Biological chromosome telomere DNA length detection device

Abstract

The utility model provides a biological chromosome telomere DNA length detection device, which relates to the technical field of medical equipment, and comprises a water bath tub main body, the rear end of the water bath tub main body is provided with a mobile detection assembly, the mobile detection assembly comprises a fixed block and sliding chutes, the outer surfaces of the front and rear ends of the fixed block are provided with the sliding chutes, and the fixed block is provided with the sliding chutes. And a one-way screw rod is inserted into the fixed block. According to the biological chromosome telomere DNA length detection device, when length detection needs to be carried out on biological chromosome telomere DNA, the motor can be started firstly to drive the one-way screw rod to rotate, the one-way screw rod drives the movable frame to move through thread rotation, and when the movable frame moves to a proper position, the motor is started; the electric push rod is started to drive the biological chromosome telomere DNA to extend into the water bath tub main body to carry out water bath on the biological chromosome telomere DNA, and then the EP tube after water bath treatment is detected by the luminoscope to obtain the accurate length of the biological chromosome telomere DNA, so that the stability of the moving frame during moving can be effectively improved through the transmission mode.

Description

Technical Field

[0001] The utility model relates to the technical field of medical equipment, in particular to a biological chromosome telomere DNA length detection device. Background Art

[0002] Telomeres are a small piece of special telomeric DNA present at the end of eukaryotic cell chromosomes. Their main function is to stabilize the chromosome end structure, prevent chromosome end connection, protect chromosome ends from fusion and degeneration, maintain chromosome integrity and control the cell division cycle. They play an important role in controlling cell growth and lifespan.

[0003] As disclosed in publication number CN206828550U, a device for detecting the length of telomere DNA of biological chromosomes relates to the field of medical equipment, and comprises a mechanical arm, a drain frame, a moving device, two bathtubs and a reaction cylinder which are distributed in a straight line, wherein heating resistors and drain valves are arranged in the two bathtubs and the reaction cylinder, and the moving device is located on the same side of the two bathtubs and the reaction cylinder, and the moving device comprises a fixed horizontal guide rail, a workbench slidably connected to the horizontal guide rail, a vertical guide rail connected to the upper part of the workbench, and a lifting platform slidably connected to the vertical guide rail, wherein both the horizontal guide rail and the vertical guide rail are provided with racks, the workbench is provided with a first stepper motor, the first stepper motor is connected with a gear meshing with the rack on the horizontal guide rail, the lifting platform is provided with a second stepper motor, the second stepper motor is connected with a gear meshing with the rack on the vertical guide rail, and the two ends of the mechanical arm are respectively connected with the lifting platform and the drain frame; the utility model can detect the length of telomere DNA without manual operation.

[0004] This patent can detect the length of telomere DNA without manual operation, but the existing device causes the moving frame to shake when it moves by rotating the gears, which in turn affects the detection of telomere DNA length. Therefore, we propose a new type of biological chromosome telomere DNA length detection device. Utility Model Content

[0005] The utility model aims to solve the problem that the existing device in the prior art drives the moving frame to move by rotating the gears, which causes the moving frame to shake, thereby affecting the detection of telomere DNA length.

[0006] In order to achieve the above-mentioned purpose, the utility model adopts the following technical scheme: a biological chromosome telomere DNA length detection device, comprising a water bathtub main body, a mobile detection component is arranged at the rear end of the water bathtub main body, the mobile detection component comprises a fixed block and a slide groove, the front and rear end outer surfaces of the fixed block are both provided with slide grooves, a one-way screw is inserted into the interior of the fixed block, a bearing is arranged at one end of the one-way screw, the other end of the one-way screw is connected to the output end of a motor, a moving block is arranged on the surface of the one-way screw, a threaded hole is arranged inside the moving block, a moving frame is fixedly connected to the top of the moving block, a slider is connected to the front and rear end surfaces of the moving frame, a connecting rod is connected to the top of the moving frame, an electric push rod is connected to the bottom surface of one side of the connecting rod, the output end of the electric push rod is connected to a leakage frame, and the interior of the leakage frame is slidably connected to a PCR base.

[0007] Furthermore, the motor is electrically connected to an external power source via a control switch, and the motor is fixedly connected to the one-way screw after penetrating the fixed block.

[0008] Furthermore, the one-way screw is rotationally connected to the bearing through the fixed block, and the one-way screw is threadedly connected to the moving block through the threaded hole.

[0009] Furthermore, the slider has a U-shape, and a sliding connection is formed between the slider and the slide groove.

[0010] Furthermore, a moving assembly is provided at the bottom of the bathtub body, and the moving assembly includes universal wheels and connecting blocks. Four groups of universal wheels are respectively connected to the four corners of the bottom of the bathtub body, and one side of each group of universal wheels is connected to a connecting block.

[0011] Furthermore, a threaded groove is provided inside the connection block, a threaded rod is provided inside the threaded groove, and a handle is connected to the top of the threaded rod.

[0012] Furthermore, a round block is connected to the bottom of the threaded rod, a suction cup is connected to the bottom of the round block, and the threaded rod is threadedly connected to the connecting block via a thread groove.

[0013] Compared with the prior art, the advantages and positive effects of the utility model are:

[0014] 1. In the utility model, when it is necessary to detect the length of the biological chromosome telomere DNA, the motor can be turned on first to drive the one-way screw to rotate, and the one-way screw can be made to drive the moving frame to move through the rotation of the thread. When it moves to a suitable position, the electric push rod is turned on to drive the biological chromosome telomere DNA to extend into the water bathtub body to bathe the biological chromosome telomere DNA. After that, the EP tube treated with the water bath is tested by a fluorescence instrument to obtain the accurate length of the biological chromosome telomere DNA. This transmission method can effectively provide stability when the moving frame moves.

[0015] 2. In the utility model, when the bathtub body needs to be moved, it can be pushed by the universal wheel. After the bathtub body is pushed to the designated ground, the handle can be turned to drive the suction cup to move downward through the threaded rod, so that the suction cup is adsorbed on the ground and plays a fixing role. This avoids the problem that the existing bathtub body is large in size and inconvenient to move. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 The utility model provides a three-dimensional structural schematic diagram of a biological chromosome telomere DNA length detection device;

[0017] Figure 2 This is a schematic diagram of the three-dimensional structure from another angle of a biological chromosome telomere DNA length detection device proposed by the utility model;

[0018] Figure 3 The utility model provides a schematic diagram of the explosion structure of a biological chromosome telomere DNA length detection device;

[0019] Figure 4 for Figure 3 The enlarged structural diagram at A in the middle;

[0020] Figure 5 The utility model provides a schematic diagram of the explosion structure of a connecting block of a biological chromosome telomere DNA length detection device.

[0021] Legend: 1. Bathtub body; 2. Mobile detection component; 201. Fixed block; 202. Slide; 203. One-way screw; 204. Bearing; 205. Motor; 206. Threaded hole; 207. Slider; 208. Mobile frame; 209. Connecting rod; 210. Electric push rod; 211. Leakage frame; 212. PCR base; 213. Mobile block; 3. Mobile component; 301. Universal wheel; 302. Connecting block; 303. Threaded groove; 304. Threaded rod; 305. Handle; 306. Round block; 307. Suction cup. DETAILED DESCRIPTION

[0022] In order to more clearly understand the above-mentioned purpose, features and advantages of the utility model, the utility model is further described below in conjunction with the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features in the embodiments can be combined with each other without conflict.

[0023] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments of the following disclosure.

[0024] Embodiment 1, as Figure 1-Figure 4 As shown, the utility model provides a biological chromosome telomere DNA length detection device, including a water bathtub body 1, a mobile detection component 2 is arranged at the rear end of the water bathtub body 1, and the mobile detection component 2 includes a fixed block 201 and a slide groove 202. The front and rear end outer surfaces of the fixed block 201 are both provided with the slide groove 202. A one-way screw 203 is inserted into the interior of the fixed block 201, a bearing 204 is arranged at one end of the one-way screw 203, and the other end of the one-way screw 203 is connected to the output end of a motor 205. A moving block 213 is arranged on the surface of the one-way screw 203, a threaded hole 206 is arranged in the interior of the moving block 213, and a moving frame 208 is fixedly connected to the top of the moving block 213, and the front and rear end surfaces of the moving frame 208 are both A slider 207 is connected, a connecting rod 209 is connected to the top of the movable frame 208, an electric push rod 210 is connected to the bottom surface of one side of the connecting rod 209, an output end of the electric push rod 210 is connected to a leak frame 211, the inside of the leak frame 211 is slidably connected to a PCR base 212, the motor 205 is electrically connected to an external power supply through a control switch, the motor 205 passes through the fixed block 201 and is fixedly connected to the one-way screw 203, the one-way screw 203 is rotatably connected to the bearing 204 through the fixed block 201, the one-way screw 203 is threadedly connected to the movable block 213 through the threaded hole 206, the slider 207 is "U"-shaped, and a sliding connection is formed between the slider 207 and the slide groove 202.

[0025] The effect achieved by the entire embodiment 1 is that when it is necessary to detect the length of the biological chromosome telomere DNA, water is first injected into the water bathtub body, and then the heating resistance wire is turned on. The water temperature in the three tanks can be measured by a thermometer or a temperature gun or other temperature measuring equipment. When the water temperature in the three tanks reaches the required temperature, the heating resistance wire is turned off. At this time, the EP tube of the biological chromosome telomere DNA to be detected can be inserted into the hole on the PCR base 212. The biological chromosome telomere DNA is marked with a fluorescent probe in advance, and then the PCR base 212 is slidably installed in the leakage frame 211. At this time, the forward function of the motor 205 can be turned on by the control switch, so that the motor 205 can drive the one-way screw rod 203 to rotate forward through the output end, and while the one-way screw rod 203 rotates forward, it will also rotate forward with the moving block 213 through the threaded hole 206, and the one-way screw rod 203 drives the moving frame 208 to move inward through the threaded rotation. While the moving frame 208 moves, it will also drive the slider 207 in the slide groove 2 02, when the moving frame 208 moves to a suitable position, the motor 205 can be turned off, and the electric push rod 210 can be turned on by the control switch at this time, so that the electric push rod 210 can push the PCR base 212 to extend into the water bathtub body 1 to perform water bathing on the biological chromosome telomere DNA. After the water bathing, the electric push rod 210 can be turned on to draw the PCR base 212 out of the water bathtub body 1, and the reverse rotation function of the motor 205 can be turned on, so that the motor 205 drives the one-way screw 203 to rotate in the opposite direction, and drives the moving frame 208 to move outward through the moving block 213, and then the EP tube can be drawn out of the PCR base 212, and the EP tube treated with the water bath can be detected by the fluorescence instrument. After processing the data of the fluorescence detection device, the accurate biological chromosome telomere DNA length can be obtained. The method of driving the moving frame 208 to move by the motor 205 can effectively improve the stability during movement, thereby improving the accuracy of the detection of the biological chromosome telomere DNA length.

[0026] Embodiment 2, as Figure 1 , Figure 2 and Figure 5 As shown, a moving assembly 3 is provided at the bottom of the bathtub body 1, and the moving assembly 3 includes universal wheels 301 and a connecting block 302. Four sets of universal wheels 301 are respectively connected to the four corners of the bottom of the bathtub body 1, and one side of each set of universal wheels 301 is connected to a connecting block 302. A threaded groove 303 is provided inside the connecting block 302, and a threaded rod 304 is provided inside the threaded groove 303. A handle 305 is connected to the top of the threaded rod 304, a round block 306 is connected to the bottom of the threaded rod 304, and a suction cup 307 is connected to the bottom of the round block 306. The threaded rod 304 is threadedly connected to the connecting block 302 through the threaded groove 303.

[0027] The effect achieved by the entire embodiment 2 is that when the water bathtub body 1 needs to be pushed to move, it can be pushed directly by the universal wheel 301. When the water bathtub body 1 is pushed to the designated location, the threaded rod 304 can be driven to rotate forward by rotating the handle 305 forward, so that the threaded rod 304 can be threadedly rotated with the connecting block 302 through the thread groove 303, and the suction cup 307 is driven to move downward, so that the suction cup 307 is adsorbed on the ground and plays a fixing role. When the water bathtub body 1 needs to be moved, the handle 305 can be rotated in the opposite direction. In this way, the problem that the existing water bathtub body 1 is large in size and inconvenient to move is avoided, and the overall practicality is improved.

[0028] Working principle: when it is necessary to detect the length of biological chromosome telomere DNA, the motor 205 can be turned on first to drive the one-way screw 203 to rotate, and the one-way screw 203 can drive the moving frame 208 to move through the rotation of the thread. When it moves to the appropriate position, the electric push rod 210 is turned on to drive the biological chromosome telomere DNA to extend into the water bathtub body 1 to bathe the biological chromosome telomere DNA. After that, the EP tube treated with the water bath is tested by a fluorescence instrument to obtain the accurate length of the biological chromosome telomere DNA. This transmission method can effectively provide stability when the moving frame 208 moves. When it is necessary to push the water bathtub body 1 to move, it can be pushed by the universal wheel 301. After the water bathtub body 1 is pushed to the specified ground, the handle 305 can be turned to drive the suction cup 307 to move downward through the threaded rod 304, so that the suction cup 307 is adsorbed on the ground to play a fixing role, thereby avoiding the problem that the existing water bathtub body 1 is large in size and inconvenient to move.

[0029] The above are only preferred embodiments of the present invention and are not intended to limit the present invention in other forms. Any technician familiar with the profession may use the technical contents disclosed above to change or modify them into equivalent embodiments with equivalent changes and apply them to other fields. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A biological chromosome telomere DNA length detection device, comprising a water bathtub body (1), characterized in that: A movement detection component (2) is provided at the rear end of the bathtub body (1); The movement detection component (2) comprises a fixed block (201) and a slide groove (202); the front and rear end outer surfaces of the fixed block (201) are both provided with slide grooves (202); a one-way screw (203) is inserted into the interior of the fixed block (201); a bearing (204) is provided at one end of the one-way screw (203); the other end of the one-way screw (203) is connected to the output end of a motor (205); a moving block (213) is provided on the surface of the one-way screw (203); A threaded hole (206) is provided inside, the top of the moving block (213) is fixedly connected to a moving frame (208), the front and rear end surfaces of the moving frame (208) are both connected to sliders (207), the top of the moving frame (208) is connected to a connecting rod (209), the bottom surface of one side of the connecting rod (209) is connected to an electric push rod (210), the output end of the electric push rod (210) is connected to a leakage frame (211), and the inside of the leakage frame (211) is slidably connected to a PCR base (212).

2. The biological chromosome telomere DNA length detection device according to claim 1, characterized in that: The motor (205) is electrically connected to an external power source via a control switch, and the motor (205) passes through the fixed block (201) to form a fixed connection with the one-way screw rod (203).

3. The biological chromosome telomere DNA length detection device according to claim 2, characterized in that: The one-way screw (203) is rotationally connected to the bearing (204) via the fixed block (201), and the one-way screw (203) is threadedly connected to the moving block (213) via the threaded hole (206).

4. The biological chromosome telomere DNA length detection device according to claim 3, characterized in that: The sliding block (207) has a "U" shape, and a sliding connection is formed between the sliding block (207) and the sliding groove (202).

5. The biological chromosome telomere DNA length detection device according to claim 1, characterized in that: A moving assembly (3) is provided at the bottom of the water bathtub body (1), and the moving assembly (3) comprises universal wheels (301) and connecting blocks (302). Four groups of universal wheels (301) are respectively connected to the four corners of the bottom of the water bathtub body (1), and one side of each group of universal wheels (301) is connected to a connecting block (302).

6. The biological chromosome telomere DNA length detection device according to claim 5, characterized in that: A threaded groove (303) is provided inside the connection block (302), a threaded rod (304) is provided inside the threaded groove (303), and a handle (305) is connected to the top of the threaded rod (304).

7. The biological chromosome telomere DNA length detection device according to claim 6, characterized in that: The bottom of the threaded rod (304) is connected to a round block (306), the bottom of the round block (306) is connected to a suction cup (307), and the threaded rod (304) is threadedly connected to the connecting block (302) via the thread groove (303).

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