arranged on one side of the ketal conveying assembly and one side of the ibuprofen conveying assembly in a matched mode, and a heat exchange coil pipe set is arranged in the rearrangement reactor and comprises four heat exchange coil pipes. One ends of the four heat exchange coils are jointly connected with an inlet pipeline, and the other ends of the four heat exchange coils are jointly connected with an outlet pipeline. The device can avoid energy waste caused by long-time operation of the rearrangement reactor, and the production efficiency is improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of chemical equipment, and in particular relates to a pre-reaction device for mixing ingredients for preparing ibuprofen ester. Background Art

[0002] As a traditional non-steroidal anti-inflammatory analgesic, ibuprofen is widely used in the medical field. It can relieve the pain caused by various chronic inflammations such as rheumatoid arthritis and osteoarthritis. It also has excellent analgesic effects on mild and moderate pain in daily life such as headaches and toothaches, which relieves the pain of many patients. In the synthesis of ibuprofen API, ibuprofen ketal and ibuprofen zinc will undergo a rearrangement reaction to continuously generate ibuprofen esters. Ibuprofen esters are further hydrolyzed and the ester group is removed to obtain the final ibuprofen API. In continuous production, ibuprofen esters are intermediates in the synthesis of ibuprofen APIs, and the quality of the ibuprofen esters is directly related to the output and quality of ibuprofen APIs.

[0003] Chinese patent CN114405447A discloses a method for continuous production of ibuprofen ester, comprising the following steps: 1. The water-washed ketal generated by the condensation reaction is pumped into a primary rearrangement reactor, the catalyst is pumped into the primary rearrangement reactor, and a solvent is added to carry out a rearrangement reaction; 2. The rearrangement reaction is carried out in a plurality of series-connected continuous rearrangement reactors in sequence, and the multi-stage reaction is overflowed; 3. The gas phase of the multi-stage reaction enters the condenser, and the condensed material enters the reflux tank; the excess solvent overflows from the side of the reflux tank and enters the condensation reaction process. 4. The rearrangement liquid overflows from the last stage of the rearrangement reactor and enters the next process. This patent shortens the reaction time and realizes the continuous production of ibuprofen ester. However, a large amount of energy is consumed in the stirring and mixing process of ibuprofen ketal and ibuprofen zinc and the early heating stage of the rearrangement reactor. At the same time, the heat release of the rearrangement reaction itself will change at different stages, and it needs to be carried out sequentially in multiple rearrangement reactors connected in series. This not only causes the equipment to be in a high-energy consumption operation state for a long time, but also prolongs the cycle of continuous production of the rearrangement reaction, reducing production efficiency. Utility Model Content

[0004] The utility model aims to provide a pre-reaction device for mixing ingredients for preparing ibuprofen ester, so as to avoid energy waste caused by long-term operation of multiple rearrangement reactors, make the connection of various production links smoother, and improve production efficiency.

[0005] To achieve the above purpose, the technical solution of the utility model is:

[0006] A batch mixing pre-reaction device for preparing ibuprofen ester comprises a rearrangement reactor, one end of the rearrangement reactor is connected to a material mixer, a preheating coil and a stirrer are arranged in the material mixer, one end of the material mixer away from the rearrangement reactor is connected to a ketal conveying component and an ibuprofen zinc conveying component, one side of the ketal conveying component and one side of the ibuprofen zinc conveying component are arranged with a control unit, a heat exchange coil group is arranged in the rearrangement reactor, the heat exchange coil group comprises four heat exchange coils, one end of the four heat exchange coils is commonly connected to an inlet pipe, and the other end of the four heat exchange coils is commonly connected to an outlet pipe.

[0007] in:

[0008] The material mixer comprises a stirring chamber which is arranged in a cylindrical shape as a whole, and the stirrer is arranged on the central axis of the stirring chamber.

[0009] One end of the stirrer passes through the material mixer and is connected with a motor.

[0010] The preheating coil is arranged in conjunction with the stirrer in a surrounding manner inside the stirring chamber.

[0011] One end of the preheating coil is connected to a preheating medium inlet pipe, and the other end of the preheating coil is connected to a preheating medium outlet pipe. The preheating medium inlet pipe and the preheating medium outlet pipe are both arranged through the side wall of the mixing bin.

[0012] The rearrangement reactor comprises a reaction chamber, which is arranged in a cylindrical shape as a whole, and four heat exchange coils are arranged in the reaction chamber in a surrounding manner in accordance with the central axis of the reaction chamber.

[0013] The reaction chamber is provided with a heat medium inlet pipe and a heat medium outlet pipe.

[0014] One end of the inlet pipe away from the heat exchange coil group is connected to the material mixer, and one end of the outlet pipe away from the heat exchange coil group penetrates the rearrangement reactor and extends outward.

[0015] The ketal delivery component is provided with a ketal metering device and a ketal delivery pump, and the ibuprofen zinc delivery component is provided with an ibuprofen zinc metering device and an ibuprofen zinc delivery pump.

[0016] The ketal metering device, the ketal delivery pump, the ibuprofen zinc metering device and the ibuprofen zinc delivery pump are all electrically connected to the control unit.

[0017] The beneficial effects of the utility model are:

[0018] The preheating coil in the material mixer can quickly heat the materials when ibuprofen ketal and ibuprofen zinc are mixed, thereby reducing the time consumed in heating up when the rearrangement reaction is started; heat is released violently in the early stage of the rearrangement reaction, and the rotation of the agitator can quickly and evenly mix the ibuprofen ketal and ibuprofen zinc, so that the heat released by the rearrangement reaction is evenly transferred to the entire mixed material; the heat released decreases and tends to be stable in the later stage of the rearrangement reaction, and the rearrangement reactor and the heat exchange coil group cooperate to stabilize the temperature of the mixed material, thereby improving the conversion rate and purity of ibuprofen ester; the control unit cooperates with the ketal conveying component and the ibuprofen zinc conveying component to automatically control the delivery amount of ibuprofen ketal and ibuprofen zinc. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the structure of the utility model;

[0020] Figure 2 It is a partial structural schematic diagram of the mixing chamber, the agitator and the motor in the utility model;

[0021] Figure 3 It is a partial structural schematic diagram of the stirring chamber, the stirrer, the motor, the preheating coil, the preheating medium inlet pipe and the preheating medium outlet pipe in the utility model;

[0022] Figure 4 This is a schematic diagram of the structure of the removal and rearrangement reactor of the utility model;

[0023] Figure 5 It is a schematic diagram of the structure of the heat exchange coil unit, the inlet pipe and the outlet pipe in the utility model;

[0024] In the figure:

[0025] 1. Rearrangement reactor; 101. Reaction chamber; 102. Heat medium inlet pipe; 103. Heat medium outlet pipe; 2. Material mixer; 201. Stirring chamber; 202. Preheating medium inlet pipe; 203. Preheating medium outlet pipe; 3. Preheating coil; 4. Agitator; 5. Ketal conveying assembly; 6. Ibuprofen zinc conveying assembly; 7. Control unit; 8. Heat exchange coil group; 9. Inlet pipe; 10. Outlet pipe; 11. Motor. DETAILED DESCRIPTION

[0026] The present invention will be specifically described and illustrated below in conjunction with the embodiments.

[0027] Example 1

[0028] like Figure 1-5As shown, the ingredient mixing pre-reaction device for preparing ibuprofen ester described in the utility model comprises a rearrangement reactor 1, one end of the rearrangement reactor 1 is connected to a material mixer 2, a preheating coil 3 and a stirrer 4 are arranged inside the material mixer 2, an end of the material mixer 2 away from the rearrangement reactor 1 is connected to a ketal conveying component 5 and an ibuprofen zinc conveying component 6, one side of the ketal conveying component 5 and one side of the ibuprofen zinc conveying component 6 are arranged with a control unit 7, a heat exchange coil group 8 is arranged inside the rearrangement reactor 1, the heat exchange coil group 8 comprises four heat exchange coils, one end of the four heat exchange coils is commonly connected to an inlet pipe 9, and the other end of the four heat exchange coils is commonly connected to an outlet pipe 10.

[0029] The material mixer 2 comprises a stirring chamber 201 . The stirring chamber 201 is cylindrical in shape as a whole, and the stirrer 4 is cooperatively arranged on the central axis of the stirring chamber 201 .

[0030] One end of the agitator 4 passes through the material mixer 2 and is connected to a motor 11 .

[0031] The preheating coil 3 cooperates with the stirrer 4 and is arranged in a surrounding manner inside the stirring chamber 201 .

[0032] One end of the preheating coil 3 is connected to a preheating medium inlet pipe 202 , and the other end of the preheating coil 3 is connected to a preheating medium outlet pipe 203 . Both the preheating medium inlet pipe 202 and the preheating medium outlet pipe 203 are arranged through the side wall of the stirring chamber 201 .

[0033] The rearrangement reactor 1 comprises a reaction chamber 101 . The reaction chamber 101 is cylindrical in shape as a whole. Four heat exchange coils are arranged in the reaction chamber 101 around the central axis of the reaction chamber 101 .

[0034] The reaction chamber 101 is provided with a heat medium inlet pipe 102 and a heat medium outlet pipe 103 .

[0035] One end of the inlet pipe 9 away from the heat exchange coil group 8 is connected to the material mixer 2, and one end of the outlet pipe 10 away from the heat exchange coil group 8 penetrates the rearrangement reactor 1 and extends outward.

[0036] The ketal delivery component 5 is provided with a ketal metering device and a ketal delivery pump, and the ibuprofen zinc delivery component 6 is provided with an ibuprofen zinc metering device and an ibuprofen zinc delivery pump.

[0037] The ketal metering device, the ketal delivery pump, the ibuprofen zinc metering device and the ibuprofen zinc delivery pump are all electrically connected to the control unit 7 .

[0038] Working process and principle:

[0039] 1. Material transportation and proportioning

[0040] The control unit 7 sends instructions to the ketal conveying component 5 and the ibuprofen zinc conveying component 6. The ketal metering device in the ketal conveying component 5 meters the ibuprofen ketal, and the ketal conveying pump conveys the measured ibuprofen ketal to the material mixer 2. The ibuprofen zinc metering device in the ibuprofen zinc conveying component 6 meters the ibuprofen zinc, and the ibuprofen zinc conveying pump conveys the measured ibuprofen zinc to the material mixer 2.

[0041] 2. Pre-treatment of rearrangement reaction

[0042] The ibuprofen ketal and ibuprofen zinc entering the material mixer 2 are mixed in the stirring chamber 201 , and the motor 11 drives the stirrer 4 to rotate, so that the ibuprofen ketal and ibuprofen zinc are quickly dispersed and fully mixed to form a mixed material.

[0043] The preheating medium enters the preheating coil 3 through the preheating medium inlet pipe 202, and the preheating medium flows in the preheating coil 3, transferring heat to the mixed material to preheat the mixed material. When the temperature of the preheated mixed material rises to 140-150°C, the rearrangement reaction starts.

[0044] In the early stage of the rearrangement reaction, the reaction will release heat violently. The continuous stirring action of the stirrer 4 allows the heat released by the rearrangement reaction to be evenly transferred to the entire mixed material to avoid local overheating.

[0045] 3. Post-processing of rearrangement reaction

[0046] As the rearrangement reaction proceeds to the later stage, the heat release of the rearrangement reaction decreases and tends to be stable. At this time, the mixed material enters the heat exchange coil group 8 inside the rearrangement reactor 1 through the inlet pipe 9, and the heat medium enters the reaction chamber 101 through the heat medium inlet pipe 102, and cooperates with the heat exchange coil group 8 to control the temperature in the reaction chamber 101 between 120 and 130° C., so that the temperature of the mixed material remains stable, thereby improving the conversion rate and purity of ibuprofen ester.

[0047] After the rearrangement reaction is completed, the reaction product in the heat exchange coil group 8 flows out of the rearrangement reactor 1 through the outlet pipe 10 and enters the next process to finally obtain the ibuprofen raw material.

Claims

1. A pre-reaction device for mixing ingredients for preparing ibuprofen ester, comprising a rearrangement reactor (1), characterized in that: One end of the rearrangement reactor (1) is connected to a material mixer (2), a preheating coil (3) and a stirrer (4) are arranged in the material mixer (2), an end of the material mixer (2) away from the rearrangement reactor (1) is connected to a ketal conveying assembly (5) and an ibuprofen zinc conveying assembly (6), one side of the ketal conveying assembly (5) and one side of the ibuprofen zinc conveying assembly (6) are arranged with a control unit (7), a heat exchange coil group (8) is arranged in the rearrangement reactor (1), the heat exchange coil group (8) comprises four heat exchange coils, one end of the four heat exchange coils is commonly connected to an inlet pipe (9), and the other end of the four heat exchange coils is commonly connected to an outlet pipe (10).

2. The pre-reaction device for mixing ingredients for preparing ibuprofen ester according to claim 1, characterized in that: The material mixer (2) comprises a stirring chamber (201), the stirring chamber (201) being arranged in a cylindrical shape as a whole, and the stirrer (4) being arranged on the central axis of the stirring chamber (201).

3. The pre-reaction device for mixing ingredients for preparing ibuprofen ester according to claim 2, characterized in that: One end of the agitator (4) passes through the material mixer (2) and is connected to a motor (11).

4. The pre-reaction device for mixing ingredients for preparing ibuprofen ester according to claim 2, characterized in that: The preheating coil (3) cooperates with the stirrer (4) and is disposed in a surrounding manner inside the stirring chamber (201).

5. The pre-reaction device for mixing ingredients for preparing ibuprofen ester according to claim 4, characterized in that: One end of the preheating coil (3) is connected to a preheating medium inlet pipe (202), and the other end of the preheating coil (3) is connected to a preheating medium outlet pipe (203). Both the preheating medium inlet pipe (202) and the preheating medium outlet pipe (203) are arranged through the side wall of the stirring chamber (201).

6. The ingredient mixing pre-reaction device for preparing ibuprofen ester according to claim 1, characterized in that: The rearrangement reactor (1) comprises a reaction chamber (101), the reaction chamber (101) being arranged in a cylindrical shape as a whole, and four heat exchange coils being arranged in the reaction chamber (101) in a surrounding manner in accordance with the central axis of the reaction chamber (101).

7. The pre-reaction device for mixing ingredients for preparing ibuprofen ester according to claim 6, characterized in that: The reaction chamber (101) is provided with a heat medium inlet pipe (102) and a heat medium outlet pipe (103).

8. The pre-reaction device for mixing ingredients for preparing ibuprofen ester according to claim 6, characterized in that: One end of the inlet pipe (9) away from the heat exchange coil group (8) is connected to the material mixer (2), and one end of the outlet pipe (10) away from the heat exchange coil group (8) penetrates the rearrangement reactor (1) and extends outward.

9. The ingredient mixing pre-reaction device for preparing ibuprofen ester according to claim 1, characterized in that: The ketal delivery component (5) is provided with a ketal metering device and a ketal delivery pump, and the ibuprofen zinc delivery component (6) is provided with an ibuprofen zinc metering device and an ibuprofen zinc delivery pump.

10. The ingredient mixing pre-reaction device for preparing ibuprofen ester according to claim 9, characterized in that: The ketal metering device, the ketal delivery pump, the ibuprofen zinc metering device and the ibuprofen zinc delivery pump are all electrically connected to the control unit (7).

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